Elucidation of pathogenesis and novel therapeutics for refractory leukemias

• Project/Area Number: 18H04052
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
• Research Institution: The University of Tokyo
• Principal Investigator: KUROKAWA MINEO 東京大学, 医学部附属病院, 教授 (80312320)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥44,460,000 (Direct Cost: ¥34,200,000、Indirect Cost: ¥10,260,000); Fiscal Year 2020: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000); Fiscal Year 2019: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000); Fiscal Year 2018: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
• Keywords: 急性骨髄性白血病 / 難治性白血病 / 転写因子

Outline of Final Research Achievements

The pathogenesis of EVI1-positive leukemia, known as refractory acute myeloid leukemia (AML), has been elucidated using mouse models and genetically modified cell lines. Specifically, we extracted molecules that contribute to the pathogenesis of the normal, preleukemic, and AML states, and clarified some of the functions of EVI1, such as co-factors, histone modifications, enhancers, transcriptional regulation, and metabolic regulation, that are involved in the pathogenesis of refractory AML.
The functional significance of EVI1 in AML was elucidated by NGS analysis using DNMT3A mutation repair strains.
Using human AML specimens, we identified BCOR and MAP4K2 as novel mutations that confer resistance to treatment, and elucidated part of the mechanism of resistance to treatment.

Academic Significance and Societal Importance of the Research Achievements

難治性白血病の治療開発を推進するためには、網羅的解析技術により遺伝子異常を同定することに加え、エピジェネティクス、代謝、骨髄造血環境など、難治性病態を形成する異常の相互作用を、in vitro、in vivoの適切なモデルを活用して明らかにし、治療標的化する必要がある。今回我々はEVI1陽性型白血病の発症・難治化機構の解明と、白血病特異的な標的・協調因子の探索、エピジェネティクス異常に基づく白血病モデルマウスを用いた解析、治療抵抗性をもたらす新規遺伝子変異の同定とその機能解析を行い、難治性白血病の病態の一端を明らかにした。
これらの結果より、難治性白血病の新規治療開発の基盤モデルを確立した。

Research Products

• [Journal Article] MECOM permits pancreatic acinar cell dedifferentiation avoiding cell death under stress conditions (2021)
  • Author(s): Backx Elyne、Wauters Elke、Baldan Jonathan、Van Bulck Mathias、Michiels Ellis、Heremans Yves、 De Paep Diedert Luc、Kurokawa Mineo、Goyama Susumu、Bouwens Luc、Jacquemin Patrick、Houbracken Isabelle、Rooman Ilse
  • Journal Title: Cell Death & Differentiation Volume: 1 Issue: 9 Pages: 1-1
  • DOI: 10.1038/s41418-021-00771-6
  • Peer Reviewed
• [Journal Article] Physical interaction between BAALC and DBN1 induces chemoresistance in leukemia (2021)
  • Author(s): Maki Hiroaki、Yoshimi Akihide、Shimada Takashi、Arai Shunya、Morita Ken、Kamikubo Yasuhiko、 Ikegawa Masaya、Kurokawa Mineo
  • Journal Title: Experimental Hematology Volume: 94 Pages: 31-36
  • DOI: 10.1016/j.exphem.2020.12.003
  • Peer Reviewed / Open Access
• [Journal Article] Difference of preventing effects of G-CSF according to age in patients with malignant lymphoma: A nation-wide analysis in Japan (2021)
  • Author(s): Matsuda Kensuke、Jo Taisuke、Miyauchi Masashi、Toyama Kazuhiro、Nakazaki Kumi、Matsui Hiroki、Fushimi Kiyohide、Yasunaga Hideo、Kurokawa Mineo
  • Journal Title: Journal of Infection and Chemotherapy Volume: 1 Issue: 8 Pages: 1-1
  • DOI: 10.1016/j.jiac.2021.03.004
