Molecular mechanisms of cancer cell survival and maintenance

• Project/Area Number: 18H04032
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Medium-sized Section 50:Oncology and related fields
• Research Institution: Kobe University
• Principal Investigator: Matozaki Takashi 神戸大学, 医学研究科, 教授 (80252782)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥44,720,000 (Direct Cost: ¥34,400,000、Indirect Cost: ¥10,320,000); Fiscal Year 2020: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000); Fiscal Year 2019: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000); Fiscal Year 2018: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
• Keywords: がん微小環境 / 腫瘍免疫 / マクロファージ / 樹状細胞 / SIRPα / がん免疫療法 / 抗体医薬 / CD47 / 自然免疫細胞

Outline of Final Research Achievements

Tumor cells create a favorable environment for their own survival and maintenance by controlling the "tumor microenvironment" that consists of surrounding immune cells. The CD47-SIRPα signaling pathway has been considered as a key molecular signal in the regulation of the tumor microenvironment, which protects cancer cells from innate immune cells such as dendritic cells and macrophages. In the present study, we clarified new regulatory mechanisms of tumor immuity by innate immune cells, which is regulated by the CD47-SIRPα system and other SIRP faminily molecules.

Academic Significance and Societal Importance of the Research Achievements

本研究によって、研究代表者が見出している「がん細胞が細胞間シグナルCD47-SIRPα系を利用して貪食細胞からの排除を逃れる機構」による、これまで未解明であったがん細胞による「自然系細胞を介したがん排除」を回避する分子機構を解明する意味で学術的意義を有すると共に、新規がん治療法の創出に資する社会的意義の高い研究成果を得られた。

Research Products

• [Int'l Joint Research] Sanquin研究所(オランダ)
• [Int'l Joint Research] Sanquin研究所(オランダ)
• [Journal Article] Macrocyclic Peptide-Mediated Blockade of the CD47-SIRPα Interaction as a Potential Cancer Immunotherapy (2020)
  • Author(s): Hazama Daisuke、Yin Yizhen、Murata Yoji、Matsuda Makoto、Okamoto Takeshi、Tanaka Daisuke、Terasaka Naohiro、Zhao Jinxuan、Sakamoto Mariko、Kakuchi Yuka、Saito Yasuyuki、Kotani Takenori、Nishimura Yoshihiro、Nakagawa Atsushi、Suga Hiroaki、Matozaki Takashi
  • Journal Title: Cell Chemical Biology Volume: 27 Issue: 9 Pages: 1181-1191.e7
  • DOI: 10.1016/j.chembiol.2020.06.008
  • Peer Reviewed / Open Access
• [Journal Article] Blockade of CD47 or SIRPα: a new cancer immunotherapy (2020)
  • Author(s): Murata Yoji、Saito Yasuyuki、Kotani Takenori、Matozaki Takashi
  • Journal Title: Expert Opinion on Therapeutic Targets Volume: 24 Issue: 10 Pages: 945-951
  • DOI: 10.1080/14728222.2020.1811855
  • Peer Reviewed / Open Access
• [Journal Article] Regulation of colonic epithelial cell homeostasis by mTORC1 (2020)
  • Author(s): Kotani Takenori、Setiawan Jajar、Konno Tasuku、Ihara Noriko、Okamoto Saki、Saito Yasuyuki、Murata Yoji、Noda Tetsuo、Matozaki Takashi
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 13810-13810
  • DOI: 10.1038/s41598-020-70655-1
  • NAID: 120006892085
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] SIRPα on Mouse B1 Cells Restricts Lymphoid Tissue Migration and Natural Antibody Production (2020)
  • Author(s): Franke Katka、Pillai Saravanan、Hoogenboezem Mark、Gijbels Marion、Matlung Hanke、Geissler Judy、Olsman Hugo、Pottgens Chantal、van Gorp Patrick、Ozsvar-Kozma Maria、Saito Yasuyuki、Matozaki Takashi、Kuijpers Taco、Hendriks Rudi、Kraal Georg、Binder Christoph、de Winther Menno、van den Berg Timo
  • Journal Title: Frontiers in Immunology Volume: 11 Pages: 570963-570963
  • DOI: 10.3389/fimmu.2020.570963
