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Molecular mechanism of organella homeostasis regulated by quantity and quality of lipids

Research Project

Project/Area Number 18H04051
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
Research InstitutionUniversity of Tsukuba

Principal Investigator

SHIMANO HITOSHI  筑波大学, 医学医療系, 教授 (20251241)

Co-Investigator(Kenkyū-buntansha) 松坂 賢  筑波大学, 医学医療系, 教授 (70400679)
関谷 元博  筑波大学, 医学医療系, 准教授 (50420245)
韓 松伊  筑波大学, 国際統合睡眠医科学研究機構, 研究員 (80729541)
中川 嘉  筑波大学, 国際統合睡眠医科学研究機構, 准教授 (80361351)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥44,720,000 (Direct Cost: ¥34,400,000、Indirect Cost: ¥10,320,000)
Fiscal Year 2020: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2019: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2018: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Keywords多価不飽和脂肪酸 / 小胞体 / ミトコンドリア / 脂質 / 脂肪酸 / オルガネラ / 転写因子 / リピドミクス / 酵素 / ライブセルイメージング / 脂肪毒性 / 脂質代謝 / 脂肪酸伸長酵素 / オルガネラリピッドコード
Outline of Final Research Achievements

SREBP and CREB3L3 are membrane-bound transcription factors involved in the maintenance of lipid metabolism in the liver. CREB3L3 deficiency results in the accumulation of nuclear SREBP proteins. Because both transcriptional factors share the cleavage system for nuclear transactivation, full-length CREB3L3 and SREBPs in the endoplasmic reticulum (ER) functionally inhibit each other. CREB3L3 promotes the formation of the SREBP-insulin induced gene 1 complex to suppress SREBPs for ER-Golgi transport, resulting in ER retention and inhibition of proteolytic activation at the Golgi and vice versa.
ELOVL fatty acid elongase 6 (Elovl6) is responsible for converting C16 saturated and monounsaturated fatty acids into C18 species. Our study demonstrated that C18:0-ceramide suppresses hepatic insulin sensitivity and its production involves the formation of an Elovl6-ceramide synthase 4 (CerS4) complex in the endoplasmic reticulum and a Pnpla3-CerS4 complex on lipid droplets.

Academic Significance and Societal Importance of the Research Achievements

本研究によって、脂質制御による生体機能と病態の分子機序を、オルガネラレベルでの脂質の量と質の変化として捉え、その構造も含めた破綻(オルガネラ脂肪毒性)が病態の端緒となることを一部証明できた。本研究成果を踏まえ、今後さらに解析対象を様々な細胞オルガネラレベルに高度化し、エネルギー代謝、シグナル伝達、ストレス応答、増殖・分化など多様なバイオロジーにおいて、どのオルガネラの、どのリピッドが、どの分子をいかに制御しているか、ホメオスタシス(オルガネラリピッドコード)の共通原理を分子レベルで理解したい。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (66 results)

All 2021 2020 2019 2018 Other

All Journal Article (28 results) (of which Int'l Joint Research: 17 results,  Peer Reviewed: 28 results,  Open Access: 23 results) Presentation (34 results) (of which Int'l Joint Research: 2 results,  Invited: 7 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Hepatocellular carcinoma development in diabetic patients: a nationwide survey in Japan2021

    • Author(s)
      Tateishi R、Matsumura T、Okanoue T、Shima T、Uchino K、Fujiwara N、Senokuchi T、Kon K、Sasako T、Taniai M、Kawaguchi T、Inoue H、Watada H、Kubota N、Shimano H、Kaneko S、Hashimoto E、Watanabe S、Shiota G、Ueki K、Kashiwabara K、Matsuyama Y、Tanaka H、Kasuga M、Araki E、Koike K
    • Journal Title

      Journal of Gastroenterology

      Volume: 56 Issue: 3 Pages: 261

    • DOI

      10.1007/s00535-020-01754-z

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-term safety and efficacy of alogliptin, a DPP-4 inhibitor, in patients with type 2 diabetes: a 3-year prospective, controlled, observational study (J-BRAND Registry)2021

