| Budget Amount *help |
¥45,240,000 (Direct Cost: ¥34,800,000、Indirect Cost: ¥10,440,000)
Fiscal Year 2021: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2020: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2019: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2018: ¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000)
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| Outline of Final Research Achievements |
C1R is the gene responsible for periodontal Ehlers-Danlos syndrome, a syndrome associated with periodontal disease. Using gingival epithelial cells with knockdown or knockout of C1R , we established a three-dimensional culture method of gingival epithelium. Three-dimensional observation of this gingival epithelial model revealed decreased expression of specific tight junction-related proteins using confocal microscopy. These results suggest that the gene responsible for periodontal Ehlers-Danlos syndrome is involved in the expression of tight junction-related proteins. This technique has made it possible to study disease model tissues that mimic the Periodontal Ehlers-Danlos syndrome.
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