| Budget Amount *help |
¥45,370,000 (Direct Cost: ¥34,900,000、Indirect Cost: ¥10,470,000)
Fiscal Year 2020: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Fiscal Year 2018: ¥27,430,000 (Direct Cost: ¥21,100,000、Indirect Cost: ¥6,330,000)
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| Outline of Final Research Achievements |
In our genomic analysis, we found that rare genomic copy number variations (CNVs) in the glial-related gene ASTN2 are associated with the risk of psychiatric disorders (e.g., bipolar disorder). In gene expression analysis of neurospheres derived from iPS cells with ASTN2 deletion, we also found a marked decrease in expression of the ZNF558, which is suggested to be involved in the pathogenesis of psychiatric disorders. For the 22q11.2 deletion, which is associated with the risk of schizophrenia and glial abnormalities, we revealed a decrease in PERK signaling in midbrain neurons using a mouse model. Furthermore, analysis of brain tissue from schizophrenia patients identified pathological findings suggestive of myelin-oligodendrocyte abnormalities.
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