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] SIRPα on CD11c+ cells induces Th17 cell differentiation and subsequent inflammation in the CNS in experimental autoimmune encephalomyelitis (2020)
  • Author(s): Nishimura Taichi、Saito Yasuyuki、Washio Ken、Komori Satomi、Respatika Datu、Kotani Takenori、Murata Yoji、Ohnishi Hiroshi、Mizobuchi Satoshi、Matozaki Takashi
  • Journal Title: European Journal of Immunology Volume: 50 Issue: 10 Pages: 1560-1570
  • DOI: 10.1002/eji.201948410
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Tetrameric glycoprotein complex gH/gL/gQ1/gQ2 is a promising vaccine candidate for human herpesvirus 6B (2020)
  • Author(s): Wang Bochao、Hara Kouichi、Kawabata Akiko、Nishimura Mitsuhiro、Wakata Aika、Tjan Lidya Handayani、Poetranto Anna Lystia、Yamamoto Chisato、Haseda Yasunari、Aoshi Taiki、Munakata Lisa、Suzuki Ryo、Komatsu Masato、Tsukamoto Ryuko、Itoh Tomoo、Nishigori Chikako、Saito Yasuyuki、Matozaki Takashi、Mori Yasuko
  • Journal Title: PLOS Pathogens Volume: 16 Issue: 7 Pages: e1008609-e1008609
  • DOI: 10.1371/journal.ppat.1008609
  • NAID: 120006940234
  • Peer Reviewed / Open Access
• [Journal Article] Importance of methodology in the evaluation of renal mononuclear phagocytes and analysis of a model of experimental nephritis with Shp1 conditional knockout mice (2020)
  • Author(s): Watanabe Mitsuharu、Kaneko Yoriaki、Ohishi Yuko、Kinoshita Masato、Sakairi Toru、Ikeuchi Hidekazu、Maeshima Akito、Saito Yasuyuki、Ohnishi Hiroshi、Nojima Yoshihisa、Matozaki Takashi、Hiromura Keiju
  • Journal Title: Biochemistry and Biophysics Reports Volume: 22 Pages: 100741-100741
  • DOI: 10.1016/j.bbrep.2020.100741
  • Peer Reviewed / Open Access
• [Journal Article] An animal model that mimics human herpesvirus 6B pathogenesis (2019)
  • Author(s): Wang B, Saito Y, Nishimura M, Ren Z, Tjan LH, Refaat A, Iida-Norita R, Tsukamoto R, Komatsu M, Itoh T, Matozaki T, Mori Y
  • Journal Title: Journal of Virology Volume: 94 Issue: 6
  • DOI: 10.1128/jvi.01851-19
  • Peer Reviewed / Open Access
• [Journal Article] Deletion of SIRPα (signal regulatory protein-α) promotes phagocytic clearance of myelin debris in Wallerian degeneration, axon regeneration, and recovery from nerve injury (2019)
  • Author(s): Elberg G, Liraz-Zaltsman S, Reichert F, Matozaki T, Tal M, Rotshenker S
  • Journal Title: Journal of Neuroinflammation Volume: 16 Issue: 1 Pages: 277-277
  • DOI: 10.1186/s12974-019-1679-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] SIRPα+ dendritic cells promote the development of fibroblastic reticular cells in murine peripheral lymph nodes (2019)
  • Author(s): Komori S, Saito Y, Respatika D, Nishimura T, Kotani T, Murata Y, Matozaki T
  • Journal Title: European Journal of Immunology Volume: 49 Issue: 9 Pages: 1364-1371
  • DOI: 10.1002/eji.201948103
  • NAID: 120006778280
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Role of lysophosphatidic acid in proliferation and differentiation of intestinal epithelial cells (2019)
  • Author(s): Konno T, Kotani T, Setiawan J, Nishigaito Y, Sawada N, Imada S, Saito Y, Murata Y, Matozaki T
  • Journal Title: PLOS ONE Volume: 14 Issue: 4 Pages: e0215255-e0215255
  • DOI: 10.1371/journal.pone.0215255
  • NAID: 120006634675
  • Peer Reviewed / Open Access
• [Journal Article] Microglial SIRPα regulates the emergence of CD11c+ microglia and demyelination damage in white matter. (2019)
  • Author(s): Sato-Hashimoto M, Nozu T, Toriba R, Horikoshi A, Akaike M, Kawamoto K, Hirose A, Hayashi H, Nagai H, Shimizu W, Saiki A., Ishikawa T, Elhanbaly R, Kotani T, Murata Y, Saito Y, Naruse M, Shibasaki K, Oldenborg P.-A, Jung S, Matozaki T, Fukazawa Y, Ohnishi H.