  • Peer Reviewed
• [Journal Article] Primary prophylaxis with pegfilgrastim during the first cycle of R-CHOP to avoid reduction of dose intensity in elderly patients (2021)
  • Author(s): Ise Masataka、Matsuda Kensuke、Shimura Arika、Masamoto Yosuke、Kurokawa Mineo
  • Journal Title: International Journal of Hematology Volume: 1 Pages: 1-1
  • DOI: 10.1007/s12185-021-03118-6
  • Peer Reviewed
• [Journal Article] Severe cellulitis caused by Achromobacter xylosoxidans after allogeneic hematopoietic stem cell transplantation (2021)
  • Author(s): Oyama Yu、Yasunaga Megumi、Honda Akira、Maki Hiroaki、Masamoto Yosuke、Kobayashi Tatsuya、Wakabayashi Yoshitaka、Okugawa Shu、Moriya Kyoji、Kurokawa Mineo
  • Journal Title: Journal of Infection and Chemotherapy Volume: 27 Issue: 5 Pages: 770-772
  • DOI: 10.1016/j.jiac.2020.12.025
  • Peer Reviewed
• [Journal Article] Pivotal role of DPYSL2A in KLF4-mediated monocytic differentiation of acute myeloid leukemia cells (2020)
  • Author(s): Noura Mina、Morita Ken、Kiyose Hiroki、Matsuo Hidemasa、Nishinaka-Arai Yoko、Kurokawa Mineo、 Kamikubo Yasuhiko、Adachi Souichi
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 1-1
  • DOI: 10.1038/s41598-020-76951-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation (2020)
  • Author(s): Toda G、Soeda K、Okazaki Y、Kobayashi N、Masuda Y、Arakawa N、Suwanai H、Masamoto Y、Izumida Y、Kamei N、Sasako T、Suzuki R、Kubota T、Kubota N、Kurokawa M、Tobe K、Noda T、Honda K、Accili D、Yamauchi T、Kadowaki T、Ueki K
  • Journal Title: Molecular Cell Volume: 79 Issue: 1 Pages: 1-2
  • DOI: 10.1016/j.molcel.2020.04.033
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] PRDM3 attenuates pancreatitis and pancreatic tumorigenesis by regulating inflammatory response (2020)
  • Author(s): Ye Jie、Huang Anpei、Wang Haitao、Zhang Anni M. Y.、Huang Xiaojun、Lan Qingping、Sato Tomohiko、Goyama Susumu、Kurokawa Mineo、Deng Chuxia、Sander Maike、Schaeffer David F.、Li Wen、Kopp Janel L.、Xie Ruiyu
  • Journal Title: Cell Death & Disease Volume: 11 Issue: 3 Pages: 1-1
  • DOI: 10.1038/s41419-020-2371-x
  • Peer Reviewed
• [Journal Article] The conserved and divergent roles of Prdm3 and Prdm16 in zebrafish and mouse craniofacial development (2020)
  • Author(s): Shull Lomeli Carpio、Sen Rwik、Menzel Johannes、Goyama Susumu、Kurokawa Mineo、Artinger Kristin Bruk
  • Journal Title: Developmental Biology Volume: 461 Issue: 2 Pages: 132-144
  • DOI: 10.1016/j.ydbio.2020.02.006
  • Peer Reviewed
• [Journal Article] A case of transplantation-associated thrombotic microangiopathy with autopsy-proven fatal myocardial ischemia after allogeneic hematopoietic stem cell transplantation (2020)
  • Author(s): Sasaki Ken、Honda Akira、Shinozaki-Ushiku Aya、Fujioka Yosei、Maki Hiroaki、Toyama Kazuhiro、Ushiku Tetsuo、Kurokawa Mineo
  • Journal Title: Annals of Hematology Volume: 1 Issue: 6 Pages: 1-1
  • DOI: 10.1007/s00277-020-04027-0
  • Peer Reviewed
• [Journal Article] Posterior Reversible Encephalopathy Syndrome Concurrent with Human Herpesvirus-6B Encephalitis after Allogeneic Hematopoietic Stem Cell Transplantation. (2020)
  • Author(s): Ito Y, Toyama K, Honda A, Nakazaki K, Arai S, and Kurokawa M.
