Elucidation of the mechanisms of the Parkinson's disease genes and Lewy Body formation and alpha-synuclein propagation mechanisms

• Project/Area Number: 18H04043
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Medium-sized Section 52:General internal medicine and related fields
• Research Institution: Juntendo University
• Principal Investigator: Hattori Nobutaka 順天堂大学, 医学(系)研究科(研究院), 教授 (80218510)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥44,720,000 (Direct Cost: ¥34,400,000、Indirect Cost: ¥10,320,000); Fiscal Year 2020: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000); Fiscal Year 2019: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000); Fiscal Year 2018: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
• Keywords: パーキンソン病 / α-シヌクレイン / SNCA / Lewy小体 / ミトコンドリア / オートファジー / CHCHD2 / PLA2G6 / レヴィ小体 / ＳＮＣＡ / 遺伝性パーキンソン病 / α-synuclein / 脂質組成 / 遺伝子解析 / 神経細胞死 / 伝播形式

Outline of Final Research Achievements

In models of CHCHD2 knockout flies, knockout mice, and patient-derived iPS cells, mitochondrial function declines in an age-dependent manner, forming SNCA-positive Lewy body-like inclusion bodies. Furthermore, analysis of PLA2G6 knockout flies showed shortening of the acyl group of brain phospholipids. It was clarified that the homeostasis of mitochondrial protein and phospholipid composition is the primary cause of the mechanism of aggregate formation in Parkinson's disease.

Academic Significance and Societal Importance of the Research Achievements

封入体を形成する遺伝性パーキンソン病に着目し、モデル動物の解析により封入体形成のメカニズム解明に迫ることができた。本研究の成果は多くを占める孤発性パーキンソン病の病態解明につながるものであり、今後の疾患予防や治療法開発に向けて基礎的な知見となる。

Research Products

• [Journal Article] Clinical manifestations of Parkinson's disease harboring VPS35 retromer complex component p.D620N with long-term follow-up (2021)
  • Author(s): Ishiguro Mayu、Li Yuanzhe、Yoshino Hiroyo、Daida Kensuke、Ishiguro Yuta、Oyama Genko、Saiki Shinji、Funayama Manabu、Hattori Nobutaka、Nishioka Kenya
  • Journal Title: Parkinsonism & Related Disorders Volume: 84 Pages: 139-143
  • DOI: 10.1016/j.parkreldis.2021.02.014
  • Peer Reviewed
• [Journal Article] The identified clinical features of Parkinson's disease in homo-, heterozygous and digenic variants of PINK1 (2021)
  • Author(s): Hayashida Arisa、Li Yuanzhe、Yoshino Hiroyo、Daida Kensuke、Ikeda Aya、et al.
  • Journal Title: Neurobiology of Aging Volume: 97 Pages: 3301-3301
  • DOI: 10.1016/j.neurobiolaging.2020.06.017
  • Peer Reviewed / Open Access
• [Journal Article] Homeostatic p62 levels and inclusion body formation in CHCHD2 knockout mice (2021)
  • Author(s): Sato Shigeto、Noda Sachiko、Torii Satoru、Amo Taku、Ikeda Aya、Funayama Manabu、Yamaguchi Junji、Fukuda Takahiro、Kondo Hiromi、Tada Norihiro、Arakawa Satoko、Watanabe Masahiko、Uchiyama Yasuo、Shimizu Shigeomi、Hattori Nobutaka
  • Journal Title: Human Molecular Genetics Volume: 30 Issue: 6 Pages: 443-453
  • DOI: 10.1093/hmg/ddab057
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sato S, Noda S, Hattori N. (2020)
  • Author(s): Pathogenic insights to Parkin-linked model mice.
  • Journal Title: Neurosci Res. Volume: 159 Pages: 47-51
  • DOI: 10.1016/j.neures.2020.03.014
  • Peer Reviewed / Open Access
• [Journal Article] Loss of Parkin contributes to mitochondrial turnover and dopaminergic neuronal loss in aged mice. (2020)
  • Author(s): Noda S, Sato S, Fukuda T, Tada N, Uchiyama Y, Tanaka K, Hattori N.
