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Dynamic regulation system of brain network by the spontaneous eyeblinks

Research Project

Project/Area Number 18H04084
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
Research InstitutionOsaka University

Principal Investigator

Nakano Tamami  大阪大学, 大学院情報科学研究科, 教授 (90589201)

Co-Investigator(Kenkyū-buntansha) 黄田 育宏  国立研究開発法人情報通信研究機構, 未来ICT研究所脳情報通信融合研究センター, 副室長 (60374716)
Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥43,680,000 (Direct Cost: ¥33,600,000、Indirect Cost: ¥10,080,000)
Fiscal Year 2022: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2021: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
Fiscal Year 2020: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2019: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2018: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Keywords自発性瞬目 / デフォルトモードネットワーク / 自律神経 / サリエンスネットワーク / 瞳孔 / サリエンス・ネットワーク / 自己 / 他者 / 1人称視点 / 3人称視点 / 瞬き / 脳内ネットワーク / 動的制御 / 瞳孔拡大 / 動的ネットワーク / 瞳孔径 / 神経ネットワーク / MRS / DMN / 瞬目
Outline of Final Research Achievements

This study aims to elucidate the functional role and the neural mechanisms of spontaneous blinking. Using magnetoencephalography, we have revealed that each blink leads to a state transition to the default mode network. Furthermore, it has been demonstrated using functional resonance imaging that the salience network is involved in monitoring one's own state, while the default mode network is involved in monitoring the states of others. Additionally, our findings show that blinking-induced resets of brain networks affect cognitive states and memory recall rate. These discoveries suggest that blinking may have a proactive influence on brain information processing and cognitive functions.

Academic Significance and Societal Importance of the Research Achievements

本研究の成果は、自発的な瞬きが単なる眼の保護機能を超え、脳の情報処理や認知機能に重要な役割を果たしていることを示しています。この発見は、脳内ネットワークの間のバランスや自律神経との相互作用のメカニズムに関して全く新しい視点を提供することになり、神経科学や生理学の分野において重要な意義を持ちます。さらに、この研究は、認知症や注意欠陥障害などの神経系疾患の診断や治療に役立つ可能性があり、社会的にも大きな影響を与えることが期待されます。

Report

(6 results)
  • 2023 Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (24 results)

All 2023 2022 2021 2020 2019 2018

All Journal Article (10 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 10 results,  Open Access: 8 results) Presentation (10 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results) Book (2 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] The salience network is activated during self‐recognition from both first‐person and third‐person perspectives2022

    • Author(s)
      Asakage Shoko、Nakano Tamami
    • Journal Title

      Human Brain Mapping

      Volume: 44 Issue: 2 Pages: 559-570

    • DOI

      10.1002/hbm.26084

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] You trust a face like yours2022

    • Author(s)
      Nakano Tamami、Yamamoto Takuto
    • Journal Title

      Humanities and Social Sciences Communications

      Volume: 9 Issue: 1 Pages: 226-226

    • DOI

      10.1057/s41599-022-01248-8

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pupil constriction via the parasympathetic pathway precedes perceptual switch of ambiguous stimuli2021

    • Author(s)
      Nakano Tamami、Ichiki Arata、Fujikado Takashi
    • Journal Title

      International Journal of Psychophysiology

      Volume: 167 Pages: 15-21

    • DOI

      10.1016/j.ijpsycho.2021.06.006

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Early phase of pupil dilation is mediated by the peripheral parasympathetic pathway2021

    • Author(s)
      Marumo Chinatsu、Nakano Tamami
    • Journal Title

      Journal of Neurophysiology

      Volume: 126 Issue: 6 Pages: 2130-2137

    • DOI

      10.1152/jn.00401.2021

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neural correlates of beauty retouching to enhance attractiveness of self-depictions in women2021

    • Author(s)
      Ota Chisa、Nakano Tamami
    • Journal Title

      Social Neuroscience

      Volume: 16 Issue: 2 Pages: 121-133

    • DOI

      10.1080/17470919.2021.1873178

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phylogeny and ontogeny of mental time2020

    • Author(s)
      Hirata Satoshi、Betsuyaku Toru、Fujita Kazuo、Nakano Tamami、Ikegaya Yuji
    • Journal Title

