| Budget Amount *help |
¥34,190,000 (Direct Cost: ¥26,300,000、Indirect Cost: ¥7,890,000)
Fiscal Year 2021: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2020: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2019: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2018: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
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| Outline of Final Research Achievements |
Daily variations in biological functions are important factors affecting the efficacy and toxicity of drugs; a large number of drugs cannot be expected to have the same potency at different administration times. Dosing time-dependent differences in the therapeutic effects of drugs are, at least in part, due to diurnal changes in drug disposition such as absorption, distribution, metabolism and elimination. The expression and function of several xenobiotic transporters and drug metabolism enzymes exhibit diurnal variation, resulting in dosing time-dependent differences in drug disposition. The present study demonstrated that adenosine deaminase acting on RNA (ADAR) was involved in the circadian regulation of xenobiotic transporters and drug metabolism enzymes in human renal proximal tubular epithelial cells and hepatic cells. ADAR1 regulate the expression of these pharmacokinetics-related factors through modulating the transcription, translation, formation of splicing variant.
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