Biocompatible devices with soft wet electrodes

• Project/Area Number: 18H04158
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Medium-sized Section 90:Biomedical engineering and related fields
• Research Institution: Tohoku University
• Principal Investigator: Nishizawa Matsuhiko 東北大学, 工学研究科, 教授 (20273592)
• Co-Investigator(Kenkyū-buntansha): 田中 徹 東北大学, 医工学研究科, 教授 (40417382)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥42,900,000 (Direct Cost: ¥33,000,000、Indirect Cost: ¥9,900,000); Fiscal Year 2021: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000); Fiscal Year 2020: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000); Fiscal Year 2019: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000); Fiscal Year 2018: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
• Keywords: ハイドロゲル / 酵素電池 / 経皮通電 / 生体親和性 / ハイドロゲル電極 / 電極システム / 脳波計測 / 頭蓋内電極 / てんかん

Outline of Final Research Achievements

The soft-wet electrodes (enzyme-modified fabric electrode and hydrogel electrode) were developed and utilized to create platforms of medical devices for minimally invasive self-medication (self-medication) and electrical measurement and stimulation (diagnosis and treatment). The developed bio-power patch had flexibility applicable for skin, and exhibited drug penetration enhancement and analgesic effects through enzyme-induced redox reaction. The effectiveness of the hydrogel-based organic electrodes as intracranial electrodes in sheet form and vagus nerve electrodes in cuff form was demonstrated in animal experiments.

Academic Significance and Societal Importance of the Research Achievements

本研究で開発したソフトウェット電極デバイスは、生体組織と同等の柔軟性を有し、低侵襲の服薬・診断・治療に有効である。このような生体親和性に優れるウェアラブルおよび埋込型の電極デバイスは、AI/IoTを基盤とする高効率なネットワーク化IT医療システムの端末として必須であり、超高齢化社会化が抱える医療費・医療アクセス・介護などの深刻な問題への対応に貢献すると期待できる。

Research Products

• [Journal Article] Totally Organic Hydrogel-Based Self-Closing Cuff Electrode for Vagus Nerve Stimulation (2022)
  • Author(s): Daigo Terutsuki, Hayato Yoroizuka, Shin-ichiro Osawa, Yuka Ogihara, Hiroya Abe, Atsuhiro Nakagawa, Masaki Iwasaki and Matsuhiko Nishizawa
  • Journal Title: Advanced Healthcare Materials Volume: 11 Issue: 23 Pages: 2201627-2201627
  • DOI: 10.1002/adhm.202201627
  • Peer Reviewed
• [Journal Article] Transdermal electroosmotic flow generated by a porous microneedle array patch (2021)
  • Author(s): Shinya Kusama, Kaito Sato, Yuuya Matsui, Natsumi Kimura, Hiroya Abe, Shotaro Yoshida, Matsuhiko Nishizawa
  • Journal Title: Nature Communications Volume: 12 Issue: 1 Pages: 658-658
  • DOI: 10.1038/s41467-021-20948-4
  • Peer Reviewed / Open Access
• [Journal Article] Totally transparent hydrogel-based subdural electrode with patterned salt bridge (2020)
  • Author(s): Nishimura Ayaka、Suwabe Ryota、Ogihara Yuka、Yoshida Shotaro、Abe Hiroya、Osawa Shin-ichiro、Nakagawa Atsuhiro、Tominaga Teiji、Nishizawa Matsuhiko
  • Journal Title: Biomedical Microdevices Volume: 22 Issue: 3 Pages: 57-57
  • DOI: 10.1007/s10544-020-00517-0
  • Peer Reviewed / Open Access
• [Journal Article] Hydrogel-Based Organic Subdural Electrode with High Conformability to Brain Surface (2019)
  • Author(s): Oribe Shuntaro、Yoshida Shotaro、Kusama Shinya、Osawa Shin-ichiro、Nakagawa Atsuhiro、Iwasaki Masaki、Tominaga Teiji、Nishizawa Matsuhiko
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 13379-13379
  • DOI: 10.1038/s41598-019-49772-z
  • Peer Reviewed / Open Access
• [Journal Article] Self‐Moisturizing Smart Contact Lens Employing Electroosmosis (2019)
  • Author(s): Kusama Shinya、Sato Kaito、Yoshida Shotaro、Nishizawa Matsuhiko
  • Journal Title: Advanced Materials Technologies Volume: 5 Issue: 1 Pages: 1900889-1900889
  • DOI: 10.1002/admt.201900889
  • Peer Reviewed
• [Journal Article] Series-Connected Flexible Biobatteries for Higher Voltage Electrical Skin Patches (2019)
  • Author(s): Yoshida Shotaro、Mizuno Takaya、Kusama Shinya、Sato Kaito、Raut Bibek、Nishizawa Matsuhiko
  • Journal Title: ACS Applied Electronic Materials Volume: 2 Issue: 1 Pages: 170-176
  • DOI: 10.1021/acsaelm.9b00671
  • Peer Reviewed
• [Journal Article] Organic Electrochromic Timer for Enzymatic Skin Patches (2018)
  • Author(s): H. Kai, W. Suda, S. Yoshida, M. Nishizawa
  • Journal Title: Biosensor and Bioelectronics Volume: 123 Pages: 108-113
  • DOI: 10.1016/j.bios.2018.07.013
  • Peer Reviewed
• [Journal Article] Contractile Skeletal Muscle Cells Cultured with a Conducting Soft Wire for Effective, Selective Stimulation (2018)
  • Author(s): Kuniaki Nagamine, Hirotaka Sato, Hiroyuki Kai, Hirokazu Kaji, Makoto Kanzaki, Matsuhiko Nishizawa
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 2253-2253
  • DOI: 10.1038/s41598-018-20729-y
  • Peer Reviewed / Open Access
• [Presentation] Soft, Wet Bio-Iontronic Devices (2020)
  • Author(s): Matsuhiko Nishizawa
  • Organizer: The 3rd Symposium for The Core Research Clusters for Materials Science and Spintronics
  • Int'l Joint Research / Invited
• [Presentation] Soft, Wet and Ionic Microelectrode Systems (2019)
  • Author(s): Matsuhiko Nishizawa
  • Organizer: isCEBT 2019
  • Int'l Joint Research / Invited
• [Presentation] 医工学応用のための自己変形ハイドロゲル電極 (2018)
  • Author(s): 出貝信悟、李沢謙介、吉田昭太郎、西澤松彦
  • Organizer: 第28回日本MRS年次大会
• [Presentation] 生体親和性ソフトウェット電極システムの創出 (2018)
  • Author(s): 西澤松彦
  • Organizer: 高分子東北支部講演会
  • Invited
• [Book] 酵素トランスデューサーと酵素技術展開 (2020)
  • Author(s): 西澤松彦（監修 三林浩二）
  • Total Pages: 300
  • Publisher: シーエムシー出版
  • ISBN: 4781314880
• [Patent(Industrial Property Rights)] 吸水体及びこれを用いた通電パッチ (2020)
  • Inventor(s): 西澤松彦、吉田昭太郎、小松原椋
  • Industrial Property Rights Holder: 西澤松彦、吉田昭太郎、小松原椋
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2020-012024
  • Filing Date: 2020