Epigenetic regulation of developmental synapse elimination

• Project/Area Number: 18H04012
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Medium-sized Section 46:Neuroscience and related fields
• Research Institution: The University of Tokyo
• Principal Investigator: Kano Masanobu 東京大学, 大学院医学系研究科(医学部), 教授 (40185963)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥44,720,000 (Direct Cost: ¥34,400,000、Indirect Cost: ¥10,320,000); Fiscal Year 2020: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000); Fiscal Year 2019: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000); Fiscal Year 2018: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
• Keywords: シナプス刈り込み / 生後発達 / 小脳 / プルキンエ細胞 / 登上線維 / エピジェネティクス / 遺伝子発現 / マウス

Outline of Final Research Achievements

Synapse pruning in the developing nervous system is widely thought to be crucial for shaping mature neural circuits, which enables animals to adapt their environments. It is not well understood how neural activity triggers synapse pruning and induces persistent changes in neural circuits through gene expression. In this study, we pursued the mechanisms of synapse pruning in the mouse cerebellum during postnatal development and identified several epigenetic factors and transcription factors that are involved in synapse pruning.

Academic Significance and Societal Importance of the Research Achievements

シナプス刈り込みは、大脳皮質を含めた生後発達期の神経系で普遍的にみられる現象であり、正常な脳機能の発達に必須である。したがって、そのメカニズムの解明は、脳機能の発達の仕組みを理解するうえで極めて重要である。さらに、生後発達期のシナプス刈り込みの障害が自閉スペクトラム症の、また、思春期における過剰なシナプス刈り込みが統合失調症の発症に関連すると広く考えられており、これらの病態解明や治療法開発の点からも極めて重要である。シナプス刈り込みに関わることが知られている因子の中に精神神経疾患の関連遺伝子が含まれていることからも、その重要性が示唆される。

Research Products

• [Int'l Joint Research] TUM School of Medicine(ドイツ)
• [Journal Article] Calcium imaging of adult-born neurons in freely moving mice (2021)
  • Author(s): Carrier-Ruiz Alvaro、Sugaya Yuki、Kumar Deependra、Vergara Pablo、Koyanagi Iyo、Srinivasan Sakthivel、Naoi Toshie、Kano Masanobu、Sakaguchi Masanori
  • Journal Title: STAR Protocols Volume: 2 Issue: 1 Pages: 100238-100238
  • DOI: 10.1016/j.xpro.2020.100238
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Tonic GABAergic inhibition is essential for nerve injury-induced afferent remodeling in the somatosensory thalamus and associated ectopic sensations (2020)
  • Author(s): Nagumo Y, Ueta Y, Nakayama H, Osaki H, Takeuchi Y, Uesaka N, Kano M, Miyata M
  • Journal Title: Cell Rep Volume: 31 Issue: 12 Pages: 107797-107797
  • DOI: 10.1016/j.celrep.2020.107797
  • Peer Reviewed / Open Access
• [Journal Article] Sparse activity of hippocampal adult-born neurons during REM sleep is necessary for memory consolidation (2020)
  • Author(s): Kumar D, Koyanagi I, Carrier-Ruiz A, Vergara P, Srinivasan S, Sugaya Y, Kasuya M, Yu TS, Vogt K, Muratani M, Ohnishi T, Singh S, Teixeira CM, Cherasse Y, Naoi T, Wang Y, Nondhalee P, Osman BAH, Kaneko N, Sawamoto K, Kernie SG, Sakurai T, McHugh TJ, Kano M, Yanagisawa M, Sakaguchi M
  • Journal Title: Neuron Volume: 107 Issue: 3 Pages: 1-14
  • DOI: 10.1016/j.neuron.2020.05.008
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A recurrent PJA1 variant in trigonocephaly and neurodevelopmental disorders. (2020)
  • Author(s): Suzuki Toshimitsu、Suzuki Toshifumi、Raveau Matthieu、Miyake Noriko、Sudo Genki、Tsurusaki Yoshinori、Watanabe Takaki、Sugaya Yuki、.....Kano Masanobu、Shimoji Takeyoshi、Matsumoto Naomichi、Yamakawa Kazuhiro
  • Journal Title: Annals of Clinical and Translational Neurology Volume: 7 Issue: 7 Pages: 1117-1131
  • DOI: 10.1002/acn3.51093
  • Peer Reviewed / Open Access
• [Journal Article] Traceable stimulus-dependent rapid molecular changes in dendritic spines in the brain (2020)
  • Author(s): Kuboyama Kazuya、Inoue Takafumi、Hashimotodani Yuki、Itoh Takuya、Suzuki Tohsuke、Tetsuzawa Aya、Ohtsuka Yosuke、Kinoshita Ryo、Takara Ren、Miyazawa Tohru、Gusain Pooja、Kano Masanobu、Yamada Maki K.