  • Journal Title: Neurobiol Dis. Volume: 136 Pages: 104717-104717
  • DOI: 10.1016/j.nbd.2019.104717
  • Peer Reviewed / Open Access
• [Journal Article] Reduced astrocytic reactivity in human brains and midbrain organoids with PRKN mutations (2020)
  • Author(s): Kano Masayoshi、Takanashi Masashi、Oyama Genko、Yoritaka Asako、Hatano Taku、Shiba-Fukushima Kahori、Nagai Makiko、Nishiyama Kazutoshi、Hasegawa Kazuko、Inoshita Tsuyoshi、Ishikawa Kei-ichi、Akamatsu Wado、Imai Yuzuru、Bolognin Silvia、Schwamborn Jens Christian、Hattori Nobutaka
  • Journal Title: npj Parkinson's Disease Volume: 6 Issue: 1 Pages: 33-33
  • DOI: 10.1038/s41531-020-00137-8
  • Peer Reviewed / Open Access
• [Journal Article] Identifying Therapeutic Agents for Amelioration of Mitochondrial Clearance Disorder in Neurons of Familial Parkinson Disease (2020)
  • Author(s): Yamaguchi Akihiro、Ishikawa Kei-ichi、Inoshita Tsuyoshi、Shiba-Fukushima Kahori、Saiki Shinji、Hatano Taku、Mori Akio、Oji Yutaka、Okuzumi Ayami、Li Yuanzhe、Funayama Manabu、Imai Yuzuru、Hattori Nobutaka、Akamatsu Wado
  • Journal Title: Stem Cell Reports Volume: 14 Issue: 6 Pages: 1060-1075
  • DOI: 10.1016/j.stemcr.2020.04.011
  • Peer Reviewed / Open Access
• [Journal Article] Steroid‐Responsive Parkinsonism Caused by Cerebral Amyloid Angiopathy‐Related Inflammation (2020)
  • Author(s): Yamashita Yuri、Hatano Taku、Ogawa Takashi、Daida Kensuke、Motoi Yumiko、Hattori Nobutaka
  • Journal Title: Movement Disorders Clinical Practice Volume: 7 Issue: 3 Pages: 329-331
  • DOI: 10.1002/mdc3.12901
  • Peer Reviewed / Open Access
• [Journal Article] Variants in saposin D domain of prosaposin gene linked to Parkinson’s disease (2020)
  • Author(s): Oji Y, Hatano T, Ueno SI, Funayama M, Ishikawa KI, Okuzumi A, Noda S, Sato S, Satake W, Toda T, Li Y, Hino-Takai T, Kakuta S, Tsunemi T, Yoshino H, Nishioka K, Hattori T, Mizutani Y, Mutoh T, Yokochi F, et al.
  • Journal Title: Brain Volume: 143 Issue: 4 Pages: 1190-1205
  • DOI: 10.1093/brain/awaa064
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pathological findings in a patient with alpha-synuclein p.A53T and familial Parkinson's disease (2020)
  • Author(s): Nishioka K, Hashizume Y, Takanashi M, Daida K, Li Y, Yoshino H, Tambasco N, Prontera P, Hattori Y, Ueda A, Watanabe H, Hattori N.
