Molecular mechanisms of cancer cell survival and maintenance
Project/Area Number |
18H04032
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Review Section |
Medium-sized Section 50:Oncology and related fields
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Research Institution | Kobe University |
Principal Investigator |
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Project Period (FY) |
2018-04-01 – 2021-03-31
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Project Status |
Completed (Fiscal Year 2020)
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Budget Amount *help |
¥44,720,000 (Direct Cost: ¥34,400,000、Indirect Cost: ¥10,320,000)
Fiscal Year 2020: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2019: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2018: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
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Keywords | がん微小環境 / 腫瘍免疫 / マクロファージ / 樹状細胞 / SIRPα / がん免疫療法 / 抗体医薬 / CD47 / 自然免疫細胞 |
Outline of Final Research Achievements |
Tumor cells create a favorable environment for their own survival and maintenance by controlling the "tumor microenvironment" that consists of surrounding immune cells. The CD47-SIRPα signaling pathway has been considered as a key molecular signal in the regulation of the tumor microenvironment, which protects cancer cells from innate immune cells such as dendritic cells and macrophages. In the present study, we clarified new regulatory mechanisms of tumor immuity by innate immune cells, which is regulated by the CD47-SIRPα system and other SIRP faminily molecules.
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Academic Significance and Societal Importance of the Research Achievements |
本研究によって、研究代表者が見出している「がん細胞が細胞間シグナルCD47-SIRPα系を利用して貪食細胞からの排除を逃れる機構」による、これまで未解明であったがん細胞による「自然系細胞を介したがん排除」を回避する分子機構を解明する意味で学術的意義を有すると共に、新規がん治療法の創出に資する社会的意義の高い研究成果を得られた。
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Report
(4 results)
Research Products
(57 results)
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[Journal Article] An animal model that mimics human herpesvirus 6B pathogenesis2019
Author(s)
Wang B, Saito Y, Nishimura M, Ren Z, Tjan LH, Refaat A, Iida-Norita R, Tsukamoto R, Komatsu M, Itoh T, Matozaki T, Mori Y
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Journal Title
Journal of Virology
Volume: 94
Issue: 6
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Microglial SIRPα regulates the emergence of CD11c+ microglia and demyelination damage in white matter.2019
Author(s)
Sato-Hashimoto M, Nozu T, Toriba R, Horikoshi A, Akaike M, Kawamoto K, Hirose A, Hayashi H, Nagai H, Shimizu W, Saiki A., Ishikawa T, Elhanbaly R, Kotani T, Murata Y, Saito Y, Naruse M, Shibasaki K, Oldenborg P.-A, Jung S, Matozaki T, Fukazawa Y, Ohnishi H.
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Journal Title
eLife
Volume: -
Pages: 1-29
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis2018
Author(s)
Matlung HL, Babes L, Zhao XW, van Houdt M, Treffers LW, van Rees DJ, Franke K, Schornagel K, Verkuijlen P, Janssen H, Halonen P, Lieftink C, Beijersbergen RL, Leusen JHW, Boelens JJ, Kuhnle I, van der Werff Ten Bosch J, Seeger K, Rutella S, Pagliara D, Matozaki T, et al
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Journal Title
Cell Reports
Volume: 23
Issue: 13
Pages: 3946-3959.e6
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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