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Automated Evaluation of Cardiac Function with Data-Driven Medical Ultrasound System

Research Project

Project/Area Number 18H04122
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 62:Applied informatics and related fields
Research InstitutionThe University of Tokyo

Principal Investigator

Kotani Kiyoshi  東京大学, 先端科学技術研究センター, 准教授 (00372409)

Co-Investigator(Kenkyū-buntansha) 武田 憲彦  自治医科大学, 医学部, 教授 (40422307)
仙波 宏章  東京大学, 医学部附属病院, 届出研究員 (80747923)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥44,850,000 (Direct Cost: ¥34,500,000、Indirect Cost: ¥10,350,000)
Fiscal Year 2021: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2020: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2019: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2018: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000)
Keywords医療用超音波検査 / 医療用超音波診断 / 医療用超音波診断システム / 機械学習 / エコー画像
Outline of Final Research Achievements

In this study, we analyzed mouse echocardiograms and constructed a human echocardiographic acquisition system. In the analysis of mouse echocardiograms, the data-driven analysis using feature points in heart motion showed that the difference between the group treated with transverse aortic constriction and the control group appeared in the late systolic phase. Then we constructed an ultrasound image acquisition and analysis system for human echocardiography that is linked to the examinee's information and probe information. The system enables the echocardiographic probe to be guided to the appropriate position and posture.

Academic Significance and Societal Importance of the Research Achievements

マウス心エコー解析について,心臓の動きの特徴をデータ駆動的に解析する,心エコーに特化した説明可能な学習器を提案し構築した.この提案手法は心不全初期の特徴評価に有用であるため,今後の心エコー解析による心不全の理解に重要なものと考えられる.また,ロボットによる超音波取得についても今後の遠隔医療や個別医療の発展に向けて大きな社会的な意義がある成果と考えられる.

Report

(5 results)
  • 2022 Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (25 results)

All 2023 2022 2021 2020 2019 2018

All Journal Article (10 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 10 results,  Open Access: 6 results) Presentation (15 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] A data-driven analysis of myocardial tissue contraction on mild transverse aortic constriction2023

    • Author(s)
      Kento Fujino, Tatsuyuki Sato, Yuanbo Wang, Masato Sugino, Norihiko Takeda, Yasuhiko Jimbo, Kiyoshi Kotani
    • Journal Title

      IEEJ Transactions on electrical and eletronic engineering

      Volume: -

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hyperpolarized <sup>13</sup>C Magnetic Resonance Imaging as a Tool for Imaging Tissue Redox State, Oxidative Stress, Inflammation, and Cellular Metabolism2022

    • Author(s)
      Stewart Neil J.、Sato Tatsuyuki、Takeda Norihiko、Hirata Hiroshi、Matsumoto Shingo
    • Journal Title

      Antioxidants &amp; Redox Signaling

      Volume: 36 Issue: 1-3 Pages: 81-94

    • DOI

      10.1089/ars.2021.0139

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Osteoclasts adapt to physioxia perturbation through DNA demethylation2021

    • Author(s)
      Nishikawa Keizo、Seno Shigeto、Yoshihara Toshitada、Narazaki Ayako、Sugiura Yuki、Shimizu Reito、Kikuta Junichi、Sakaguchi Reiko、Suzuki Norio、Takeda Norihiko、Semba Hiroaki、Yamamoto Masamichi、et al
    • Journal Title

      EMBO reports

      Volume: 22 Issue: 12 Pages: 53035-53035

    • DOI

      10.15252/embr.202153035

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence2021

    • Author(s)
      Sobecki Michal、Krzywinska Ewelina、Nagarajan Shunmugam、Audig? Annette、Hu?nh Khanh、Zacharjasz Julian、Debbache Julien、Kerdiles Yann、Gotthardt Dagmar、Takeda Norihiko、Fandrey Joachim、Sommer Lukas、Sexl Veronika、Stockmann Christian
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 4700-4700

    • DOI

      10.1038/s41467-021-25065-w

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Phase-reduction for synchronization of oscillating flow by perturbation on surrounding structure2021

    • Author(s)
      Loe, I. A., Nakao H, Jimbo Y., and Kotani K.
    • Journal Title

      Journal of Fluid Mechanics

      Volume: 911 Pages: 1-12

    • DOI

      10.1017/jfm.2020.1110

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Analysis of Echocardiographic Video by Dynamic Mode Decomposition2020

    • Author(s)
      水野秀哉, 小根山冬樹, 杉野正和, 仙波宏章, 神保泰彦, 小谷潔,
    • Journal Title

      IEEJ Transactions on Electronics, Information and Systems

      Volume: 140 Issue: 7 Pages: 754-761

    • DOI

      10.1541/ieejeiss.140.754

    • NAID

      130007867856

    • ISSN
      0385-4221, 1348-8155
    • Year and Date
      2020-07-01
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Study of Subject&apos;s Biological Information and Probe Operation Apply to Automate and Semi-automate Echocardiography2020

    • Author(s)
      小根山冬樹,水野秀哉,仙波宏章,神保泰彦,小谷潔
    • Journal Title

      IEEJ Transactions on Electronics, Information and Systems

      Volume: 140 Issue: 7 Pages: 747-753

    • DOI

      10.1541/ieejeiss.140.747

    • NAID

      130007867858

    • ISSN
      0385-4221, 1348-8155
    • Year and Date
      2020-07-01
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell Cycle Perturbation Induces Collagen Production in Fibroblasts2019

    • Author(s)
      Wake M, Takeda N, Isagawa T, Sato T, Nakagama Y, Morioka MS, Hirota Y, Asagiri M, Maemura K, Manabe I, Tanabe K, Komuro I.
    • Journal Title

      International Heart Journal

      Volume: 60 Issue: 4 Pages: 958-963

    • DOI

      10.1536/ihj.18-710

    • NAID

      130007684138

    • ISSN
      1349-2365, 1349-3299
    • Year and Date
      2019-07-30
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M.2019

    • Author(s)
      Abe H, Takeda N, Isagawa T, Semba H, Nishimura S, Morioka MS, Nakagama Y, Sato T, Soma K, Koyama K, Wake M, Katoh M, Asagiri M, Neugent ML, Kim JW, Stockmann C, Yonezawa T, Inuzuka R, Hirota Y, Maemura K, Yamashita T, Otsu K, Manabe I, Nagai R, Komuro I.
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 2824-2833

    • DOI

      10.1038/s41467-019-10859-w

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Therapeutic targeting of mitochondrial ROS ameliorates murine model of volume overload cardiomyopathy.2019

    • Author(s)
      Okamura K, Nakagama Y, Takeda N, Soma K, Sato T, Isagawa T, Kido Y, Sakamoto M, Manabe I, Hirata Y, Komuro I, Ono M
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 141 Issue: 1 Pages: 56-63

    • DOI

      10.1016/j.jphs.2019.09.005

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] An Intuitive User Interface for Ultrasound Operation Instruction and Training2022

    • Author(s)
      Yuanbo Wang, Kento Fujino, Natsuki Tsuchimoto, Masato Sugino, Hikaru Okuyama, Yasuhiko Jimbo, Kiyoshi Kotani
    • Organizer
      2022年 電気学会 電子・情報・システム部門大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 酸素シグナルと心血管リモデリング2022

    • Author(s)
      武田憲彦
    • Organizer
      第86回日本循環器学会学術集会シンポジウム
    • Related Report
      2021 Annual Research Report
  • [Presentation] Improvement of Fluidic Oscillator Characteristics by Synchronization with Vibrating Elastic Structure2021

    • Author(s)
      Innocentio A. Loe, 富士野健人,小谷潔,神保泰彦
    • Organizer
      2021年 電気学会 電子・情報・システム部門大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Phase-based Analysis for Control of Fluidic Oscillator Frequency by Vibrating Structure2021

    • Author(s)
      Innocentio A. Loe,杉野正和,水野秀哉,神保泰彦,小谷 潔
    • Organizer
      令和3年電気学会「マグネティックス/医用・生体工学合同研究会」
    • Related Report
      2020 Annual Research Report
  • [Presentation] プローブの位置姿勢を考慮した心エコー動画の解析と自動超音波検査システムの開発2021

    • Author(s)
      水野秀哉,冨士野健人,Loe Innocentio,杉野正和,仙波宏章,神保泰彦,小谷 潔
    • Organizer
      令和3年電気学会「マグネティックス/医用・生体工学合同研究会」
    • Related Report
      2020 Annual Research Report
  • [Presentation] Synchronization Analysis in Fluid-Structure Coupled Dynamics2020

    • Author(s)
      Loe I. A, Kotani K, Jimbo Y
    • Organizer
      42nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC'20)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Phase Response Analysis and Mode Decomposition for Dynamics Governed by Fluid-Structure Interaction,2020

    • Author(s)
      Loe, I. A.,水野秀哉,杉野正和,小根山冬樹,小谷 潔,神保泰彦
    • Organizer
      令和元年度電気学会研究会「マグネティックス/医用・生体工学合同研究会」
    • Related Report
      2019 Annual Research Report
  • [Presentation] 動的モード分解を利用した心エコー動画の解析2020

    • Author(s)
      水野秀哉,小根山冬樹,杉野正和,Loe, I. A.,仙波宏章,神保泰彦,小谷 潔
    • Organizer
      令和元年度電気学会研究会「マグネティックス/医用・生体工学合同研究会」
    • Related Report
      2019 Annual Research Report
  • [Presentation] 心エコー検査の自動化および半自動化に向けた被験者の生体情報とプローブ操作術の検討2019

    • Author(s)
      小根山冬樹,水野秀哉,小谷潔,神保泰彦
    • Organizer
      令和1年電気学会 電子・情報システム部門大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 動的モード分解による心エコー動画の解析2019

    • Author(s)
      水野秀哉, 小根山冬樹, 杉野正和, 小谷潔, 神保泰彦
    • Organizer
      令和1年電気学会 電子・情報・システム部門大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 非熟練者による超音波検査に向けたプローブの操作支援システムの開発2019

    • Author(s)
      小根山冬樹,木下郁英,沼田崇志,小谷潔,神保泰彦
    • Organizer
      平成30年度電気学会研究会「医用・生体工学研究会」
    • Related Report
      2018 Annual Research Report
  • [Presentation] 超音波検査の自動化に向けた被験者姿勢および検者手技の同時評価2018

    • Author(s)
      小根山冬樹,木下郁英,沼田崇志,小谷潔,神保泰彦
    • Organizer
      平成30年電気学会電子・情報・システム部門大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 心拍調整下における交感神経の賦活化による培養心房筋細胞の応答評価2018

    • Author(s)
      石塚 一真,酒井 洸児,榛葉 健太,小谷 潔,神保 泰彦
    • Organizer
      平成30年電気学会電子・情報・システム部門大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Analysis of Time-Delay Reservoir Computing Focusing on Dynamical Properties of Delay Differential Equations2018

    • Author(s)
      Ikuhide Kinoshita, Akihiko Akao, Kiyoshi Kotani, Yasuhiko Jimbo
    • Organizer
      The 12th AIMS Conference on Dynamical Systems, Differential Equations and Applications
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ネットワーク上の時間遅れReservoir Computingの最適化2018

    • Author(s)
      木下郁英,赤尾旭彦,小谷潔,神保泰彦
    • Organizer
      平成30年電気学会 電子・情報・システム部門大会
    • Related Report
      2018 Annual Research Report

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Published: 2018-04-23   Modified: 2024-01-30  

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