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Development of brain tumor-penetrant protein delivery system realizing immunotherapy of malignant brain tumor

Research Project

Project/Area Number 18H04170
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 90:Biomedical engineering and related fields
Research InstitutionKawasaki Institute of Industrial Promotion Innovation Center of NanoMedicine

Principal Investigator

Kataoka Kazunori  公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター), ナノ医療イノベーションセンター, センター長 (00130245)

Co-Investigator(Kenkyū-buntansha) Cabral Horacio  東京大学, 大学院工学系研究科(工学部), 准教授 (10533911)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥44,590,000 (Direct Cost: ¥34,300,000、Indirect Cost: ¥10,290,000)
Fiscal Year 2020: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2019: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2018: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Keywordsドラッグデリバリーシステム / がん免疫療法 / 脳腫瘍 / 高分子ミセル / タンパク質デリバリー / 免疫チェックポイント阻害剤 / 血液脳腫瘍関門 / 還元環境応答性 / リガンド分子
Outline of Final Research Achievements

Glioblastomas construct the blood-brain tumor barrier (BBTB) in their blood vessels, which impairs the efficacy of immune checkpoint inhibitors. In this study, we developed nanocarriers that can efficiently and selectively deliver immune checkpoint inhibitors to glioblastoma by passing BBTB. As an immune checkpoint inhibitor, we used anti-PD-L1 antibody. Two types of nanocarriers have been developed: (1) nanocarriers based on polymeric micelles that encapsulate antigen-binding fragments of anti-PD-L1 antibody and (2) nanocarriers prepared by modifying whole anti-PD-L1 antibodies with hydrophilic polymers. Both types of nanocarriers released immune checkpoint inhibitors in response to reducing or weakly acidic conditions relevant to microenvironment in glioblastoma. In particular, the latter type of nanocarriers demonstrated a potent anticancer effect against glioblastoma while avoiding immune-related adverse events.

Academic Significance and Societal Importance of the Research Achievements

悪性脳腫瘍のうち悪性度が特に高いことで知られる膠芽腫は、有効な治療法が存在せず、余命の中央値は16か月未満と悲惨な状況にある。様々ながんに対して顕著な有効性を示す免疫チェックポイント阻害剤も膠芽腫には効果がない。この一つの理由として、膠芽腫内血管の内皮細胞が血液脳腫瘍関門を形成して物質輸送を著しく制限していることが挙げられる。本研究は、免疫チェックポイント阻害剤を膠芽腫内に効率的に送り込む技術の開発に成功しただけでなく、膠芽腫内の微小環境に応じて免疫チェックポイント阻害剤を放出する機能を付加することで、臨床で問題となっている免疫関連毒性の低減にも成功した極めて意義の大きいものである。

Report

(2 results)
  • 2020 Final Research Report ( PDF )
  • 2018 Annual Research Report
  • Research Products

    (60 results)

All 2019 2018

All Journal Article (5 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 5 results,  Open Access: 2 results) Presentation (54 results) (of which Int'l Joint Research: 26 results,  Invited: 36 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] One-Pot Synthesis of PEG-Poly(amino acid) Block Copolymers Assembling Polymeric Micelles with PEG-Detachable Functionality2019

    • Author(s)
      Miyazaki Takuya、Igarashi Kazunori、Matsumoto Yu、Cabral Horacio
    • Journal Title

      ACS Biomaterials Science & Engineering

      Volume: - Issue: 11 Pages: 5727-5733

    • DOI

      10.1021/acsbiomaterials.8b01549

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Glucose transporter 1-mediated vascular translocation of nanomedicines enhances accumulation and efficacy in solid tumors2019

    • Author(s)
      Suzuki Kazumi、Miura Yutaka、Mochida Yuki、Miyazaki Takuya、Toh Kazuko、Anraku Yasutaka、Melo Vinicio、Liu Xueying、Ishii Takehiko、Nagano Osamu、Saya Hideyuki、Cabral Horacio、Kataoka Kazunori
    • Journal Title

      Journal of Controlled Release

      Volume: 301 Pages: 28-41

    • DOI

      10.1016/j.jconrel.2019.02.021

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Glucose-linked sub-50-nm unimer polyion complex-assembled gold nanoparticles for targeted siRNA delivery to glucose transporter 1-overexpressing breast cancer stem-like cells.2019

    • Author(s)
      Y. Yi, H. J. Kim, M. Zheng, P. Mi, M. Naito, B. S. Kim, H. S. Min, K. Hayashi, F. Perche, K. Toh, X. Liu, Y. Mochida, H. Kinoh, H. Cabral, K. Miyata, K. Kataoka
    • Journal Title

      J. Control. Release

      Volume: 295 Pages: 268-277

    • DOI

      10.1016/j.jconrel.2019.01.006

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Block Copolymer Micelles in Nanomedicine Applications2018

    • Author(s)
      Cabral Horacio、Miyata Kanjiro、Osada Kensuke、Kataoka Kazunori
    • Journal Title

      Chemical Reviews

      Volume: 118 Issue: 14 Pages: 6844-6892

    • DOI

      10.1021/acs.chemrev.8b00199

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Tuned Density of Anti-Tissue Factor Antibody Fragment onto siRNA-Loaded Polyion Complex Micelles for Optimizing Targetability into Pancreatic Cancer Cells2018

    • Author(s)
      Min Hyun Su、Kim Hyun Jin、Ahn Jooyeon、Naito Mitsuru、Hayashi Kotaro、Toh Kazuko、Kim Beob Soo、Matsumura Yasuhiro、Kwon Ick Chan、Miyata Kanjiro、Kataoka Kazunori
    • Journal Title

      Biomacromolecules

      Volume: 19 Issue: 6 Pages: 2320-2329

    • DOI

      10.1021/acs.biomac.8b00507

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] 夢を形に:ナノテクノロジーで創る体内病院~あらゆる微小空間で生体機能をコントロールするナノマシンの創製~2019

    • Author(s)
      片岡一則
    • Organizer
      CPhI Japan 2019 国際医薬品開発展
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Self-assembled supramolecular nanosystems for smart diagnosis and targeted therapy of intractable diseases2019

    • Author(s)
      K. Kataoka
    • Organizer
      6th International Conference on Multifunctional, Hybrid and Nanomaterials
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Delivering positively charged anticancer peptide drug using crosslinked and pH responsive nanomedicine2019

    • Author(s)
      A. R. Maity, S. Quader, S. Osawa, K. Kataoka
    • Organizer
      6th International Conference on Multifunctional, Hybrid and Nanomaterials
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Supramolecular polymeric micelle for treating cancer and brain diseases2019

    • Author(s)
      K. Kataoka
    • Organizer
      Mini-Symposium on “Nanomedicine for Treating Cancer and Brain Diseases”(CNRS UMR 7325)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Self-assembled supramolecular nanosystems for smart diagnosis and targeted therapy of intractable diseases2019

    • Author(s)
      K. Kataoka
    • Organizer
      12th Annual Symposium on Nanobiotechnology From basic science to clinical relevance: nano-theranostics, nanocarrier delivery and nanosafety
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 高分子テクノロジーで創る日本発の革新的DDS2019

    • Author(s)
      片岡一則
    • Organizer
      第4回日本医療研究開発機構レギュラトリーサイエンス公開シンポジウム 日本発の革新的医薬品の創出~求められるレギュラトリーサイエンスとは~
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 夢を形に:ナノテクノロジーで創る体内病院~ドラッグデリバリー・システムの先鋭化とそのインパクト~2019

    • Author(s)
      片岡一則
    • Organizer
      第4回橋渡し研究戦略的推進プログラムシンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 夢を形に:ナノテクノロジーで創る体内病院~身体におけるシンギュラリティ~2019

    • Author(s)
      片岡一則
    • Organizer
      慶應義塾大学ジュニアドクター育成塾(KEIO WIZARD)
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 夢を形に:ナノテクノロジーで創る体内病院~身体におけるシンギュラリティ~2019

    • Author(s)
      片岡一則
    • Organizer
      TISソリューションリンク講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 夢を形に:ナノテクノロジーで創る体内病院 ~スマートライフケア社会への変革を先導するものづくりオープンイノベーション拠点(COINS)~2018

    • Author(s)
      片岡一則
    • Organizer
      2019年度先端創薬科学講座セミナー(公益財団法人薬学振興会)
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] In vitro blood-brain barrier spherical platform of glioblastoma2018

    • Author(s)
      Y. -L. Su, S. Quader, K. Kataoka
    • Organizer
      5th COINS Symposium Shaping a dream! In-body hospitals -Future health care created by Kawasaki ventures-
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of the innovative nanomachine for central nervous system2018

    • Author(s)
      T. Nishiono, Y. Anraku, H. Kuwahara, T. Yokota, K. Kataoka
    • Organizer
      5th COINS Symposium Shaping a dream! In-body hospitals -Future health care created by Kawasaki ventures-
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Self-assembled supramolecular nanosystems for smart diagnosis and targeted therapy of intractable diseases2018

    • Author(s)
      K. Kataoka
    • Organizer
      The 6th Thailand International Nanotechnology Conference (NanoThailand2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Engineering tumor microenvironment toward enhanced drug delivery2018

    • Author(s)
      J. Martin, T. Khan, M. Panagi, T. Stylianopoulos, K. Kataoka, H. Cabral
    • Organizer
      The 6th Thailand International Nanotechnology Conference (NanoThailand2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Analysis of the interaction between target membrane proteins and ligand molecules on polymeric micelles2018

    • Author(s)
      N. Nakamura, Y. Anraku, S. Fukushima, K. Toh, H. Cabral, K. Kataoka
    • Organizer
      The 12th SPSJ International Polymer Conference (IPC2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Self-assembled supramolecular nanosystems for smart diagnosis and targeted therapy of intractable diseases2018

    • Author(s)
      K. Kataoka
    • Organizer
      The 12th SPSJ International Polymer Conference (IPC2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Self-assembled supramolecular nanosystems for smart diagnosis and targeted therapy of intractable diseases2018

    • Author(s)
      K. Kataoka
    • Organizer
      China Medical University Special Lecture
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Interaction between target membrane proteins and ligand-decorated polymeric micelles penetrating blood-brain barrier2018

    • Author(s)
      N. Nakamura, Y. Anraku, S. Fukushima, K. Toh, H. Cabral, K. Kataoka
    • Organizer
      2018 MRS fall meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 夢を形に:ナノテクノロジーで創る体内病院~身体におけるシンギュラリティ~2018

    • Author(s)
      片岡一則
    • Organizer
      TM研究会2018年度第7回研究交流会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Self-assembled supramolecular nanosystems for smart diagnosis and targeted therapy of intractable diseases2018

    • Author(s)
      K. Kataoka
    • Organizer
      13th France-Japan DDS Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 難治がんのイメージングと標的治療に向けた自己組織型超分子ナノマシンの開発2018

    • Author(s)
      片岡一則
    • Organizer
      第56回日本癌治療学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Self-assembled supramolecular nanosystems for smart diagnosis and targeted therapy of intractable diseases2018

    • Author(s)
      K. Kataoka
    • Organizer
      2018 KSBB (Korean Society for Biotechnology and Bioengineering) International Academia-Industry Joint Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Targeting notch-regulated non-coding RNA, TUG1, with antisense oligonucleotide as an effective treatment in glioma2018

    • Author(s)
      Y. Kondo, K. Katsushima, K. Miyata, K. Kataoka, S. Akinaga, A. Natsume
    • Organizer
      The 14th Annual Meeting of the Oligonucleotide Therapeutics Society
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] がんに核酸医薬を送達するナノメディシンの開発2018

    • Author(s)
      片岡一則
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Nanomedicine to target glioblastoma2018

    • Author(s)
      S. Quader, X. Liu, H. Kinoh, K. Kataoka
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Nanomachine to deliver positively charged anticancer peptidic drug using crosslinked and pH responsive platform2018

    • Author(s)
      A. R. Maity, S. Quader, S. Osawa, K. Kataoka
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ~化学が先導する未来医療への挑戦~夢を形に:ナノテクノロジーで創る体内病院2018

    • Author(s)
      片岡一則
    • Organizer
      日本化学会関東支部講演会「化学が先導するライフ・イノベーション ~医療・創薬研究の最前線~」
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Self-assembled supramolecular nanosystems for smart diagnosis and targeted therapy of intractable diseases2018

    • Author(s)
      K. Kataoka
    • Organizer
      5th Symposium on Innovative Polymers for Controlled Delivery (SIPCD2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 血液脳関門突破を指向したグルコース修飾高分子ミセルの標的認識能の解析2018

    • Author(s)
      中村乃理子、安楽泰孝、福島重人、藤加珠子、H. Cabral、片岡一則
    • Organizer
      第67回高分子討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Self-assembled supramolecular nanosystems for smart diagnosis and targeted therapy of intractable diseases2018

    • Author(s)
      K. Kataoka
    • Organizer
      NIM Conference “The Future of Nanoscience”
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Self‐assembled supramolecular polymeric nanosystems for smart diagnosis and targeted therapy of intractable diseases2018

    • Author(s)
      K. Kataoka
    • Organizer
      11th European and Global Summit for Clinical Nanomedicine, Targeted Delivery and Precision Medicine The Building Blocks to Personalized Medicine
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Block copolymer micelles for crossing blood-brain barrier (BBB)2018

    • Author(s)
      K. Kataoka
    • Organizer
      Lecture at the Awarding Ceremony of Honorary Doctorate at Johannes Gutenberg University
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 夢を形に:ナノテクノロジーで創る体内病院~ドラッグデリバリー・システムの先鋭化とそのインパクト~2018

    • Author(s)
      片岡一則
    • Organizer
      第22回薬物動態談話会セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Glucose-conjugated polymeric micelles for crossing blood-brain barrier (BBB)2018

    • Author(s)
      K. Kataoka
    • Organizer
      Gordon Research Conference on “Drug Carriers in Medicine and Biology”
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 夢を形に:ナノテクノロジーで創る体内病院~あらゆる微小空間で生体機能をコントロールするナノマシンの創製~2018

    • Author(s)
      片岡一則
    • Organizer
      2018年プラチナ未来人財育成塾@二子玉川
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Interaction analysis of ligand molecules on the polymeric micelle penetrating blood-brain barrier2018

    • Author(s)
      Noriko Nakamura, Y. Anraku, S. Fukushima, K. Toh, H. Cabral, K. Kataoka
    • Organizer
      Biomaterials International 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Self-assembled supramolecular nanosystems for smart diagnosis and targeted therapy of intractable diseases2018

    • Author(s)
      K. Kataoka
    • Organizer
      Biomaterials International 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 薬剤耐性および再発/転移する難治癌に対して著効するナノDDS製剤の開発2018

    • Author(s)
      喜納宏昭、S. Quader、持田祐希、片岡一則
    • Organizer
      第27回日本がん転移学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 自己組織型超分子ナノシステムによる難病のスマート診断と標的治療2018

    • Author(s)
      片岡一則
    • Organizer
      新製剤技術とエンジニアリングを考える会 第16回技術講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 抗体リガンド搭載高分子ミセルの構築とがんへの核酸医薬デリバリー2018

    • Author(s)
      宮田完二郎、H. -S. Min、H. -J. Kim、内藤瑞、松村保広、片岡一則
    • Organizer
      日本核酸医薬学会第4回年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Self-assembled supramolecular nanosystems for smart diagnosis and targeting therapy of intractable diseases2018

    • Author(s)
      K. Kataoka
    • Organizer
      World Polymer Congress (Macro 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] pH及びグルコースに応答してPEGが脱離する高分子ミセルの構築2018

    • Author(s)
      小路恭子、宮崎拓也、持田祐希、L. Hespel、籐加珠子、福島重人、松本有、松元亮、H. Cabral、片岡一則
    • Organizer
      第34回日本DDS学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 夢を形に:ナノテクノロジーで創る体内病院2018

    • Author(s)
      片岡一則
    • Organizer
      第34回日本DDS学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Self-assembled supramolecular nanosystems for smart diagnosis and targeted therapy of intractable diseases2018

    • Author(s)
      K. Kataoka
    • Organizer
      International biomaterials forum on the progress and priority of contemporary biomaterials
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Self-assembled supramolecular nanosystems for smart diagnosis and targeting therapy of intractable diseases2018

    • Author(s)
      K. Kataoka
    • Organizer
      The Opening and the First CBMS Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 夢を形に:ナノテクノロジーで創る体内病院 ~あらゆる微小空間で生体機能をコントロールするナノマシンの創製~2018

    • Author(s)
      片岡一則
    • Organizer
      第119回日本耳鼻咽喉科学会総会・学術講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 夢を形に:ナノテクノロジーで創る体内病院2018

    • Author(s)
      片岡一則
    • Organizer
      日本分子イメージング学会 第13回学会総会・学術集会 / JSMI 2018
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Smart diagnosis and targeting therapy by self-assembled supramolecular nanosystems2018

    • Author(s)
      K. Kataoka
    • Organizer
      The first Bordeaux Polymer Conference (BPC 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 血液脳関門突破を指向したDDSキャリアに装着したリガンド分子の標的認識能評価2018

    • Author(s)
      中村乃理子、安楽泰孝、福島重人、藤加珠子、H. Cabral、片岡一則
    • Organizer
      第67回高分子学会年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Delivering positively charged peptide/drug using crossninked and pH responsive nanomicelles2018

    • Author(s)
      A. R. Maity, S. Quader, S. Osawa, K. Kataoka
    • Organizer
      第67回高分子学会年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] グルコース濃度に応答して血中から脳内に薬剤を届ける高分子ミセルの開発2018

    • Author(s)
      安楽泰孝、桑原宏哉、横田隆徳、片岡一則
    • Organizer
      第67回高分子学会年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Development of thiol-crosslinked micelle for systemic delivery of antisense oligonucleotide to treat brain diseases2018

    • Author(s)
      H. -J. Kim, H. -S. Min, K. Katsushima, Y. Kondo, K. Miyata, K. Kataoka
    • Organizer
      第67回高分子学会年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Tuning the drug release kinetics of pH-responsive polymer micelle to achieve better therapy outcome in glioblastoma model2018

    • Author(s)
      S. Quader, K. Kataoka
    • Organizer
      第67回高分子学会年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 夢を形に!ナノテクノロジーで創る体内病院~あらゆる微小空間で生体機能をコントロールするナノマシンの創製~2018

    • Author(s)
      片岡一則
    • Organizer
      関西化学工業協会第71回定時総会記念講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Patent(Industrial Property Rights)] 脳への薬剤送達用のキャリアおよびこれを含んでなる組成物2018

    • Inventor(s)
      片岡一則、安楽泰孝、中村乃理子
    • Industrial Property Rights Holder
      川崎市産業振興財団
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
    • Overseas

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Published: 2018-04-23   Modified: 2022-01-27  

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