| Budget Amount *help |
¥44,200,000 (Direct Cost: ¥34,000,000、Indirect Cost: ¥10,200,000)
Fiscal Year 2021: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
Fiscal Year 2020: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2019: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2018: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
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| Outline of Final Research Achievements |
In this study, human iMG and iN cells were generated as disease model cells from patients with various neuropsychiatric disorders. Human iN cells and iMG cells were used to measure items that can only be assessed in living cells, and correlation analysis with clinical symptoms was conducted to detect disease specificity and elucidate pathophysiology at the dynamic cellular level. Specific characteristics were found in iN and iMG cells derived from patients with developmental disorders and dementia-related diseases. Furthermore, we found that human blood-derived iMG cells resemble human brain microglial cells, and revealed the usefulness of iMG cells as surrogate cells for reverse-translational research.
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