| Budget Amount *help |
¥43,810,000 (Direct Cost: ¥33,700,000、Indirect Cost: ¥10,110,000)
Fiscal Year 2022: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2021: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2020: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2019: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2018: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
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| Outline of Final Research Achievements |
We previously revealed that the intracerebral Na sensor, Nax, monitors the serum Na level and controls thirst and salt appetite. In this study, we discovered the involvement of this sensor in the development of salt-sensitive hypertension. Additionally, we successfully identified a novel Na sensor that induces thirst sensation. Furthermore, we identified the neural mechanism that inhibits thirst in the subfornical organ (SFO), which is the center for thirst regulation. Moreover, we identified new features of the autoimmune adipsic hypernatremia caused by anti-SFO antibodies through case analyses.
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