Mechanisms underlying Information processing in idling brain

• Project/Area Number: 18H05213
• Research Category: Grant-in-Aid for Specially Promoted Research
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: University of Toyama
• Principal Investigator: 井ノ口 馨 富山大学, 学術研究部医学系, 教授 (20318827)
• Co-Investigator(Kenkyū-buntansha): 深井 朋樹 沖縄科学技術大学院大学, 神経情報・脳計算ユニット, 教授 (40218871) ; 高雄 啓三 富山大学, 学術研究部医学系, 教授 (80420397)
• Project Period (FY): 2018-04-23 – 2023-03-31
• Project Status: Granted (Fiscal Year 2022)
• Budget Amount: ¥555,360,000 (Direct Cost: ¥427,200,000、Indirect Cost: ¥128,160,000); Fiscal Year 2022: ¥95,810,000 (Direct Cost: ¥73,700,000、Indirect Cost: ¥22,110,000); Fiscal Year 2021: ¥101,400,000 (Direct Cost: ¥78,000,000、Indirect Cost: ¥23,400,000); Fiscal Year 2020: ¥116,220,000 (Direct Cost: ¥89,400,000、Indirect Cost: ¥26,820,000); Fiscal Year 2019: ¥141,830,000 (Direct Cost: ¥109,100,000、Indirect Cost: ¥32,730,000); Fiscal Year 2018: ¥100,100,000 (Direct Cost: ¥77,000,000、Indirect Cost: ¥23,100,000)
• Keywords: 神経科学 / アイドリング脳 / 睡眠 / 潜在意識 / 記憶エングラム / リプレイ / セルアセンブリ / 固定化 / カルシウムイメージング / 数理モデル / 脳海馬 / 瞑想脳

Outline of Annual Research Achievements

１．①マウス推論課題における前頭前野の神経活動を測定し、PCA-ICA法で神経細胞活動を解析した。正しい推論をしたときに出現する同期活動細胞アンサンブルは、学習中には認められず、学習後の睡眠時に出現してきた。ノンレム睡眠とレム睡眠中のアンサンブル活動には相違が認められ、アイドリング中の推論形成過程において両睡眠が異なる機能を果たすメカニズムを反映していると推察され、推論などの高次脳機能における両睡眠の役割分担を解明する手がかりになると期待できる。②海馬サイレントエングラムがその後の類似体験の記憶増強を引き起こすこと、増強には睡眠中のサイレントエングラム細胞の活動が重要であったことから、アイドリング脳の新たな機能が明らかとなった。③海馬CA1のノンエングラム細胞には、学習直後の睡眠時にアンサンブル活動としてプレプレイし始めて、将来の類似体験のエングラム細胞アンサンブルを形成する細胞群（engram-to-be細胞）が存在することを見いだした。④社会性威圧（social defeat: SoD）を受けてストレス状態の雄マウスでは、恐怖記憶の保存・想起の上昇が認められた。海馬CA1におけるSoD記憶のエングラム細胞が恐怖記憶の亢進に関わっていた。恐怖記憶のエングラム細胞アンサンブルが、SoD時や恐怖条件付け直後の睡眠時に出現しており、脳のネガティブな内部状態を表現するアンサンブル活動が、ネガティブ体験の記憶の亢進に関わっていることが示唆された。
２．時間空間情報に含まれる意味のあるまとまりをセグメント化するための神経メカニズムを考案した。この結果をさらに発展させ、神経回路の自発発火が入力刺激の事前確率モデルを表現するようになるための回路学習メカニズムを考案した。
３．バイオフィードバックによりマウスに遅い呼吸をさせるよう訓練したマウスは、社会的なアプローチ行動が増加した。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

１．アイドリング脳の活動と機能：　本研究の目的は、「アイドリング中の脳機能と脳活動を明らかにすることで、覚醒時を含めた脳機能全体の中でのアイドリング脳活動が占める位置づけを明確にすること」である。現在までに、①推論・共通性抽出・スキーマ・論理的意思決定などの高次の情報処理過程において、学習後のアイドリング脳活動が重要な働きをしていることを示すとともに、その時に重要な神経細胞の活動を明らかにした。それらの知見に加えて、アイドリング脳の新たな機能として、② engram -to-be細胞を発見し、将来の記憶エングラム細胞の生成にアイドリング脳活動が関与することを示し、③睡眠中のサイレントエングラム活動が、将来の類似体験の記憶増強に必要であることを発見した。このように当初の目標に向けて研究は順調に進捗しており、アイドリング脳研究という新たな学術分野の創成への展望が拓けてきた。
２．数理モデル：　自発発火が記憶や推論において果たす役割の中で、内部モデルの形成過程は実験的にも理論的にも理解が進んでいない。本年度の成果により、連続的な入力情報から統計的に頻出するパターンを自動的に検出し、それらのパターンを経験した確率で繰り返す自発発火を有する神経回路モデルの構築が可能になった。これにより、脳が階層的内部モデルを構築する過程の理解が進むことが期待される。このように研究は順調に進んでいる。

Strategy for Future Research Activity

最終年度は研究期間中に得られる成果を基にして、脳機能の中でアイドリング脳活動が占める位置づけを明確にすることことと、研究成果を複数の原著論文としてまとめる。具体的には以下の研究を進める。
１．アイドリング脳の活動と機能：　「推論」、「論理的意思決定」について、in vivoカルシウムイメージングデータの数理解析を続行し、アイドリング時の神経細胞集団の活動がどのように生成されてくるのかを明らかにする。また、engram-to-be細胞群の活動を手がかりにして、アイドリング状態が過去の経験と将来の経験に対して果たす役割を考察する。情動などの内部状態を表現するアイドリング中の神経活動が、その後の経験にどのような影響を与えるのかを解析すると共に、そのメカニズムを解明する。5年間の結果を総括し、アイドリング中の脳活動と顕在意識上の脳活動がどのように相互作用し、かつ機能分担して複雑な脳機能を担っているのかを考察する。
２．数理モデル：　提案した学習モデルは数学的な完成度は高いが生物学的な現実性が乏しい。そこで神経生理学的知見と整合性が高い学習メカニズムを探る。提案したモデルの改良や、実験で得た海馬や大脳皮質の神経活動の解析を通して、脳が推論課題等を解くメカニズムと自発発火の役割をモデル化する。
３．瞑想モデル：　遅い呼吸を訓練したモデルマウスで誘導される情動行動の変化はアイドリング脳に影響を与えたものと考えられるため、この時に活性化し、行動変化に重要と考えられる脳部位を特定する。

Assessment Rating

Interim Assessment Comments (Rating)

A: In light of the aim of introducing the research area into the research categories, the expected progress has been made in research.