  • Journal Title: Parkinsonism and related disorders Volume: In press Pages: 183-187
  • DOI: 10.1016/j.parkreldis.2020.11.001
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Identification of Disease-Associated Variants by Targeted Gene Panel Resequencing in Parkinson's Disease (2020)
  • Author(s): Daida Kensuke、Funayama Manabu、Li Yuanzhe、Yoshino Hiroyo、Hayashida Arisa、Ikeda Aya、Ogaki Kotaro、Nishioka Kenya、Hattori Nobutaka
  • Journal Title: Frontiers in Neurology Volume: 11 Pages: 576465-576465
  • DOI: 10.3389/fneur.2020.576465
  • Peer Reviewed / Open Access
• [Journal Article] Astrocytes Protect Human Dopaminergic Neurons from α-Synuclein Accumulation and Propagation (2020)
  • Author(s): Tsunemi Taiji、Ishiguro Yuta、Yoroisaka Asako、Valdez Clarissa、Miyamoto Kengo、Ishikawa Keiichi、Saiki Shinji、Akamatsu Wado、Hattori Nobutaka、Krainc Dimitri
  • Journal Title: The Journal of Neuroscience Volume: 40 Issue: 45 Pages: 8618-8628
  • DOI: 10.1523/jneurosci.0954-20.2020
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lipids: Key Players That Modulate -Synuclein Toxicity and Neurodegeneration in Parkinson’s Disease (2020)
  • Author(s): Akio Mori, Yuzuru Imai, Nobutaka Hattori
  • Journal Title: International Journal of Molecular Sciences Volume: 21 Issue: 9 Pages: 9-9
  • DOI: 10.3390/ijms21093301
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Nonmercaptalbumin as an oxidative stress marker in Parkinson's and PARK2 disease (2020)
  • Author(s): Ueno SI, Hatano T, Okuzumi A, Saiki S, Oji Y, Mori A, Koinuma T, Fujimaki M, Takeshige-Amano H, Kondo A, Yoshikawa N, Nojiri T, Kurano M, Yasukawa K, Yatomi Y, Ikeda H, Hattori N
  • Journal Title: Ann Clin Transl Neurol Volume: 7 Issue: 3 Pages: 307-317
  • DOI: 10.1002/acn3.50990
  • Peer Reviewed / Open Access
• [Journal Article] Neuromelanin or DaT-SPECT: which is the better marker for discriminating advanced Parkinson's disease? (2019)
  • Author(s): Okuzumi A, Hatano T, Kamagata K, Hori M, Mori A, Oji Y, Taniguchi D, Daida K, Shimo Y, Yanagisawa N, Nojiri S, Aoki S, Hattori N
  • Journal Title: Eur J Neurol Volume: 26 Issue: 11 Pages: 1408-1416
  • DOI: 10.1111/ene.14009
  • Peer Reviewed
• [Journal Article] Clinical heterogeneity of frontotemporal dementia and Parkinsonism linked to chromosome 17 caused by MAPT N279K mutation in relation to tau positron emission tomography features (2019)
  • Author(s): Ikeda Aya、Shimada Hitoshi、Nishioka Kenya、Takanashi Masashi、Hayashida Arisa、Li Yuanzhe、Yoshino Hiroyo、Funayama Manabu、Ueno Yuji、Hatano Taku、Sahara Naruhiko、Suhara Tetsuya、Higuchi Makoto、Hattori Nobutaka
  • Journal Title: Movement Disorders Volume: 34 Issue: 4 Pages: 568-574
  • DOI: 10.1002/mds.27623
  • Peer Reviewed / Open Access
• [Journal Article] Loss of nuclear REST/NRSF in aged-dopaminergic neurons in Parkinson’s disease patients (2019)
  • Author(s): Kawamura Miwako、Sato Shigeto、Matsumoto Gen、Fukuda Takahiro、Shiba-Fukushima Kahori、Noda Sachiko、Takanashi Masashi、Mori Nozomu、Hattori Nobutaka
  • Journal Title: Neuroscience Letters Volume: 699 Pages: 59-63
  • DOI: 10.1016/j.neulet.2019.01.042
  • Peer Reviewed
• [Journal Article] Iron Supply via NCOA4-Mediated Ferritin Degradation Maintains Mitochondrial Functions (2019)
  • Author(s): Fujimaki Motoki、Furuya Norihiko、Saiki Shinji、Amo Taku、Imamichi Yoko、Hattori Nobutaka
  • Journal Title: Molecular and Cellular Biology Volume: 39 Issue: 14
  • DOI: 10.1128/mcb.00010-19
  • Peer Reviewed / Open Access