      Neuroscience Research

      Volume: in press Pages: 13-17

    • DOI

      10.1016/j.neures.2020.07.008

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Risk Factors Leading to Preference for Extreme Facial Retouching2020

    • Author(s)
      Nakano Tamami、Uesugi Yusuke
    • Journal Title

      Cyberpsychology, Behavior, and Social Networking

      Volume: 23 Issue: 1 Pages: 52-59

    • DOI

      10.1089/cyber.2019.0545

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Threat anticipation in pulvinar and in superficial layers of primary visual cortex (V1). Evidence from layer-specific ultra-high field 7T fMRI.2019

    • Author(s)
      Koizumi A, Zhan M, Ban H, Kida I, De Martino FJ, Vaessen M, de Gelder B & Amano K
    • Journal Title

      eNeuro

      Volume: 6 Issue: 6 Pages: 0429-19

    • DOI

      10.1523/eneuro.0429-19.2019

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Blink synchronization is an indicator of interest while viewing videos2019

    • Author(s)
      Nakano Tamami、Miyazaki Yuta
    • Journal Title

      International Journal of Psychophysiology

      Volume: 135 Pages: 1-11

    • DOI

      10.1016/j.ijpsycho.2018.10.012

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Brain tissue segmentation based on MP2RAGE multi-contrast images in 7 T MRI.2019

    • Author(s)
      Choi US, Kawaguchi H, Matsuoka Y, Kober T, Kida I
    • Journal Title

      PLoS ONE

      Volume: 14 Issue: 2 Pages: 0210803-0210803

    • DOI

      10.1371/journal.pone.0210803

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] The salience network is activated during self-recognition from both first- and third-person perspectives2022

    • Author(s)
      Shoko Asakage, Tamami Nakano
    • Organizer
      日本神経科学大会2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] Early phase of pupil dilation is mediated by the peripheral parasympathetic pathway2022

    • Author(s)
      Marumo Chinatsu、Nakano Tamami
    • Organizer
      第99回日本生理学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 双安定仮現運動の内因的知覚交替に先行する自律神経活動と脳活動2020

    • Author(s)
      一木新、中野珠実
    • Organizer
      日本生理学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 深層学習を用いた瞬き確率推定によるハイライト映像の自動抽出2020

    • Author(s)
      中野 珠実、阪田 篤哉、岸本 章宏
    • Organizer
      情報処理学会全国大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 双安定仮現運動の内因的知覚交替に先行する自律神経活動と脳活動2020

    • Author(s)
      一木 新、中野 珠実
    • Organizer
      第97回日本生理学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Assessment of the olfactory function in the brain using ultra-high field functional magnetic resonance imaging2020

    • Author(s)
      黄田 育宏
    • Organizer
      Kyudai Oral Bioscience & OBT Research Center Joint International Symposium 2020
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Why do we blink so frequently?2019

    • Author(s)
      中野 珠実
    • Organizer
      第13回箱根ドライアイクラブ研究集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 視覚刺激の色と形が嗅覚知覚に及ぼす影響:NIRSによる影響2019

    • Author(s)
      姜 毅男、前川 修太、黄田 育宏、坂井 信之
    • Organizer
      日本味と匂学会第53回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Cognitive and social functions of spontaneous blinks2018

    • Author(s)
      Nakano Tamami
    • Organizer
      41st European Conference of Visual Perception
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] なぜ我々は瞬きをするのか?2018

    • Author(s)
      中野 珠実
    • Organizer
      第36回日本生理心理学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Book] 顔に取り憑かれた脳2023

    • Author(s)
      中野珠実
    • Total Pages
      247
    • Publisher
      講談社
    • ISBN
      9784065338728
    • Related Report
      2022 Annual Research Report
  • [Book] 生理心理学と精神生理学 第III巻 展開 第9章2018

    • Author(s)
      中野 珠実
    • Total Pages
      380
    • Publisher
      北大路書房
    • ISBN
      4762830194
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 瞬きに基づく関心率の測定システム2018

    • Inventor(s)
      中野 珠実
    • Industrial Property Rights Holder
      国立研究開発法人科学技術振興機構
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 瞬き制御によるコミュニケーション促進2018

    • Inventor(s)
      中野 珠実
    • Industrial Property Rights Holder
      国立研究開発法人科学技術振興機構
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report

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Published: 2018-04-23   Modified: 2025-01-30  

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