• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of the cause of diabetes in the Japanese population using whole genome information and development of diagnostic and therapeutic methods using iPS cells

Research Project

Project/Area Number 18H04053
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
Research InstitutionThe University of Tokyo

Principal Investigator

Yamauchi Toshimasa  東京大学, 医学部附属病院, 教授 (40372370)

Co-Investigator(Kenkyū-buntansha) 岩部 真人  東京大学, 医学部附属病院, 講師 (30557236)
岩部 美紀  東京大学, 医学部附属病院, 特任准教授 (70392529)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥44,850,000 (Direct Cost: ¥34,500,000、Indirect Cost: ¥10,350,000)
Fiscal Year 2020: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2019: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2018: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
Keywords遺伝因子機能解析
Outline of Final Research Achievements

AFunctional analysis of variants of the type 2 diabetes susceptibility gene region was performed. It was shown that two different variants of the same gene region could regulate the expression of different genes in different tissues (Nature 2020). As a result of performing chromatin immunoprecipitation sequence and evaluating which transcription factor binding site the variant accumulates, FOXA2 and the like were found (Nat Genet 2020). We have shown that the GP2 variant can be a molecular mechanism for both type 2 diabetes and pancreatic cancer (Nat Commun 2020). When an Asian characteristic variant was expressed in pancreatic β-cells, GLP-1R altered insulin secretion (Nat Genet 2019) and PAX4 showed abnormal expression of endoplasmic reticulum calcium chaperone (HGV 2021). Genome editing was added to iPS cells, and functional analysis of variants in diabetic target cells was also performed (unpublished).

Academic Significance and Societal Importance of the Research Achievements

2型糖尿病とその合併症の発症・進展には遺伝因子の影響が極めて大きいにも関わらず、これまで大部分は未解明であった。また糖尿病の表現型は、欧米人と東アジア人で極めて異なるのに、これまで欧米主導で原因遺伝子探索が行われてきた。本研究は、史上初めて欧米を凌駕する糖尿病サンプル数を用いて行ったゲノムワイド関連解析の結果を基に、インスリン分泌が少なく、顕著に肥満しない場合にも糖尿病を発症する東アジア人の原因となる遺伝素因とその分子機序を明らかにしたことより、学術的意義は極めて高い。世界の1/3を占めるアジア人型の糖尿病の発症・進展予測と予防・治療法開発に直結する研究成果であり社会的意義も極めて高い。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (53 results)

All 2021 2020 2019 2018

All Journal Article (16 results) (of which Int'l Joint Research: 10 results,  Peer Reviewed: 16 results,  Open Access: 16 results) Presentation (19 results) (of which Int'l Joint Research: 2 results,  Invited: 11 results) Book (18 results)

  • [Journal Article] AdipoR agonist increases insulin sensitivity and exercise endurance in AdipoR-humanized mice2021

    • Author(s)
      Iwabu Masato、Okada-Iwabu Miki、Tanabe Hiroaki、Ohuchi Nozomi、Miyata Keiko、Kobori Toshiko、Odawara Sara、Kadowaki Yuri、Yokoyama Shigeyuki、Yamauchi Toshimasa、Kadowaki Takashi
    • Journal Title

      Communications Biology

      Volume: 4 Issue: 1 Pages: 45-45

    • DOI

      10.1038/s42003-020-01579-9

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genome-Wide Association Studies Identify Two Novel Loci Conferring Susceptibility to Diabetic Retinopathy in Japanese Patients with Type 2 Diabetes.2021

    • Author(s)
      Imamura M,・・・・・・・・・ Yamauchi T, Tobe K, Maegawa H, Kadowaki T, Maeda S.
    • Journal Title

      Hum Mol Genet.