• [Journal Article] A metabolic profile of polyamines in parkinson disease: A promising biomarker (2019)
  • Author(s): Saiki Shinji、Sasazawa Yukiko、Fujimaki Motoki、Kamagata Koji、Kaga Naoko、Taka Hikari、Li Yuanzhe、Souma Sanae、Hatano Taku、Imamichi Yoko、Furuya Norihiko、Mori Akio、Oji Yutaka、Ueno Shin‐Ichi、Nojiri Shuko、Miura Yoshiki、Ueno Takashi、Funayama Manabu、Aoki Shigeki、Hattori Nobutaka
  • Journal Title: Annals of Neurology Volume: 86 Issue: 2 Pages: 251-263
  • DOI: 10.1002/ana.25516
  • Peer Reviewed / Open Access
• [Journal Article] Plasma metabolite biomarkers for multiple system atrophy and progressive supranuclear palsy (2019)
  • Author(s): Mori Akio、Ishikawa Kei-Ichi、Saiki Shinji、Hatano Taku、Oji Yutaka、Okuzumi Ayami、Fujimaki Motoki、Koinuma Takahiro、Ueno Shin-Ichi、Imamichi Yoko、Hattori Nobutaka
  • Journal Title: PLOS ONE Volume: 14 Issue: 9 Pages: e0223113-e0223113
  • DOI: 10.1371/journal.pone.0223113
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Parkinson's disease-associated iPLA2-VIA/PLA2G6 regulates neuronal functions and α-synuclein stability through membrane remodeling. (2019)
  • Author(s): Mori A, Hatano T, Inoshita T, Shiba-Fukushima K, Koinuma T, Meng H, Kubo SI, Spratt S, Cui C, Yamashita C, Miki Y, Yamamoto K, Hirabayashi T, Murakami M, Takahashi Y, Shindou H, Nonaka T, Hasegawa M, Okuzumi A, Imai Y, Hattori N.
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 116(41) Issue: 41 Pages: 20689-20699
  • DOI: 10.1073/pnas.1902958116
  • NAID: 120007132272
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Light-driven activation of mitochondrial proton-motive force improves motor behaviors in a Drosophila model of Parkinson's disease. (2019)
  • Author(s): Imai Y, Inoshita T, Meng H, Shiba-Fukushima K, Hara KY, Sawamura N, Hattori N.
  • Journal Title: Commun Biol. Volume: 2 Issue: 1 Pages: 424-424
  • DOI: 10.1038/s42003-019-0674-1
  • Peer Reviewed
• [Journal Article] Mutations in CHCHD2 cause α-synuclein aggregation (2019)
  • Author(s): Ikeda A., Nishioka K., Meng H., Takanashi M., Hasegawa I., Inoshita T., Shiba-Fukushima K., Li Y., Yoshino H., Mori A., Okuzumi A., Yamaguchi A., Nonaka R., Izawa N., Ishikawa K.I., Saiki H., Morita M., Hasegawa M., Hasegawa K., Elahi M., et al.
  • Journal Title: Human Molecular Genetics Volume: 28 Issue: 23 Pages: 3895-3911
  • DOI: 10.1093/hmg/ddz241
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Metabolomics‐based identification of metabolic alterations in PARK2 (2019)
  • Author(s): Okuzumi Ayami、Hatano Taku、Ueno Shin‐Ichi、Ogawa Takashi、Saiki Shinji、Mori Akio、Koinuma Takahiro、Oji Yutaka、Ishikawa Kei‐Ichi、Fujimaki Motoki、Sato Shigeto、Ramamoorthy Sivapriya、Mohney Robert P.、Hattori Nobutaka
  • Journal Title: Annals of Clinical and Translational Neurology Volume: 6 Issue: 3 Pages: 525-536
  • DOI: 10.1002/acn3.724
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Twin CHCH Proteins, CHCHD2, and CHCHD10: Key Molecules of Parkinson’s Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia (2019)
  • Author(s): Imai Yuzuru、Meng Hongrui、Shiba-Fukushima Kahori、Hattori Nobutaka
  • Journal Title: International Journal of Molecular Sciences Volume: 20 Issue: 4 Pages: 908-908
  • DOI: 10.3390/ijms20040908
  • Peer Reviewed / Open Access
• [Journal Article] Zonisamide Administration Improves Fatty Acid β-Oxidation in Parkinson's Disease. (2018)
  • Author(s): Ueno SI, Saiki S, Fujimaki M, Takeshige-Amano H, Hatano T, Oyama G, Ishikawa KI, Yamguchi A, Nojiri S, Akamatsu W, Hattori N.