  • Journal Title: eLife Volume: - Pages: 1-29
  • DOI: 10.7554/elife.42025
  • NAID: 120006604638
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Signal regulatory protein alpha blockade potentiates tumoricidal effects of macrophages on gastroenterological neoplastic cells in syngeneic immunocompetent mice (2018)
  • Author(s): Abe Tomoyuki、Tanaka Yuka、Piao Jinlian、Tanimine Naoki、Oue Naohide、Hinoi Takao、Garcia Noel Verjan、Miyasaka Masayuki、Matozaki Takashi、Yasui Wataru、Ohdan Hideki
  • Journal Title: Annals of Gastroenterological Surgery Volume: 2 Issue: 6 Pages: 451-462
  • DOI: 10.1002/ags3.12205
  • Peer Reviewed / Open Access
• [Journal Article] Role of Csk in intestinal epithelial barrier function and protection against colitis (2018)
  • Author(s): Sun Chunxiao、Murata Yoji、Imada Shinya、Konno Tasuku、Kotani Takenori、Saito Yasuyuki、Yamada Hideto、Matozaki Takashi
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 504 Issue: 1 Pages: 109-114
  • DOI: 10.1016/j.bbrc.2018.08.140
  • NAID: 120006775950
  • Peer Reviewed
• [Journal Article] Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis (2018)
  • Author(s): Matlung HL, Babes L, Zhao XW, van Houdt M, Treffers LW, van Rees DJ, Franke K, Schornagel K, Verkuijlen P, Janssen H, Halonen P, Lieftink C, Beijersbergen RL, Leusen JHW, Boelens JJ, Kuhnle I, van der Werff Ten Bosch J, Seeger K, Rutella S, Pagliara D, Matozaki T, et al
  • Journal Title: Cell Reports Volume: 23 Issue: 13 Pages: 3946-3959.e6
  • DOI: 10.1016/j.celrep.2018.05.082
  • NAID: 120006491924
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] CD47-signal regulatory protein α signaling system and its application to cancer immunotherapy (2018)
  • Author(s): Murata Yoji、Saito Yasuyuki、Kotani Takenori、Matozaki Takashi
  • Journal Title: Cancer Science Volume: 109 Issue: 8 Pages: 2349-2357
  • DOI: 10.1111/cas.13663
  • NAID: 120006517719
  • Peer Reviewed
• [Presentation] 腸上皮細胞の増殖・分化制御におけるK-Ras活性の役割-Role of K-Ras activity in regulation of intestinal proliferation and differentiatiojn of intestinal epithelial cells (2020)
  • Author(s): 小谷 武徳、井原 紀子、ジャジャル セティアワン、岡本 沙樹、齊藤 泰之、村田 陽二、的崎 尚
  • Organizer: 第93回日本生化学会大会
• [Presentation] 細胞間シグナルCD47-SIRPα系を制御する大環状ペプチドの創出と抗腫瘍剤としての応用-Identification of macrocyclic peptides that regulate the CD47-SIRPαsystem, and their potential as anti-cancer drugs (2020)
  • Author(s): 村田 陽二、羽間 大祐、Yin Yizhen、松田 真、岡本 武士、 田中 大介、坂本 茉莉子、角地 宥香、寺坂 尚紘、 Zhao Jinxuan、齊藤 泰之、小谷 武徳、中川 敦史、菅 裕明、的崎 尚
  • Organizer: 第93回日本生化学会大会
• [Presentation] Srcファミリーキナーゼ、Ras, ｍTORC1シグナルによる腸上皮細胞の恒常性制御 (2020)
  • Author(s): 小谷 武徳、岡本 沙樹、村田 陽二、齊藤 泰之、的崎 尚
  • Organizer: 第19回生体機能研究会
