| Budget Amount *help |
¥43,940,000 (Direct Cost: ¥33,800,000、Indirect Cost: ¥10,140,000)
Fiscal Year 2021: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
Fiscal Year 2020: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2019: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2018: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
|
|---|
| Outline of Final Research Achievements |
Here, we have clarified a new electron transfer pathway in which ERdj5 receives the electrons from the oxidase Ero1 and utilizes them for reductase activity. Furthermore, we found that the deprivation of electrons from Ero1 reduces the amount of hydrogen peroxide produced in the ER lumen. In addition, the reductase ERp18 usually exists as a dimer and functions as a reductase, but it has been shown that when it forms oligomers depending on the binding of zinc ions, it has catalase-like activity. Finally, we showed that the hydrogen peroxide scavenging mechanisms of ERdj5 and ERp18 play an essential role in maintaining redox homeostasis in the ER.
|
