| Budget Amount *help |
¥43,810,000 (Direct Cost: ¥33,700,000、Indirect Cost: ¥10,110,000)
Fiscal Year 2022: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2021: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2020: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2019: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2018: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
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| Outline of Final Research Achievements |
Mathematical modeling of cells using differential equations integrates various genetic information such as expression levels and mutations, analyzes network dynamics, and quantitatively evaluates the effects of each element to identify cancer mechanisms and drugs sensitivity. In this study, we constructed a comprehensive mathematical model of the cancer signaling network, input gene expression and mutation information as initial values and parameters, respectively, and simulated dynamics to clarify the effects of each element and the mechanism of cancer development. We have developed computational tools that integrate mathematical models and disease omics data, and by using these analysis tools, we have succeeded in prognostic classification and drug response prediction of breast cancer from network dynamics.
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