• [Presentation] 抗SIRPα抗体を用いた膀胱がんに対する新規がん免疫療法開発 (2020)
  • Author(s): 坂本 茉莉子、村田 陽二、田中 大介、岡本 武士、羽間 大祐、角地 宥加、齊藤 泰之、小谷 武徳、的崎 尚
  • Organizer: 第19回生体機能研究会
• [Presentation] 膜型分子CD47を介した成熟T細胞の寿命制御 (2020)
  • Author(s): 小森 里美、齊藤 泰之、西村 太一、吉田 弘樹、杉原 理紗、飯田 理恵、小谷 武徳、村田 陽二、的崎 尚
  • Organizer: 第19回生体機能研究会
• [Presentation] Humanized mouse models for in vivo evaluation of cancer immunotherapy targeting human macrophages-免疫系ヒト化マウスモデルによるヒトマクロファージを標的としたがん免疫療法の開発- (2020)
  • Author(s): Yasuyuki Saito, Rie Iida, Daisuke Hazama, Takenori Kotani, Yoji Murata, Takashi Matozaki
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] 膜型分子SIRPα/SIRPβ特異抗体を用いた膀胱がんに対する新規抗体療法-The novel antitumor effect of an antibody to SIRPα/SIRPβagainst bladder cancers- (2020)
  • Author(s): 坂本 茉莉子、村田 陽二、羽間 大祐、岡本 武士、角地 宥香、齊藤 泰之、小谷 武徳、藤沢 正人、的崎 尚
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] 腸上皮細胞の増殖・分化制御におけるK-Ras活性の役割-Role of K-Ras activity in regulation of proliferation and differentiatiojn of intestinal epithelial cells- (2020)
  • Author(s): 小谷 武徳、井原 紀子、ジャジャル セティアワン、岡本 沙樹、齊藤 泰之、村田 陽二、的崎 尚
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] ランゲルハンス細胞組織球症に対する新規治療標的分子SIRPα-SIRPα targeting as a potential therapy of Langerhans cell histiocytosis- (2020)
  • Author(s): 岡本 武士、村田 陽二、羽間 大祐、坂本 茉莉子、角地 宥香、齊藤 泰之、小谷 武徳、眞庭 謙昌、的崎 尚
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] A novel humanized mouse model for assessing human macrophage-targeted cancer immunotherapy in vivo (2020)
  • Author(s): Rie Iida-Norita, Yasuyuki Saito, Daisuke Hazama, Satomi Komori, Hiroki Yoshida, Risa Sugihara, Yoji Murata, and Takashi Matozaki
  • Organizer: 14th International Conference on Protein Phosphatase
  • Int'l Joint Research
• [Presentation] Role of CD47 on the regulation of peripheral T cell survival by dendritic cells (2020)
  • Author(s): Satomi Komori, Yasuyuki Saito, Taichi Nishimura, Hiroki Yoshida, Risa Sugihara, Rie Iida, Takenori Kotani, Yoji Murata, Takashi Matozaki
  • Organizer: 14th International Conference on Protein Phosphatase
  • Int'l Joint Research
• [Presentation] Roles of Shp2-Ras, Src family kinases, and mTOR signaling in intestinal epithelial homeostasis (2020)
  • Author(s): Takenori Kotani, Saki Okamoto, Yoji Murata, Yasuyuki Saito, Takashi Matozaki
  • Organizer: 14th International Conference on Protein Phosphatase
  • Int'l Joint Research
• [Presentation] Blockade of the CD47-SIRPα interaction by SIRPα-binding macrocyclic peptides as a potential cancer immunotherapy (2020)
  • Author(s): Yoji Murata, Daisuke Hazama, Yizhen Yin, Mariko Sakamoto, Yasuyuki Saito, Takenori Kotani, Hiroaki Suga, Takashi Matozaki
  • Organizer: 14th International Conference on Protein Phosphatase