      Volume: なし Issue: 8 Pages: 716-726

    • DOI

      10.1093/hmg/ddab044

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of type 2 diabetes loci in 433,540 East Asian individuals2020

    • Author(s)
      Spracklen, C.N., Horikoshi, M., Kim, Y.J., Lin K, Bragg F, Nakatochi M, et al.
    • Journal Title

      Nature

      Volume: 582 Issue: 7811 Pages: 240

    • DOI

      10.1038/s41586-020-2263-3

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases2020

    • Author(s)
      Ishigaki K, Akiyama M, Kanai M, Takahashi A, Kawakami E, Sugishita H, Sakaue S, Matoba N, Low SK, Okada Y, Yamaji T, et al
    • Journal Title

      Nature Genetics

      Volume: 52 Issue: 7 Pages: 669-679

    • DOI

      10.1038/s41588-020-0640-3

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer2020

    • Author(s)
      Lin Y, Nakatochi M, Hosono Y, Ito H, Kamatani Y, Inoko A, Sakamoto H, Kinoshita F, Kobayashi Y, Ishii H, Yamaji T,et al.
    • Journal Title

      Nature Communications

      Volume: 11 Issue: 1 Pages: 3175-3175

    • DOI

      10.1038/s41467-020-16711-w

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clinical usefulness of multigene screening with phenotype-driven bioinformatics analysis for the diagnosis of patients with monogenic diabetes or severe insulin resistance2020

    • Author(s)
      Hosoe Jun, ... Fujiwara Toyofumi et al.
    • Journal Title

      Diabetes Research and Clinical Practice

      Volume: 169 Pages: 108461-108461

    • DOI

      10.1016/j.diabres.2020.108461

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] NFIA differentially controls adipogenic and myogenic gene program through distinct pathways to ensure brown and beige adipocyte differentiation2020

    • Author(s)
      Hiraike Yuta、Waki Hironori、Miyake Kana、Wada Takahito、Oguchi Misato、Saito Kaede、Tsutsumi Shuichi、Aburatani Hiroyuki、Yamauchi Toshimasa、Kadowaki Takashi
    • Journal Title

      PLOS Genetics

      Volume: 16 Issue: 9 Pages: e1009044-e1009044

    • DOI

      10.1371/journal.pgen.1009044

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prolyl Hydroxylase Domain Inhibitor Protects against Metabolic Disorders and Associated Kidney Disease in Obese Type 2 Diabetic Mice2020

    • Author(s)
      Mai Sugahara、Shinji Tanaka、Tetsuhiro Tanaka、Hisako Saito、Yu Ishimoto、Takeshi Wakashima、Masatoshi Ueda、Kenji Fukui、Akira Shimizu、Reiko Inagi、Toshimasa Yamauchi、Takashi Kadowaki、Masaomi Nangaku
    • Journal Title

      Journal of the American Society of Nephrology

      Volume: 31 Issue: 3 Pages: 560-577

    • DOI

      10.1681/asn.2019060582

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] NAD + supplementation rejuvenates aged gut adult stem cells2019

    • Author(s)
      Igarashi M*, Miura M, Williams E, Jaksch F, Kadowaki T, Yamauchi T* , Guarente L
    • Journal Title

      Aging Cell

      Volume: - Issue: 3 Pages: 1-10

    • DOI

      10.1111/acel.12935

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Robust and highly efficient hiPSC generation from patient non-mobilized peripheral blood-derived CD34+ cells using the auto-erasable Sendai virus vector.2019

    • Author(s)
      Okumura T, Horie Y, et al.
    • Journal Title

      Stem Cell Res Ther.

      Volume: 10 Issue: 1 Pages: 185-185

    • DOI

      10.1186/s13287-019-1273-2

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Adiponectin/AdipoR Research and Its Implications for Lifestyle-Related Diseases2019

    • Author(s)
      Iwabu Masato、Okada-Iwabu Miki、Yamauchi Toshimasa、Kadowaki Takashi
    • Journal Title

      Frontiers in Cardiovascular Medicine

      Volume: 6 Pages: 116-116

    • DOI

      10.3389/fcvm.2019.00116

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Drug development research for novel adiponectin receptor-targeted antidiabetic drugs contributing to healthy longevity2019

    • Author(s)
      Okada-Iwabu Miki、Iwabu Masato、Yamauchi Toshimasa、Kadowaki Takashi
    • Journal Title