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 15266-15266
  • DOI: 10.1038/s41598-020-72248-4
  • Peer Reviewed / Open Access
• [Journal Article] Setd1a Insufficiency in Mice Attenuates Excitatory Synaptic Function and Recapitulates Schizophrenia-Related Behavioral Abnormalities (2020)
  • Author(s): Nagahama Kenichiro、Sakoori Kazuto、Watanabe Takaki、Kishi Yusuke、Kawaji Keita、Koebis Michinori、Nakao Kazuki、Gotoh Yukiko、Aiba Atsu、Uesaka Naofumi、Kano Masanobu
  • Journal Title: Cell Reports Volume: 32 Issue: 11 Pages: 108126-108126
  • DOI: 10.1016/j.celrep.2020.108126
  • Peer Reviewed / Open Access
• [Journal Article] Autism spectrum disorder-like behavior caused by reduced excitatory synaptic transmission in pyramidal neurons of mouse prefrontal cortex. (2020)
  • Author(s): Sacai Hiroaki、Sakoori Kazuto、Konno Kohtarou、Nagahama Kenichiro、Suzuki Honoka、Watanabe Takaki、Watanabe Masahiko、Uesaka Naofumi、Kano Masanobu
  • Journal Title: Nature Communications Volume: 11 Issue: 1 Pages: 5140-5140
  • DOI: 10.1038/s41467-020-18861-3
  • Peer Reviewed / Open Access
• [Journal Article] Improved hyperacuity estimation of spike timing from calcium imaging (2020)
  • Author(s): Hoang Huu、Sato Masa-aki、Shinomoto Shigeru、Tsutsumi Shinichiro、Hashizume Miki、Ishikawa Tomoe、Kano Masanobu、Ikegaya Yuji、Kitamura Kazuo、Kawato Mitsuo、Toyama Keisuke
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 17844-17844
  • DOI: 10.1038/s41598-020-74672-y
  • Peer Reviewed / Open Access
• [Journal Article] AUTS2 Governs Cerebellar Development, Purkinje Cell Maturation, Motor Function and Social Communication (2020)
  • Author(s): Yamashiro Kunihiko、Hori Kei、Lai Esther S.K.、Aoki Ryo、Shimaoka Kazumi、Arimura Nariko、Egusa Saki F.、Sakamoto Asami、Abe Manabu、Sakimura Kenji、Watanabe Takaki、Uesaka Naofumi、Kano Masanobu、Hoshino Mikio
  • Journal Title: iScience Volume: 23 Issue: 12 Pages: 101820-101820
  • DOI: 10.1016/j.isci.2020.101820
  • NAID: 120006979860
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Phospholipase C β3 is required for climbing fiber synapse elimination in aldolase C-positive compartments of the developing mouse cerebellum (2020)
  • Author(s): Rai Yurie、Watanabe Takaki、Matsuyama Kyoko、Sakimura Kenji、Uesaka Naofumi、Kano Masanobu
  • Journal Title: Neuroscience Volume: 462 Pages: 36-43
  • DOI: 10.1016/j.neuroscience.2020.04.035
  • Peer Reviewed / Open Access
• [Journal Article] G Protein-Coupled Glutamate and GABA Receptors Form Complexes and Mutually Modulate Their Signals (2020)
  • Author(s): Sakairi Hakushun、Kamikubo Yuji、Abe Masayoshi、Ikeda Keisuke、Ichiki Arata、Tabata Toshihide、Kano Masanobu、Sakurai Takashi
  • Journal Title: ACS Chemical Neuroscience Volume: 11 Issue: 4 Pages: 567-578
  • DOI: 10.1021/acschemneuro.9b00599
  • Peer Reviewed / Open Access
• [Journal Article] Comprehensive analysis of a novel mouse model of the 22q11.2 deletion syndrome: a model with the most common 3.0-Mb deletion at the human 22q11.2 locus (2020)
  • Author(s): Saito Ryo、Koebis Michinori、Nagai Taku、Shimizu Kimiko、Liao Jingzhu、Wulaer Bolati、Sugaya Yuki、Nagahama Kenichiro、Uesaka Naofumi、Kushima Itaru、Mori Daisuke、Maruyama Kazuaki、Nakao Kazuki、Kurihara Hiroki、Yamada Kiyofumi、Kano Masanobu、Fukada Yoshitaka、Ozaki Norio、Aiba Atsu
  • Journal Title: Translational Psychiatry Volume: 10 Issue: 1 Pages: 35-35
  • DOI: 10.1038/s41398-020-0723-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A Glial-Neuronal Circuit in the Median Eminence Regulates Thyrotropin-Releasing Hormone-Release via the Endocannabinoid System (2020)
  • Author(s): Farkas Erzsevet、Varga Edina、Kovacs Balazs、....、Watanabe Masahiko、Kano Masanobu、...、Charli Jean-Louis、Joseph-Bravo Patricia、Fekete Csaba
  • Journal Title: iScience Volume: 23 Issue: 3 Pages: 100921-100921
  • DOI: 10.1016/j.isci.2020.100921
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Rational engineering of XCaMPs, a multicolor GECI suite for in vivo imaging of complex brain circuit dynamics. (2019)
  • Author(s): Inoue M, Takeuchi A, Manita S, Horigane S-i, Sakamoto M, Kawakami R, Yamaguchi K, Otomo K, Yokoyama H, Kim R, Yokoyama T, Takemoto-Kimura S, Abe M, Okamura M, Kondo Y, Quirin S, Ramakrishnan C, Imamura T, Sakimura K, Nemoto T, Kano M, Fujii H, Deisseroth K, Kitamura K, Bito H.
  • Journal Title: Cell Volume: 177 Issue: 5 Pages: 1346-1360
  • DOI: 10.1016/j.cell.2019.04.007
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] mGluR1 in cerebellar Purkinje cells is essential for the formation but not expression of associative eyeblink memory (2019)
  • Author(s): Nakao Harumi、Kishimoto Yasushi、Hashimoto Kouichi、Kitamura Kazuo、Yamasaki Miwako、Nakao Kazuki、Watanabe Masahiko、Kano Masanobu、Kirino Yutaka、Aiba Atsu
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 7353-7353
  • DOI: 10.1038/s41598-019-43744-z
  • Peer Reviewed / Open Access
• [Journal Article] Developmental synapse remodeling in the cerebellum and visual thalamus. (2019)
  • Author(s): Kano M, Watanabe T.
  • Journal Title: F1000Research Volume: 8 Pages: 1191-1191
  • DOI: 10.12688/f1000research.18903.1
  • Peer Reviewed / Open Access
• [Journal Article] Monoacylglycerol lipase blockade impairs fine motor coordination and triggers cerebellar neuroinflammation through cyclooxygenase-2 (2019)
  • Author(s): Martinez-Torres Sara、Cutando Laura、Pastor Antoni、Kato Ako、Sakimura Kenji、de la Torre Rafael、Valjent Emmanuel、Maldonado Rafael、Kano Masanobu、Ozaita Andres
  • Journal Title: Brain, Behavior, and Immunity Volume: 81 Pages: 399-409
  • DOI: 10.1016/j.bbi.2019.06.036
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Modular organization of cerebellar climbing fiber inputs during goal-directed behavior. (2019)
  • Author(s): Tsutsumi S, Hidaka N, Isomura Y, Matsuzaki M, Sakimura K, Kano M, Kitamura K.
