Comprehensive studies on thirst and salt-appetite controls
Project/Area Number |
18H04055
|
Research Category |
Grant-in-Aid for Scientific Research (A)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Review Section |
Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
|
Research Institution | Tottori University (2022) Okayama University (2019-2022) National Institute for Basic Biology (2018) |
Principal Investigator |
|
Project Period (FY) |
2018-04-01 – 2023-03-31
|
Project Status |
Completed (Fiscal Year 2022)
|
Budget Amount *help |
¥43,810,000 (Direct Cost: ¥33,700,000、Indirect Cost: ¥10,110,000)
Fiscal Year 2022: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2021: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2020: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2019: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2018: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
|
Keywords | 恒常性 / 体液 / 口渇 / 塩 / 高血圧 / 神経内分泌 / グリア細胞 / イオンチャネル / 口渇感 / 塩欲求 / 脳 / 末梢神経 / 行動制御 / 内分泌 / グリア / Naセンサー / 脳室周囲器官 / 飲水 / アンジオテンシンII |
Outline of Final Research Achievements |
We previously revealed that the intracerebral Na sensor, Nax, monitors the serum Na level and controls thirst and salt appetite. In this study, we discovered the involvement of this sensor in the development of salt-sensitive hypertension. Additionally, we successfully identified a novel Na sensor that induces thirst sensation. Furthermore, we identified the neural mechanism that inhibits thirst in the subfornical organ (SFO), which is the center for thirst regulation. Moreover, we identified new features of the autoimmune adipsic hypernatremia caused by anti-SFO antibodies through case analyses.
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Academic Significance and Societal Importance of the Research Achievements |
口渇と塩欲求の制御機構の全体像が明らかになったことにより、精神疾患患者における水中毒、高Na血症の発症機序、高齢者における口渇低下と脱水のメカニズム解明につながる包括的な理解が可能になった。さらに体液Naレベルが上昇した時に起きる、塩欲求抑制と血圧上昇(圧利尿によるNa排出)が1種類のセンサーで担われていることが明らかになったが、これにより、生体の塩恒常性における入口と出口を統一的に理解する学術的基盤が整った。
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Report
(2 results)
Research Products
(6 results)