      DIABETOLOGY INTERNATIONAL

      Volume: 10 Issue: 4 Pages: 237-244

    • DOI

      10.1007/s13340-019-00409-6

    • NAID

      40022039924

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Critical Role of SREBP-1c Large-VLDL Pathway in Environment-Induced Hypertriglyceridemia of Apo AV Deficiency2019

    • Author(s)
      Takanashi M, Kimura T, Li C, Tanaka M, Matsuhashi A, Yoshida H, Noda A, Xu P, Takase S, Okazaki S, Iizuka Y, Kumagai H, Ikeda Y, Gotoda T, Takahashi M, Yagyu H, Ishibashi S, Yamauchi T, Kadowaki T, Liang G, Okazaki H.
    • Journal Title

      Arteriosclerosis, Thrombosis, and Vascular Biology

      Volume: 39 Issue: 3 Pages: 373-386

    • DOI

      10.1161/atvbaha.118.311931

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population.2019

    • Author(s)
      Suzuki K, Akiyama M, Ishigaki K, Kanai M, Hosoe J, Shojima N, Hozawa A, Kadota A, Kuriki K, Naito M, Tanno K, Ishigaki Y, et al.
    • Journal Title

      Nat Genet.

      Volume: 51 Issue: 3 Pages: 379-386

    • DOI

      10.1038/s41588-018-0332-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity2018

    • Author(s)
      Kubota Tetsuya、Inoue Mariko、Kubota Naoto、Takamoto Iseki、Mineyama Tomoka、Iwayama Kaito、Tokuyama Kumpei、Moroi Masao、Ueki Kohjiro、Yamauchi Toshimasa、Kadowaki Takashi
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 4863-4863

    • DOI

      10.1038/s41467-018-07358-9

    • NAID

      120007133395

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes2018

    • Author(s)
      Taira M, Imamura M,・, Yamauchi T, ・Kadowaki T, Maeda S:
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 12 Pages: e0208654-e0208654

    • DOI

      10.1371/journal.pone.0208654

    • NAID

      120006822492

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] インスリン抵抗性の分子機序2021

    • Author(s)
      山内 敏正
    • Organizer
      第55回糖尿病学の進歩
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 糖尿病と内臓脂肪2021

    • Author(s)
      山内 敏正
    • Organizer
      第41回日本肥満学会・第38回日本肥満症治療学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] アディポネクチン受容体AdipoRの病態生理的意義の解明2020

    • Author(s)
      山内 敏正
    • Organizer
      第52回日本動脈硬化学会総会・学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] インスリン抵抗性の分子機序と治療戦略―アディポネクチンを中心に―2020

    • Author(s)
      山内 敏正
    • Organizer
      第94回日本糖尿病学会中部地方会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 超・超高齢社会における糖尿病・代謝疾患の克服と健康長寿の実現に向けた体質医学研究2020

    • Author(s)
      山内 敏正
    • Organizer
      第70回日本体質医学会総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 糖尿病・代謝疾患の克服と健康長寿実現に向けて2020

    • Author(s)
      山内 敏正
    • Organizer
      日本糖尿病学会中国四国地方会第58回総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Predictive :ゲノム、エピゲノム情報による糖尿病発症・重症化の予測2019

    • Author(s)
      山内 敏正
    • Organizer
      第62回日本糖尿病学会年次学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 新規マイオカインの同定と糖・脂質・エネルギー代謝に対する作用の検討2019

    • Author(s)
      小田原 紗羅、岩部美紀、岩部真人、山内敏正
    • Organizer
      第62回日本糖尿病学会年次学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 「内分泌代謝とエピゲノム「糖尿病や肥満症の病態形成に影響 を及ぼすメタボリックメモリー理解に 向けたエピゲノム解析」2019

    • Author(s)
      山内 敏正
    • Organizer
      第92回日本内分泌学会学術総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 糖尿病・代謝疾患の克服と健康長寿実現に向けて2019

    • Author(s)
      山内 敏正
    • Organizer
      Young! Diabetologists Research Forum
    • Related Report
      2019 Annual Research Report
  • [Presentation] 糖尿病・代謝疾患の克服と健康長寿の実現に向けて2019

