| Budget Amount *help |
¥44,330,000 (Direct Cost: ¥34,100,000、Indirect Cost: ¥10,230,000)
Fiscal Year 2020: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2019: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Fiscal Year 2018: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
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| Outline of Final Research Achievements |
In this study, we elucidated the mechanisms of how regulatory T (Treg) cells acquire their characteristic epigenome and how their effector differentiation is controlled. As for the former question, our results suggested an important role for the T cell receptor (TCR)-mTORC1 signaling and the TET-family proteins. In addition, we also found that the potential of CD4 T cells to acquire Foxp3 expression and the characteristic epigenome of Treg cells decline as they undergo differentiation and maturation from the thymus to the periphery. As for the latter question, we found that the transcription factors Foxp3 and BATF cooperate to regulate the TCR-dependent effector differentiation program of Treg cells.
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