| Project/Area Number |
18H04079
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Medium-sized Section 58:Society medicine, nursing, and related fields
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
岡村 智教 慶應義塾大学, 医学部(信濃町), 教授 (00324567)
寳澤 篤 東北大学, 東北メディカル・メガバンク機構, 教授 (00432302)
原田 成 慶應義塾大学, 医学部(信濃町), 講師 (10738090)
曽我 朋義 慶應義塾大学, 政策・メディア研究科(藤沢), 教授 (60338217)
仰木 裕嗣 慶應義塾大学, 政策・メディア研究科(藤沢), 教授 (90317313)
三浦 克之 滋賀医科大学, 医学部, 教授 (90257452)
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| Project Period (FY) |
2018-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥43,940,000 (Direct Cost: ¥33,800,000、Indirect Cost: ¥10,140,000)
Fiscal Year 2022: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2021: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2019: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2018: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
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| Keywords | フレイル / サルコペニア / 認知機能 / コホート研究 / メタボローム / メタボロミクス疫学 / メタボロミクス |
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| Outline of Final Research Achievements |
In the Tsuruoka Metabolomics cohort study, frail/sarcopenia sub-study was conducted with 2,916 individuals aged 65 to 80 years. Long sleep duration showed a positive association with sarcopenia and a strong association with low muscle strength and low physical performance. However, poor sleep quality was only associated with normal sleepers. Cognitive sub-study recruited 855 community-dwelling individuals aged 65 to 80 years. Number with mild cognitive impairment, assessed determined by the dementia specialist, was 43. MRI examinations showed a higher prevalence of asymptomatic brain infarctions in males and deep subcortical white matter lesions in females. Mild atrophy was observed in the perirhinal cortex, hippocampus, and amygdala in approximately 10% of both males and females. The sensitivity for mild cognitive impairment was highest with the MoCA-J, while the AD8-J had the highest specificity as screening indices.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、エイジングの階層間の関連性やライフスタイル、環境、社会、ストレス要因との関連性に着目して、地域在住者を対象とするコホート研究において、身体的フレイル・サルコペニア研究および認知機能研究を実施、長時間睡眠とサルコペニア、低筋力、低身体パフォーマンスとの関連を明らかにした。新型コロナ感染症の影響を受けた認知機能研究では、軽度認知機能低下の有病率、頭部MRI検査有所見率、認知機能検査のスクリーニング感度・特異度の評価を終え、認知機能や生体内分子マーカーとの関連性を検討している。
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