Research Products

• [Journal Article] A cortical cell ensemble in the posterior parietal cortex controls past experience-dependent memory updating (2022)
  • Author(s): Suzuki Akinobu、Kosugi Sakurako、Murayama Emi、Sasakawa Eri、Ohkawa Noriaki、Konno Ayumu、Hirai Hirokazu、Inokuchi Kaoru
  • Journal Title: Nature Communications Volume: 13 Pages: 41-41
  • DOI: 10.1038/s41467-021-27763-x
  • Peer Reviewed / Open Access
• [Journal Article] The hippocampus as a sorter and reverberatory integrator of sensory inputs (2022)
  • Author(s): Nomoto Masanori、Murayama Emi、Ohno Shuntaro、Okubo-Suzuki Reiko、Muramatsu Shin-ichi、Inokuchi Kaoru
  • Journal Title: bioRxiv Volume: -
  • DOI: 10.1101/2022.01.10.475731
  • Open Access
• [Journal Article] Intrinsic bursts facilitate learning of L?vy flight movements in recurrent neural network models (2022)
  • Author(s): Ohta Morihiro、Asabuki Toshitake、Fukai Tomoki
  • Journal Title: Scientific Reports Volume: 12 Pages: 1-9
  • DOI: 10.1038/s41598-022-08953-z
  • Peer Reviewed / Open Access
• [Journal Article] Perturbation of monoamine metabolism and enhanced fear responses in mice defective in the regeneration of tetrahydrobiopterin (2022)
  • Author(s): K Miyajima, Y Sudo, S Sanechika, Y Hara, M Horiguchi, F Xu, M Suzuki, S Hara, K Tanda, K Inoue, M Takada, N Yoshioka, H Takebayashi, M Mori-Kojima, M Sugimoto, C Sumi-Ichinose, K Kondo, K Takao, T Miyakawa, H Ichinose
  • Journal Title: Journal of Neurochemistry Volume: 161(2) Pages: 129-145
  • DOI: 10.1111/jnc.15600
  • Peer Reviewed / Open Access
• [Journal Article] Uncovering long-term existence of a silent short-term memory trace (2021)
  • Author(s): Wally Maha E.、Nomoto Masanori、Abdou Kareem、Inokuchi Kaoru
  • Journal Title: bioRxiv Volume: -
  • DOI: 10.1101/2021.05.08.443276
  • Open Access
• [Journal Article] Offline knowledge assimilations ensue online obscurity to inspire implicit learning (2021)
  • Author(s): Aly Mohamed H.、Abdou Kareem、Okubo-Suzuki Reiko、Nomoto Masanori、Inokuchi Kaoru
  • Journal Title: bioRxiv Volume: -
  • DOI: 10.1101/2021.04.06.438726
  • Open Access
• [Journal Article] Inspiring cognitive inference in a cortical network during REM sleep (2021)
  • Author(s): Kareem Abdou, Kiriko Choko, Mohamed H. Aly, Reiko Okubo-Suzuki, Shin-ichi Muramatsu, Kaoru Inokuchi
  • Journal Title: bioRxiv Volume: -
  • DOI: 10.1101/2021.04.08.439095
  • Open Access
• [Journal Article] Neural mechanisms for learning hierarchical structures of information (2021)
  • Author(s): Fukai Tomoki、Asabuki Toshitake、Haga Tatsuya
  • Journal Title: Current Opinion in Neurobiology Volume: 70 Pages: 145-153
  • DOI: 10.1016/j.conb.2021.10.011
  • Peer Reviewed
• [Journal Article] Astrocyte GluN2C NMDA receptors control basal synaptic strengths of hippocampal CA1 pyramidal neurons in the stratum radiatum (2021)
  • Author(s): Chipman Peter H、Fung Chi Chung Alan、Pazo Fernandez Alejandra、Sawant Abhilash、Tedoldi Angelo、Kawai Atsushi、Ghimire Gautam Sunita、Kurosawa Mizuki、Abe Manabu、Sakimura Kenji、Fukai Tomoki、Goda Yukiko
  • Journal Title: eLife Volume: 10 Pages: 1-32
  • DOI: 10.7554/elife.70818
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Multiscale representations of community structures in attractor neural networks (2021)
  • Author(s): Haga Tatsuya、Fukai Tomoki
  • Journal Title: PLOS Computational Biology Volume: 17 Pages: 1-26
  • DOI: 10.1371/journal.pcbi.1009296
  • Peer Reviewed / Open Access
• [Journal Article] Concomitant Processing of Choice and Outcome in Frontal Corticostriatal Ensembles Correlates with Performance of Rats (2021)
  • Author(s): Takashi Handa, Rie Harukuni, Tomoki Fukai
  • Journal Title: Cerebral Cortex Volume: - Pages: 4357-4375
  • DOI: 10.1093/cercor/bhab091
  • Peer Reviewed / Open Access
• [Journal Article] Statistical Analysis of Ultrasonic Scattered Echoes Enables the Non-invasive Measurement of Temperature Elevations inside Tumor Tissue during Oncological Hyperthermia (2021)
  • Author(s): Takeuchi Michio、Sakai Toshihiko、Andocs Gabor、Takanaka Tsuyoshi、Taka Masashi、Yamashita Kuniko、Kawahara Masahiro、Nojiri Tomoko、Tanaka Asaka、Norishima Azusa、Omoto Yoshitaka、Omura Masaaki、Nagaoka Ryo、Takao Keizo、Hasegawa Hideyuki
  • Journal Title: Ultrasound in Medicine & Biology Volume: 47 Pages: 3301-3309
  • DOI: 10.1016/j.ultrasmedbio.2021.07.019
  • Peer Reviewed / Open Access
• [Journal Article] ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function (2021)
  • Author(s): Sugiyama T, Murao N, Kadowaki H, Takao K, Miyakawa T, Matsushita Y, Katagiri T, Futatsugi A, Shinmyo Y, Kawasaki H, Sakai J, Shiomi K, Nakazato M, Takeda K, Mikoshiba K, Ploegh HL, Ichijo H, Nishitoh H
  • Journal Title: iScience Volume: 24 Pages: 102758-102758
  • DOI: 10.1016/j.isci.2021.102758
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mice with mutations in Trpml, a gene within the locus of 15q13.3 microdeletion syndrome, display pronounced hyperactivity and decreased anxiety-like behavior. (2021)
  • Author(s): Tesshu Hori, Shohei Ikuta, Satoko Hattori, Keizo Takao, Tsuyoshi Miyakawa, Chieko Koike
  • Journal Title: Molecular Brain Volume: 14：61 Issue: 1 Pages: 1-16
  • DOI: 10.1186/s13041-021-00749-y
  • Peer Reviewed / Open Access
• [Journal Article] Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice (2021)
  • Author(s): Yoshida T, Yamagata A, Imai A, Kim J, Izumi H, Maenaka K, Shimada T, Fukata M, Nishijo H, Takao K, Okabe S, Tabuchi K, Mishina M, Mori H, Fukai S.
  • Journal Title: Nature communications Volume: 12(1) Issue: 1 Pages: 1848-1848
  • DOI: 10.1038/s41467-021-22059-6
  • NAID: 120006996978
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Heterogeneity of microglial proton channel in different brain regions and its relationship with aging. (2021)
  • Author(s): Kawai T,Takao K,Akter S,Abe M,Sakimura K,Miyakawa T,Okamura Y
  • Journal Title: Journal of Neurochemistry Volume: - Pages: 624-641
  • DOI: 10.1111/jnc.15292
  • Peer Reviewed / Open Access
• [Journal Article] Vascular PDGFR-alpha protects against BBB dysfunction after stroke in mice. (2021)
  • Author(s): Nguyen QL, Okuno N, Hamashima T, Dang ST, Fujikawa M, Ishii Y, Enomoto A, Maki T, Nguyen HN, Nguyen VT, Fujimori T, Mori H, Andrae J, Betsholtz C, Takao K, Yamamoto S, Sasahara M.
