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Optically detected magnetic resonance imaging

Research Project

Project/Area Number 18H04165
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 90:Biomedical engineering and related fields
Research InstitutionKyoto University

Principal Investigator

Takeda Kazuyuki  京都大学, 理学研究科, 准教授 (20379308)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥35,230,000 (Direct Cost: ¥27,100,000、Indirect Cost: ¥8,130,000)
Fiscal Year 2021: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2020: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2019: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2018: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
KeywordsMRI / NMR / オプトメカニクス / 薄膜振動子
Outline of Final Research Achievements

To improve the sensitivity of MRI, we applied the idea of signal up-conversion from radio-frequency to optical regimes to MRI. First, we have developed an MRI system from scratch using an existing 7 T superconducting magnet, demonstrating MRI of water in a glass tube and of fruits. In addition, we have designed and fabricated a radiofrequency-to-light signal transducer which is compact enough to be put inside the superconducting magnet with a bore size of ca. 70 mm, and successfully detected the optical signals that was transduced from the electrical signals. We also invented a new method for acquiring MRI without requiring wide-band detectors, showing a future direction toward unification of MRI and optical signal detection.

Academic Significance and Societal Importance of the Research Achievements

磁気共鳴画像法(MRI)は物体内部の解剖学的構造を非破壊で観測することのできる強力な診断法である。現在MRIは医療に欠かせないツールとなっており、診断の観点からすると、感度と分解能の両方が高いことが望まれる。しかしMRIの感度は決して満足いくものではなく、撮像に比較的長時間を要する。また空間分解能を上げてより詳細な診断を行おうとすればするほど、感度が犠牲になる。本課題は、将来的にMRIの高感度化につながる研究であり、患者を長時間にわたる拘束から解放したり、あるいは与えられた撮像時間で達成できる空間分解能を向上することにつながる。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (22 results)

All 2022 2021 2020 2019 2018 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (15 results) (of which Int'l Joint Research: 9 results,  Invited: 5 results) Book (3 results) Remarks (1 results)

  • [Journal Article] An electro-mechano-optical NMR probe for 1H-13C double resonance in a superconducting magnet2022

    • Author(s)
      Tominaga Yusuke、Takeda Kazuyuki
    • Journal Title

      The Analyst

      Volume: - Issue: 9 Pages: 1847-1852

    • DOI

      10.1039/d2an00220e

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Studies on NMR-signal up-conversion from radio-frequency to optical regimes using a lightweight nanomembrane transducer2019

    • Author(s)
      Tominaga Yusuke、Nagasaka Kentaro、Usami Koji、Takeda Kazuyuki
    • Journal Title

      Journal of Magnetic Resonance

      Volume: 298 Pages: 6-15

    • DOI

      10.1016/j.jmr.2018.11.003

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electro-Mechano-Optical (EMO) NMRの研究開発2018

    • Author(s)
      武田和行
    • Journal Title

      BULLETIN OF THE NUCLEAR MAGNETIC RESONANCE SOCIETY OF JAPAN

      Volume: 9 Pages: 14-16

    • NAID

      40021787151

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] Exploring NMR through mechanics and optics2021

    • Author(s)
      Kazuyuki Takeda
    • Organizer
      Joint Conference of 22nd ISMAR and 9th APNMR
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] SWIFT with Magnetic-Field Sweep2021

    • Author(s)
      Haruka Sawada, Yoita Kobayashi, Kazuyuki Takeda
    • Organizer
      Joint Conference of 22nd ISMAR and 9th APNMR
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Efficient Optical Detection of NMR through a Membrane Transducer2021

    • Author(s)
      Yusuke Tominaga
    • Organizer
      Joint Conference of 22nd ISMAR and 9th APNMR
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Electro-mechano-optical NMR through (2,2)-mode characteristic oscillation of a SiN membrane with separated matasurface mirror and capacitor electrode2021

    • Author(s)
      Atsushi Mikami, Yusuke Tominaga, Akiya Iwamura, Koji Usami, Kazuyuki Takeda
    • Organizer
      Joint Conference of 22nd ISMAR and 9th APNMR
    • Related Report
      2021 Annual Research Report
  • [Presentation] ハイブリッド量子技術を用いた高効率なラジオ波-光変換によるNMR信号検出2021

    • Author(s)
      冨永雄介, 武田和行
    • Organizer
      日本物理学会第76回年次大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] オプトメカニクスを利用したNMR信号の高感度検出技術2020

    • Author(s)
      武田和行
    • Organizer
      東北・北海道支部/第1回材料研究会合同研究会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] High efficiency rf-to-light conversion through improved electromechanical coupling for NMR detection2020

    • Author(s)
      Y. Tominaga, K. Takeda
    • Organizer
      The 3rd International Forum on Quantum Metrology and Sensing (IFQMS)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Up-conversion of NMR signals from radio-frequency to optical regimes through a mechanical transducer2019

    • Author(s)
      Kazuyuki Takeda
    • Organizer
      EUROISMAR 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] In situ solid-state measurements of a magnetically oriented microcrystal suspension / Up-conversion of radio-frequency NMR signals to an optical regime using a membrane transducer2019

    • Author(s)
      Kazuyuki Takeda
    • Organizer
      2nd India-Japan Workshop on Magnetic Resonance
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A compact-rf-to-light transducer for Electro-Mechano-Optical NMR2019

    • Author(s)
      Yusuke Tominaga, Takaaki Matsukawa, Wern Ng, Kazuyuki Takeda
    • Organizer
      EUROISMAR 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] NMR信号の高効率な光変換のための小型薄膜モジュールの開発2019

    • Author(s)
      冨永雄介 松川陽亮 Ng Wern 武田和行
    • Organizer
      第58回NMR討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 磁場掃引を用いたSWIFT法2019

    • Author(s)
      小林洋太 竹腰清乃理 武田和行
    • Organizer
      第58回NMR討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] NMR信号の高感度光検出に向けた超小型オプトメカ・エレクトロメカ結合モジュールの開発2019

    • Author(s)
      冨永雄介、仙波佑奈、武田和行
    • Organizer
      第65回 固体NMR・材料フォーラム
    • Related Report
      2019 Annual Research Report
  • [Presentation] Electro-mechano-optical detection of nuclear magnetic resonance2018

    • Author(s)
      Kazuyuki Takeda
    • Organizer
      Spin Cavitronics
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Electro-Mechano-Optical detection of NMR2018

    • Author(s)
      Kazuyuki Takeda
    • Organizer
      1st India-Japan NMR workshop
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] NMRによる有機材料分析とその試料前処理、データ解釈(第2章1節)2021

    • Author(s)
      冨永雄介、武田和行
    • Total Pages
      676
    • Publisher
      技術情報協会
    • ISBN
      9784861048609
    • Related Report
      2021 Annual Research Report
  • [Book] 量子センシングハンドブック(第1章 スピン量子センシング 第9節 ハイブリッド量子技術を用いた磁気共鳴検出)2021

    • Author(s)
      冨永雄介、武田和行
    • Total Pages
      336
    • Publisher
      エヌ・ティー・エス
    • ISBN
      9784860436612
    • Related Report
      2021 Annual Research Report
  • [Book] 第1章 スピン量子センシング 第9節 ハイブリッド量子技術を用いた磁気共鳴検出,「量子センシングハンドブック~量子科学が切り拓く新たな領域~」2021

    • Author(s)
      冨永雄介, 武田和行
    • Total Pages
      13
    • Publisher
      (株)エヌ・ティー・エス
    • ISBN
      9784860436612
    • Related Report
      2020 Annual Research Report
  • [Remarks] 核磁気共鳴のレーザー検出器の小型化に成功―量子技術による化学分析の道を開拓―

    • URL

      https://www.kyoto-u.ac.jp/ja/research-news/2022-04-27-4

    • Related Report
      2021 Annual Research Report

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Published: 2018-04-23   Modified: 2023-01-30  

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