| Budget Amount *help |
¥43,940,000 (Direct Cost: ¥33,800,000、Indirect Cost: ¥10,140,000)
Fiscal Year 2022: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2021: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2020: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2019: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2018: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
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| Outline of Final Research Achievements |
We investigated the mechanisms of motivation regulation involving dopamine and serotonin in macaque monkeys as a model for humans. Dopamine transmission was found to be involved in two distinct mechanisms of motivation regulation mediated by D1 and D2 receptors. In addition, we showed that serotonin transmission, specifically the reduction of serotonin signaling through 5-HT1B and 5-HT1A receptors, leads to a decrease in motivation that is dependent or independent of reward value, respectively. Together with the localization of these receptor subtypes, our findings provided insights into the neural circuits involved. Moreover, we advanced the application of chemogenetics, DREADDs, in macaque monkeys and successfully achieved selective and reversible control of dopamine neuron activity. These achievements hold great promise for advancing our understanding of monoamine control of motivation and the pathophysiology of mental disorders.
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