  • Int'l Joint Research
• [Presentation] Antibodies to SIRPα/SIRPβ as a potential tool for immunotherapy of bladder cancer (2020)
  • Author(s): Mariko Sakamoto, Yoji Murata, Yuka Kakuchi, Daisuke Takana, Takeshi Okamoto, Yasuyuki Saito, Takenori Kotani, Masato Fujisawa, Takashi Matozaki
  • Organizer: 14th International Conference on Protein Phosphatase
  • Int'l Joint Research
• [Presentation] A novel humanized mouse model for assessing human macrophage-targeted cancer immunotherapy in vivo (2020)
  • Author(s): Rie Iida-Norita, Yasuyuki Saito, Daisuke Hazama, Satomi Komori, Hiroki Yoshida, Risa Sugihara, Yoji Murata, and Takashi Matozaki
  • Organizer: 神戸大学・理研BDR合同シンポジウム
• [Presentation] がん細胞の生存・維持の分子機構とその臨床応用 (2019)
  • Author(s): 的崎 尚
  • Organizer: 徳島大学研究クラスター「統合的がん創薬研究クラスター」第3回合同ミーティング
  • Invited
• [Presentation] Importance of CD47-SIRPa system for regulation of macrophages in the tumor microenvironment (2019)
  • Author(s): Matozaki T
  • Organizer: The 4th Taiwan-Japan Bilateral Conference on Protein Phosphatases 2019
  • Int'l Joint Research / Invited
• [Presentation] SIRPα抗体を用いた新規のがん免疫療法:CD20及びPD-1抗体との併用による有効性 (2019)
  • Author(s): 的崎 尚、村田 陽二、齊藤 泰之、小谷 武徳
  • Organizer: 第78回日本癌学会総会
• [Presentation] Role of Tsc2-mTORC1 signaling in regulation of colonic epithelial homeostasis (2019)
  • Author(s): Kotani, T, Setiawan J, Ihara N, Okamoto S, Murata Y, Saito Y, Matozaki T
  • Organizer: 第78回日本癌学会総会
• [Presentation] A nobel macrocycle peptide targets CD47-SIRPalpha axis and enhances the macrophage-mediated tumor killing (2019)
  • Author(s): Hazama D, Murata Y, Tanaka D, Okamoto T, Saito Y, Kotani T, Nishimura Y, Matozaki T
  • Organizer: 第78回日本癌学会総会
• [Presentation] Importance of SIRPα+ dendric cells for the development of fibroblastic reticular cells of peripheral lymph nodes (2019)
  • Author(s): Komori S, Saito Y, Resppatika D, Nishimura T, Kotani T, Murata Y, Matozaki T
  • Organizer: 第92回日本生化学会大会
• [Presentation] チロシンホスファターゼ SHP-1/2 結合タンパク質 SIRPαによる自然免疫細胞の機能制御 (2019)
  • Author(s): 村田 陽二、齊藤 泰之、小谷 武徳、的崎 尚
  • Organizer: 第92回日本生化学会大会
• [Presentation] 細胞間シグナルCD47-SIRPα系による血球寿命制御とその臨床応用 (2019)
  • Author(s): 的崎 尚、齊藤 泰之、小谷 武徳、村田 陽二
  • Organizer: 第92回日本生化学会大会
  • Invited
• [Presentation] 新規SIRPα阻害剤の開発とその抗腫瘍効果 (2019)
  • Author(s): 村田 陽二、羽間 大祐、田中 大介、岡本 武士、齊藤 泰之、小谷 武徳、的崎 尚
  • Organizer: 第18回生体機能研究会
• [Presentation] SIRPα陽性樹状細胞による末梢リンパ節ストローマ細胞の発達制御 (2019)
  • Author(s): 小森 里美、齊藤 泰之、、ダトゥ レスパティカ、西村 太一、小谷 武徳、村田 陽二、的崎 尚
  • Organizer: 第9回ホスファターゼ研究会学術集会
• [Presentation] 膜型分子SIRPαを標的とする新たな免疫チェックポイント阻害剤の開発 (2019)
  • Author(s): 羽間 大祐、村田 陽二、田中 大介、岡本 武士、齊藤 泰之、小谷 武徳、西村 善博、的崎 尚
  • Organizer: 第9回ホスファターゼ研究会学術集会