  • Journal Title: Elife. Volume: 8
  • DOI: 10.7554/elife.47021
  • Peer Reviewed / Open Access
• [Journal Article] Endocannabinoid signaling from 2-arachidonoylglycerol to CB1 cannabinoid receptor facilitates reward-based learning of motor sequence. (2019)
  • Author(s): Tanigami H, Yoneda M, Tabata Y, Echigo R, Kikuchi Y, Yamazaki M, Kishimoto Y, Sakimura K, Kano M, Ohno-Shosaku T
  • Journal Title: Neuroscience Volume: 421 Pages: 1-16
  • DOI: 10.1016/j.neuroscience.2019.09.040
  • Peer Reviewed
• [Journal Article] Hyperactivation of mTORC1 disrupts cellular homeostasis in cerebellar Purkinje cells. (2019)
  • Author(s): Sakai Y, Kassai H, Nakayama H, Fukaya M, Maeda T, Nakao K, Hashimoto K, Sakagami H, Kano M, Aiba A.
  • Journal Title: Scientific Reports Volume: Feb 26;9(1) Issue: 1 Pages: 2799-2799
  • DOI: 10.1038/s41598-019-38730-4
  • Peer Reviewed / Open Access
• [Journal Article] Ectopic positioning of Bergmann glia and impaired cerebellar wiring in Mlc1-over-expressing mice (2018)
  • Author(s): Kikuchihara Saori、Sugio Shouta、Tanaka Kenji F.、Watanabe Takaki、Kano Masanobu、Yamazaki Yoshihiko、Watanabe Masahiko、Ikenaka Kazuhiro
  • Journal Title: Journal of Neurochemistry Volume: 147 Issue: 3 Pages: 344-360
  • DOI: 10.1111/jnc.14486
  • Peer Reviewed
• [Journal Article] Supramammillary nucleus afferents to the dentate gyrus co-release glutamate and GABA and potentiate granule cell output. (2018)
  • Author(s): Hashimotodani Y, Karube F, Yanagawa Y, Fujiyama F, Kano M
  • Journal Title: Cell Reports Volume: 25 Issue: 10 Pages: 2704-2715
  • DOI: 10.1016/j.celrep.2018.11.016
  • Peer Reviewed / Open Access
• [Journal Article] Monoacylglycerol lipase deficiency affects diet‐induced obesity, fat absorption, and feeding behavior in CB1 cannabinoid receptor-deficient mice (2018)
  • Author(s): Yoshida Kenji、Kita Yoshihiro、Tokuoka Suzumi M.、Hamano Fumie、Yamazaki Maya、Sakimura Kenji、Kano Masanobu、Shimizu Takao
  • Journal Title: The FASEB Journal Volume: 33 Issue: 2 Pages: 2484-2497
  • DOI: 10.1096/fj.201801203r
  • Peer Reviewed
• [Journal Article] Control of excessive neural circuit excitability and prevention of epileptic seizures by endocannabinoid signaling (2018)
  • Author(s): Sugaya Yuki, Kano Masanobu
  • Journal Title: Cellular and Molecular Life Sciences Volume: 75 Issue: 15 Pages: 2793-2811
  • DOI: 10.1007/s00018-018-2834-8
  • Peer Reviewed
• [Journal Article] Multiple Phases of Climbing Fiber Synapse Elimination in the Developing Cerebellum (2018)
  • Author(s): Kano Masanobu、Watanabe Takaki、Uesaka Naofumi、Watanabe Masahiko
  • Journal Title: The Cerebellum Volume: 17 Issue: 6 Pages: 722-734
  • DOI: 10.1007/s12311-018-0964-z
  • Peer Reviewed
• [Presentation] Shaping mature neural circuits through synapse pruning (2020)
  • Author(s): Masanobu Kano
  • Organizer: 第43回日本神経科学大会
  • Int'l Joint Research / Invited
• [Presentation] The transcription factor ZFP64 facilitates climbing-fiber synapse elimination along signaling pathway mediated by P/Q-type voltage-dependent Ca2+ channel in the developing cerebellum (2020)
  • Author(s): Jianling Zhang, Takaki Watanabe, Naofumi Uesaka, Masanobu Kano
  • Organizer: 第43回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Protocadherin 10 delays developmental climbing fiber synapse elimination in a subset of aldolase C-positive Purkinje cells in the cerebellum (2020)
  • Author(s): Takaki Watanabe, Kazuto Sakoori, Honoka Suzuki, Tsubasa Akamatsu, Kyoko Matsuyama, Shutaro Inoue, Manabu Abe, Kenji Sakimura, Naofumi Uesaka, Masanobu Kano
  • Organizer: 第43回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Visualizing network level endocannabinoid signaling in the hippocampus (2020)
  • Author(s): Henry Paul Denny, Ao Dong, Kaikai He, Yulong Li, Yuki Sugaya, Masanobu Kano
  • Organizer: 第43回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Protocadherin 10 delays developmental climbing fiber synapse elimination in a subset of aldolase C-positive Purkinje cells in the cerebellum (2020)
  • Author(s): Takaki Watanabe, Honoka Suzuki, Kazuto Sakoori, Shutaro Inoue, Tsubasa Akamatsu, Manabu Abe, Kenji Sakimura, Naofumi Uesaka, Masanobu Kano
  • Organizer: 第97回日本生理学会
  • Int'l Joint Research
• [Presentation] The endocannabinoid 2-arachidonoyl glycerol in dentate granule cells suppresses kainate-induced seizures (2020)
  • Author(s): Yuki Sugaya, Kenji Sakimura, Masanobu Kano
  • Organizer: 第97回日本生理学会
  • Int'l Joint Research
• [Presentation] Cerebellar climbing fiber signals represent voluntary forelimb lever-pull trajectories (2019)
  • Author(s): Naoki Hidaka, Koji Ikezoe, Shinichiro Tsutsumi, Yoshikazu Isomura, Masanobu Kano, Kazuo Kitamura
  • Organizer: 第42回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Loss of the psychiatric disorder-related epigenetic factor reduces excitatory synaptic inputs to pyramidal neurons of the medial prefrontal cortex and causes abnormal behavior in mice (2019)
  • Author(s): Kenichiro Nagahama, Kazuto Sakoori Takaki Watanabe, Michinori Koebis, Naofumi Uesaka, Atsu Aiba, Masanobu Kano
  • Organizer: 第42回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Rational engineering of XCaMPs, a multiclolor GECI suite for in vivo imaging of complex brain circuit dynamics (2019)
  • Author(s): Masatoshi Inoue, Atsuya Takeuchi, Satoshi Manita, ..., Masanobu Kano, Hajime Fujii Deisseroth Karl, Kazuo Kitamura, Haruhiko Bito
  • Organizer: 第42回日本神経科学大会
  • Int'l Joint Research
• [Presentation] AiCE mouse: A novel tool to probe LTP-related change in dendritic spines (2019)
  • Author(s): Kazuya Kuboyama, Takafumi Inoue, Yuki Hashimotodani, Takuya Itoh, Tohsuke Suzuki, Yosuke Ohtuska, Ryo Kinoshita, Pooja Gusain, Masanobu Kano, Shigeo Okabe, Maki K Yamada
  • Organizer: 第42回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Assessment of visual evoked potential in a mouse line with 22q11.2 deletion, a putative mouse model of schizophrenia (2019)
  • Author(s): Ryo Saito, Michinori Koebis, Yuki Sugaya, Masanobu Kano, Atsu Aiba
  • Organizer: 第42回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Climbing fiber synapse elimination in aldolase C-positive Purkinje cells is delayed compared to aldolase C-positive Purkinje cells and requires phospholipase C β3 in the developmental cerebellum (2019)
  • Author(s): Takaki Watanabe, Yurie Rai, Honoka Suzuki, Tsubasa Akamatsu, Naofumi Uesaka, Masanobu Kano
  • Organizer: 第42回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Modulation of dentate granule cell activity during fear memory extinction in freely moving mice (2019)
  • Author(s): Alvaro Carrier Ruiz, Yuki Sugaya, Masanobu Kano
  • Organizer: 第42回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Neural mechanisms of synapse remodeling in the developing brain (2019)
  • Author(s): Masanobu Kano
  • Organizer: The 10th IBRO World Congress of Neuroscience
  • Int'l Joint Research / Invited
• [Presentation] Function of adult-born neurons in maturation of fear memory engram during sleep (2019)
  • Author(s): Masanori Sakaguchi, Iyo Koyanagi, Alvaro Carrier-Ruiz, Pable Vergara, ... Masanobu Kano, Masashi Yanagisawa, Deependra Kumar
  • Organizer: The 10th IBRO World Congress of Neuroscience
  • Int'l Joint Research
• [Presentation] Expression mapping, quantification, and complex formation of GluD1 and GluD2 glutamate receptors in adult mouse brain (2019)
  • Author(s): Kohtarou Konno, Chihiro Nakamoto, Kenji Sakimura, Masanobu Kano, Masahiko Watanabe
  • Organizer: The 10th IBRO World Congress of Neuroscience
  • Int'l Joint Research
• [Presentation] Synapse remodeling in developing Purkinje cells (2019)
  • Author(s): Kano, Masanobu
  • Organizer: Society for Neuroscience
  • Int'l Joint Research
• [Presentation] Cellular and Circuit Mechanisms of Developmental Synapse Pruning in the Cerebellum (2019)
  • Author(s): Kano, Masanobu
  • Organizer: NUS Neuroscience & Technology Symposium
  • Int'l Joint Research / Invited
• [Presentation] Molecular, cellular and circuit mechanisms of activity-dependent synapse elimination in the developing cerebellum (2019)
  • Author(s): Masanobu Kano
  • Organizer: International Symposium: Current Perspectives on Functional and Dysfunctional Neural Circuits
  • Int'l Joint Research / Invited
• [Presentation] Discovery and investigation of cerebellar long-term depression at Masao Ito’s lab (2019)
  • Author(s): Masanobu Kano
  • Organizer: FAOPS2019
  • Int'l Joint Research
• [Presentation] Reduced synaptic inputs in prefrontal cortex by lack of a mental disorder-related epigenetic factor (2019)
  • Author(s): Kenichiro Nagahama, Kazuto Sakoori, Takaki Watanabe, Naofumi Uesaka, Masanobu Kano
  • Organizer: FAOPS2019
  • Int'l Joint Research
• [Presentation] Fndc3b promotes climbing fiber synapse elimination partly by inhibiting STAT3 in the cerebellum (2019)
  • Author(s): Kushibe Kyoko, Celine Mercier, Takaki Watanabe, Taisuke Miyazaki, Miwako Yamasaki, Masahiko Watanabe, Naofumi Uesaka, Masanobu Kano
  • Organizer: FAOPS2019
  • Int'l Joint Research
• [Presentation] Activity-dependent synapse elimination in the developing cerebellum (2019)
  • Author(s): Naofumi Uesaka, Tzu-Huei Kao, Masanobu Kano
  • Organizer: FAOPS2019
  • Int'l Joint Research
• [Presentation] Accelerated climbing fiber synapse elimination in cerebellar Purkinje cells lacking protocadherin 10 (2019)
  • Author(s): Takaki Watanabe, Shutaro Inoue, Tsubasa Akamatsu, Honoka Suzuki, Manabu Abe, Kenji Sakimura, Naofumi Uesaka, Masanobu Kano
  • Organizer: FAOPS2019
  • Int'l Joint Research
• [Presentation] Modulation of dentate granule cell activity during fear memory extinction in freely moving mice (2019)
  • Author(s): Alvaro Carrier Ruiz, Yuki Sugaya, Masanobu Kano
  • Organizer: FAOPS2019
  • Int'l Joint Research
• [Presentation] Neural circuit mechanisms of synapse elimination in the developing cerebellum (2018)
  • Author(s): Masanobu Kano
  • Organizer: The 9th International Symposium of the Society for Research on the Cerebellum and Ataxias
  • Int'l Joint Research / Invited
• [Presentation] Neural circuit mechanisms underlying activity-dependent synapse elimination in the developing cerebellum (2018)
  • Author(s): Masanobu Kano
  • Organizer: 第41回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Retrograde BDNF signaling required for synapse elimination in the developing cerebellum (2018)
  • Author(s): Myeong Jeong Choo, Naofumi Uesaka, Masahiko Watanabe, Kenji Sakimura, Masanobu Kano
  • Organizer: 第41回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Impaired synapse development in mouse medial prefrontal cortex by deletion of a histone-modifying enzyme implicated in psychiatricc disorder (2018)
  • Author(s): Kenichiro Nagahama, Kazuto Sakoori, Takaki Watanabe, Naofumi Uesaka, Masanobu Kano
  • Organizer: 第41回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Roles of synaptic transmission in climbing fiber to Purkinje cell synapse elimination during postnatal cerebellar development (2018)
  • Author(s): Tzu-Huei Kao, Kyoko Matsuyama, Naofumi Uesaka, Masanobu Kano
  • Organizer: 第41回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Dentate granule cell activity druing fear memory extinction in freely moving mice (2018)
  • Author(s): Alvaro Carrier Ruiz, Yuki Sugaya, Masanobu Kano
  • Organizer: 第41回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Near-infrared deep brain stimulation via upconversion nanoparticle-mediated optogenetics (2018)
  • Author(s): Linmeng He, Shuo Chen, Adam Xachary Weitemier, Xiyu Wang, Yanqiu Tao, ... Masanobu Kano, ... Kenji F Tanaka, Thomas J McHugh
  • Organizer: 第41回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Near-infrared deep brain stimulation via upconversion nanoparticle-mediated optogenetics (2018)
  • Author(s): S. Chen, A. Z. Weitemier, X. Zeng, L. He, X. Wwang, Y. Tao, A. Huang, Y. Hashimotodani, M. Kano, H. Iwasaki, L. K. Parajuli, S. Okabe, D. Loong, A. H. All, I. Tsutsui-Kimura, K. F. Tanaka, X. Liu, T. J. Mchugh
  • Organizer: Society for Neuroscience
  • Int'l Joint Research
• [Presentation] Function of the adult-born neurons in memory consolidation during sleep (2018)
  • Author(s): D. Kumar, I. Koyanagi, A. C. Ruiz, P. Vergara, Y. Sugaya, S. Srinivasan, M. Kasuya, T.-S. Yu, K. Vogt, M. Muratani, T. Ohnishi, S. Singh, C. M. Teixeira, P. Nondhalee, T. Naoi, T. J. Mchugh, S. G. Kernie, M. Kano, T. Ssakurai, M. Yanagisawa, M. Sakaguchi
  • Organizer: Society for Neuroscience
  • Int'l Joint Research
• [Presentation] Activity of cerebellar climbing fibers represents forelimb movements during voluntary lever-pull task in mice (2018)
  • Author(s): N. Hidaka, S. Tsutsumi, K. Ikezoe, Y. Isomura, M. Kano, K. Kitamura
  • Organizer: Society for Neuroscience
  • Int'l Joint Research
• [Presentation] Organization of the functional inputs from the sensorimotor cortex to the cerebellum revealed by transcranial optogenetic mapping (2018)
  • Author(s): M. Choo, R. Hira, M. Matsuzaki, K. Ikezoe, G. J. Augustine, M. Kano, K. Kitamura
  • Organizer: Society for Neuroscience
  • Int'l Joint Research
• [Presentation] Mechanisms underlying climbing fiber synapse elimination during postnatal cerebellar development (2018)
  • Author(s): Masanobu Kano
  • Organizer: The 75th FUJIHARA Seminar: Cerebellum as a CNS Hub - from its evolution to therapeutic strategy
  • Int'l Joint Research / Invited