  • Journal Title: Journal of Infection and Chemotherapy Volume: 26(2) Issue: 2 Pages: 265-268
  • DOI: 10.1016/j.jiac.2019.07.016
• [Journal Article] Tocilizumab for focal segmental glomerulosclerosis secondary to multicentric Castleman’s disease (2019)
  • Author(s): Ebisawa Kazutoshi、Masamoto Yosuke、Tokushige Junji、Nishi Hiroshi、Honda Kenjiro、Hinata Munetoshi、Toyama Kazuhiro、Nangaku Masaomi、Kurokawa Mineo
  • Journal Title: Annals of Hematology Volume: 印刷中 Issue: 8 Pages: 1995-1997
  • DOI: 10.1007/s00277-019-03616-y
  • Peer Reviewed
• [Journal Article] Arteritis after the administration of granulocyte colony-stimulating factor: a case series. (2019)
  • Author(s): Sasaki K, Miyauchi M, Ogura M, Shimura-Nukina A, Toyama K, Nakazaki K, Watadani T, Abe O, and Kurokawa M.
  • Journal Title: International Journal of Hematology Volume: 110(3) Issue: 3 Pages: 370-374
  • DOI: 10.1007/s12185-019-02662-6
• [Journal Article] Significance of biopsy with ERCP for diagnosis of bile duct invasion of DLBCL. (2019)
  • Author(s): Ito Y, Miyauchi M, Nakamura T, Takahara N, Nakai Y, Taoka K, Toyama K, Shinozaki-Ushiku K, Koike K, and Kurokawa M.
  • Journal Title: International Journal of Hematology Volume: 110(3) Issue: 3 Pages: 381-384
  • DOI: 10.1007/s12185-019-02661-7
• [Journal Article] Long-term remission by brentuximab vedotin for non-mediastinal gray zone lymphoma refractory to autologous stem cell transplantation. (2019)
  • Author(s): Ebisawa K, Masamoto Y, Koya J, Shimura A, Shinozaki-Ushiku A, Toyama K, Nakazaki K, and Kurokawa M.
  • Journal Title: Clinical Lymphoma, Myeloma and Leukemia Volume: 19(11) Issue: 11 Pages: e602-e604
  • DOI: 10.1016/j.clml.2019.08.017
  • Peer Reviewed
• [Journal Article] Hlf marks the developmental pathway for hematopoietic stem cells but not for erythro-myeloid progenitors., (2019)
  • Author(s): Tomomasa Yokomizo, Naoki Watanabe, Terumasa Umemoto, Junichi Matsuo, Ryota Harai, Yoshihiko Kihara, Eri Nakamura, Norihiro Tada, Tomohiko Sato, Tomoiku Takaku, Akihiko Shimono, Hitoshi Takizawa, Naomi Nakagata, Seiichi Mori, Mineo Kurokawa, Daniel Tenen, Motomi Osato, Toshio Suda, and Norio Komatsu.
  • Journal Title: J Exp Med Volume: 216 Issue: 7 Pages: 1599-1614
  • DOI: 10.1084/jem.20181399
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Efficacy and safety of tyrosine kinase inhibitors for newly diagnosed chronic-phase chronic myeloid leukemia over a 5-year period: results from the Japanese registry obtained by the New TARGET system. (2019)
  • Author(s): Kizaki M, Takahashi N, Iriyama N, Okamoto S, Ono T, Usui N, Inokuchi K, Nakaseko C, Kurokawa M, Sumi M, Nakamura F, Kawaguchi T, Suzuki R, Yamamoto K, Ohnishi K, Matsumura I, Naoe T; New TARGET investigators.