  • Journal Title: Cells Volume: 8 Issue: 1 Pages: 14-14
  • DOI: 10.3390/cells8010014
  • Peer Reviewed / Open Access
• [Journal Article] Syntaxin 17 regulates the localization and function of PGAM5 in mitochondrial division and mitophagy (2018)
  • Author(s): Sugo Masashi、Kimura Hana、Arasaki Kohei、Amemiya Toshiki、Hirota Naohiko、Dohmae Naoshi、Imai Yuzuru、Inoshita Tsuyoshi、Shiba‐Fukushima Kahori、Hattori Nobutaka、Cheng Jinglei、Fujimoto Toyoshi、Wakana Yuichi、Inoue Hiroki、Tagaya Mitsuo
  • Journal Title: The EMBO Journal Volume: 37 Issue: 21
  • DOI: 10.15252/embj.201798899
  • Peer Reviewed / Open Access
• [Journal Article] Rapid dissemination of alpha-synuclein seeds through neural circuits in an in-vivo prion-like seeding experiment (2018)
  • Author(s): Okuzumi Ayami、Kurosawa Masaru、Hatano Taku、Takanashi Masashi、Nojiri Shuuko、Fukuhara Takeshi、Yamanaka Tomoyuki、Miyazaki Haruko、Yoshinaga Saki、Furukawa Yoshiaki、Shimogori Tomomi、Hattori Nobutaka、Nukina Nobuyuki
  • Journal Title: Acta Neuropathologica Communications Volume: 6 Issue: 1 Pages: 96-96
  • DOI: 10.1186/s40478-018-0587-0
  • Peer Reviewed / Open Access
• [Journal Article] Dopaminergic Neuron-Specific Autophagy-Deficient Mice (2018)
  • Author(s): Sato S, Hattori N.
  • Journal Title: Methods Mol Biol. Volume: 1759 Pages: 173-175
  • DOI: 10.1007/7651_2018_156
  • ISBN: 9781493977499, 9781493977505
  • Peer Reviewed
• [Journal Article] Regulation of membrane dynamics by Parkinson's disease-associated genes. Review. (2018)
  • Author(s): Inoshita T, Cui C, Hattori N, Imai Y.
  • Journal Title: J Genet. Volume: 97 Pages: 715-725
  • Peer Reviewed
• [Journal Article] Loss of autophagy in dopaminergic neurons causes Lewy pathology and motor dysfunction in aged mice. (2018)
  • Author(s): Sato S, Uchihara T, Fukuda T, Noda S, Kondo H, Saiki S, Komatsu M, Uchiyama Y, Tanaka K, Hattori N.
  • Journal Title: Sci Rep. Volume: ８ Issue: 1 Pages: 2813-2813
  • DOI: 10.1038/s41598-018-21325-w
  • Peer Reviewed / Open Access
• [Journal Article] Serum caffeine and metabolites are reliable biomarkers of early Parkinson disease. (2018)
  • Author(s): Fujimaki M, Saiki S, Li Y, Kaga N, Taka H, Hatano T, Ishikawa KI, Oji Y, Mori A, Okuzumi A, Koinuma T, Ueno SI, Imamichi Y, Ueno T, Miura Y, Funayama M, Hattori N.
