| Budget Amount *help |
¥44,720,000 (Direct Cost: ¥34,400,000、Indirect Cost: ¥10,320,000)
Fiscal Year 2020: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Fiscal Year 2019: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Fiscal Year 2018: ¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
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| Outline of Final Research Achievements |
A radical treatment method for most of inherited neuronal diseases has not been developed yet. In this study, we elucidated the molecular mechanism of genome editing in brain. Based on the mechanism, we have developed novel genome-editing method “SATI” that can repair many kinds of mutations in vivo. Using this method, we treated an HGPS premature mouse model carrying a dominant point mutation and demonstrated amelioration of aging-related phenotypes in multiple organs and extension of lifespan.
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