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Transplantable liver fabrication in a xenogeneic porcine as in vivo bioreactor

Research Project

Project/Area Number 18H04058
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
Research InstitutionShiga University of Medical Science (2020)
Kyoto University (2018-2019)

Principal Investigator

Uemoto Shinji  滋賀医科大学, 医学部, 学長 (40252449)

Co-Investigator(Kenkyū-buntansha) 小林 英司  慶應義塾大学, 医学部(信濃町), 特任教授 (00245044)
羽賀 博典  京都大学, 医学研究科, 教授 (10252462)
伊佐 正  京都大学, 医学研究科, 教授 (20212805)
八木 真太郎  京都大学, 医学研究科, 講師 (60447969)
政野 裕紀  京都大学, 医学研究科, 客員研究員 (50806718)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥44,200,000 (Direct Cost: ¥34,000,000、Indirect Cost: ¥10,200,000)
Fiscal Year 2020: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2019: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
Fiscal Year 2018: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Keywords肝移植 / 異種移植 / 肝再生 / in vivo bioreactor / 超急性拒絶反応 / 臓器作成
Outline of Final Research Achievements

Our study showed that after auxiliary liver transplantation, the liver graft from Japanese monkey could survive 7days inside the pig body. Furthermore, we demonstrated that the signs of hyperacute rejection, which is specific in xenotransplantation were almost lacked in monkey to pig liver xenotransplantation within 24-hours after transplantation. This study also showed that donor specific antibodies against monkeys were absent in pigs i.e., the xenotransplantation from monkey to pig is an immunologically concordant combination. This suggests the possibility of the use of pig as an in-vivo bio reactor for liver regeneration.

Academic Significance and Societal Importance of the Research Achievements

ブタやサルといった大動物のレベルで、超急性拒絶反応を生じない、いわゆるconcordantな組み合わせを発見した報告はこれまでになく本研究の新規性の一つである。本研究結果を応用することで、ドナーから取り出した小さな肝グラフトを異種動物である第1レシピエントへ移植し、大きい肝グラフトへと再生させた上で第2レシピエントへ再移植する、つまり異種動物であるブタをin-vivo bioreactorとして利用した肝再生戦略の実用化に向けた研究へとつながることが期待される。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (44 results)

All 2021 2020 2019 2018

All Journal Article (42 results) (of which Peer Reviewed: 42 results,  Open Access: 5 results) Presentation (2 results) (of which Invited: 1 results)

  • [Journal Article] Visceral adiposity is an independent risk factor for high intra-operative blood loss during living-donor liver transplantation; could preoperative rehabilitation and nutritional therapy mitigate that risk?2021

    • Author(s)
      Macshut Mahmoud、Kaido Toshimi、Yao Siyuan、Miyachi Yosuke、Sharshar Mohamed、Iwamura Sena、Hirata Masaaki、Shirai Hisaya、Kamo Naoko、Yagi Shintaro、Uemoto Shinji
    • Journal Title

      Clinical Nutrition

      Volume: 40 Issue: 3 Pages: 956-965

    • DOI

      10.1016/j.clnu.2020.06.023

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pretransplantation splenomegaly frequently persists after liver transplantation and can manifest as hypersplenism and graft fibrosis ‐ a retrospective study2020

    • Author(s)
      Nam Nguyen Hai、Taura Kojiro、Yao Siyuan、Kaido Toshimi、Uemoto Yusuke、Kimura Yusuke、Anazawa Takayuki、Fukumitsu Ken、Ito Takashi、Yagi Shintaro、Kamo Naoko、Hata Koichiro、Uemoto Shinji
    • Journal Title

      Transplant International

      Volume: 33 Issue: 12 Pages: 1807-1820

    • DOI

      10.1111/tri.13761

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Left-posterior approach for artery-first en bloc resection in laparoscopic distal pancreatectomy for left-sided pancreatic cancer2020

    • Author(s)
      Nagai Kazuyuki、Kiguchi Gozo、Yogo Akitada、Anazawa Takayuki、Yagi Shintaro、Taura Kojiro、Takaori Kyoichi、Masui Toshihiko
    • Journal Title

      Langenbeck's Archives of Surgery

      Volume: 405 Issue: 8 Pages: 1251-1258

    • DOI

      10.1007/s00423-020-02021-8

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Donor‐dominant one‐way matching of human leukocyte antigen‐A/B/DR alleles predicts graft‐versus‐host disease following living donor liver transplantation2020

    • Author(s)
      Hirata Masaaki、Yagi Shintaro、Shindo Takero、Yoshizawa Atsushi、Kiguchi Gozo、Kaneshiro Masakatsu、Yurugi Kimiko、Miyachi Yosuke、Iwamura Sena、Yao Siyuan、Uemoto Shinji
    • Journal Title

      Hepatology Research

      Volume: 51 Issue: 1 Pages: 135-148

    • DOI

      10.1111/hepr.13579

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Is 0.6% reasonable as the minimum requirement of the graft-to-recipient weight ratio regardless of lobe selection in adult living-donor liver transplantation?2020

    • Author(s)
      Kusakabe Jiro、Yagi Shintaro、Sasaki Kazunari、Uozumi Ryuji、Abe Hiroyasu、Okamura Yusuke、Taura Kojiro、Kaido Toshimi、Uemoto Shinji
    • Journal Title

      Transplantation

      Volume: Publish Ahead of Print Issue: 9 Pages: 2007-2017

    • DOI

      10.1097/tp.0000000000003472

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reply2020

    • Author(s)
      Kusakabe Jiro、Yagi Shintaro、Uemoto Shinji
    • Journal Title

      Liver Transplantation

      Volume: 27 Issue: 2 Pages: 307-308

    • DOI

      10.1002/lt.25900

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Liver transplantation in patients with portal vein thrombosis: A strategic road map throughout management2020

    • Author(s)
      Sharshar Mohamed、Yagi Shintaro、Iida Taku、Yao Siyuan、Miyachi Yosuke、Macshut Mahmoud、Iwamura Sena、Hirata Masaaki、Ito Takashi、Hata Koichiro、Taura Kojiro、Okajima Hideaki、Kaido Toshimi、Uemoto Shinji
    • Journal Title

      Surgery

      Volume: 168 Issue: 6 Pages: 1160-1168

    • DOI

      10.1016/j.surg.2020.07.023

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] De novo hepatocellular carcinoma developing in the living donor liver grafts: A Japanese multicenter experience2020

    • Author(s)
      Goto R, Kosai-Fujimoto Y, Yagi S, Kobayashi T, Akamatsu N, Shimamura T, Imura S, Ogiso S, Mizuno S, Takatsuki M, Fukuhara T, Kanto T, Eguchi S, Yanaga K, Ogura Y, Fukumoto T, Shimada M, Hasegawa K, Ohdan H, Uemoto S, Soejima Y, Ikegami T, Yoshizumi T, Taketomi A, Maehara Y
    • Journal Title

      Hepatol Res

      Volume: 50 Issue: 12 Pages: 1365-1374

    • DOI

      10.1111/hepr.13565

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Living donor liver transplantation for combined hepatocellular-cholangiocarcinoma: A case series of four patients2020

    • Author(s)
      Ito Takashi、Ishii Takamichi、Sumiyoshi Shinji、Ogiso Satoshi、Fukumitsu Ken、Ito Takashi、Yagi Shintaro、Seo Satoru、Hata Koichiro、Taura Kojiro、Uemoto Shinji
    • Journal Title

      International Journal of Surgery Case Reports

      Volume: 74 Pages: 46-52

    • DOI

      10.1016/j.ijscr.2020.07.069

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Utility of Mac‐2 Binding Protein Glycosylation Isomer to Evaluate Graft Status After Liver Transplantation2020

    • Author(s)
      Kimura Yusuke、Taura Kojiro、Hai Nam Nguyen、Uemoto Yusuke、Yoshino Kenji、Ikeno Yoshinobu、Okuda Yukihiro、Nishio Takahiro、Yamamoto Gen、Tanabe Kazutaka、Koyama Yukinori、Anazawa Takayuki、Fukumitsu Ken、Ito Takashi、Yagi Shintaro、Kamo Naoko、Seo Satoru、Iwaisako Keiko、Hata Koichiro、Imai Takumi、Uemoto Shinji
    • Journal Title

      Liver Transplantation

      Volume: 27 Issue: 3 Pages: 403-415

    • DOI

      10.1002/lt.25870

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diagnostic potential of presepsin in bacterial infection following hepato‐biliary‐pancreatic surgery: A prospective observational study2020

    • Author(s)
      Yao Siyuan、Kaido Toshimi、Uozumi Ryuji、Hirata Masaaki、Iwamura Sena、Miyachi Yosuke、Macshut Mahmoud、Sharshar Mohamed、Yagi Shintaro、Uemoto Shinji
    • Journal Title

      Journal of Hepato-Biliary-Pancreatic Sciences

      Volume: 27 Issue: 10 Pages: 756-766

    • DOI

      10.1002/jhbp.802

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Living-donor liver transplantation: Right versus left2020

    • Author(s)
      Yagi Shintaro、Singhal Ashish、Jung Dong-Hwan、Hashimoto Koji
    • Journal Title

      International Journal of Surgery

      Volume: 82 Pages: 128-133

    • DOI

      10.1016/j.ijsu.2020.06.022

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of administration of β-hydroxy-β-methyl butyrate?enriched formula after liver transplantation: A pilot randomized controlled trial2020

    • Author(s)
      Kamo Naoko、Kaido Toshimi、Uozumi Ryuji、Ito Takashi、Yagi Shintaro、Hata Koichiro、Taura Kojiro、Uemoto Shinji
    • Journal Title

      Nutrition

      Volume: 79-80 Pages: 110871-110871

    • DOI

      10.1016/j.nut.2020.110871

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Etiology of Liver Steatosis Influences the Severity of Ischemia/Reperfusion Injury and Survival After Liver Transplantation in Rats2020

    • Author(s)
      Miyachi Yosuke、Yagi Shintaro、Hirata Masaaki、Iwamura Sena、Yao Siyuan、Shirai Hisaya、Okumura Shinya、Iida Taku、Ito Takashi、Uozumi Ryuji、Kaido Toshimi、Uemoto Shinji
    • Journal Title

      Liver Transplantation

      Volume: 26 Issue: 11 Pages: 1504-1515

    • DOI

      10.1002/lt.25814

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Middle Hepatic Vein Branch-Guided Approach for Laparoscopic Resection of Liver Segment 8 Is Simple, Reliable, and Reproducible2020

    • Author(s)
      Ogiso Satoshi、Seo Satoru、Ishii Takamichi、Anazawa Takayuki、Nagai Kazuyuki、Uchida Yoichiro、Fukumitsu Ken、Ito Takashi、Yagi Shintaro、Kamo Naoko、Hata Koichiro、Masui Toshihiko、Taura Kojiro
    • Journal Title

      Annals of Surgical Oncology

      Volume: 27 Issue: 13 Pages: 5195-5195

    • DOI

      10.1245/s10434-020-08652-x

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preoperative abnormal body composition is closely related to bacteremia after living donor liver transplantation2020

    • Author(s)
      Kamo Naoko、Kaido Toshimi、Miyachi Yosuke、Iwamura Sena、Yao Siyuan、Shirai Hisaya、Yagi Shintaro、Uemoto Shinji
    • Journal Title

      Nutrition

      Volume: 77 Pages: 110798-110798

    • DOI

      10.1016/j.nut.2020.110798

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The combination of male donor’s high muscle mass and quality is an independent protective factor for graft loss after living donor liver transplantation.2020

    • Author(s)
      Miyachi Y, Kaido T, Hirata M, Iwamura S, Yao S, Shirai H, Kamo N, Uozumi R, Yagi S, Uemoto S
    • Journal Title

      Am J Transpl

      Volume: in press Issue: 12 Pages: 3401-3412

    • DOI

      10.1111/ajt.15884

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of preoperative bone mineral density on the outcomes after resection of pancreatic cancer.2020

    • Author(s)
      Sharshar M, Kaido T, Shirai H, Okumura S, Yao S, Miyachi Y, Iwamura S, Kamo N, Yagi S, Macshut M, Uemoto S
    • Journal Title

      Surg Today

      Volume: in press Issue: 7 Pages: 757-766

    • DOI

      10.1007/s00595-019-01954-y

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Use of Nakanuma staging and cytokeratin 7 staining for diagnosing recurrent primary biliary cholangitis after living‐donor liver transplantation2020

    • Author(s)
      Yamashiki Noriyo、Haga Hironori、Ueda Yoshihide、Ito Takashi、Yagi Shintaro、Kamo Naoko、Hata Koichiro、Mori Akira、Kaido Toshimi、Okajima Hideaki、Uemoto Shinji
    • Journal Title

      Hepatology Research

      Volume: 50 Issue: 4 Pages: 478-487

    • DOI

      10.1111/hepr.13476

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Living donor liver transplantation in situs inversus totalis with a patient‐specific three‐dimensional printed liver model2020

    • Author(s)
      Ishii Takamichi、Fukumitsu Ken、Ogawa Eri、Okamoto Tatsuya、Uemoto Shinji
    • Journal Title

      Pediatric Transplantation

      Volume: 24 Issue: 3 Pages: 13675-13675

    • DOI

      10.1111/petr.13675

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic index consisting of early post‐transplant variables <2?weeks in adult living‐donor liver transplantation2020

    • Author(s)
      Kusakabe Jiro、Hata Koichiro、Tanaka Shiro、Omae Katsuhiro、Okamura Yusuke、Tajima Tetsuya、Tamaki Ichiro、Miyauchi Hidetaka、Kubota Toyonari、Tanaka Hirokazu、Uemoto Shinji
    • Journal Title

      Hepatology Research

      Volume: 3 Issue: 6 Pages: 741-753

    • DOI

      10.1111/hepr.13489

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Impact of Biliary Reconstruction Methods on Small Partial Liver Grafts2020

    • Author(s)
      Yoshikawa Junichi、Hata Koichiro、Nakamura Kojiro、Okamura Yusuke、Uemoto Shinji
    • Journal Title

      Transplantation Direct

      Volume: 6 Issue: 2 Pages: e523-e523

    • DOI

      10.1097/txd.0000000000000966

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Multicenter Japanese Survey Assessing the Long-Term Outcomes of Liver Retransplantation using Living Donor Grafts2020

    • Author(s)
      Kuramitsu Kaori、Fukumoto Takumi、Egawa Hiroto、Ohdan Hideki、Umeshita Koji、Uemoto Shinji、Hibi Taizo、Kasahara Mureo、Yoshizumi Tomoharu、Mizuta Koichi、Shimamura Tsuyoshi、Furukawa Hiroyuki
    • Journal Title

      Transplantation

      Volume: 104 Issue: 4 Pages: 754-761

    • DOI

      10.1097/tp.0000000000002958

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term impact and clinical significance of living donor liver transplantation with respect to donor liver restoration and spleen size: A prospective study2020

    • Author(s)
      Yoshino, K. Taura, K. Ikeno, Y. Kimura, Y. Hai Nam, N. Uemoto, Y. Okuda, Y. Nishio, T. Yamamoto, G. Iwaisako, K. Seo, S. Kaido, T. Uemoto, S.
    • Journal Title

      Am J Transplant

      Volume: 20 Issue: 3 Pages: 808-816

    • DOI

      10.1111/ajt.15627

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anatomical Pitfall in Right Posterior Sector Graft Procurement in Living Donor Liver Transplantation.2020

    • Author(s)
      Kusakabe J, Yagi S, Okamura Y, Iida T, Ogawa E, Ito T, Hata K, Taura K, Okajima H, Kaido T, Uemoto S.
    • Journal Title

      Liver Transpl.

      Volume: Feb;26(2) Issue: 2 Pages: 299-303

    • DOI

      10.1002/lt.25648

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bortezomib Against Refractory Antibody-Mediated Rejection After ABO-Incompatible Living-Donor Liver Transplantation2019

    • Author(s)
      Tajima Tetsuya、Hata Koichiro、Okajima Hideaki、Nishikori Momoko、Yasuchika Kentaro、Kusakabe Jiro、Yoshizawa Atsushi、Fukumitsu Ken、Anazawa Takayuki、Tanaka Hirokazu、Wada Seidai、Doi Junshi、Takaori-Kondo Akifumi、Uemoto Shinji
    • Journal Title

      Transplantation Direct

      Volume: 5 Issue: 10 Pages: e491-e491

    • DOI

      10.1097/txd.0000000000000932

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Assessment and significance of sarcopenia in liver transplantation.2019

    • Author(s)
      Nam NH, Kaido T, Uemoto S
    • Journal Title

      Clin Transplant

      Volume: 33 Issue: 12

    • DOI

      10.1111/ctr.13741

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Dual Protective Effect of Intestinal Remote Ischemic Conditioning in a Rat Model of Total Hepatic Ischemia2019

    • Author(s)
      Czigany Zoltan、Hata Koichiro、Lai Wei、Schwandt Timo、Yamamoto Yuzo、Uemoto Shinji、Tolba Rene H.
    • Journal Title

      Journal of Clinical Medicine

      Volume: 8 Issue: 10 Pages: 1546-1546

    • DOI

      10.3390/jcm8101546

    • NAID

      120006841692

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Including body composition in MELD scores improves mortality prediction among patients awaiting liver transplantation.2019

    • Author(s)
      Hamaguchi Y, Kaido T, Okumura S, Kobayashi A, Shirai H, Yao S, Yagi S, Kamo N, Uemoto S
    • Journal Title

      Clin Nutr

      Volume: in press Issue: 6 Pages: 1885-1892

    • DOI

      10.1016/j.clnu.2019.08.012

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Auxiliary xenotransplantation as an in vivo bioreactor- Development of a transplantable liver graft from a tiny partial liver2019

    • Author(s)
      Masano Yuki、Yagi Shintaro、Miyachi Yosuke、Okumura Shinya、Kaido Toshimi、Haga Hironori、Kobayashi Eiji、Uemoto Shinji
    • Journal Title

      Xenotransplantation

      Volume: 26 Issue: 6

    • DOI

      10.1111/xen.12545

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of Graft Quality and Fluid Overload on Postoperative Massive Ascites After Living Donor Liver Transplantation2019

    • Author(s)
      Iwaki Kentaro、Yagi Shintaro、Morita Satoshi、Hamaguchi Yuhei、Masano Yuki、Yamamoto Gen、Ogawa Eri、Nagai Kazuyuki、Kamo Naoko、Hata Koichiro、Taura Kojiro、Okajima Hideaki、Kaido Toshimi、Uemoto Shinji
    • Journal Title

      Transplantation Proceedings

      Volume: 51 Issue: 6 Pages: 1779-1784

    • DOI

      10.1016/j.transproceed.2019.03.038

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bolus Administration of Polyamines Boosts Effects on Hepatic Ischemia-Reperfusion Injury and Regeneration in Rats2019

    • Author(s)
      Doi Junshi、Fujimoto Yasuhiro、Teratani Takumi、Kasahara Naoya、Maeda Masashi、Tsuruyama Tatsuaki、Iida Taku、Yagi Shintaro、Uemoto Shinji
    • Journal Title

      European Surgical Research

      Volume: 60 Issue: 1-2 Pages: 63-73

    • DOI

      10.1159/000497434

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Impact of a Nitric Oxide Synthase Inhibitor (L-NAME) on Ischemia?Reperfusion Injury of Cholestatic Livers by Pringle Maneuver and Liver Resection after Bile Duct Ligation in Rats2019

    • Author(s)
      Iwasaki Junji、Afify Mamdouh、Bleilevens Christian、Klinge Uwe、Weiskirchen Ralf、Steitz Julia、Vogt Michael、Yagi Shintaro、Nagai Kazuyuki、Uemoto Shinji、Tolba Rene H.
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 20 Issue: 9 Pages: 2114-2114

    • DOI

      10.3390/ijms20092114

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preoperative Visceral Adiposity and Muscularity Predict Poor Outcomes after Hepatectomy for Hepatocellular Carcinoma.2019

    • Author(s)
      Hamaguchi Y, Kaido T, Okumura S, Kobayashi A, Shirai H, Yao S, Yagi S, Kamo N, Seo S, Taura K, Okajima H, Uemoto S.
    • Journal Title

      Liver Cancer

      Volume: 8 Issue: 2 Pages: 92-109

    • DOI

      10.1159/000488779

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of imbalanced graft‐to‐spleen volume ratio on outcomes following living donor liver transplantation in an era when simultaneous splenectomy is not typically indicated2019

    • Author(s)
      Yao Siyuan、Kaido Toshimi、Yagi Shintaro、Uozumi Ryuji、Iwamura Sena、Miyachi Yosuke、Shirai Hisaya、Kamo Naoko、Taura Kojiro、Okajima Hideaki、Uemoto Shinji
    • Journal Title

      American Journal of Transplantation

      Volume: 印刷中 Issue: 10 Pages: 2783-2794

    • DOI

      10.1111/ajt.15337

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone mineral density correlates with survival after resection of extrahepatic biliary malignancies.2018

    • Author(s)
      Yao S, Kaido T, Okumura S, Iwamura S, Miyachi Y, Shirai H, Kobayashi A, Hamaguchi Y, Kamo N, Uozumi R, Yagi S, Uemoto S.
    • Journal Title

      Clin Nutr

      Volume: 37 Issue: 6 Pages: 32570-6

    • DOI

      10.1016/j.clnu.2018.12.004

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Etiologies, risk factors, and outcomes of bacterial cholangitis after living donor liver transplantation.2018

    • Author(s)
      Yao S, Yagi S, Nagao M, Uozumi R, Iida T, Iwamura S, Miyachi Y, Shirai H, Kobayashi A, Okumura S, Hamaguchi Y, Masano Y, Kaido T, Okajima H, Uemoto S.
    • Journal Title

      Eur J Clin Microbiol Infect Dis.

      Volume: 10 Issue: 10 Pages: 1973-1982

    • DOI

      10.1007/s10096-018-3333-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Liver Transplantation for Intermediate-Stage Hepatocellular Carcinoma2018

    • Author(s)
      Kamo Naoko、Kaido Toshimi、Yagi Shintaro、Okajima Hideaki、Uemoto Shinji
    • Journal Title

      Liver Cancer

      Volume: 7 Issue: 2 Pages: 179-189

    • DOI

      10.1159/000487058

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of Enteral Nutrition with an Immunomodulating Diet Enriched with Hydrolyzed Whey Peptide on Infection After Liver Transplantation2018

    • Author(s)
      Kamo Naoko、Kaido Toshimi、Hamaguchi Yuhei、Uozumi Ryuji、Okumura Shinya、Kobayashi Atsushi、Shirai Hisaya、Yagi Shintaro、Okajima Hideaki、Uemoto Shinji
    • Journal Title

      World Journal of Surgery

      Volume: 42 Issue: 11 Pages: 3715-3725

    • DOI

      10.1007/s00268-018-4680-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Is Portal Venous Pressure Modulation Still Indicated for All Recipients in Living Donor Liver Transplantation?2018

    • Author(s)
      Yao Siyuan、Kaido Toshimi、Uozumi Ryuji、Yagi Shintaro、Miyachi Yosuke、Fukumitsu Ken、Anazawa Takayuki、Kamo Naoko、Taura Kojiro、Okajima Hideaki、Uemoto Shinji
    • Journal Title

      Liver Transplantation

      Volume: 24 Issue: 11 Pages: 1578-1588

    • DOI

      10.1002/lt.25180

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low Preoperative Platelet Count Predicts Risk of Subclinical Posthepatectomy Liver Failure in Right Lobe Donors for Liver Transplantation2018

    • Author(s)
      Yoshino Kenji、Taura Kojiro、Ikeno Yoshinobu、Okuda Yukihiro、Nishio Takahiro、Yamamoto Gen、Seo Satoru、Yagi Shintaro、Hata Koichiro、Kaido Toshimi、Okajima Hideaki、Uemoto Shinji
    • Journal Title

      Liver Transplantation

      Volume: 24 Issue: 9 Pages: 1178-1185

    • DOI

      10.1002/lt.25181

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human leukocyte antigen compatibility and lymphocyte cross-matching play no significant role in the current adult-to-adult living donor liver transplantation2018

    • Author(s)
      Badawy Amr、Kaido Toshimi、Yoshizawa Atsushi、Yagi Shintaro、Fukumitsu Ken、Okajima Hideaki、Uemoto Shinji
    • Journal Title

      Clinical Transplantation

      Volume: 32 Issue: 4

    • DOI

      10.1111/ctr.13234

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] 異種動物を In vivo bioreactor とした肝再生戦略―ヒト過小グラフトへの展望2020

    • Author(s)
      八木真太郎、政野裕紀、宮地洋介、平田真章、白井久也、姚思遠、上本伸二、小林英司
    • Organizer
      第22回異種移植研究会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 異種動物を In vivo bioreactor とした肝再生戦略―ヒト過小グラフトへの展望2020

    • Author(s)
      八木真太郎、政野裕紀、宮地洋介、平田真章、白井久也、姚思遠、上本伸二、小林英司
    • Organizer
      第22回日本異種移植研究会
    • Related Report
      2019 Annual Research Report
    • Invited

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Published: 2018-04-23   Modified: 2023-12-25  

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