• [Presentation] 大腸上皮の恒常性制御におけるTsc2-mTORC1シグナルの役割 (2019)
  • Author(s): 小谷 武徳、ジャジャル セティアワン、井原 紀子、岡本 沙樹、村田 陽二、齊藤 泰之、的崎 尚
  • Organizer: 第9回ホスファターゼ研究会学術集会
• [Presentation] Role of Tsc2-mTORC1 signaling in homeostasis of intestinal epithelium and its relation to inflammation and cancer (2019)
  • Author(s): Kotani T, Setiawan J, Murata Y, Saito Y, Matozaki T
  • Organizer: AACR Annual Meeting 2019
  • Int'l Joint Research
• [Presentation] SIRPα＋Dendritic Cells regulate organization of lymph node stromal sells in vivo (2018)
  • Author(s): Komori S, Saito Y, Respatika D, Kotani T, Murata Y, Matozaki T
  • Organizer: 第47回日本免疫学学術集会
• [Presentation] Importance of SIRPα on dendritic cells for the development of exprerimental autoimmune encephalomyelitis (2018)
  • Author(s): Nishimura T, Saito Y, Komori S, Respatika D, Washio K, Kotani T, Murata Y, Mizobushi S, Matozaki T
  • Organizer: 第47回日本免疫学学術集会
• [Presentation] Role of the tyrosine phosphorylation signal in homeostasis of intestinal epithelium and its relation to inflammation and cancer (2018)
  • Author(s): Matozaki T, Murata Y, Kotani T, Saito Y
  • Organizer: Workshop on Frontiers in Phosphatase Research and Drug Discovery
  • Int'l Joint Research / Invited
• [Presentation] Critical role of SIRPαon dendritic cells for the development of experimental autoimmune encephalomyelitis (2018)
  • Author(s): Nishimura T, Saito Y, Washio K, Komori S, Respatika D, Kotani T, Murata Y, Mizobuchi S, Matozaki T
  • Organizer: Workshop on Frontiers in Phosphatase Research and Drug Discovery
  • Int'l Joint Research
• [Presentation] SIRPα陽性樹状細胞による脾臓細網線維芽細胞の恒常性の制御 (2018)
  • Author(s): 齊藤 泰之、小森 里美、Datu Respatika、鷲尾 健、西村 太一、小谷 武徳、村田 陽二、的崎 尚
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] Srcファミリーキナーゼの炎症性腸疾患における重要性 (2018)
  • Author(s): 孫 春暁、村田 陽二、今田 慎也、小谷 武徳、齊藤 泰之、山田 秀人、的崎 尚
  • Organizer: 第91回日本生化学会大会
• [Presentation] 抗SIRPα抗体による新規がん免疫療法 (2018)
  • Author(s): 羽間 大祐、村田 陽二、栁田 匡彦、田中 大介、齊藤 泰之、小谷 武徳、西村 善博、的崎 尚
  • Organizer: 第17回生体機能研究会
• [Presentation] 実験的自己免疫性脳脊髄炎の発症制御におけるCD47-SIRPα系の役割について (2018)
  • Author(s): 西村 太一、齊藤 泰之、鷲尾 健、小森 里美、小谷 武徳、村田 陽二、溝渕 知司、的崎 尚
  • Organizer: 第17回生体機能研究会
• [Presentation] SIRPα＋ Dendritic Cells regulate homeostasis of fibroblastic reticular cells via TNF receptor ligands in the adult spleen (2018)
  • Author(s): Saito Y, Respatika D, Komori S, Washio K, Nishimura T, Kotani T, Murata Y, Matozaki T
  • Organizer: 15th International Symposium on Dendritic Cells (DC)
  • Int'l Joint Research
• [Remarks] シグナル統合学分野HP
  • URL: https://www.med.kobe-u.ac.jp/tougou/signal/Home.html
• [Remarks] シグナル統合学分野ホームページ
  • URL: https://www.med.kobe-u.ac.jp/tougou/signal/Home.html