    • Author(s)
      Ueki K, Tanizawa Y, Nakamura J, Yamada Y, Inagaki N, Watada H, Shimomura I, Nishimura R, Miyoshi H, Abiko A, Katagiri H, Hayashi M, Shimada A, Naruse K, Fujimoto S, Fujiwara M, Shikata K, Okada Y, Araki E, Yamazaki T, Kadowaki T; J-BRAND Registry Group.
    • Journal Title

      BMJ Open Diabetes Research & Care

      Volume: 9 Issue: 1 Pages: e001787-e001787

    • DOI

      10.1136/bmjdrc-2020-001787

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enterohepatic Transcription Factor CREB3L3 Protects Atherosclerosis via SREBP Competitive Inhibition2021

    • Author(s)
      Nakagawa Yoshimi、Wang Yunong、Han Song-iee、Okuda Kanako、Oishi Asayo、Yagishita Yuka、Kumagai Kae、Ohno Hiroshi、Osaki Yoshinori、Mizunoe Yuhei、Araki Masaya、Murayama Yuki、Iwasaki Hitoshi、Konishi Morichika、Itoh Nobuyuki、Matsuzaka Takashi、Sone Hirohito、Yamada Nobuhiro、Shimano Hitoshi
    • Journal Title

      Cellular and Molecular Gastroenterology and Hepatology

      Volume: 11 Issue: 4 Pages: 949-971

    • DOI

      10.1016/j.jcmgh.2020.11.004

    • NAID

      120006939158

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association between use of Qingfei Paidu Tang and mortality in hospitalized patients with COVID-19: A national retrospective registry study2021

    • Author(s)
      Zhang Lihua、Zheng Xin、Bai Xueke、Wang Qing、Chen Bowang、Wang Haibo、Lu Jiapeng、Hu Shuang、Zhang Xiaoyan、Zhang Haibo、Liu Jiamin、Shi Ying、Zhou Zhiye、Gan Lanxia、Li Xi、Li Jing
    • Journal Title

      Phytomedicine

      Volume: 85 Pages: 153531-153531

    • DOI

      10.1016/j.phymed.2021.153531

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Severity of hypertension as a predictor of initiation of dialysis among study participants with and without diabetes mellitus2020

    • Author(s)
      Osawa Taeko、Fujihara Kazuya、Harada Yamada Mayuko、Yamamoto Masahiko、Kitazawa Masaru、Matsubayashi Yasuhiro、Iwanaga Midori、Yamada Takaho、Seida Hiroyasu、Kodama Satoru、Nakagawa Yoshimi、Shimano Hitoshi、Sone Hirohito
    • Journal Title

      Journal of Investigative Medicine

      Volume: 69 Issue: 3 Pages: 724-729

    • DOI

      10.1136/jim-2020-001489

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxidative stress and Liver X Receptor agonist induce hepatocellular carcinoma in Non‐alcoholic steatohepatitis model2020

    • Author(s)
      Shimizu Yoshio、Tamura Takafumi、Kemmochi Akira、Owada Yohei、Ozawa Yusuke、Hisakura Katsuji、Matsuzaka Takashi、Shimano Hitoshi、Nakano Noriyuki、Sakashita Shingo、Oda Tatsuya、Ohkohchi Nobuhiro
    • Journal Title

      Journal of Gastroenterology and Hepatology

      Volume: 36 Issue: 3 Pages: 800-810

    • DOI

      10.1111/jgh.15239

    • NAID

      120007165441

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diabetes mellitus and risk of new-onset and recurrent heart failure: a systematic review and meta-analysis2020

    • Author(s)
      Kodama S, Fujihara K, Horikawa C, Sato T, Iwanaga M, Yamada T, Kato K, Watanabe K, Shimano H, Izumi T, Sone H
    • Journal Title

      ESC heart failure

      Volume: 7 (5) Issue: 5 Pages: 2146-74

    • DOI

      10.1002/ehf2.12782

    • NAID

      120007163352

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Srebp-1c/Fgf21/Pgc-1α Axis Regulated by Leptin Signaling in Adipocytes?Possible Mechanism of Caloric Restriction-Associated Metabolic Remodeling of White Adipose Tissue2020

