| Budget Amount *help |
¥44,590,000 (Direct Cost: ¥34,300,000、Indirect Cost: ¥10,290,000)
Fiscal Year 2020: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Fiscal Year 2019: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Fiscal Year 2018: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
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| Outline of Final Research Achievements |
We aimed to understand the functions of BACH1 and BACH2 in the regulation of hematopoietic cell differentiation. By generating and analyzing mice lacking both of these genes, we found that these mice showed reduced differentiation of red blood cells and lymphoid cells, which were similar to alterations observed in myelodysplastic syndrome (MDS). By analyzing gene expression of the bone marrow cells of patients of MDS, we found that the expression of BACH2 was reduced along the progression of the disease, suggesting that a reduction in the function of BACH2 is involved in the disease progress including anemia and immunodeficiency. BACH1 and BACH2 were found to promote differentiation of erythroid cells and lymphoid cells by repressing the expression of genes important for the differentiation and/or function of myeloid cells.
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