Neural circuit basis of behavioral change induced by social signals

• Project/Area Number: 18H04014
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Medium-sized Section 46:Neuroscience and related fields
• Research Institution: Kyoto University
• Principal Investigator: Watanabe Dai 京都大学, 医学研究科, 教授 (90303817)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥44,720,000 (Direct Cost: ¥34,400,000、Indirect Cost: ¥10,320,000); Fiscal Year 2020: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000); Fiscal Year 2019: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000); Fiscal Year 2018: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
• Keywords: 意思決定 / 社会性 / 音声コミュニケーション / 行動選択 / Ca2+イメージング / ERK活性イメージング / 感覚情報 / 大脳皮質 / 基底核 / 音声 / 聴覚刺激 / イメージング

Outline of Final Research Achievements

To study neural basis of behavioral change induced by social signals such as vocal communication, it is essential to establish technologies that enable measurements of neural functions without affecting natural behaviors. We developed novel endomicroscopy and conducted live cell imaging of neural activity and intracellular ERK activity in a freely behaving subject. We also applied Designer Receptors Exclusively Activated by Designer Drugs (DREADD)-based chemogenetic manipulation of neural activity to behavioral analysis using a touchscreen operant platform, in order to address how the cortico-basal ganglia circuit is involved in cognitive processes for controlling behavior.

Academic Significance and Societal Importance of the Research Achievements

ヒトは集団を形成し社会的に行動する。したがって、ヒトの行動原理の神経基盤を理解するためには、このような社会的認知の側面を踏まえた上で、「意思決定」のプロセスが「脳という生物学的な仕組み」にどのように実装されているか解明することが重要である。本研究により開発された技術を応用することにより、意思決定に関わる神経回路メカニズムを解析するとともに、社会的情報を媒介する音声コミュニケーションのような個体間の情報伝達の神経回路と、意思決定に関わる神経回路の相互作用に関する理解が進むことが期待される。

Research Products

• [Journal Article] MicroRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity. (2021)
  • Author(s): Horie T, Nakao T, Miyasaka Y, Nishino T, Matsumura S, Nakazeki F, Ide Y, Kimura M, Tsuji S, Ruiz Rodriguez R, WatanabeT, Yamasaki T, Xu S, Otani C, Miyagawa S, Matsushita K, Sowa N, Omori A, Tanaka J, Nishimura C, Picciotto MR, Inoue H, Watanabe D, Nakamura K, Sasaki T, Kimura T, Ono K, et al.
  • Journal Title: Nat Commun. Volume: 12 Issue: 1 Pages: 843-843
  • DOI: 10.1038/s41467-021-21107-5
  • NAID: 120006958077
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Chemogenetic Suppression of the Subthalamic Nucleus Induces Attentional Deficits and Impulsive Action in a Five-Choice Serial Reaction Time Task in Mice (2020)
  • Author(s): Nishioka Tadaaki、Hamaguchi Kosuke、Yawata Satoshi、Hikida Takatoshi、Watanabe Dai
  • Journal Title: Frontiers in Systems Neuroscience Volume: 14 Pages: 1-13
  • DOI: 10.3389/fnsys.2020.00038
  • Peer Reviewed / Open Access
• [Journal Article] The potential role of Arhgef33 RhoGEF in foveal development in the zebra finch retina (2020)
  • Author(s): Sugiyama Takefumi、Yamamoto Haruka、Kon Tetsuo、Chaya Taro、Omori Yoshihiro、Suzuki Yutaka、Abe Kentaro、Watanabe Dai、Furukawa Takahisa
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 21450-21450
  • DOI: 10.1038/s41598-020-78452-6
  • NAID: 120006952776
  • Peer Reviewed / Open Access
• [Journal Article] Generation of a MOR‐CreER knock‐in mouse line to study cells and neural circuits involved in mu opioid receptor signaling (2019)
  • Author(s): Okunomiya Taro、Hioki Hiroyuki、Nishimura Chika、Yawata Satoshi、Imayoshi Itaru、Kageyama Ryoichiro、Takahashi Ryosuke、Watanabe Dai
  • Journal Title: genesis Volume: 58 Issue: 1 Pages: 1-10
  • DOI: 10.1002/dvg.23341
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of Deep Learning and Image Processing for Tracking the Cognitive Motion of a Laboratory Mouse (2019)
  • Author(s): Seohyun Lee, Tomohiko Hayakawa, Chika Nishimura, Satoshi Yawata, Hiroki Yagi, Dai Watanabe, Masatoshi Ishikawa
  • Journal Title: 2019 IEEE Biomedical Circuits and Systems Conference (BioCAS) Volume: 19 Pages: 8919239-8919239
  • DOI: 10.1109/biocas.2019.8919239
  • Peer Reviewed
• [Presentation] 実行機能における視床下核の因果的役割 (2019)
  • Author(s): 西岡忠昭、濱口航介、矢和多智、疋田貴俊、渡邉 大
  • Organizer: 日本神経科学大会2019
  • Int'l Joint Research
• [Presentation] 内部モデルに基づいた意思決定とマウス前頭皮質の神経表現 (2019)
  • Author(s): 濱口航介、渡邉 大
  • Organizer: 日本神経科学大会2019
  • Int'l Joint Research
• [Presentation] 新規に作成したノックインマウスMOR-CreERによるmu-オピオイド受容体陽性神経回路の可視化 (2019)
  • Author(s): 奥宮太郎、今吉格、日置寛之、西村知華、矢和多智、影山龍一郎、高橋良輔、渡邉 大
  • Organizer: 日本神経科学大会2019
  • Int'l Joint Research
• [Remarks]
  • URL: https://www.phy.med.kyoto-u.ac.jp/publications.html