  • Journal Title: Int J Hematol Volume: 109 Issue: 4 Pages: 426-439
  • DOI: 10.1007/s12185-019-02613-1
  • Peer Reviewed / Open Access
• [Journal Article] TUBB1 dysfunction identified in inherited thrombocytopenia causes impaired proplatelet formation and genome instability (2019)
  • Author(s): Matsumura T, Nakamura-Ishizu A, Maki H, Takaoka K, Naga SSA, Muddineni A, COW CQW, Suzushima H, Kawakita M, Asou N, Matsuoka M, Kurokawa M, Osato M,, Suda T
  • Journal Title: Brit J Haematol. Volume: 0 Issue: 5 Pages: 0-0
  • DOI: 10.1111/bjh.15835
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A germline HLTF mutation in familial MDS induces DNA damage accumulation through impaired PCNA polyubiquitination (2019)
  • Author(s): Takaoka Kensuke、Kawazu Masahito、Koya Junji、Yoshimi Akihide、Masamoto Yosuke、Maki Hiroaki、Toya Takashi、Kobayashi Takashi、Nannya Yasuhito、Arai Shunya、Ueno Toshihide、Ueno Hironori、Suzuki Kenshi、Harada Hironori、Manabe Atsushi、Hayashi Yasuhide、Mano Hiroyuki、Kurokawa Mineo
  • Journal Title: Leukemia Volume: 印刷中 Issue: 7 Pages: 1773-1782
  • DOI: 10.1038/s41375-019-0385-0
  • Peer Reviewed
• [Journal Article] Modeling ASXL1 mutation revealed impaired hematopoiesis caused by derepression of p16Ink4a through aberrant PRC1-mediated histone modification (2018)
  • Author(s): Uni Masahiro、Masamoto Yosuke、Sato Tomohiko、Kamikubo Yasuhiko、Arai Shunya、Hara Eiji、Kurokawa Mineo
  • Journal Title: Leukemia Volume: 33 Issue: 1 Pages: 191-204
  • DOI: 10.1038/s41375-018-0198-6
  • Peer Reviewed / Open Access
• [Journal Article] Role of ASXL1 mutation in impaired hematopoiesis and cellular senescence (2018)
  • Author(s): Uni Masahiro、Kurokawa Mineo
  • Journal Title: Oncotarget Volume: 9 Issue: 96 Pages: 36828-36829
  • DOI: 10.18632/oncotarget.26423
  • Peer Reviewed / Open Access
• [Journal Article] Using patient-derived iPSCs to develop humanized mouse models for chronic myelomonocytic leukemia and therapeutic drug identification, including liposomal clodronate. (2018)
  • Author(s): 1.Taoka K, Arai S, Kataoka K, Hosoi M, Miyauchi M, Yamazaki S, Honda A, Aixinjueluo W, Kobayashi T, Kumano K, Yoshimi A, Otsu M, Niwa A, Nakahata T, Nakauchi H, Kurokawa M.
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 15855-15867
  • DOI: 10.1038/s41598-018-34193-1
  • NAID: 120006534582
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] HMGA1 IS UPREGULATED IN MYELODYSPLASTIC SYNDROMES WITH MUTATION IN PRE-MRNA SPLICING GENES AND INHIBITS LEUKEMIA CELL DIFFERENTIATION (2020)
  • Author(s): Kazutoshi Ebisawa, Yosuke Masamoto, Mineo Kurokawa
  • Organizer: 2020 ASH Annual Meeting 2020. Virtual
  • Int'l Joint Research
• [Presentation] GFI1 Is a Downstream Target of EVI1 in Normal Hematopoiesis (2020)
  • Author(s): Akira Chiba, Yosuke Masamoto, Hideaki Mizuno, Mineo Kurokawa
  • Organizer: 2020 ASH Annual Meeting 2020. Virtual
  • Int'l Joint Research