  • Journal Title: Neurology. Volume: 90 Issue: 5 Pages: 1-8
  • DOI: 10.1212/wnl.0000000000004888
  • Peer Reviewed / Open Access
• [Presentation] Loss of CHCHD2 affects mitochondrial structure and dopaminergic neuronal loss in aged mice (2020)
  • Author(s): 佐藤栄人、野田幸子、舩山 学、服部信孝
  • Organizer: 第61回日本神経学会学術大会
• [Presentation] Genetic analysis of VPS13A/B/D: paralogous genes of VPS13C in Parkinson's disease (2020)
  • Author(s): 吉野浩代、李 元哲、林田有紗、舩山 学、西岡健弥、服部信孝
  • Organizer: 第61回日本神経学会学術大会
• [Presentation] Next-generation sequencing expand the possibilities to detect more variants in Parkinson's disease (2020)
  • Author(s): 李 元哲、吉野浩代、舩山 学、戸田達史、西岡健弥、服部信孝
  • Organizer: 第61回日本神経学会学術大会
• [Presentation] ATP13A2/PARK9 protects brains from a-synuclein propagation (2020)
  • Author(s): 常深泰司、石黒雄太、鎧坂朝子、奥住文美、貫名信行、服部信孝
  • Organizer: 第61回日本神経学会学術大会
• [Presentation] PINK1 heterozygote変異はalpha-synucleinopathyに部分的に関与する (2020)
  • Author(s): 西岡健弥、李 元哲、林田有紗、代田健祐、池田 彩、大垣光太郎、吉野浩代、舩山 学、服部信孝
  • Organizer: 第61回日本神経学会学術大会
• [Presentation] Variants in saposin D domain of prosaposin gene linked to Parkinson's diseases (2020)
  • Author(s): Oji Y, Hattori N.
  • Organizer: GEoPD Meeting in Milan 2020, 15th International Meeting, Virtual , Milano
  • Int'l Joint Research
• [Presentation] Therapeutics and treatments targeting mitochondria in PD (2020)
  • Author(s): Hattori N.
  • Organizer: 5th Taiwan International Congress of Parkinson's Disease and Movement Disorders (The 5th TIC-PDMD), Jan 16-18, 2021, Taipei
  • Int'l Joint Research / Invited
• [Presentation] Synaptic dysfuncion in a Drosophila model of PARK14. (2019)
  • Author(s): Hatano T, Mori A, Inoshita T, Fukushima-Shiba K, Koinuma T, Yamashita C, Imai Y, Hattori N.
  • Organizer: 2019 International Congress of Parkinson’s Disease and Movement Disorders
  • Int'l Joint Research
• [Presentation] Parkinson’s disease-associated mutations of PLA2G6 alters the membrane dynamics and α-synuclein stability. (2019)
  • Author(s): Mori A, Hatano T, Inoshita T, Fukushima-Shiba K, Koinuma T, Yamashita C, Okuzumi A, Imai Y, Hattori N.
  • Organizer: 2019 International Congress of Parkinson’s Disease and Movement Disorders
  • Int'l Joint Research
• [Presentation] 生体膜恒常性の変調によるα-Synuclein凝集メカニズム (2019)
  • Author(s): 今居 譲、森 聡生、井下 強、柴-福島 佳保里、孟 紅蕊、服部 信孝．
  • Organizer: 第42回日本分子生物学会年会 ワークショップ（タンパク質クオリティ -修飾・老化・病態のタンパク質品質解析-）
• [Presentation] alpha-synucleinの伝播抑制因子の探索と複合療法の検討 (2019)
  • Author(s): 奥住 文美, 波田野 琢, 福原 武志, 常深 泰司, 貫名 信行, 服部 信孝
  • Organizer: 第13回パーキンソン病・運動障害疾患コングレス
• [Presentation] パーキンソン病関連遺伝子はsmall GTPase, Arl-8の動態制御を介しα-シヌクレインのターンオーバーを調節する (2019)
  • Author(s): 井下 強、劉 俊逸、谷口大祐、髙梨雅史、今居 譲、服部信孝
  • Organizer: 第13回パーキンソン病・運動障害性疾患コングレス
• [Presentation] Parkin mutation analysis in Juntendo University and Parkinson’s disease model mice (2019)
  • Author(s): 佐藤栄人、服部信孝．
  • Organizer: 第60回日本神経学会学術大会
• [Presentation] Therapeutics and Treatments Targeting Mitochondria, SY7-1 (Speaker) (2019)
  • Author(s): Hattori N.
