| Budget Amount *help |
¥43,550,000 (Direct Cost: ¥33,500,000、Indirect Cost: ¥10,050,000)
Fiscal Year 2022: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2021: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2020: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2019: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2018: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
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| Outline of Final Research Achievements |
We tested the hypothesis that the metastable state of the gene expression regulatory network led to the evolution of novel cell types, as well as the hypothesis that its flexibility was the driving force behind the evolution of novel cell types. Theoretical studies revealed that the distribution of inputs and outputs of gene expression regulation plays an important role in network stability. Our results of the evolutionary mechanism of the sea urchin Pmar1/HesC dual repression mechanism also provided insight into the mechanism by which modifications of early developmental processes can be achieved without disrupting development. Finally, we also revealed distinct individual differences in gene expression during sea urchin development, providing clear evidence for the flexibility of the gene expression regulatory network.
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