• [Presentation] CD62L Expression Level Dictates the Cell Fate of Myeloid Progenitors in Mice and Humans (2020)
  • Author(s): Yusuke Ito, Fumio Nakahara, Yuki Kagoya, Mineo Kurokawa
  • Organizer: 2020 ASH Annual Meeting 2020. Virtual
  • Int'l Joint Research
• [Presentation] モノソミー7を伴う急性骨髄性白血病においてEEDはPRC1依存性に白血病維持に寄与する (2020)
  • Author(s): 松田健佑、籠谷勇紀、水野秀明、山崎翔、宮内将、黒川峰夫
  • Organizer: 第82回 日本血液学会学術総会（web開催 2020.10.10-11.18）
• [Presentation] EVI1陽性AML幹細胞は化学療法抵抗性を示し、高悪性度のAMLを起こす (2020)
  • Author(s): 正本庸介、千葉晶輝、水野秀明、竹崎俊晶、佐藤智彦、黒川峰夫
  • Organizer: 第82回 日本血液学会学術総会（web開催 2020.10.10-11.18）
• [Presentation] The role of HMGA1 in myelodysplastic syndrome with mutations in pre-mRNA splicing genes. (2020)
  • Author(s): Kazutoshi Ebisawa, Yosuke Masamoto, Mineo Kurokawa
  • Organizer: 第82回 日本血液学会学術総会（web開催 2020.10.10-11.18）
• [Presentation] Production of functional neutrophils from human iPSCs applicable to granulocyte transfusion therapy (2020)
  • Author(s): Yusuke Ito, Masashi Miyauchi, Toshiya Hino, Fumi Nakamura, Yuki Iwasaki, Taiki Kawagoshi, Shunya Arai, Yuki Kagoya, Fumio Nakahara, and Mineo Kurokawa
  • Organizer: 第82回 日本血液学会学術総会（web開催 2020.10.10-11.18）
• [Presentation] CD62L expression level refines the definition of myeloid progenitors in mice and humans (2020)
  • Author(s): Yusuke Ito, Yuki Kagoya, Fumio Nakahara, and Mineo Kurokawa
  • Organizer: 第82回 日本血液学会学術総会（web開催 2020.10.10-11.18）
• [Presentation] Identification of EED as an essential survival factor in acute myeloid leukemia with monosomy 7 (2020)
  • Author(s): Kensuke Matsuda, Yuki Kagoya, Hideaki Mizuno, Sho Yamazaki, Masashi Miyauchi, Mineo Kurokawa
  • Organizer: 第43回日本分子生物学会, 2020年12月2日～4日, web開催
• [Presentation] The role of HMGA1 in myelodysplastic syndrome with mutations in pre-mRNA splicing genes (2020)
  • Author(s): Kazutoshi Ebisawa, Yosuke Masamoto, Mineo Kurokawa
  • Organizer: 第79回 日本癌学会学術総会（広島&web開催 2020.10.1-3）
• [Presentation] EVI1-positive acute myeloid leukemia (AML) stem cells survive cytotoxic chemotherapy and induce highly aggressive AML (2020)
  • Author(s): Yosuke Masamoto, Hideaki Mizuno, Tomohiko Sato, Mineo Kurokawa
  • Organizer: 第79回 日本癌学会学術総会（広島&web開催 2020.10.1-3）
• [Presentation] PRC1 activity of EED as an essential survival factor in acute myeloid leukemia with monosomy 7 (2020)
  • Author(s): Kensuke Matsuda, Yuki Kagoya, Hideaki Mizuno, Sho Yamazaki, Masashi Miyauchi, Mineo Kurokawa
  • Organizer: 第79回 日本癌学会学術総会（広島&web開催 2020.10.1-3）
• [Presentation] CD62L EXPRESSION LEVEL DICTATES THE CELL FATE OF COMMON MYELOID PROGENITORS AND GRANULOCYTE-MONOCYTE PROGENITORS BOTH IN MICE AND HUMAN (2020)
  • Author(s): Yusuke Ito, Fumio Nakahara, Yuki Kagoya, and Mineo Kurokawa
  • Organizer: ISSCR 2020 Virtual（VIRTUAL 2020.6.23-27）
  • Int'l Joint Research
• [Presentation] ACTIVATED PENTOSE PHOSPHATE PATHWAY MEDIATED BY FBP1 UPREGULATION SUPPORTS PROGRESSION OF ACUTE MYELOID LEUKEMIA WITH HIGH EVI1 EXPRESSION (2020)
  • Author(s): Hideaki Mizuno, Yuki Kagoya, Junji Koya, Yosuke Masamoto, Mineo Kurokawa
  • Organizer: 25th EHA Congress (virtual 2020.6.11-21)
  • Int'l Joint Research
• [Presentation] EED or BRD4 inhibition as a novel therapeutic strategy in acute myeloid leukemia with monosomy 7 (2020)
  • Author(s): Kensuke Matsuda, Yuki Kagoya, Hideaki Mizuno, Sho Yamazaki, Masashi Miyauchi, Mineo Kurokawa
  • Organizer: AACR Annual Meeting 2020 (web開催 2020.4.24-4.29)
  • Int'l Joint Research
• [Presentation] Glucose metabolism alteration mediated by FBP1 upregulation supports progression of EVI1high AML（英語・口演） (2019)
  • Author(s): Hideaki Mizuno, Yuki Kagoya, Junji Koya, Yosuke Masamoto, Mineo Kurokawa
  • Organizer: 第78回 日本癌学会学術総会（京都 2019.9.26-28）
• [Presentation] 骨髄線維症におけるMPLシグナルとカルシウムカルモジュリン依存性タンパク質キナーゼγの関連について（英語・ポスター） (2019)
  • Author(s): 佐々木謙 宮内将 田岡和城 正本庸介 山崎翔 籠谷勇紀 黒川峰夫
  • Organizer: 第78回 日本癌学会学術総会（京都 2019.9.26-28）
• [Presentation] Interactions between MPL and Calcium/Calmodulin dependent protein kinase 2 gamma in myelofibrosis（英語・口演） (2019)
  • Author(s): Ken Sasaki, Masashi Miyauchi, Kazuki Taoka, Yosuke Masamoto, Sho Yamazaki, Syunya Arai, Yuki Kagoya, Mineo Kurokawa
  • Organizer: 第81回 日本血液学会学術集会（東京 2019.10.11-13）
• [Presentation] FBP1は糖代謝の変容を介してEVI1高発現白血病の進展に寄与する（日本語・口演） (2019)
  • Author(s): 水野 秀明、籠谷 勇紀、古屋 淳史、正本 庸介、黒川 峰夫
  • Organizer: 第81回 日本血液学会学術集会（東京 2019.10.11-13）
• [Presentation] 骨髄線維症の治療標的としてのカルシウムカルモジュリン依存性タンパク質キナーゼ2G（日本語・ポスター） (2019)
  • Author(s): Ken Sasaki, Masashi Miyauchi, Kazuki Taoka, Yosuke Masamoto, Sho Yamazaki, Syunya Arai, Yuki Kagoya, Mineo Kurokawa
  • Organizer: 第42回 日本分子生物学会年会（福岡 2019.12.3-6）
• [Presentation] A Synthetic Lethality-based Approach Identified EED and BRD4 as Critical Survival Factors in Acute Myeloid Leukemia with Monosomy 7 (2019)
  • Author(s): Kensuke Matsuda, Yuki Kagoya, Sho Yamazaki, Masashi Miyauchi, Mineo Kurokawa
  • Organizer: 2019 ASH Annual Meeting 2019.12.7-10 Orland, FL
• [Presentation] Activated Pentose Phosphate Pathway Mediated By Fbp-1 Upregulation Supports Progression of Acute Myeloid Leukemia with High EVI-1 Expression (2018)
  • Author(s): Hideaki Mizuno, Yuki Kagoya, Junji Koya, Yosuke Masamoto and Mineo Kurokawa
  • Organizer: Annual Meeting of American Society of Hematology
  • Int'l Joint Research
• [Presentation] The Prognostic Value of IgH Clonality in Bone Marrow with Negative Pathology in B Cell Lymphoma (2018)
  • Author(s): Kazuhiro Toyama, Ayato Tsukamoto, Sho Yamazaki, Fumihiko Nakamura and Mineo Kurokawa
  • Organizer: Annual Meeting of American Society of Hematology
  • Int'l Joint Research
• [Presentation] Calcium/Calmodulin Dependent Protein Kinase 2 Gamma Is Identified As a Potential Therapeutic Target of Myelofibrosis Using Disease-Specific Induced Pluripotent Stem Cells (2018)
  • Author(s): Masashi Miyauchi, Ken Sasaki, Kazuki Taoka, Yosuke Masamoto, Sho Yamazaki, Shunya Arai and Mineo Kurokawa
  • Organizer: Annual Meeting of American Society of Hematology
  • Int'l Joint Research