  • Journal Title: Angiogenesis Volume: 24 Pages: 35-46
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Oscillation-Driven Memory Encoding, Maintenance, and Recall in an Entorhinal-Hippocampal Circuit Model (2021)
  • Author(s): Tomoki Kurikawa, Kenji Mizuseki, Tomoki Fukai
  • Journal Title: Cerebral Cortex Volume: 31 Pages: 2038-2057
  • DOI: 10.1093/cercor/bhaa343
  • Peer Reviewed / Open Access
• [Journal Article] Pcdhb deficiency affects hippocampal CA1 ensemble activity and contextual fear discrimination (2020)
  • Author(s): Asai H, Ohkawa N, Saitoh Y, Ghandour K, Murayama E, Nishizono H, Matsuo M, Hirayama T, Kaneko R, Muramatsu S, Yagi T, Inokuchi K
  • Journal Title: Molecular Brain Volume: 13 Pages: 7-7
  • DOI: 10.1186/s13041-020-0547-z
  • Peer Reviewed / Open Access
• [Journal Article] Selective targeting of mRNA and the following protein synthesis of CaMKIIα at the long-term potentiation-induced site (2020)
  • Author(s): Nihonmatsu Itsuko#、Ohkawa Noriaki#,*、Saitoh Yoshito#、Okubo-Suzuki Reiko、Inokuchi Kaoru
  • Journal Title: Biology Open Volume: 9
  • DOI: 10.1242/bio.042861
  • Peer Reviewed / Open Access
• [Journal Article] Guide for Ca²⁺ Imaging from Deep Brain Regions (2020)
  • Author(s): 大川宣昭，竹川高志，野本真順，井ノ口馨
  • Journal Title: Nihon Shinkei Kairo Gakkaishi Volume: 77 Issue: 2 Pages: 74-86
  • DOI: 10.3902/jnns.27.74
  • NAID: 130007882378
  • ISSN: 1340-766X, 1883-0455
  • Open Access
• [Journal Article] Maternal dietary imbalance between omega-6 and omega-3 fatty acids triggers the offspring's overeating in mice (2020)
  • Author(s): Sakayori, N, Katakura, M, Hamazaki, K, Higuchi, O, Fujii, K, Fukabori, R, Iguchi, Y, Setogawa, S, Takao, K, Miyazawa, T, Arita, M, Kobayashi, K
  • Journal Title: Communications Biology Volume: 3 Issue: 1 Pages: 1-13
  • DOI: 10.1038/s42003-020-01209-4
  • NAID: 120007169782
  • Peer Reviewed / Open Access
• [Journal Article] Temperature elevation in tissue detected in vivo based on statistical analysis of ultrasonic scattered echoes (2020)
  • Author(s): Takeuchi Michio、Sakai Toshihiko、Andocs Gabor、Takao Keizo、Nagaoka Ryo、Hasegawa Hideyuki
  • Journal Title: Sci Rep Volume: 10 Pages: 9030-9030
  • DOI: 10.1038/s41598-020-65562-4
  • Peer Reviewed / Open Access
• [Journal Article] Somatodendritic consistency check for temporal feature segmentation (2020)
  • Author(s): Asabuki Toshitake、Fukai Tomoki
  • Journal Title: Nature Communications Volume: 11 Pages: 1-13
  • DOI: 10.1038/s41467-020-15367-w
  • Peer Reviewed / Open Access
• [Journal Article] Spontaneous and stimulus-induced coherent states of critically balanced neuronal networks (2020)
  • Author(s): Takashi Hayakawa, Tomoki Fukai
  • Journal Title: Physical Review Research Volume: 2
  • DOI: 10.1103/physrevresearch.2.013253
  • Peer Reviewed / Open Access
• [Journal Article] Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice (2020)
  • Author(s): Takeuchi Hiroki、Imamura Keiko、Ji Bin、Tsukita Kayoko、Enami Takako、Takao Keizo、Miyakawa Tsuyoshi、Hasegawa Masato、Sahara Naruhiko、Iwata Nobuhisa、Inoue Makoto、Hara Hideo、Tabira Takeshi、Ono Maiko、Trojanowski John Q.、Lee Virginia M.-Y.、Takahashi Ryosuke、Suhara Tetsuya、Higuchi Makoto、Inoue Haruhisa
  • Journal Title: NPJ Vaccines Volume: 5 Pages: 28-28
  • DOI: 10.1038/s41541-020-0172-y
  • NAID: 120006817588
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] GluD1 knockout mice with a pure C57BL/6N background show impaired fear memory, social interaction, and enhanced depressive-like behavior (2020)
  • Author(s): Nakamoto Chihiro、Kawamura Meiko、Nakatsukasa Ena、Natsume Rie、Takao Keizo、Watanabe Masahiko、Abe Manabu、Takeuchi Tomonori、Sakimura Kenji
  • Journal Title: PLOS ONE Volume: 15 Pages: 0229288-0229288
  • DOI: 10.1371/journal.pone.0229288
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Orchestrated ensemble activities constitute a hippocampal memory engram. (2019)
  • Author(s): Ghandour K, Ohkawa N, Chung C, Fung A, Asai H, Saitoh Y, Takekawa T, Okubo-Suzuki R, Soya S, Nishizono H, Matsuo M, Osanai M, Sato M, Ohkura M, Nakai J, Hayashi Y, Sakurai T, Kitamura T, Fukai T, Inokuchi K
  • Journal Title: Nature Communications Volume: 10 Pages: 1-14
  • DOI: 10.1038/s41467-019-10683-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 総論 記憶研究の現状 (2019)
  • Author(s): 井ノ口馨
  • Journal Title: 月刊細胞 特集 記憶のしくみ Volume: 51 Pages: 264-265
• [Journal Article] 記憶痕跡と記憶の関連付け (2019)
  • Author(s): 横瀬 淳，井ノ口 馨
  • Journal Title: 月刊細胞 特集 記憶のしくみ Volume: 51 Pages: 270-273
• [Journal Article] Synaptic identity of memory engrams. (2019)
  • Author(s): Abdou K, and Inokuchi K.
  • Journal Title: 月刊細胞 特集 記憶のしくみ Volume: 51 Pages: 282-285
• [Journal Article] 記憶痕跡セル・アンサンブルを利用した人工連合記憶の創出 (2019)
  • Author(s): 大川 宜昭，井ノ口 馨
  • Journal Title: Dementia Japan・特集 記憶のメカニズムとシナプスイメージング Volume: 33 Pages: 2-9
• [Journal Article] Extended Temporal Association Memory by Modulations of Inhibitory Circuits (2019)
  • Author(s): Haga Tatsuya、Fukai Tomoki
  • Journal Title: Physical Review Letters Volume: 123
  • DOI: 10.1103/physrevlett.123.078101
  • Peer Reviewed / Open Access
• [Journal Article] Unsupervised Detection of Cell-Assembly Sequences by Similarity-Based Clustering (2019)
  • Author(s): Watanabe Keita、Haga Tatsuya、Tatsuno Masami、Euston David R.、Fukai Tomoki
  • Journal Title: Frontiers in Neuroinformatics Volume: 13 Pages: 1-19
  • DOI: 10.3389/fninf.2019.00039
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Comprehensive behavioral analysis of heterozygous Syngap1 knockout mice (2019)
  • Author(s): Nakajima Ryuichi、Takao Keizo、Hattori Satoko、Shoji Hirotaka、Komiyama Noboru H.、Grant Seth G. N.、Miyakawa Tsuyoshi
  • Journal Title: Neuropsychopharmacol Reports Volume: 39 Pages: 223-237
  • DOI: 10.1002/npr2.12073
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Comprehensive behavioral analysis of mice repeatedly treated with propofol (2019)
  • Author(s): Kazuki Fujii, Hinano Otofuji, Yu Nakamura, Yumie Koshidaka, Mayumi Adachi, Eri Sasakawa, Mohamed Darwish, Keizo Takao
  • Journal Title: Translational and Regulatory Sciences Volume: 1 Issue: 2 Pages: 46-57
  • DOI: 10.33611/trs.1_46
  • NAID: 130007753982
  • ISSN: 2434-4974
  • Peer Reviewed / Open Access
• [Journal Article] High-resolution MR image by high precision signal analysis method for accurately analyze complex signals (2019)
  • Author(s): Hasegawa Masaya、Juanda Ruha Ahmad Naif Syaihan B.、Hirobayashi Kanna、Fuji Kazuki、Takao Keizo、Noguchi Kyo、Hirobayashi Shigeki
  • Journal Title: Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues Volume: 10881 Pages: 52-52
  • DOI: 10.1117/12.2509050
  • Peer Reviewed / Open Access
• [Journal Article] 武道の可能性を探る・学問の府から見た武道の意義 (2019)
  • Author(s): 高雄 啓三
  • Journal Title: 武道 Volume: 635 Pages: 74-79
• [Journal Article] Artificial association of memory events by optogenetic stimulation of hippocampal CA3 cell ensembles (2019)
  • Author(s): Oishi Naoya、Nomoto Masanori、Ohkawa Noriaki、Saitoh Yoshito、Sano Yoshitake、Tsujimura Shuhei、Nishizono Hirofumi、Matsuo Mina、Muramatsu Shin-ichi、Inokuchi Kaoru
  • Journal Title: Molecular Brain Volume: 12 Pages: 111111-111111
  • DOI: 10.1186/s13041-018-0424-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Discrete-Attractor-like Tracking in Continuous Attractor Neural Networks (2019)
  • Author(s): Fung Chi Chung Alan、Fukai Tomoki
  • Journal Title: Physical Review Letters Volume: 122 Pages: 018102-018102
  • DOI: 10.1103/physrevlett.122.018102
  • Peer Reviewed
• [Journal Article] Rapid and high-efficient generation of mutant mice using freeze-thawed embryos of the C57BL/6J strain (2019)
  • Author(s): Darwish Mohamed、Nishizono Hirofumi、Uosaki Hideki、Sawada Hitomi、Sadahiro Taketaro、Ieda Masaki、Takao Keizo
  • Journal Title: Journal of Neuroscience Methods Volume: 317 Pages: 149-156
  • DOI: 10.1016/j.jneumeth.2019.01.010
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Establishment of a mouse model of atopic dermatitis by deleting Ikk2 in dermal fibroblasts (2019)
  • Author(s): Satoshi Nunomura, Naoko Ejiri, Midori Kitajima, Yasuhiro Nanri, Kazuhiko Arima, Yasutaka Mitamura, Tomohito Yoshihara, Kazuki Fujii, Keizo Takao, Johji Imura, Hans Joerg Fehling, Kenji Izuhara, Isao Kitajima
  • Journal Title: Journal of Investigative Dermatology Volume: 202X Pages: 1274-1283
  • DOI: 10.1016/j.jid.2018.10.047
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Open source code for behavior analysis in rodents (2019)
  • Author(s): Hattori Satoko、Okumura Yoshihiro、Takao Keizo、Yamaguchi Yoko、Miyakawa Tsuyoshi
  • Journal Title: Neuropsychopharmacology Reports Volume: 39 Pages: 67-69
  • DOI: 10.1002/npr2.12047
  • Peer Reviewed
• [Journal Article] Alteration of parvalbumin expression and perineuronal nets formation in the cerebral cortex of aged mice (2019)
  • Author(s): Ueno Hiroshi、Fujii Kazuki、Takao Keizo、Suemitsu Shunsuke、Murakami Shinji、Kitamura Naoya、Wani Kenta、Matsumoto Yosuke、Okamoto Motoi、Ishihara Takeshi
  • Journal Title: Molecular and Cellular Neuroscience Volume: 95 Pages: 31-42
  • DOI: 10.1016/j.mcn.2018.12.008
  • Peer Reviewed
• [Journal Article] TRPM2 confers susceptibility to social stress but is essential for behavioral flexibility. (2019)
  • Author(s): Andoh C, Nishitani N, Hashimoto E, Nagai Y, Takao K, Miyakawa T, Nakagawa T, Mori Y, Nagayasu K, Shirakawa H, Kaneko S.
  • Journal Title: Brain Research Volume: 1704 Pages: 68-77
  • DOI: 10.1016/j.brainres.2018.09.031
  • NAID: 120006630995
  • Peer Reviewed
• [Journal Article] Synapse-specific representation of the identity of overlapping memory engrams (2018)
  • Author(s): Abdou Kareem、Shehata Mohammad、Choko Kiriko、Nishizono Hirofumi、Matsuo Mina、Muramatsu Shin-ichi、Inokuchi Kaoru
  • Journal Title: Science Volume: 360 Pages: 1227-1231
  • DOI: 10.1126/science.aat3810
  • Peer Reviewed / Open Access
• [Journal Article] Adult neurogenesis conserves hippocampal learning capacity (2018)
  • Author(s): Alam J, Kitamura T, Saitoh Y, Ohkawa N, Kondo T, Inokuchi K
  • Journal Title: The Journal of Neuroscience Volume: 38 Pages: 6854-6863
  • DOI: 10.1523/jneurosci.2976-17.2018
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects of chronic fentanyl administration on behavioral characteristics of mice (2018)
  • Author(s): Fujii Kazuki、Koshidaka Yumie、Adachi Mayumi、Takao Keizo
  • Journal Title: Neuropsychopharmacology Reports Volume: 39 Pages: 17-35
  • DOI: 10.1002/npr2.12040
  • Peer Reviewed
• [Journal Article] Comprehensive behavioral analysis and quantification of brain free amino acids of C57BL/6J congenic mice carrying the 1473G allele in tryptophan hydroxylase-2 (2018)
  • Author(s): Koshimizu Hisatsugu、Hirata Nao、TaIchinokao Keizo、Toyama Keiko、se Takashi、Furuya Shigeki、Miyakawa Tsuyoshi
  • Journal Title: Neuropsychopharmacology Reports Volume: 39 Pages: 56-60
  • DOI: 10.1002/npr2.12041
  • Peer Reviewed
• [Journal Article] Distribution of Caskinl protein and phenotypic characterization of its knockout mice using a comprehensive behavioral test battery (2018)
  • Author(s): Katano T., Takao K., Abe M., Yamazaki M., Watanabe M., Miyakawa T., Sakimura K., Ito S.
  • Journal Title: Molecular Brain Volume: 11 Pages: 1-20
  • DOI: 10.1186/s13041-018-0407-2
  • Peer Reviewed / Open Access
• [Journal Article] Expression of aggrecan components in perineuronal nets in the mouse cerebral cortex (2018)
  • Author(s): Ueno H, Fujii K, Suemitsu S, Murakami S, Kitamura N, Wani K, Aoki S, Okamoto M, Ishihara T, Takao K
  • Journal Title: IBRO Reports Volume: 4 Pages: 22-37
  • DOI: 10.1016/j.ibror.2018.01.002
  • Peer Reviewed / Open Access
• [Journal Article] Comprehensive behavioral analysis of tryptophan 2,3-dioxygenaso (Tdo2) knockout mice (2018)
  • Author(s): Hattori S, Takao K, Funakoshi H, *Miyakawa T
  • Journal Title: Neuropsychopharmacology Reports Volume: 38 Pages: 52-60
  • DOI: 10.1002/npr2.12006
  • NAID: 120006496928
  • Peer Reviewed / Open Access
• [Journal Article] Dissociated role of D-serine in extinction during consolidation vs. reconsolidation of context conditioned fear. (2018)
  • Author(s): Inoue R, Talukdar G, Takao K, Miyakawa T, Mori H.
  • Journal Title: Frontiers in Molecular Neuroscience Volume: 11 Pages: 161-161
  • DOI: 10.3389/fnmol.2018.00161
  • Peer Reviewed / Open Access
• [Journal Article] Comprehensive behavioral analysis of the Cdkl5 knockout mice revealed significant enhancement in anxiety- and fear-related behaviors and impairment in both acquisition and long-term retention of spatial reference memory (2018)
  • Author(s): Okuda Kosuke、Takao Keizo、Watanabe Aya、Miyakawa Tsuyoshi、Mizuguchi Masashi、Tanaka Teruyuki
  • Journal Title: PLOS ONE Volume: 13
  • DOI: 10.1371/journal.pone.0196587
  • Peer Reviewed / Open Access
• [Journal Article] Cellular tagging framework: The spatial overlapping of ensemble allocation for behavioral tagging (2018)
  • Author(s): 野本 真順、井ノ口 馨
  • Journal Title: 生化学 Volume: 90 Issue: 1 Pages: 84-89
  • DOI: 10.14952/SEIKAGAKU.2018.900084
  • NAID: 40021494482
  • ISSN: 0037-1017
• [Journal Article] 特集・記憶エングラムの神経回路と精神疾患・行動タグと精神疾患 (2018)
  • Author(s): 野本 真順、井ノ口 馨
  • Journal Title: 分子精神医学 Volume: 18 Pages: 58-65
• [Journal Article] 特集・記憶エングラムの神経回路と精神疾患・記憶の関連付けから迫る精神疾患 (2018)
  • Author(s): 5.横瀬 淳、井ノ口 馨
  • Journal Title: 分子精神医学 Volume: 18 Pages: 66-72
• [Journal Article] 記憶は人為的に書き換えられる (2018)
  • Author(s): 野本 真順、井ノ口 馨
  • Journal Title: 医学書院．BRAIN and NERVE．記憶と忘却に関わる脳のしくみー分子機構から健忘の症候まで Volume: 70 Pages: 699-711
• [Journal Article] 記憶の操作 (2018)
  • Author(s): 大川 宜昭、横瀬 淳、井ノ口 馨
  • Journal Title: Clinical Neuroscience・特集 光が開く神経科学の未来－オプトジェネティクスと光イメージング Volume: 36 Pages: 916-920
• [Journal Article] Behavioral, cellular, and synaptic tagging frameworks (2018)
  • Author(s): Nomoto Masanori、Inokuchi Kaoru
  • Journal Title: Neurobiology of Learning and Memory Volume: 18 Pages: 30065-0
  • DOI: 10.1016/j.nlm.2018.03.010
  • Peer Reviewed / Open Access
• [Journal Article] 記憶を改変する-記憶の物理化学的実体の理解に基づいて (2018)
  • Author(s): 井ノ口馨
  • Journal Title: 麻酔 増刊 Volume: 67 Pages: 31-38
• [Presentation] Extracting Cell Assembly Patterns from Large-scale Recording Data (2022)
  • Author(s): Tomoki Fukai
  • Organizer: Grant-in-Aid for Transformative Research Areas Symposium:Morphological Features and Gene Expression Patterns in Hub Neurons
  • Invited
• [Presentation] 大脳新皮質における－細胞を起点としたプレシナプスネットワークの多様性解析 (2022)
  • Author(s): 倉林伸博、高雄啓三
  • Organizer: 第15回 神経発生討論会
• [Presentation] プロテインキナーゼ A (PKA) 結合配列を持つマイクロプロテイン Akain1 欠損マウスは 類似条件弁別障害を示す (2022)
  • Author(s): 藤井 一希, 腰高 由美恵, 安達 真由美, 柳橋 裕子, 松尾 美奈, 西園 啓文, 黒田 信幸, 相澤 康則, 高雄 啓三
  • Organizer: 先端モデル動物支援プラットフォーム 2021年度 成果発表会
• [Presentation] Cyclin-dependent kinase-like 5 (CDKL5) キナーゼ活性欠損ノックインマウスの作製と網羅的行動解析 (2022)
  • Author(s): 田中輝幸, 安藤さくら, 阿部学, 崎村健司, 藤井一希, 高雄 啓三
  • Organizer: 先端モデル動物支援プラットフォーム 2021年度 成果発表会
• [Presentation] 脳における硫酸化制御因子PAPS輸送体1の解析 (2022)
  • Author(s): 江川秀夫, 嶌井美幸, 神田祐樹, 黒川和樹, 平野和己, 高雄啓三, 宮川剛, 義江 修, 西原祥子
  • Organizer: 先端モデル動物支援プラットフォーム 2021年度 成果発表会
• [Presentation] 免疫グロブリンＡの欠損により免疫および神経機能の破綻 (2022)
  • Author(s): 安達貴弘, 藤井一希, 高雄啓三, 永石宇司
  • Organizer: 先端モデル動物支援プラットフォーム 2021年度 成果発表会
• [Presentation] マウス行動解析、その前と後 (2022)
  • Author(s): 高雄啓三
  • Organizer: 先端モデル動物支援プラットフォーム 2021年度 成果発表会
• [Presentation] 海馬におけるアンサンブル反響活動による連合記憶の制御 (2021)
  • Author(s): 野本真順，井ノ口馨
  • Organizer: 2021年度生理研研究会・記憶研究会2021「記憶・学習の多角的理解に向けたアプローチ」
  • Invited
• [Presentation] Functional roles of the idling brain (2021)
  • Author(s): Inokuchi K.
  • Organizer: The 44th Annual Meeting of the Japan Neuroscience Society/the 1st CJK International Meeting
  • Int'l Joint Research / Invited
• [Presentation] Brain functions in subconscious: from memory engram (2021)
  • Author(s): Inokuchi K.
  • Organizer: The 44th Annual Meeting of the Japan Neuroscience Society/the 1st CJK International Meeting, Luncheon Seminar
  • Int'l Joint Research / Invited
• [Presentation] 記憶のメカニズム (2021)
  • Author(s): 井ノ口馨
  • Organizer: 日本ペインクニック学会 第55回学術集会
  • Invited
• [Presentation] Ensemble reverberatory activity in hippocampus encodes associative memory (2021)
  • Author(s): Nomoto M., Murayama E., Ohno S., Okubo-Suzuki R., Inokuchi K.
  • Organizer: The 44th Annual Meeting of the Japan Neuroscience Society/the 1st CJK International Meeting
  • Int'l Joint Research
• [Presentation] Engineering cognitive inference in cortical network during REM sleep (2021)
  • Author(s): Abdou K., Choko K., Mostafa M., Okubo-Suzuki R., Muramatsu S., Inokuchi K.
  • Organizer: The 44th Annual Meeting of the Japan Neuroscience Society/the 1st CJK International Meeting
  • Int'l Joint Research
• [Presentation] Pre-configured ensembles are recruited into upcoming hippocampal engram (2021)
  • Author(s): Ghandour K., Ohkawa N., Fung CCA, Saitoh Y., Takekawa T., Sato M., Fukai T., Inokuchi K.
  • Organizer: The 44th Annual Meeting of the Japan Neuroscience Society/the 1st CJK International Meeting
  • Int'l Joint Research
• [Presentation] Orbitofrontal cortex governs wise decisions throughout awake and sleep states (2021)
  • Author(s): Fayed MR., Ghandour K., Okubo-Suzuki R., Abdou K., Inokuchi K.
  • Organizer: The 44th Annual Meeting of the Japan Neuroscience Society/the 1st CJK International Meeting
  • Int'l Joint Research
• [Presentation] iSeq: seqNMF based on Itakura-Saito divergence for extraction of comparable temporal sequences in neuronal activities (2021)
  • Author(s): Ohno S., Nomoto M., Inokuchi K.
  • Organizer: The 44th Annual Meeting of the Japan Neuroscience Society/the 1st CJK International Meeting
  • Int'l Joint Research
• [Presentation] The role for remote memory formation in the secondary auditory cortex. (2021)
  • Author(s): Nakayama S., Yokose J., Ohno S., Choko K., Inokuchi K.
  • Organizer: The 44th Annual Meeting of the Japan Neuroscience Society/the 1st CJK International Meeting
  • Int'l Joint Research
• [Presentation] A myosin/septin-dependent postsynaptic regulation required for memory consolidation (2021)
  • Author(s): Ageta-Ishihara N., Fukazawa Y., Takao K., Kengaku M., Miyakawa T., Inokuchi K., Bito H., Kinoshita M.
  • Organizer: The 44th Annual Meeting of the Japan Neuroscience Society/the 1st CJK International Meeting
  • Int'l Joint Research
• [Presentation] Old and new findings on cell-assembly hypothesis (2021)
  • Author(s): Tomoki Fukai
  • Organizer: CNBE Symposium 2021, The University of Electro-Communications
  • Invited
• [Presentation] Multiscale and extended retrieval of associative memory structures in a cortical model of local-global inhibition balance. (2021)
  • Author(s): Thomas F Burns, Tatsuya Haga and Tomoki Fukai
  • Organizer: Neuromatch 4.0 (Online)
  • Int'l Joint Research
• [Presentation] Learning hierarchical and probabilistic input structures in neural networks (2021)
  • Author(s): Toshitake Asabuki and Tomoki Fukai
  • Organizer: Topical Problems of Nonlinear Wave Physics (NWP-2021)
  • Int'l Joint Research / Invited
• [Presentation] Learning spontaneously reactivatable prior distributions for causal inference (2021)
  • Author(s): Toshitake Asabuki and Tomoki Fukai
  • Organizer: RIKEN-OIST Joint Symposium Series 2 "Kinds of Minds - what is thinking?"
• [Presentation] Role of Spontaneous Neural Activity in Memory Function (2021)
  • Author(s): Roman Koshkin and Tomoki Fukai
  • Organizer: RIKEN-OIST Joint Symposium Series 2 "Kinds of Minds - what is thinking?"
• [Presentation] Plenary Symposium: Synaptic Plasticity and Emergent Functions (Chair: Masami Tatsuno), 14th Canadian Neuroscience Meeting, Online (Canada) (August 23, 2021) (2021)
  • Author(s): Tomoki Fukai
  • Organizer: 14th Canadian Neuroscience Meeting
  • Int'l Joint Research / Invited
• [Presentation] Assemblies of low-frequency firing neurons in the motor cortex of behaving rats (2021)
  • Author(s): Tomoki Fukai, Ruxandra Cojocaru and Takashi Takekawa
  • Organizer: The 44th Annual Meeting of the Japan Neuroscience Society/The 1st CJK International Meeting
  • Int'l Joint Research
• [Presentation] Neural mechanisms of segmentation in sensory and memory processing (2021)
  • Author(s): Tomoki Fukai
  • Organizer: Connecting Brains: A worldwide Neuroscience Lecture Series (Max Planck Institute for Brain Research)
  • Int'l Joint Research / Invited
• [Presentation] Chemogenetic activation of prefrontal parvalbumin interneurons in combination with clinically comparable antipsychotic treatment restores working memory deficits in a mouse model of schizophrenia. (2021)
  • Author(s): Yosefu Arime, Yoshito Saitoh, Yasuo Uchida, Mikiko Ishikawa, Chikako Kamiyoshihara, Kazuki Fujii, Keizo Takao, Noriaki Ohkawa
  • Organizer: 第44回 日本神経科学大会
• [Presentation] 悪経験直後の情報反響と連合学習における海馬CA3 NMDA受容体の関与 (2020)
  • Author(s): 野本真順, 村山絵美, 芳賀達也, 村松慎一, 深井朋樹, 井ノ口馨
  • Organizer: 第43回日本神経科学大会
• [Presentation] Dissociable roles of sleep stages in the emergence and consolidation of transitive inference. (2020)
  • Author(s): Abdou K., Choko K., Mostafa M., Okubo-Suzuki R., and Inokuchi K.
  • Organizer: 第43回日本神経科学大会
• [Presentation] Pre-configured ensembles are recruited into upcoming hippocampal engram. (2020)
  • Author(s): Ghandour K., Ohkawa N., Fung C.C.A., Asai H., Saitoh Y., Takekawa T., Nishizono H., Sato M., Ohkura M., Nakai J., Hayashi Y., Fukai T., and Inokuchi K.
  • Organizer: 第43回日本神経科学大会
• [Presentation] 学習・記憶を担う海馬神経細胞集団の構築 (2020)
  • Author(s): 浅井裕貴, 鈴木(大久保) 玲子, 金子涼輔, 大川宜昭, 斎藤喜人, Ghandour K., 村山絵美, 西園啓文, 松尾美奈, 平山晃斉, 村松慎一, 八木健, 井ノ口馨
  • Organizer: 第43回日本神経科学大会
• [Presentation] Offline memory consolidation and assimilation independently co-occur. (2020)
  • Author(s): Mostafa M., Abdou K., and Inokuchi K.
  • Organizer: 第43回日本神経科学大会
• [Presentation] Silent hippocampal engram tags future episode for consolidation. (2020)
  • Author(s): Choucry A., Abdou K., Okubo-Suzuki R., Murayama E., and Inokuchi K.
  • Organizer: 第43回日本神経科学大会
• [Presentation] Involvement of sleep and NMDAR-activity in the storage of short-term memory engram. (2020)
  • Author(s): Wally M., Nomoto M., Abdou K., and Inokuchi K.
  • Organizer: 第43回日本神経科学大会
• [Presentation] マウス二次聴覚野における遠隔恐怖記憶に関わる神経細胞集団ダイナミクス (2020)
  • Author(s): 中山翔太, 横瀬淳, 趙康綺子，大野駿太郎, 井ノ口馨
  • Organizer: 第43回日本神経科学大会
• [Presentation] 超音波散乱波統計解析による癌温熱治療中の腫瘍組織 内温度 上昇の非侵襲測定. (2020)
  • Author(s): 竹内道雄，坂井俊彦，Andocs Gabor，高仲強，高将司，山下国子，川原昌宏，野尻智子，田中麻 香，則島あずさ， 尾本吉隆，大村眞朗，長岡亮，高雄啓三，長谷川英之．
  • Organizer: 第４１回 超音波エレクトロニクスの基礎と応用に関するシンポジウム
• [Presentation] 非調和解析（ＮＨＡ）を用いたマウス呼吸の時間周 波数解析． (2020)
  • Author(s): 淺野雄輝，藤井一希，長谷川昌也，廣林茂樹，高雄啓三．
  • Organizer: 第67回日本実験動物学会総会
• [Presentation] 共母体免疫活性化は胎児の脳における Ptprd 遺伝子微小 エクソン選択調節を撹乱する． (2020)
  • Author(s): 藤村耕平，仙道水月，藤井一希，吉田知之，高雄啓三.
  • Organizer: 第67回日本実験動物学会総会
• [Presentation] ラジオ波加熱されたラット腫瘍内の超 音波散乱波統計波の統計解析による温度変化測定． (2020)
  • Author(s): 竹内 道雄，坂井 俊彦，Andocs Gabor, 高雄 啓三，長岡 亮，長谷川 英之．
  • Organizer: 日本超音波医学会第93回学術集会
• [Presentation] Rate and temporal coding perspectives of motor processing in cortical microcircuits (2020)
  • Author(s): Tomoki Fukai
  • Organizer: Online Workshop Series Neural Control: From data to machines
  • Int'l Joint Research / Invited
• [Presentation] 情報圧縮：脳的アプローチ (2020)
  • Author(s): Tomoki Fukai
  • Organizer: 第12回数理モデリング研究会 数理モデリングの哲学--数理モデルは何のためにあるのか --
  • Invited
• [Presentation] Self-supervision mechanism of multiple dendritic compartments for temporal feature learning (2020)
  • Author(s): Milena Menezes Carvalho, Tomoki Fukai
  • Organizer: 29th Annual Computational Neuroscience Meeting (CNS 2020)
  • Int'l Joint Research
• [Presentation] Stability of spontaneous activity depends on synaptic delays in spiking network models. (2020)
  • Author(s): Thomas Burns, Tomoki Fukai
  • Organizer: Systems & Computational Neuroscience Down Under (SCiNDU) 2020
  • Int'l Joint Research
• [Presentation] 超音波エコー振幅分布モデルへの整合誤差の評価による散乱体密度推定精度の向上 (2020)
  • Author(s): 尾本吉隆，長谷川英之，長岡 亮，竹内道雄，坂井俊彦，Gabor Andocs, 高雄啓三
  • Organizer: 日本音響学会 2020年春季研究発表会
• [Presentation] 記憶の神経科学的実体. ヒトの脳回路機能の解明に向けて ～ネズミから探る・サルから探る～ (2019)
  • Author(s): .井ノ口馨
  • Organizer: 次世代脳プロジェクト冬のシンポジウム
  • Invited
• [Presentation] Organization of memory engram. (2019)
  • Author(s): .Inokuchi K.
  • Organizer: Toyama Forum for Academic Summit on" Dynamic Brain"
  • Invited
• [Presentation] Orchestrated ensemble activities constitute a hippocampal memory engram (2019)
  • Author(s): .Inokuchi K
  • Organizer: 第42回日本分子生物学会年会
  • Invited
• [Presentation] Orchestrated ensemble activities constitute a hippocampal memory engram (2019)
  • Author(s): .Inokuchi K.
  • Organizer: 14th International Conference of Neurons and Brain Diseases, Association for the study of neurons and diseases
  • Int'l Joint Research
• [Presentation] Memory can be manipulated and it could help those with PTSD. (2019)
  • Author(s): .Inokuchi K.
  • Organizer: International Brain Science Summit Forum
  • Int'l Joint Research / Invited
• [Presentation] Organization of memory engram. (2019)
  • Author(s): .Inokuchi K.
  • Organizer: MCCS-Asia 2019 in Seoul (Molecular and Cellular Cognition Society)
  • Int'l Joint Research / Invited
• [Presentation] Synapse-specific plasticity governs the identity of overlapping memory traces. (2019)
  • Author(s): 7.Abdou K.
  • Organizer: Current Trends and Future Directions of Synapse-Circuit Plasticity Research
• [Presentation] Cell ensemble mechanisms underlying memory formation. (2019)
  • Author(s): .Inokuchi K.
  • Organizer: Current Trends and Future Directions of Synapse-Circuit Plasticity Research
  • Invited
• [Presentation] Reactivation of memory engram during REM/nonREM sleep. (2019)
  • Author(s): .Inokuchi K.
  • Organizer: NEURO2019（第42回日本神経科学大会、第62回日本神経化学会大会）
• [Presentation] Memory engram and plasticity. (2019)
  • Author(s): .Inokuchi K.
  • Organizer: HEBB 70: Synapses, Plasticity, and Disease
  • Int'l Joint Research
• [Presentation] Organization of memory engram in the hippocampus. (2019)
  • Author(s): .Inokuchi K.
  • Organizer: SPRING HIPPOCAMPAL RESEARCH CONFERENCE
  • Int'l Joint Research
• [Presentation] Pre-configured Ensembles are Recruited into Upcoming Hippocampal Engram. (2019)
  • Author(s): Ghandour K., Ohkawa N., Fung C. A., Asai H., Saitoh Y., Takekawa T., Nishizono H., Sato M., Ohkura M., Nakai J., Hayashi Y., Fukai T., and Inokuchi K.
  • Organizer: Neuroscience 2019, Annual Meeting of Society for Neuroscience
  • Int'l Joint Research
• [Presentation] Deletion of cPcdhs affects cell ensemble activities in the hippocampus. (2019)
  • Author(s): Asai H., Ohkawa N., Saitoh Y., Ghandour K., Nishizono H., Matsuo M., Hirayama T., Muramatsu S., Kaneko R., Yagi T., and Inokuchi K.
  • Organizer: Neuroscience 2019, Annual Meeting of Society for Neuroscience
  • Int'l Joint Research
• [Presentation] Pre-configured Ensembles are Recruited into Upcoming Hippocampal Engram. (2019)
  • Author(s): Ghandour K., Ohkawa N., Fung C. A., Asai H., Saitoh Y., Takekawa T., Nishizono H., Sato M., Ohkura M., Nakai J., Hayashi Y., Fukai T., and Inokuchi K.
  • Organizer: The 18th Annual MCCS meeting
  • Int'l Joint Research
• [Presentation] Deletion of cPcdhs affects cell ensemble activities in the hippocampus. (2019)
  • Author(s): Asai H., Ohkawa N., Saitoh Y., Ghandour K., Nishizono H., Matsuo M., Hirayama T., Muramatsu S., Kaneko R., Yagi T., and Inokuchi K.
  • Organizer: The 18th Annual MCCS meeting
  • Int'l Joint Research
• [Presentation] Synapse-specific plasticity governs the identity of overlapping memory traces. (2019)
  • Author(s): Abdou K., Shehata M., Choko K., Nishizono H., Matsuo M., Muramatsu S, and Inokuchi K.
  • Organizer: Current Trends and Future Directions of Synapse-Circuit Plasticity Research
• [Presentation] Manipulation of fear memory association by posterior parietal cortex. (2019)
  • Author(s): Suzuki A., Kosugi S., Murayama E., Ohkawa N., Matsuo M., Nishizono H., and Inokuchi K.
  • Organizer: Current Trends and Future Directions of Synapse-Circuit Plasticity Research
• [Presentation] Pre-configured Ensembles are Recruited into Upcoming Hippocampal Engram. (2019)
  • Author(s): Ghandour K., Ohkawa N., Fung C. A., Asai H., Saitoh Y., Takekawa T., Nishizono H., Sato M., Ohkura M., Nakai J., Hayashi Y., Fukai T., and Inokuchi K.
  • Organizer: NEURO2019（第42回日本神経科学大会、第62回日本神経化学会大会）,
• [Presentation] Involvement of the CA3 recurrent circuit in the memory consolidation and retrieval. (2019)
  • Author(s): Nomoto M., Murayama E., Haga T., Ohkawa N., Muramatsu S, Fukai T, and Inokuchi K.
  • Organizer: NEURO2019（第42回日本神経科学大会、第62回日本神経化学会大会）
• [Presentation] Deletion of cPcdhs affects cell ensemble activities in the hippocampus. (2019)
  • Author(s): Asai H., Ohkawa N., Saitoh Y., Ghandour K., Nishizono H., Matsuo M., Hirayama T., Muramatsu S., Kaneko R., Yagi T., and Inokuchi K.
  • Organizer: NEURO2019（第42回日本神経科学大会、第62回日本神経化学会大会）
• [Presentation] Cognition through neural circuit dynamics. (2019)
  • Author(s): Tomoki Fukai
  • Organizer: Toyama Forum for Academic Summit on "Dynamic Brain"
  • Int'l Joint Research / Invited
• [Presentation] Extended associative memory by inhibitory modulation. (2019)
  • Author(s): Tatsuya Haga, Tomoki Fukai
  • Organizer: Neuroscience 2019 (SfN's 49th annual meeting)
  • Int'l Joint Research
• [Presentation] Temporal feature analysis in brain-inspired neural systems. (2019)
  • Author(s): Tomoki Fukai
  • Organizer: Silicon Nanoelectronics Workshop 2019
  • Int'l Joint Research / Invited
• [Presentation] Temporal feature analysis by self-supervising dendritic neurons. (2019)
  • Author(s): Tomoki Fukai
  • Organizer: 2019 Gordon Research Conference on Dendrites: Molecules, Structure and Function
  • Int'l Joint Research / Invited
• [Presentation] マウスにおけるゲノム編集と行動解析を起点とした精神疾患研究 (2019)
  • Author(s): 高雄啓三
  • Organizer: 第42回 日本分子生物学会年会
• [Presentation] 超音波散乱波統計解析によるラジオ波加熱されたラット腫瘍組織内温度上昇の非侵襲測定 (2019)
  • Author(s): 竹内 道雄, 坂井 俊彦, Andocs Gabor, 高雄 啓三，長岡 亮，長谷川 英之
  • Organizer: 第40回 超音波エレクトロニクスの基礎と応用に関するシンポジウム
• [Presentation] Mice deficient in Akain1, a novel protein kinase A-binding protein, exhibit decreased pain sensitivity and impaired context discrimination (2019)
  • Author(s): Fujii K, Koshidaka Y, Adachi M, Yanagibashi Y, Matsuo M, Nishizono H, Aizawa Y, & Takao K
  • Organizer: 49th Annual meeting of Society for Neuroscience
  • Int'l Joint Research
• [Presentation] Increased social interaction and anxiety-like behaviors in FLRT2 deficient mice (2019)
  • Author(s): Yamagishi S, Eto F, Shinoda Y, Ogawa S, Yao I, Takao K, Miyakawa T, & Sato K
  • Organizer: 49th Annual meeting of Society for Neuroscience
  • Int'l Joint Research
• [Presentation] Mice deficient in Akain1, a novel protein kinase A-binding protein, exhibit decreased pain sensitivity and impaired context discrimination (2019)
  • Author(s): Takao K, Fujii K, Koshidaka Y, Adachi M, Yanagibashi Y, Matsuo M, Nishizono H, & Aizawa Y
  • Organizer: 18th Annual meeting of MCCS (The Molecular and Cellular Cognition Society) meeting
  • Int'l Joint Research
• [Presentation] 新規プロテインキナーゼA（PKA）結合タンパクAkain1 欠損マウスは痛覚感受性低下と類似条件弁別障害を示す (2019)
  • Author(s): 藤井一希，腰高由美恵，安達真由美，柳橋裕子，松尾美奈，西園啓文，相澤康則，高雄啓三.
  • Organizer: 日本心理学会第83回大会
• [Presentation] Mice deficient in Akain1, a novel protein kinase A-binding protein, exhibit decreased pain sensitivity and impaired context discrimination (2019)
  • Author(s): Kazuki Fujii, Yumie Koshidaka, Mayumi Adachi, Yuko Yanagibashi, Mina Matsuo, Yasunori Aizawa, Keizo Takao.
  • Organizer: 第42回 日本神経科学大会
• [Presentation] Comprehensive behavioral analysis of heterozygous SynGap1 knockout mice (2019)
  • Author(s): Ryuichi Nakajima, Satoko Hattori, Hirotaka Shoji, Keizo Takao, Seth G.N. Grant, Tsuyoshi Miyakawa.
  • Organizer: 第42回 日本神経科学大会
• [Presentation] Repulsive guidance molecule FLRT2 regulates social behavior. (2019)
  • Author(s): Satoru Yamagishi, Fumihiro Eto, Yo shinoda, Shuhei Ogawa, Ikuko Yao, Keizo Takao, Tsuyoshi Miyakawa, Kohji Sato
  • Organizer: 第42回 日本神経科学大会
• [Presentation] Investigation into the role of Glra4, a functionally unknown subunit of glycine receptors, in brain function and neurological disorders. (2019)
  • Author(s): Mohamed Ibrahem Darwish, Takahiro Endo, Kyosuke Uno, Keizo Takao, Hirofumi Nishizono.
  • Organizer: 第42回 日本神経科学大会
• [Presentation] シナプスオーガナイザーPtprd 遺伝子の微小エクソン選択調節の生理的意義 (2019)
  • Author(s): 仙道水月, 和泉宏謙, 今井彩子, 高雄啓三, 森 寿, 吉田知之
  • Organizer: 日本生化学会北陸支部 第37回大会
• [Presentation] 生体の深部加温実験における超音波散乱波の統計的解析による内部温度変化測定 (2019)
  • Author(s): 高雄啓三，長岡 亮，長谷川英之
  • Organizer: 第84回日本温泉気候物理医学会総会・学術集会
• [Presentation] 生体の深部加温実験における超音波散乱波の統計的解析による内部温度変化測定. (2019)
  • Author(s): 竹内道雄, 坂井俊彦, Andocs Gabor, 高雄啓三，長岡 亮，長谷川英之
  • Organizer: 日本超音波医学会第92回学術集会
• [Presentation] メラトニン産生能が異なるマウス系統におけるメラトニン投与による行動特性変化の解析 (2019)
  • Author(s): 新山貴仁, 藤村耕平, 藤井一希, 笹川恵理, 腰高由美恵, 安達真由美, 高雄啓三
  • Organizer: 第66回日本実験動物学会
• [Presentation] 生体の深部加温実験における超音波散乱波の統計的解析による内部温度変化測定 (2019)
  • Author(s): 竹内道雄, 坂井俊彦, Andocs Gabor, 高雄啓三，長岡 亮，長谷川英之.
  • Organizer: 第84回日本温泉気候物理医学会総会・学術集会
• [Presentation] Association and identity of memory. (2019)
  • Author(s): Inokuchi K.
  • Organizer: The 9th Federation of the Asian and Oceanian Physiological Societies Congress
  • Invited
• [Presentation] Effects of chronic fentanyl administration on behavioral characteristics of mice (2019)
  • Author(s): 藤井一希, 腰高由美恵, 安達真由美, 高雄啓三
  • Organizer: 学術研究支援基盤形成先端モデル動物支援プラットフォーム成果発表会
• [Presentation] ストレス応答性翻訳制御因子NFAR2 の天然変性領域欠損マウスの網羅的行動解析 (2019)
  • Author(s): 山下 映、藤井 一希、腰高由美恵、安達真由美、笹川恵理、中川真一、高雄啓三、椎名伸之
  • Organizer: 学術研究支援基盤形成先端モデル動物支援プラットフォーム成果発表会
• [Presentation] Repulsive guidance molecule FLRT2 regulates neuronal migration and social (2019)
  • Author(s): 山岸 覚、衛藤史博、篠田 陽、小川修二、矢尾育子、宮川 剛、高雄啓三、佐藤康二
  • Organizer: 学術研究支援基盤形成先端モデル動物支援プラットフォーム成果発表会
• [Presentation] 行動学的解析支援-大規模行動解析データの二次利用方法と行動解析用ソフトウエアの紹介 (2019)
  • Author(s): 服部聡子, 昌子浩孝, 高雄啓三, 宮川 剛
  • Organizer: 学術研究支援基盤形成先端モデル動物支援プラットフォーム成果発表会
• [Presentation] IgA 欠損マウスにおける生体機能に関する解析 (2019)
  • Author(s): 安達貴弘, 高雄啓三, 永石宇司, 渡部太郎
  • Organizer: 学術研究支援基盤形成先端モデル動物支援プラットフォーム成果発表会
  • Int'l Joint Research
• [Presentation] 記憶を改変する：記憶の物理化学的実体の理解に基づいて (2018)
  • Author(s): 井ノ口馨
  • Organizer: 日本麻酔科学会 第65回学術集会
  • Invited
• [Presentation] Synapse-specific plasticity within engram assemblies governs the memory identity. (2018)
  • Author(s): Inokuchi K.
  • Organizer: The 24th IUBMB, Symposium on Brain Research, Keynote lecture.
  • Int'l Joint Research / Invited
• [Presentation] Cell ensemble mechanisms underlying memory processing. (2018)
  • Author(s): Inokuchi K.
  • Organizer: The 41st Annual Meeting of the Japan Neuroscience Society, Luncheon Seminar.
  • Int'l Joint Research / Invited
• [Presentation] Ensemble representation of contextual memory in hippocampal engram cells. (2018)
  • Author(s): Ohkawa N., and Inokuchi K.
  • Organizer: The 41st Annual Meeting of the Japan Neuroscience Society, Symposium.
  • Int'l Joint Research
• [Presentation] Synapse-specific Representation of the Identify of Overlapping Memory Engrams. (2018)
  • Author(s): Inokuchi K.
  • Organizer: 2nd Pain and Emotions Summer Meeting
  • Int'l Joint Research / Invited
• [Presentation] Identity and the association of memories. (2018)
  • Author(s): Inokuchi K.
  • Organizer: The 13th International Conference of Neurons and Brain Diseases, Association for the study of neurons and diseases
  • Int'l Joint Research
• [Presentation] Orchestrated ensembles activity constitute hippocampal memory engram. (2018)
  • Author(s): Ghandour K.
  • Organizer: The 17th Annual MCCS meeting, 2018.
  • Int'l Joint Research
• [Presentation] 記憶の物理化学的実体 (2018)
  • Author(s): 井ノ口馨
  • Organizer: 日本基礎心理学会第37回大会
  • Invited
• [Presentation] Establishment of in vivo field excitatory post synaptic potential (fEPSP) recording system at hippocampal CA3-CA3 synapses. (2018)
  • Author(s): Oishi N., Koga K., Nomoto M., Ohkawa N., Tsujimura S., Sano Y., Saitoh Y., Nishizono H., Matsuo M., Muramatsu S, and Inokuchi K.
  • Organizer: The 41st Annual Meeting of the Japan Neuroscience Society
  • Int'l Joint Research
• [Presentation] Synapse-specific representation of the identity of multiple memory engrams. (2018)
  • Author(s): Abdou K.M., Shehata M., Choko K., Nishizono H., Matsuo M., Muramatsu S, and Inokuchi K.
  • Organizer: The 41st Annual Meeting of the Japan Neuroscience Society
  • Int'l Joint Research
• [Presentation] Integrating Neuronal Ensembles Constitute and Replay Hippocampal Engram. (2018)
  • Author(s): Ghandour K., Ohkawa N., Fung C.C.A., Asai H., Saitoh Y., Takekawa T., Okubo-Suzuki R., Soya S., Nishizono H., Matsuo M., Sato M., Ohkura M., Nakai J., Hayashi Y., Sakurai T., Osanai M., Kitamura T.,Fukai T, and Inokuchi K.
  • Organizer: The 41st Annual Meeting of the Japan Neuroscience Society
  • Int'l Joint Research
• [Presentation] Impairment of memory consolidation by anesthesia immediately after conditioning. (2018)
  • Author(s): Kameyama A., Asai H., Saitoh Y., Ghandour K., Okubo-Suzuki R., Nomoto M., Tsujimura S., Ohkawa N, and Inokuchi K.
  • Organizer: The 41st Annual Meeting of the Japan Neuroscience Society
  • Int'l Joint Research
• [Presentation] Hippocampal CA3 is involved in associative memory processing via learning-induced high frequent activity. (2018)
  • Author(s): Nomoto M., Murayama E., Ohkawa N., Nishizono H., Matsuo M., Muramatsu S, and Inokuchi K.
  • Organizer: The 41st Annual Meeting of the Japan Neuroscience Society
  • Int'l Joint Research
• [Presentation] Posterior parietal cortexによる記憶連合制御 (2018)
  • Author(s): 鈴木章円，小杉桜子，村山絵美，大川宜昭，辻村周平，松尾美奈，西園啓文，井ノ口馨
  • Organizer: 生理学研究所研究会 記憶・学習の基盤機構と回路研究の新展開へのアプローチ
• [Presentation] Muramatsu S., and Inokuchi K. :Synchronous activation of distinct memory ensembles in CA3 integrate two memories. (2018)
  • Author(s): Oishi N., Koga K., Nomoto M., Ohkawa N., Tsujimura S., Sano Y., Saitoh Y., Nishizono H., Matsuo M., Muramatsu S., and Inokuchi K.
  • Organizer: 生理学研究所研究会 記憶・学習の基盤機構と回路研究の新展開へのアプローチ
• [Presentation] Synapse-specific plasticity governs the identity of overlapping memory engrams. (2018)
  • Author(s): Abdou K.M., Shehata M.H., Choko K., Nishizono H., Matsuo M., Muramatsu S, and Inokuchi K.
  • Organizer: The 17th Annual MCCS meeting
  • Int'l Joint Research
• [Presentation] Manipulation of fear memory association by posterior parietal cortex. (2018)
  • Author(s): Suzuki A., Kosugi S., Murayama E., Ohkawa N., Matsuo M., Nishizono H., and Inokuchi K.
  • Organizer: The 17th Annual MCCS meeting
  • Int'l Joint Research
• [Presentation] Orchestrated ensembles activity constitute hippocampal memory engram. (2018)
  • Author(s): Ghandour K., Ohkawa N., Fung C. A., Asai H, Saitoh Y., Takekawa T., Okubo-Suzuki R., Soya S., Nishizono H., Matsuo M. , Osanai M., Sato M., Ohkura M., Nakai J., Hayashi Y., Sakurai T., Kitamura T., Fukai T., and Inokuchi K.
  • Organizer: The 17th Annual MCCS meeting
  • Int'l Joint Research
• [Presentation] Synapse-specific plasticity governs the identity of overlapping memory engrams. (2018)
  • Author(s): Abdou K.M., Shehata M.H., Choko K., Nishizono H., Matsuo M., Muramatsu S, and Inokuchi K.
  • Organizer: Neuroscience 2018, Annual Meeting of Society for Neuroscience,
  • Int'l Joint Research
• [Presentation] Manipulation of fear memory association by posterior parietal cortex. (2018)
  • Author(s): Suzuki A., Kosugi S., Murayama E., Ohkawa N., Matsuo M., Nishizono H., and Inokuchi K.
  • Organizer: Neuroscience 2018, Annual Meeting of Society for Neuroscience
  • Int'l Joint Research
• [Presentation] Orchestrated ensembles activity constitute hippocampal memory engram. (2018)
  • Author(s): Ghandour K., Ohkawa N., Fung C. A., Asai H, Saitoh Y., Takekawa T., