| Co-Investigator(Kenkyū-buntansha) |
貴志 和生 慶應義塾大学, 医学部(信濃町), 教授 (40224919)
田谷 雄二 日本歯科大学, 生命歯学部, 准教授 (30197587)
成島 三長 三重大学, 医学系研究科, 教授 (80431873)
佐藤 貴彦 藤田医科大学, 国際再生医療センター, 講師 (30570775)
谷端 淳 東京慈恵会医科大学, 医学部, 講師 (00508426)
加治 優一 筑波大学, 医学医療系, 研究員 (50361332)
外山 史 宇都宮大学, 工学部, 准教授 (60323317)
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| Budget Amount *help |
¥44,330,000 (Direct Cost: ¥34,100,000、Indirect Cost: ¥10,230,000)
Fiscal Year 2022: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2021: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2020: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2019: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2018: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
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| Outline of Final Research Achievements |
In order to complete a realistic roadmap for newt-like regeneration of damaged organs in the human body, we have attempted to elucidate the factors that trigger newt-type reprogramming in human cells and to extend the use of newts to various areas of medicine. During the course of this project, we have demonstrated the importance of cell-autonomous properties as well as the extracellular environment, which is altered by body metamorphosis and growth, for somatic cell reprogramming in newts. In particular, we demonstrated the importance of newt's unique blood components. We have also established experimental systems that allow direct comparison of newt regeneration and mouse scar healing (fibrosis).
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