    • Author(s)
      山内 敏正
    • Organizer
      第37回内分泌代謝学サマーセミナー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Structural and functional analysis of adiponectin receptors toward development of novel antidiabetic agents.2019

    • Author(s)
      MIKI OKADA-IWABU(岩部(岡田)美紀)
    • Organizer
      2019 Asia-Pacific Diabetes and Obesity Study Group Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Obesity treatments Lifestyle modifications2019

    • Author(s)
      Toshimasa Yamauchi (山内 敏正)
    • Organizer
      International Diabetes Federation Congress2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] アディポネクチン受容体の構造・機能解析と臨床応用に向けて2018

    • Author(s)
      岩部 美紀
    • Organizer
      第23回アディポサイエンス・シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 運動器/代謝系連関による生体機能制御とその変容の仕組み2018

    • Author(s)
      岩部 真人
    • Organizer
      平成 30 年度  自然科学研究機構 生理学研究所研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Genotype-phenotype Correlations and Structural Basis of the Pathogenic         Mutations in INSR and IGF1R2018

    • Author(s)
      Jun Hosoe, Hiroko Kadowaki, Fuyuki Miya, Minaka Takakura, Ken Suzuki, Tatsuhiko Tsunoda, Nobuhiro Shojima, Toshimasa Yamauchi, Takashi Kadowaki.
    • Organizer
      the 78th Scientific Sessions of the American Diabetes Association
    • Related Report
      2018 Annual Research Report
  • [Presentation] Genotype-structure-phenotype Correlations in extreme insulin         resistance evaluate d by structural bioinformatics analysis of the insulin receptor2018

    • Author(s)
      Jun Hosoe, Minaka Takakura, Nobuhiro Shojima, Toshimasa Yamauchi, Takashi Kadowa ki
    • Organizer
      第18回東京大学生命科学シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] インスリン受容体およびIGF-1受容体のtyrosine kinase domainにおける変異と 臨床的重症度の関連の解明2018

    • Author(s)
      細江 隼, 門脇 弘子, 高倉 美菜香, 宮 冬樹, 角田 達彦, 鈴木 顕, 庄嶋 伸浩, 山内
    • Organizer
      第61回日本糖尿病学会年次学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Structural basis of mutations of the tyrosine kinase domain in INSR and the relations with clinical severity.2018

    • Author(s)
      細江隼、門脇弘子、宮冬樹、高倉美菜香、鈴木顕、田中真生、石浦浩之、辻省次、原一雄、角田達彦、庄嶋伸浩、山内敏正、門脇孝
    • Organizer
      第63回日本人類遺伝学会
    • Related Report
      2018 Annual Research Report
  • [Book] 「糖尿病」という病名と糖尿病への偏見、「糖尿病プラクティス」2021

    • Author(s)
      庄嶋伸浩、山内敏正
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2020 Annual Research Report
  • [Book] 高齢者糖尿病治療ガイド20212021

    • Author(s)
      山内敏正
    • Publisher
      文光堂
    • Related Report
      2020 Annual Research Report
  • [Book] 高度肥満症のゲノムワイドポリジェニッ クリスクスコア.2020

    • Author(s)
      庄嶋伸浩、鈴木顕、細江隼、山内敏正、門脇孝
    • Publisher
      科学評論社
    • Related Report
      2020 Annual Research Report
  • [Book] 知っておきたいことア・ラ・カルト 歌舞伎症候群」Medical Practice, 37巻12号2020

    • Author(s)
      岩部 真人、岩部 美紀、山内 敏正
    • Publisher
      文光堂
    • Related Report
      2020 Annual Research Report
  • [Book] 【高血糖毒性と組織障害】「脂肪組織」糖尿病2020

    • Author(s)
      岩部 真人、岩部 美紀、山内 敏正
    • Publisher
      一般社団法人日本糖尿病学会
    • Related Report
      2020 Annual Research Report
  • [Book] 【糖尿病エキスパートブック】食事療法・栄養指導に活かす最新情報「インスリン抵抗性はどこまで解されたか」臨床栄養2020