  • Organizer: 第16回アジアミトコンドリア学会 第19回日本ミトコンドリア 学会合同大会
  • Int'l Joint Research
• [Presentation] Pathophysiology of Parkinson's disease and mitochondria dydfunction (2019)
  • Author(s): 佐藤栄人、服部信孝
  • Organizer: 第16回アジアミトコンドリア学会 第19回日本ミトコンドリア 学会合同大会
  • Int'l Joint Research
• [Presentation] Updates on Parkinson’s disease management, Session Title: Personalised management of the diversities of non-motor symptoms in Parkinson’s disease (2019)
  • Author(s): Hattori N
  • Organizer: 2019 Chulalongkorn International Forum on Parkinson’s disease, Listening to patient’s concerns
  • Int'l Joint Research / Invited
• [Presentation] パーキンソン病の発症機序の解明（日本神経学会・楢林賞受賞者招待講演） (2018)
  • Author(s): 服部信孝
  • Organizer: 第59回日本神経学会学術大会
  • Invited
• [Presentation] Genetics forms of PD: hints from them provide us concepts of pathogenesis of nigral degeneration, Homo Hundred Age & Dementia: Alzheimer's Parkinson's Disease、Symposium (2018)
  • Author(s): Hattori N．
  • Organizer: 32nd KAST International Symposium
  • Int'l Joint Research / Invited
• [Presentation] Genetic and clinical perspectives of young onset Parkinson’s disease, Pre-Congress Symposium II (2018)
  • Author(s): Hattori N.
  • Organizer: The 4th Taiwan International Congress of Parkinson's Disease and Movement Disorders
  • Int'l Joint Research / Invited
• [Presentation] Non-motor Complications of PD, Pathophysiology of OFF: Implications for Increasing, Recognition of Motor Fluctuations, Luncheon Seminar (2018)
  • Author(s): Hattori N.
  • Organizer: International Parkinson and Movement Disorder Society, Hong Kong International Congress
  • Int'l Joint Research / Invited
• [Book] 治療薬ハンドブック2020 (2020)
  • Author(s): 髙久 史麿、堀 正二、菅野 健太郎、門脇 孝、乾 賢一、林 昌洋、服部信孝.
  • Total Pages: 1586
  • Publisher: じほう
  • ISBN: 9784840752282
• [Book] ウルトラ図解 パーキンソン病 (2020)
  • Author(s): 服部 信孝
  • Total Pages: 160
  • Publisher: 株式会社法研
  • ISBN: 9784865136128
• [Book] 最新版 順天堂大学が教えるパーキンソン病の自宅療法 (2019)
  • Author(s): 服部信孝、波田野琢、梅村淳、頼高朝子、羽鳥浩三
  • Total Pages: 192
  • Publisher: 主婦の友社
  • ISBN: 9784074342600
• [Book] 神経内科 Clinical Questions & Pearls パーキンソン病 (2019)
  • Author(s): 鈴木則宏、服部信孝、下泰司、波田野琢、王子悠、濃沼崇博、岩室宏一、他
  • Total Pages: 335
  • Publisher: ㈱中外医学社
  • ISBN: 9784498328044
• [Book] パーキンソン病診療総論、神経内科 Clinical Questions & Pearls パーキンソン病 (2019)
  • Author(s): 鈴木則宏、服部信孝、下泰司、波田野琢、王子悠、濃沼崇博、岩室宏一、他
  • Total Pages: 335
  • Publisher: 中外医学社
  • ISBN: 9784498328044
• [Book] パーキンソン病診療ガイドライン2018 (2018)
  • Author(s): 日本神経学会 (編集委員長：服部信孝)
  • Total Pages: 288
  • Publisher: 医学書院
  • ISBN: 9784260035965
• [Book] Mitophagy, Methods and Protocols, Methods in Molecular Biology 1759, (2018)
  • Author(s): Hattori N, Saiki S.: Editors, John M. Walker: Series Editor
  • Total Pages: 180
  • Publisher: Humana Press
  • ISBN: 9781493977499