    • Author(s)
      Kobayashi Masaki、Uta Seira、Otsubo Minami、Deguchi Yusuke、Tagawa Ryoma、Mizunoe Yuhei、Nakagawa Yoshimi、Shimano Hitoshi、Higami Yoshikazu
    • Journal Title

      Nutrients

      Volume: 12 Issue: 7 Pages: 2054-2054

    • DOI

      10.3390/nu12072054

    • NAID

      120007147861

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Deciphering genetic signatures by whole exome sequencing in a case of co-prevalence of severe renal hypouricemia and diabetes with impaired insulin secretion2020

    • Author(s)
      Sekiya Motohiro、Matsuda Takaaki、Yamamoto Yuki、Furuta Yasuhisa、Ohyama Mariko、Murayama Yuki、Sugano Yoko、Ohsaki Yoshinori、Iwasaki Hitoshi、Yahagi Naoya、Yatoh Shigeru、Suzuki Hiroaki、Shimano Hitoshi
    • Journal Title

      BMC Medical Genetics

      Volume: 21 Issue: 1 Pages: 91-91

    • DOI

      10.1186/s12881-020-01031-z

    • NAID

      120007147873

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A new perspective on type 2 diabetes, dyslipidemia, and non-alcoholic fatty liver disease.2020

    • Author(s)
      Matsuzaka T, Shimano H.
    • Journal Title

      J Diabetes Investig.

      Volume: in press Issue: 3 Pages: 532-534

    • DOI

      10.1111/jdi.13258

    • NAID

      120007165450

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl‐Chain Length and Hepatic Insulin Sensitivity in Mice2020

    • Author(s)
      Matsuzaka T、Kuba M、Koyasu S、Yamamoto Y、Motomura K、Arulmozhiraja S、Ohno H、Sharma R、Shimura T、Okajima Y、Han SI、Aita Y、Mizunoe Y、Osaki Y、Iwasaki H、Yatoh S、Suzuki H、Sone H、Takeuchi Y、Yahagi N、Miyamoto T、Sekiya M、Nakagawa Y、Ema M、Takahashi S、Tokiwa H、Shimano H
    • Journal Title

      Hepatology

      Volume: 71 Issue: 5 Pages: 1609-1625

    • DOI

      10.1002/hep.30953

    • NAID

      120007132717

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms2020

    • Author(s)
      Satoh Aoi、Han Song-iee、Araki Masaya、Nakagawa Yoshimi、Ohno Hiroshi、Mizunoe Yuhei、Kumagai Kae、Murayama Yuki、Osaki Yoshinori、Iwasaki Hitoshi、Sekiya Motohiro、Konishi Morichika、Itoh Nobuyuki、Matsuzaka Takashi、Sone Hirohito、Shimano Hitoshi
    • Journal Title

      iScience

      Volume: 23 Issue: 3 Pages: 100930-100930

    • DOI

      10.1016/j.isci.2020.100930

    • NAID

      120006891020

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cathepsin B overexpression induces degradation of perilipin 1 to cause lipid metabolism dysfunction in adipocytes2020

    • Author(s)
      Mizunoe Yuhei、Kobayashi Masaki、Hoshino Shunsuke、Tagawa Ryoma、Itagawa Rei、Hoshino Ayana、Okita Naoyuki、Sudo Yuka、Nakagawa Yoshimi、Shimano Hitoshi、Higami Yoshikazu
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 634-634

    • DOI

      10.1038/s41598-020-57428-6

    • NAID

      120007165462

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Elucidation of Molecular Mechanism of a Selective PPARα Modulator, Pemafibrate, through Combinational Approaches of X-ray Crystallography, Thermodynamic Analysis, and First-Principle Calculations2020

    • Author(s)
      Kawasaki Mayu、Kambe Akira、Yamamoto Yuta、Arulmozhiraja Sundaram、Ito Sohei、Nakagawa Yoshimi、Tokiwa Hiroaki、Nakano Shogo、Shimano Hitoshi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Issue: 1 Pages: 361-361

    • DOI

      10.3390/ijms21010361

    • NAID

      120007132701

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Transcriptional co-repressor CtBP2 orchestrates epithelial-mesenchymal transition through a novel transcriptional holocomplex with OCT12020

    • Author(s)
      Ma Yang、Sekiya Motohiro、Kainoh Kenta、Matsuda Takaaki、Iwasaki Hitoshi、Osaki Yoshinori、Sugano Yoko、Suzuki Hiroaki、Takeuchi Yoshinori、Miyamoto Takafumi、Yahagi Naoya、Nakagawa Yoshimi、Matsuzaka Takashi、Shimano Hitoshi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 523 Issue: 2 Pages: 354-360

    • DOI

      10.1016/j.bbrc.2019.12.070

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association between Lysosomal Dysfunction and Obesity-Related Pathology: A Key Knowledge to Prevent Metabolic Syndrome2019

    • Author(s)
      Mizunoe Yuhei、Kobayashi Masaki、Tagawa Ryoma、Nakagawa Yoshimi、Shimano Hitoshi、Higami Yoshikazu
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 20 Issue: 15 Pages: 3688-3688

    • DOI

      10.3390/ijms20153688

    • NAID

      120007133171

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) paradigm: conceptual framework and therapeutic potential2019

    • Author(s)
      Fruchart Jean-Charles、Santos Raul D.Ponte-Negretti Carlos I、Pradhan Aruna、Ray Kausik K.、Reiner ?eljko、Ridker Paul M.、Ruscica Massimiliano、Sadikot Shaukat、Shimano Hitoshi. et al
    • Journal Title

      Cardiovascular Diabetology

      Volume: 18 Issue: 1 Pages: 71-71

    • DOI

      10.1186/s12933-019-0864-7

    • NAID

      120007133397

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Octacosanol and policosanol prevent high-fat diet-induced obesity and metabolic disorders by activating brown adipose tissue and improving liver metabolism2019

    • Author(s)
      Sharma Rahu, Takafumi Miyamoto, et al.
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 5169-5169

    • DOI

      10.1038/s41598-019-41631-1

    • NAID

      120007133465

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Glucocorticoid receptor suppresses gene expression of Rev-erbα (Nr1d1) through interaction with the CLOCK complex2019

    • Author(s)
      Murayama Yuki, Takafumi Miyamoto, et al.
    • Journal Title

      FEBS Letters

      Volume: 593 Issue: 4 Pages: 423-432

    • DOI

      10.1002/1873-3468.13328

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Transcriptome network analysis identifies protective role of the LXR/SREBP-1c axis in murine pulmonary fibrosis.2019

    • Author(s)
      Shichino S, Ueha S, Hashimoto S, Otsuji M, Abe J, Tsukui T, Deshimaru S, Nakajima T, Kosugi-Kanaya M, Shand FH, Inagaki Y, Shimano H, Matsushima K.
    • Journal Title

      JCI Insight.

      Volume: 4(1) Issue: 1 Pages: 122163-122163

    • DOI

      10.1172/jci.insight.122163

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Elovl6 regulates mechanical damage-induced keratinocyte death and skin inflammation.2018

    • Author(s)
      Nakamura Y, Matsuzaka T, Tahara-Hanaoka S, Shibuya K, Shimano H, Nakahashi-Oda C, Shibuya A.
    • Journal Title

      Cell Death Dis.

      Volume: 9(12) Issue: 12 Pages: 1181-1181

    • DOI

      10.1038/s41419-018-1226-1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Protein residue networks from energetic and geometric data ? are they identical?2018

    • Author(s)
      Vladimir Sladek, Hiroaki Tokiwa, Hitoshi Shimano, Yasuteru Shigeta
    • Journal Title

      J. Chem. Theor. Comp.

      Volume: 14(12) Issue: 12 Pages: 6623-6631

    • DOI

      10.1021/acs.jctc.8b00733

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The Peroxisome Proliferator-Activated Receptor α (PPARα) Agonist Pemafibrate Protects against Diet-Induced Obesity in Mice2018

    • Author(s)
      Araki Masaya、Nakagawa Yoshimi、Oishi Asayo、Han Song-iee、Wang Yunong、Kumagai Kae、Ohno Hiroshi、Mizunoe Yuhei、Iwasaki Hitoshi、Sekiya Motohiro、Matsuzaka Takashi、Shimano Hitoshi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 19 Issue: 7 Pages: 2148-2148

    • DOI

      10.3390/ijms19072148

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Brg1 regulates pro-lipogenic transcription by modulating SREBP activity in hepatocytes2018

    • Author(s)
      Li Nan、Li Min、Hong Wenxuan、Shao Jing、Xu Huihui、Shimano Hitoshi、Lu Jun、Xu Yong
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

      Volume: 1864 Issue: 9 Pages: 2881-2889

    • DOI

      10.1016/j.bbadis.2018.05.022

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CREBH Regulates Systemic Glucose and Lipid Metabolism2018

    • Author(s)
      Nakagawa Yoshimi、Shimano Hitoshi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 19 Issue: 5 Pages: 1396-1396

    • DOI

      10.3390/ijms19051396

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Transgenic Mice Overexpressing SREBP-1a in Male ob/ob Mice Exhibit Lipodystrophy and Exacerbate Insulin Resistance.2018

    • Author(s)
      Ohno H, Matsuzaka T, Tang N, Sharma R, Motomura K, Shimura T, Satoh A, Han SI, Takeuchi Y, Aita Y, Iwasaki H, Yatoh S, Suzuki H, Sekiya M, Nakagawa Y, Sone H, Yahagi N, Yamada N, Higami Y, Shimano H.
    • Journal Title

      Endocrinology.

      Volume: 159(6) Issue: 6 Pages: 2308-2323

    • DOI

      10.1210/en.2017-03179

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Molecular association model of PPARα and its new specific and efficient ligand, pemafibrate: Structural basis for SPPARMα2018

    • Author(s)
      Yamamoto Yuta、Takei Kenta、Arulmozhiraja Sundaram、Sladek Vladimir、Matsuo Naoya、Han Song-iee、Matsuzaka Takashi、Sekiya Motohiro、Tokiwa Takaki、Shoji Mitsuo、Shigeta Yasuteru、Nakagawa Yoshimi、Tokiwa Hiroaki、Shimano Hitoshi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 499 Issue: 2 Pages: 239-245

    • DOI

      10.1016/j.bbrc.2018.03.135

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in MacrophagesHighlights2018

    • Author(s)
      Karasawa Tadayoshi、Kawashima Akira、Usui-Kawanishi Fumitake、Watanabe Sachiko、Kimura Hiroaki、Kamata Ryo、Shirasuna Koumei、Koyama Yutaro、Sato-Tomita Ayana、Matsuzaka Takashi、Tomoda Hiroshi、Park Sam-Yong、Shibayama Naoya、Shimano Hitoshi、Kasahara Tadashi、Takahashi Masafumi
    • Journal Title

      Arteriosclerosis, Thrombosis, and Vascular Biology

      Volume: 38 Issue: 4 Pages: 744-756

    • DOI

      10.1161/atvbaha.117.310581

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 肝・腸管・骨格筋Axisを基軸とした代謝栄養管理の実践 空腸切除による残存回腸の"空腸化"は生じるのか? 小腸切除マウスモデルを用いた解析2020

    • Author(s)
      佐々木 理人, 増本 幸二, 小野 健太郎, 堀口 比奈子, 西塔 翔吾, 伊藤 愛香里, 根本 悠里, 田中 尚, 相吉 翼, 千葉 史子, 神保 教広, 瓜田 泰久, 新開 統子, 高安 肇, 中川 嘉, 島野 仁
    • Organizer
      日本外科代謝栄養学会第57 回学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 糖鎖認識メカニズムによる糖質・脂質エネルギー協調制御の解明2020

    • Author(s)
      泉田 欣彦, 和田 亘弘, 呼延 宜人, 鈴木 卓也, 升田 紫, 畠山 裕康, 武内 謙憲, Saber Zahra, 村山 友樹, 會田 雄一, 山崎 悠理子, 梅原 敏弘, 大竹 啓之, 高橋 倫子, 矢作 直也, 島野 仁, 山内 敏正, 門脇 孝
    • Organizer
      第 63 回日本糖尿病学会年次学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 腸肝転写因子CREBHはSREBPの活性を制御し、動脈硬化発症を抑制する(会議録)2020

    • Author(s)
      中川 嘉, 王 雨農, 韓 松伊, 水之江 雄平, 荒木 雅弥, 関谷 元博, 松坂 賢, 島野 仁
    • Organizer
      第 63 回日本糖尿病学会年次学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 多価不飽和脂肪酸(PUFA)によるSREBP-1特異的な抑制機序の解明2020

    • Author(s)
      升田 紫, 矢作 直也, 武内 謙憲, 和田 亘弘, 呼延 宜人, 李 恩旭, Saber Zahra Mehrazad, 沢田 義一, 村山 友樹, 會田 雄一, 西 真貴子[辰巳], 泉田 欣彦, 飯塚 陽子, 位高 啓史, 片岡 一則, 島野 仁, 門脇 孝
    • Organizer
      第 63 回日本糖尿病学会年次学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 中年期2型糖尿病者の認知機能低下の特徴と、におい、バランスとの関連2020

    • Author(s)
      緑川 学, 鈴木 浩明, 鈴木 康裕, 椿 拓海, 田邉 裕基, 山内 一由, 佐藤 泰之, 根本 清貴, 菅野 洋子, 岩崎 仁, 関谷 元博, 矢藤 繁, 矢作 直也, 羽田 康司, 新井 哲明, 島野 仁
    • Organizer
      第 63 回日本糖尿病学会年次学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 肝臓特異的Elovl6欠損マウスの肝臓ではC18-ceramideが減少することによりインスリン感受性が亢進する2020

    • Author(s)
      松坂 賢, 久芳 素子, 小安 さおり, 本村 香織, 大野 博, Rahul Sharma, 武内 謙憲, 矢作 直也, 宮本 崇史, 関谷 元博, 中川 嘉, 島野 仁
    • Organizer
      第 63 回日本糖尿病学会年次学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] メタボリックシンドロームの病態形成に重要と考えられる代謝産物センサー分子CtBP2の活性化化合物の探索2020

    • Author(s)
      戒能 賢太, 関谷 元博, 松田 高明, 馬 洋, 島野 仁
    • Organizer
      第 63 回日本糖尿病学会年次学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 糖尿病入院患者を対象とした退院1年後の転倒予測因子に関する機械学習を用いた探索的検討2020

    • Author(s)
      鈴木 康裕, 鈴木 浩明, 石川 達也, 山田 康智, 石川 公久, 羽田 康司, 島野 仁
    • Organizer
      第 63 回日本糖尿病学会年次学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 生体イメージングで迫る糖・脂質代謝に重要なKLF15遺伝子発現制御機構の解明2020

    • Author(s)
      武内 謙憲, 矢作 直也, 會田 雄一, 村山 友樹, Saber Zahra Mehrazad, 何 敏煕, 呼延 宜人, 升田 紫, 泉田 欣彦, 島野 仁, 筑波大学医学医療系ニュートリゲノミクス・リサーチグループ
    • Organizer
      第 63 回日本糖尿病学会年次学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] コレステロールとトリグリセリド2020 revisit2020

    • Author(s)
      島野 仁
    • Organizer
      第35回 日本糖尿病合併症学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 小腸切除モデルマウスを用いた小腸切除後の栄養トランスポーター関連遺伝子発現変化の検討2020

    • Author(s)
      佐々木 理人, 小野 健太郎, 堀口 比奈子, 白根 和樹, 根本 悠里, 田中 尚, 相吉 翼, 千葉 史子, 神保 教広, 瓜田 泰久, 新開 統子, 高安 肇, 中川 嘉, 島野 仁, 増本 幸二
    • Organizer
      第35回日本臨床栄養代謝学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 小腸切除マウスの肝臓における脂質代謝関連遺伝子発現の検討2020

    • Author(s)
      小野 健太郎, 佐々木 理人, 松坂 賢, 島野 仁, 増本 幸二
    • Organizer
      第35回日本臨床栄養代謝学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ホスファターゼで解き明かす生理と病態のメカニズム セラミドの脂肪酸分子種によるプロテインホスファターゼ2Aの活性制御機構 脂肪酸伸長酵素Elovl6の重要性とインスリン感受性における意義2020

    • Author(s)
      松坂 賢, 島野 仁
    • Organizer
      第93回日本生化学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 学際研究で切り拓く脂質とアミノ酸のメタボダイナミズム 脂肪酸の量と質とセンシングの視点からみた脂質多様性とメタボダイナミズム2020

    • Author(s)
      島野 仁, 松坂 賢, 関谷 元博, 宮本 崇史
    • Organizer
      第93回日本生化学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 学際研究で切り拓く脂質とアミノ酸のメタボダイナミズム 質量分析を用いた組織・細胞の脂質メタボロミクスとトランスレーショナル応用2020

    • Author(s)
      林 昭夫, 松坂 賢, 島野 仁
    • Organizer
      第93回日本生化学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 患側と考えられた副腎摘出後も改善が無く治療に苦慮した副腎髄質過形成の一例2020

    • Author(s)
      古田 泰久, 大崎 芳典, 山本 由季, 大山 真理子, 村山 友樹, 菅野 洋子, 岩崎 仁, 関谷 元博, 矢作 直也, 鈴木 浩明, 笹野 公伸, 竹越 一博, 島野 仁
    • Organizer
      第89回日本内分泌学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 成人後の治療自己中断中に糖尿病を契機に指摘された、POUF1/PIT-1遺伝子異常によると考えられる複合型下垂体機能低下症の一例2020

    • Author(s)
      新田 葉月, 村山 友樹, 中島 里佳子, 大山 真理子, 大崎 芳典, 菅野 洋子, 岩崎 仁, 関谷 元博, 矢作 直也, 鈴木 浩明, 島野 仁
    • Organizer
      第89回日本内分泌学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 亜急性甲状腺炎発症後バセドウ病が明らかになった2症例2020

    • Author(s)
      菅野 洋子, 中島 里佳子, 大山 真理子, 村山 友樹, 大崎 芳典, 岩崎 仁, 関谷 元博, 矢作 直也, 鈴木 浩明, 島野 仁
    • Organizer
      第89回日本内分泌学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 機械学習を用いた原発性アルドステロン症病型診断の試み2020

    • Author(s)
      鈴木 浩明(筑波大学 医学医療系内分泌代謝・糖尿病内科), 松田 えりか, 松田 高明, 古田 泰久, 村山 友樹, 戒能 賢太, 大崎 芳典, 菅野 洋子, 岩崎 仁, 関谷 元博, 矢作 直也, 島野 仁
    • Organizer
      第89回日本内分泌学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] グルココルチコイドによるGR-Bmal/Clock複合体を介した時計遺伝子Nr1d1の抑制性転写制御機構2020

    • Author(s)
      村山 友樹, 矢作 直也, 武内 謙憲, 會田 雄一, 何 敏煕, Mehrazad Saber Zahra, 志鎌 明人, 升田 紫, 泉田 欣彦, 宮本 崇史, 関谷 元博, 中川 嘉, 松坂 賢, 大崎 芳典, 菅野 洋子, 岩崎 仁, 鈴木 浩明, 川上 康, 島野 仁
    • Organizer
      第89回日本内分泌学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 肝臓特異的Elovl6欠損マウスの肝臓ではC18-ceramideが減少することによりインスリン感受性が亢進する2020

    • Author(s)
      松坂 賢, 久芳 素子, 小安 さおり, 本村 香織, 大野 博, Rahul Sharma, 武内 謙憲, 矢作 直也, 宮本 崇史, 関谷 元博, 中川 嘉, 島野 仁
    • Organizer
      第89回日本内分泌学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 栄養環境センシングと制御(の分子基盤) 代謝産物センサー分子CtBP2を中心とした新しい代謝制御システムの同定2020

    • Author(s)
      関谷 元博, 戒能 賢太, 馬 洋, 松田 高明, Gokhan Hotamisligil, 島野 仁
    • Organizer
      第93回日本生化学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 動脈硬化とNAFLD共通病態を脂質代謝からみつめる2020

    • Author(s)
      島野 仁
    • Organizer
      第 56 回 日本肝臓学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 脂肪酸伸長酵素Elovl6による神経新生の制御機構解明2020

    • Author(s)
      大野 博, 松坂 賢, 本村 香織, 志村 拓哉, 宮本 崇史, 関谷 元博, 中川 嘉, 島野
    • Organizer
      日本臨床分子医学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 血中脂質研究の今 セラミドの脂肪酸鎖長によるインスリン感受性制御機構と血中脂質2020

    • Author(s)
      松坂 賢, 島野 仁
    • Organizer
      脂質生化学研究
    • Related Report
      2020 Annual Research Report
  • [Presentation] 心血管疾患のリスク病態としてのNAFLD/NASH(合同シンポジウム)2019

    • Author(s)
      島野仁
    • Organizer
      第51回日本動脈硬化学会総会・学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 脂質の量と質の変容がもたらす臓器病態と栄養戦略(特別講演)2019

    • Author(s)
      島野仁
    • Organizer
      第73回日本栄養・食糧学会大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] A novel aspect of fatty acid chain length in lipotoxicity: Lessons from Elovl6 KO mice2019

    • Author(s)
      Hitoshi Shimano
    • Organizer
      60th International Conference on the Bioscience of Lipids
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A metabolite sensor CtBP2 integrates metabolic flux to orchestrate glucose and lipid homeostasis in liver2019

    • Author(s)
      Motohiro Sekiya, Hitoshi Shimano, Gokhan Hotamisligil
    • Organizer
      60th International Conference on the Bioscience of Lipids
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 脂肪酸伸長酵素Elovl6による脂肪酸の質の制御と組織内蓄積脂肪2018

    • Author(s)
      松坂賢、島野仁
    • Organizer
      第40回日本臨床栄養学会総会・第39回日本臨床栄養協会総会 第16回大連合大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 骨格筋特異的HMG-CoA還元酵素ノックアウトマウスにおける筋障害メカニズム2018

    • Author(s)
      島野仁、大崎芳典、村山友樹、水之江雄平、中川嘉
    • Organizer
      第4回日本筋学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 代謝産物センサーによる新しい脂質・糖代謝制御システムの解明と医療応用2018

    • Author(s)
      関谷元博、菅澤威仁、馬 洋、戒能賢太、関根七海、Gokhan Hotamisligil、島野仁
    • Organizer
      第50回日本動脈硬化学会総会・学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 転写因子CREBHの未成熟型・成熟型による動脈硬化形成に対する二重支配の分子メカニズム2018

    • Author(s)
      中川嘉、韓松伊、大石麻代、王雨農、関谷元博、松坂賢、島野仁
    • Organizer
      第50回日本動脈硬化学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 脂肪酸の質的変化による脂質代謝、エネルギー代謝2018

    • Author(s)
      松坂賢、島野仁
    • Organizer
      第61回日本糖尿病学会年次学術集会
    • Related Report
      2018 Annual Research Report
  • [Remarks] 筑波大学 内分泌代謝・糖尿病内科

    • URL

      https://www.u-tsukuba-endocrinology.jp/

    • Related Report
      2020 Annual Research Report
  • [Remarks] 筑波大学 医学医療系 内分泌代謝・糖尿病内科

    • URL

      https://www.u-tsukuba-endocrinology.jp/

    • Related Report
      2019 Annual Research Report
  • [Remarks] 筑波大学内分泌代謝・糖尿病内科

    • URL

      https://www.u-tsukuba-endocrinology.jp/

    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 生細胞内論理ゲートによるオルガネラの形態操作法2019

    • Inventor(s)
      宮本崇史、松坂賢、島野仁
    • Industrial Property Rights Holder
      宮本崇史、松坂賢、島野仁
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-211266
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report

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Published: 2018-04-23   Modified: 2022-01-27  

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