    • Author(s)
      岩部 真人、岩部 美紀、山内 敏正
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2020 Annual Research Report
  • [Book] 【糖尿病診療update-最新の診断と治療-】「糖尿病治療薬に関する最近の話題 インスリン抵抗性改善薬 チアゾリジン薬」2020

    • Author(s)
      岩部 真人、岩部 美紀、山内 敏正
    • Publisher
      日本臨床社
    • Related Report
      2020 Annual Research Report
  • [Book] 免疫学:免疫・炎症病態×治療Update:第Ⅲ部 免疫・炎症性疾患の病態の理解と治療への展開2019

    • Author(s)
      岩部真人、山内敏正、岩部美紀、門脇孝
    • Publisher
      南山堂
    • Related Report
      2019 Annual Research Report
  • [Book] 実験医学37巻:【臓器連環による生体恒常性の破綻と疾患】脂肪細胞産生分子がつなぐ臓器連環と動的恒常性。2019

    • Author(s)
      岩部真人、岩部美紀、山内敏正、門脇孝
    • Publisher
      羊土社
    • Related Report
      2019 Annual Research Report
  • [Book] 糖尿病・内分泌代謝科48巻:【臓器連関による代謝制御と生体機能調節】運動模倣シグナルによるエネルギー代謝調節メカニズム2019

    • Author(s)
      岩部真人、岩部美紀、山内敏正、門脇孝
    • Publisher
      科学評論社
    • Related Report
      2019 Annual Research Report
  • [Book] 医学のあゆみ269巻:【AMPキナーゼと医学】肥満・糖尿病の創薬ターゲットとしてのAMPキナーゼ2019

    • Author(s)
      岩部真人、岩部美紀、山内敏正、門脇孝
    • Publisher
      医歯薬出版
    • Related Report
      2019 Annual Research Report
  • [Book] CBT-OB肥満に対する認知行動療法マニュアル2019

    • Author(s)
      リッカルド・ダッレ・グラーヴェ 、マッシミリアーノ・サルティラーナ 、マルワン・エル・ゴッチ 、シモーナ・カルージ 、吉内 一浩 ・山内 敏正 監訳
    • Total Pages
      266
    • Publisher
      金子書房
    • Related Report
      2019 Annual Research Report
  • [Book] 糖尿病 62巻8号 6.インスリン受容体遺伝子異常と糖尿病2019

    • Author(s)
      細江 隼, 庄嶋 伸浩, 山内 敏正, 門脇 孝
    • Publisher
      一般社団法人 日本糖尿病学会
    • Related Report
      2019 Annual Research Report
  • [Book] 糖尿病・内分泌代謝科 第48巻第3号:糖尿病患者の薬剤効果予測に遺伝情報をどう活かすか2019

    • Author(s)
      細江 隼, 庄嶋 伸浩, 鈴木顕、山内 敏正, 門脇 孝
    • Publisher
      科学評論社
    • Related Report
      2019 Annual Research Report
  • [Book] 糖尿病・内分泌代謝科 第49巻第5号  :パスウェイ解析を用いた2型糖尿病遺伝素因の日欧の比較2019

    • Author(s)
      細江 隼, 庄嶋 伸浩, 山内 敏正, 門脇 孝
    • Publisher
      科学評論社
    • Related Report
      2019 Annual Research Report
  • [Book] 「糖尿病学2019」:日本人集団における28の新規2型糖尿病感受性領域の同定2019

    • Author(s)
      山内敏正
    • Publisher
      診断と治療社
    • Related Report
      2019 Annual Research Report
  • [Book] 動脈硬化診療のすべて:アディポサイエンス・高インスリン血症2019

    • Author(s)
      山内敏正、庄嶋伸浩
    • Publisher
      日本医師会
    • Related Report
      2019 Annual Research Report
  • [Book] 内分泌・糖尿病・代謝内科 糖尿病患者の薬剤効果予測に遺伝情報をどう活かすか2019

    • Author(s)
      庄嶋 伸浩、山内 敏正、鈴木 顕、細江 準、門脇 孝
    • Total Pages
      78
    • Publisher
      科学評論社
    • Related Report
      2018 Annual Research Report

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi