Transplantable liver fabrication in a xenogeneic porcine as in vivo bioreactor

• Project/Area Number: 18H04058
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
• Research Institution: Shiga University of Medical Science (2020); Kyoto University (2018-2019)
• Principal Investigator: Uemoto Shinji 滋賀医科大学, 医学部, 学長 (40252449)
• Co-Investigator(Kenkyū-buntansha): 小林 英司 慶應義塾大学, 医学部(信濃町), 特任教授 (00245044) ; 羽賀 博典 京都大学, 医学研究科, 教授 (10252462) ; 伊佐 正 京都大学, 医学研究科, 教授 (20212805) ; 八木 真太郎 京都大学, 医学研究科, 講師 (60447969) ; 政野 裕紀 京都大学, 医学研究科, 客員研究員 (50806718)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥44,200,000 (Direct Cost: ¥34,000,000、Indirect Cost: ¥10,200,000); Fiscal Year 2020: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000); Fiscal Year 2019: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000); Fiscal Year 2018: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
• Keywords: 肝移植 / 異種移植 / 肝再生 / in vivo bioreactor / 超急性拒絶反応 / 臓器作成

Outline of Final Research Achievements

Our study showed that after auxiliary liver transplantation, the liver graft from Japanese monkey could survive 7days inside the pig body. Furthermore, we demonstrated that the signs of hyperacute rejection, which is specific in xenotransplantation were almost lacked in monkey to pig liver xenotransplantation within 24-hours after transplantation. This study also showed that donor specific antibodies against monkeys were absent in pigs i.e., the xenotransplantation from monkey to pig is an immunologically concordant combination. This suggests the possibility of the use of pig as an in-vivo bio reactor for liver regeneration.

Academic Significance and Societal Importance of the Research Achievements

ブタやサルといった大動物のレベルで、超急性拒絶反応を生じない、いわゆるconcordantな組み合わせを発見した報告はこれまでになく本研究の新規性の一つである。本研究結果を応用することで、ドナーから取り出した小さな肝グラフトを異種動物である第1レシピエントへ移植し、大きい肝グラフトへと再生させた上で第2レシピエントへ再移植する、つまり異種動物であるブタをin-vivo bioreactorとして利用した肝再生戦略の実用化に向けた研究へとつながることが期待される。

Research Products

• [Journal Article] Visceral adiposity is an independent risk factor for high intra-operative blood loss during living-donor liver transplantation; could preoperative rehabilitation and nutritional therapy mitigate that risk? (2021)
  • Author(s): Macshut Mahmoud、Kaido Toshimi、Yao Siyuan、Miyachi Yosuke、Sharshar Mohamed、Iwamura Sena、Hirata Masaaki、Shirai Hisaya、Kamo Naoko、Yagi Shintaro、Uemoto Shinji
  • Journal Title: Clinical Nutrition Volume: 40 Issue: 3 Pages: 956-965
  • DOI: 10.1016/j.clnu.2020.06.023
  • Peer Reviewed
• [Journal Article] Pretransplantation splenomegaly frequently persists after liver transplantation and can manifest as hypersplenism and graft fibrosis ‐ a retrospective study (2020)
  • Author(s): Nam Nguyen Hai、Taura Kojiro、Yao Siyuan、Kaido Toshimi、Uemoto Yusuke、Kimura Yusuke、Anazawa Takayuki、Fukumitsu Ken、Ito Takashi、Yagi Shintaro、Kamo Naoko、Hata Koichiro、Uemoto Shinji
  • Journal Title: Transplant International Volume: 33 Issue: 12 Pages: 1807-1820
  • DOI: 10.1111/tri.13761
  • Peer Reviewed
• [Journal Article] Left-posterior approach for artery-first en bloc resection in laparoscopic distal pancreatectomy for left-sided pancreatic cancer (2020)
  • Author(s): Nagai Kazuyuki、Kiguchi Gozo、Yogo Akitada、Anazawa Takayuki、Yagi Shintaro、Taura Kojiro、Takaori Kyoichi、Masui Toshihiko
  • Journal Title: Langenbeck's Archives of Surgery Volume: 405 Issue: 8 Pages: 1251-1258
  • DOI: 10.1007/s00423-020-02021-8
  • Peer Reviewed
• [Journal Article] Donor‐dominant one‐way matching of human leukocyte antigen‐A/B/DR alleles predicts graft‐versus‐host disease following living donor liver transplantation (2020)
  • Author(s): Hirata Masaaki、Yagi Shintaro、Shindo Takero、Yoshizawa Atsushi、Kiguchi Gozo、Kaneshiro Masakatsu、Yurugi Kimiko、Miyachi Yosuke、Iwamura Sena、Yao Siyuan、Uemoto Shinji
  • Journal Title: Hepatology Research Volume: 51 Issue: 1 Pages: 135-148
  • DOI: 10.1111/hepr.13579
  • Peer Reviewed
• [Journal Article] Is 0.6% reasonable as the minimum requirement of the graft-to-recipient weight ratio regardless of lobe selection in adult living-donor liver transplantation? (2020)
  • Author(s): Kusakabe Jiro、Yagi Shintaro、Sasaki Kazunari、Uozumi Ryuji、Abe Hiroyasu、Okamura Yusuke、Taura Kojiro、Kaido Toshimi、Uemoto Shinji
  • Journal Title: Transplantation Volume: Publish Ahead of Print Issue: 9 Pages: 2007-2017
  • DOI: 10.1097/tp.0000000000003472
  • Peer Reviewed
• [Journal Article] Reply (2020)
  • Author(s): Kusakabe Jiro、Yagi Shintaro、Uemoto Shinji
  • Journal Title: Liver Transplantation Volume: 27 Issue: 2 Pages: 307-308
  • DOI: 10.1002/lt.25900
  • Peer Reviewed
• [Journal Article] Liver transplantation in patients with portal vein thrombosis: A strategic road map throughout management (2020)
  • Author(s): Sharshar Mohamed、Yagi Shintaro、Iida Taku、Yao Siyuan、Miyachi Yosuke、Macshut Mahmoud、Iwamura Sena、Hirata Masaaki、Ito Takashi、Hata Koichiro、Taura Kojiro、Okajima Hideaki、Kaido Toshimi、Uemoto Shinji
  • Journal Title: Surgery Volume: 168 Issue: 6 Pages: 1160-1168
  • DOI: 10.1016/j.surg.2020.07.023
  • Peer Reviewed
• [Journal Article] De novo hepatocellular carcinoma developing in the living donor liver grafts: A Japanese multicenter experience (2020)
  • Author(s): Goto R, Kosai-Fujimoto Y, Yagi S, Kobayashi T, Akamatsu N, Shimamura T, Imura S, Ogiso S, Mizuno S, Takatsuki M, Fukuhara T, Kanto T, Eguchi S, Yanaga K, Ogura Y, Fukumoto T, Shimada M, Hasegawa K, Ohdan H, Uemoto S, Soejima Y, Ikegami T, Yoshizumi T, Taketomi A, Maehara Y
  • Journal Title: Hepatol Res Volume: 50 Issue: 12 Pages: 1365-1374
  • DOI: 10.1111/hepr.13565
  • Peer Reviewed
• [Journal Article] Living donor liver transplantation for combined hepatocellular-cholangiocarcinoma: A case series of four patients (2020)
  • Author(s): Ito Takashi、Ishii Takamichi、Sumiyoshi Shinji、Ogiso Satoshi、Fukumitsu Ken、Ito Takashi、Yagi Shintaro、Seo Satoru、Hata Koichiro、Taura Kojiro、Uemoto Shinji
  • Journal Title: International Journal of Surgery Case Reports Volume: 74 Pages: 46-52
  • DOI: 10.1016/j.ijscr.2020.07.069
  • Peer Reviewed / Open Access
• [Journal Article] Utility of Mac‐2 Binding Protein Glycosylation Isomer to Evaluate Graft Status After Liver Transplantation (2020)
  • Author(s): Kimura Yusuke、Taura Kojiro、Hai Nam Nguyen、Uemoto Yusuke、Yoshino Kenji、Ikeno Yoshinobu、Okuda Yukihiro、Nishio Takahiro、Yamamoto Gen、Tanabe Kazutaka、Koyama Yukinori、Anazawa Takayuki、Fukumitsu Ken、Ito Takashi、Yagi Shintaro、Kamo Naoko、Seo Satoru、Iwaisako Keiko、Hata Koichiro、Imai Takumi、Uemoto Shinji
  • Journal Title: Liver Transplantation Volume: 27 Issue: 3 Pages: 403-415
  • DOI: 10.1002/lt.25870
  • Peer Reviewed
• [Journal Article] Diagnostic potential of presepsin in bacterial infection following hepato‐biliary‐pancreatic surgery: A prospective observational study (2020)
  • Author(s): Yao Siyuan、Kaido Toshimi、Uozumi Ryuji、Hirata Masaaki、Iwamura Sena、Miyachi Yosuke、Macshut Mahmoud、Sharshar Mohamed、Yagi Shintaro、Uemoto Shinji
  • Journal Title: Journal of Hepato-Biliary-Pancreatic Sciences Volume: 27 Issue: 10 Pages: 756-766
  • DOI: 10.1002/jhbp.802
  • Peer Reviewed
• [Journal Article] Living-donor liver transplantation: Right versus left (2020)
  • Author(s): Yagi Shintaro、Singhal Ashish、Jung Dong-Hwan、Hashimoto Koji
  • Journal Title: International Journal of Surgery Volume: 82 Pages: 128-133
  • DOI: 10.1016/j.ijsu.2020.06.022
  • Peer Reviewed
• [Journal Article] Effect of administration of β-hydroxy-β-methyl butyrate?enriched formula after liver transplantation: A pilot randomized controlled trial (2020)
  • Author(s): Kamo Naoko、Kaido Toshimi、Uozumi Ryuji、Ito Takashi、Yagi Shintaro、Hata Koichiro、Taura Kojiro、Uemoto Shinji
  • Journal Title: Nutrition Volume: 79-80 Pages: 110871-110871
  • DOI: 10.1016/j.nut.2020.110871
  • Peer Reviewed
• [Journal Article] Etiology of Liver Steatosis Influences the Severity of Ischemia/Reperfusion Injury and Survival After Liver Transplantation in Rats (2020)
  • Author(s): Miyachi Yosuke、Yagi Shintaro、Hirata Masaaki、Iwamura Sena、Yao Siyuan、Shirai Hisaya、Okumura Shinya、Iida Taku、Ito Takashi、Uozumi Ryuji、Kaido Toshimi、Uemoto Shinji
  • Journal Title: Liver Transplantation Volume: 26 Issue: 11 Pages: 1504-1515
  • DOI: 10.1002/lt.25814
  • Peer Reviewed
• [Journal Article] Middle Hepatic Vein Branch-Guided Approach for Laparoscopic Resection of Liver Segment 8 Is Simple, Reliable, and Reproducible (2020)
  • Author(s): Ogiso Satoshi、Seo Satoru、Ishii Takamichi、Anazawa Takayuki、Nagai Kazuyuki、Uchida Yoichiro、Fukumitsu Ken、Ito Takashi、Yagi Shintaro、Kamo Naoko、Hata Koichiro、Masui Toshihiko、Taura Kojiro
  • Journal Title: Annals of Surgical Oncology Volume: 27 Issue: 13 Pages: 5195-5195
  • DOI: 10.1245/s10434-020-08652-x
  • Peer Reviewed
• [Journal Article] Preoperative abnormal body composition is closely related to bacteremia after living donor liver transplantation (2020)
  • Author(s): Kamo Naoko、Kaido Toshimi、Miyachi Yosuke、Iwamura Sena、Yao Siyuan、Shirai Hisaya、Yagi Shintaro、Uemoto Shinji
  • Journal Title: Nutrition Volume: 77 Pages: 110798-110798
  • DOI: 10.1016/j.nut.2020.110798
  • Peer Reviewed
• [Journal Article] The combination of male donor’s high muscle mass and quality is an independent protective factor for graft loss after living donor liver transplantation. (2020)
  • Author(s): Miyachi Y, Kaido T, Hirata M, Iwamura S, Yao S, Shirai H, Kamo N, Uozumi R, Yagi S, Uemoto S
  • Journal Title: Am J Transpl Volume: in press Issue: 12 Pages: 3401-3412
  • DOI: 10.1111/ajt.15884
  • Peer Reviewed
• [Journal Article] Impact of preoperative bone mineral density on the outcomes after resection of pancreatic cancer. (2020)
  • Author(s): Sharshar M, Kaido T, Shirai H, Okumura S, Yao S, Miyachi Y, Iwamura S, Kamo N, Yagi S, Macshut M, Uemoto S
  • Journal Title: Surg Today Volume: in press Issue: 7 Pages: 757-766
  • DOI: 10.1007/s00595-019-01954-y
  • Peer Reviewed
• [Journal Article] Use of Nakanuma staging and cytokeratin 7 staining for diagnosing recurrent primary biliary cholangitis after living‐donor liver transplantation (2020)
  • Author(s): Yamashiki Noriyo、Haga Hironori、Ueda Yoshihide、Ito Takashi、Yagi Shintaro、Kamo Naoko、Hata Koichiro、Mori Akira、Kaido Toshimi、Okajima Hideaki、Uemoto Shinji
  • Journal Title: Hepatology Research Volume: 50 Issue: 4 Pages: 478-487
  • DOI: 10.1111/hepr.13476
  • Peer Reviewed
• [Journal Article] Living donor liver transplantation in situs inversus totalis with a patient‐specific three‐dimensional printed liver model (2020)
  • Author(s): Ishii Takamichi、Fukumitsu Ken、Ogawa Eri、Okamoto Tatsuya、Uemoto Shinji
  • Journal Title: Pediatric Transplantation Volume: 24 Issue: 3 Pages: 13675-13675
  • DOI: 10.1111/petr.13675
  • Peer Reviewed
• [Journal Article] Prognostic index consisting of early post‐transplant variables <2?weeks in adult living‐donor liver transplantation (2020)
  • Author(s): Kusakabe Jiro、Hata Koichiro、Tanaka Shiro、Omae Katsuhiro、Okamura Yusuke、Tajima Tetsuya、Tamaki Ichiro、Miyauchi Hidetaka、Kubota Toyonari、Tanaka Hirokazu、Uemoto Shinji
  • Journal Title: Hepatology Research Volume: 3 Issue: 6 Pages: 741-753
  • DOI: 10.1111/hepr.13489
  • Peer Reviewed
• [Journal Article] The Impact of Biliary Reconstruction Methods on Small Partial Liver Grafts (2020)
  • Author(s): Yoshikawa Junichi、Hata Koichiro、Nakamura Kojiro、Okamura Yusuke、Uemoto Shinji
  • Journal Title: Transplantation Direct Volume: 6 Issue: 2 Pages: e523-e523
  • DOI: 10.1097/txd.0000000000000966
  • Peer Reviewed
• [Journal Article] A Multicenter Japanese Survey Assessing the Long-Term Outcomes of Liver Retransplantation using Living Donor Grafts (2020)
  • Author(s): Kuramitsu Kaori、Fukumoto Takumi、Egawa Hiroto、Ohdan Hideki、Umeshita Koji、Uemoto Shinji、Hibi Taizo、Kasahara Mureo、Yoshizumi Tomoharu、Mizuta Koichi、Shimamura Tsuyoshi、Furukawa Hiroyuki
  • Journal Title: Transplantation Volume: 104 Issue: 4 Pages: 754-761
  • DOI: 10.1097/tp.0000000000002958
  • Peer Reviewed
• [Journal Article] Long-term impact and clinical significance of living donor liver transplantation with respect to donor liver restoration and spleen size: A prospective study (2020)
  • Author(s): Yoshino, K. Taura, K. Ikeno, Y. Kimura, Y. Hai Nam, N. Uemoto, Y. Okuda, Y. Nishio, T. Yamamoto, G. Iwaisako, K. Seo, S. Kaido, T. Uemoto, S.
  • Journal Title: Am J Transplant Volume: 20 Issue: 3 Pages: 808-816
  • DOI: 10.1111/ajt.15627
  • Peer Reviewed
• [Journal Article] Anatomical Pitfall in Right Posterior Sector Graft Procurement in Living Donor Liver Transplantation. (2020)
  • Author(s): Kusakabe J, Yagi S, Okamura Y, Iida T, Ogawa E, Ito T, Hata K, Taura K, Okajima H, Kaido T, Uemoto S.
  • Journal Title: Liver Transpl. Volume: Feb;26(2) Issue: 2 Pages: 299-303
  • DOI: 10.1002/lt.25648
  • Peer Reviewed / Open Access
• [Journal Article] Bortezomib Against Refractory Antibody-Mediated Rejection After ABO-Incompatible Living-Donor Liver Transplantation (2019)
  • Author(s): Tajima Tetsuya、Hata Koichiro、Okajima Hideaki、Nishikori Momoko、Yasuchika Kentaro、Kusakabe Jiro、Yoshizawa Atsushi、Fukumitsu Ken、Anazawa Takayuki、Tanaka Hirokazu、Wada Seidai、Doi Junshi、Takaori-Kondo Akifumi、Uemoto Shinji
  • Journal Title: Transplantation Direct Volume: 5 Issue: 10 Pages: e491-e491
  • DOI: 10.1097/txd.0000000000000932
  • Peer Reviewed / Open Access
• [Journal Article] Assessment and significance of sarcopenia in liver transplantation. (2019)
  • Author(s): Nam NH, Kaido T, Uemoto S
  • Journal Title: Clin Transplant Volume: 33 Issue: 12
  • DOI: 10.1111/ctr.13741
  • Peer Reviewed
• [Journal Article] A Dual Protective Effect of Intestinal Remote Ischemic Conditioning in a Rat Model of Total Hepatic Ischemia (2019)
  • Author(s): Czigany Zoltan、Hata Koichiro、Lai Wei、Schwandt Timo、Yamamoto Yuzo、Uemoto Shinji、Tolba Rene H.
  • Journal Title: Journal of Clinical Medicine Volume: 8 Issue: 10 Pages: 1546-1546
  • DOI: 10.3390/jcm8101546
  • NAID: 120006841692
  • Peer Reviewed
• [Journal Article] Including body composition in MELD scores improves mortality prediction among patients awaiting liver transplantation. (2019)
  • Author(s): Hamaguchi Y, Kaido T, Okumura S, Kobayashi A, Shirai H, Yao S, Yagi S, Kamo N, Uemoto S
  • Journal Title: Clin Nutr Volume: in press Issue: 6 Pages: 1885-1892
  • DOI: 10.1016/j.clnu.2019.08.012
  • Peer Reviewed
• [Journal Article] Auxiliary xenotransplantation as an in vivo bioreactor- Development of a transplantable liver graft from a tiny partial liver (2019)
  • Author(s): Masano Yuki、Yagi Shintaro、Miyachi Yosuke、Okumura Shinya、Kaido Toshimi、Haga Hironori、Kobayashi Eiji、Uemoto Shinji
  • Journal Title: Xenotransplantation Volume: 26 Issue: 6
  • DOI: 10.1111/xen.12545
  • Peer Reviewed
• [Journal Article] Impact of Graft Quality and Fluid Overload on Postoperative Massive Ascites After Living Donor Liver Transplantation (2019)
  • Author(s): Iwaki Kentaro、Yagi Shintaro、Morita Satoshi、Hamaguchi Yuhei、Masano Yuki、Yamamoto Gen、Ogawa Eri、Nagai Kazuyuki、Kamo Naoko、Hata Koichiro、Taura Kojiro、Okajima Hideaki、Kaido Toshimi、Uemoto Shinji
  • Journal Title: Transplantation Proceedings Volume: 51 Issue: 6 Pages: 1779-1784
  • DOI: 10.1016/j.transproceed.2019.03.038
  • Peer Reviewed
• [Journal Article] Bolus Administration of Polyamines Boosts Effects on Hepatic Ischemia-Reperfusion Injury and Regeneration in Rats (2019)
  • Author(s): Doi Junshi、Fujimoto Yasuhiro、Teratani Takumi、Kasahara Naoya、Maeda Masashi、Tsuruyama Tatsuaki、Iida Taku、Yagi Shintaro、Uemoto Shinji
  • Journal Title: European Surgical Research Volume: 60 Issue: 1-2 Pages: 63-73
  • DOI: 10.1159/000497434
  • Peer Reviewed / Open Access
• [Journal Article] The Impact of a Nitric Oxide Synthase Inhibitor (L-NAME) on Ischemia?Reperfusion Injury of Cholestatic Livers by Pringle Maneuver and Liver Resection after Bile Duct Ligation in Rats (2019)
  • Author(s): Iwasaki Junji、Afify Mamdouh、Bleilevens Christian、Klinge Uwe、Weiskirchen Ralf、Steitz Julia、Vogt Michael、Yagi Shintaro、Nagai Kazuyuki、Uemoto Shinji、Tolba Rene H.
  • Journal Title: International Journal of Molecular Sciences Volume: 20 Issue: 9 Pages: 2114-2114
  • DOI: 10.3390/ijms20092114
  • Peer Reviewed
• [Journal Article] Preoperative Visceral Adiposity and Muscularity Predict Poor Outcomes after Hepatectomy for Hepatocellular Carcinoma. (2019)
  • Author(s): Hamaguchi Y, Kaido T, Okumura S, Kobayashi A, Shirai H, Yao S, Yagi S, Kamo N, Seo S, Taura K, Okajima H, Uemoto S.
  • Journal Title: Liver Cancer Volume: 8 Issue: 2 Pages: 92-109
  • DOI: 10.1159/000488779
  • Peer Reviewed
• [Journal Article] Impact of imbalanced graft‐to‐spleen volume ratio on outcomes following living donor liver transplantation in an era when simultaneous splenectomy is not typically indicated (2019)
  • Author(s): Yao Siyuan、Kaido Toshimi、Yagi Shintaro、Uozumi Ryuji、Iwamura Sena、Miyachi Yosuke、Shirai Hisaya、Kamo Naoko、Taura Kojiro、Okajima Hideaki、Uemoto Shinji
  • Journal Title: American Journal of Transplantation Volume: 印刷中 Issue: 10 Pages: 2783-2794
  • DOI: 10.1111/ajt.15337
  • Peer Reviewed
• [Journal Article] Bone mineral density correlates with survival after resection of extrahepatic biliary malignancies. (2018)
  • Author(s): Yao S, Kaido T, Okumura S, Iwamura S, Miyachi Y, Shirai H, Kobayashi A, Hamaguchi Y, Kamo N, Uozumi R, Yagi S, Uemoto S.
  • Journal Title: Clin Nutr Volume: 37 Issue: 6 Pages: 32570-6
  • DOI: 10.1016/j.clnu.2018.12.004
  • Peer Reviewed
• [Journal Article] Etiologies, risk factors, and outcomes of bacterial cholangitis after living donor liver transplantation. (2018)
  • Author(s): Yao S, Yagi S, Nagao M, Uozumi R, Iida T, Iwamura S, Miyachi Y, Shirai H, Kobayashi A, Okumura S, Hamaguchi Y, Masano Y, Kaido T, Okajima H, Uemoto S.
  • Journal Title: Eur J Clin Microbiol Infect Dis. Volume: 10 Issue: 10 Pages: 1973-1982
  • DOI: 10.1007/s10096-018-3333-4
  • Peer Reviewed / Open Access
• [Journal Article] Liver Transplantation for Intermediate-Stage Hepatocellular Carcinoma (2018)
  • Author(s): Kamo Naoko、Kaido Toshimi、Yagi Shintaro、Okajima Hideaki、Uemoto Shinji
  • Journal Title: Liver Cancer Volume: 7 Issue: 2 Pages: 179-189
  • DOI: 10.1159/000487058
  • Peer Reviewed
• [Journal Article] Impact of Enteral Nutrition with an Immunomodulating Diet Enriched with Hydrolyzed Whey Peptide on Infection After Liver Transplantation (2018)
  • Author(s): Kamo Naoko、Kaido Toshimi、Hamaguchi Yuhei、Uozumi Ryuji、Okumura Shinya、Kobayashi Atsushi、Shirai Hisaya、Yagi Shintaro、Okajima Hideaki、Uemoto Shinji
  • Journal Title: World Journal of Surgery Volume: 42 Issue: 11 Pages: 3715-3725
  • DOI: 10.1007/s00268-018-4680-0
  • Peer Reviewed
• [Journal Article] Is Portal Venous Pressure Modulation Still Indicated for All Recipients in Living Donor Liver Transplantation? (2018)
  • Author(s): Yao Siyuan、Kaido Toshimi、Uozumi Ryuji、Yagi Shintaro、Miyachi Yosuke、Fukumitsu Ken、Anazawa Takayuki、Kamo Naoko、Taura Kojiro、Okajima Hideaki、Uemoto Shinji
  • Journal Title: Liver Transplantation Volume: 24 Issue: 11 Pages: 1578-1588
  • DOI: 10.1002/lt.25180
  • Peer Reviewed
• [Journal Article] Low Preoperative Platelet Count Predicts Risk of Subclinical Posthepatectomy Liver Failure in Right Lobe Donors for Liver Transplantation (2018)
  • Author(s): Yoshino Kenji、Taura Kojiro、Ikeno Yoshinobu、Okuda Yukihiro、Nishio Takahiro、Yamamoto Gen、Seo Satoru、Yagi Shintaro、Hata Koichiro、Kaido Toshimi、Okajima Hideaki、Uemoto Shinji
  • Journal Title: Liver Transplantation Volume: 24 Issue: 9 Pages: 1178-1185
  • DOI: 10.1002/lt.25181
  • Peer Reviewed
• [Journal Article] Human leukocyte antigen compatibility and lymphocyte cross-matching play no significant role in the current adult-to-adult living donor liver transplantation (2018)
  • Author(s): Badawy Amr、Kaido Toshimi、Yoshizawa Atsushi、Yagi Shintaro、Fukumitsu Ken、Okajima Hideaki、Uemoto Shinji
  • Journal Title: Clinical Transplantation Volume: 32 Issue: 4
  • DOI: 10.1111/ctr.13234
  • Peer Reviewed
• [Presentation] 異種動物を In vivo bioreactor とした肝再生戦略―ヒト過小グラフトへの展望 (2020)
  • Author(s): 八木真太郎、政野裕紀、宮地洋介、平田真章、白井久也、姚思遠、上本伸二、小林英司
  • Organizer: 第22回異種移植研究会
• [Presentation] 異種動物を In vivo bioreactor とした肝再生戦略―ヒト過小グラフトへの展望 (2020)
  • Author(s): 八木真太郎、政野裕紀、宮地洋介、平田真章、白井久也、姚思遠、上本伸二、小林英司
  • Organizer: 第22回日本異種移植研究会
  • Invited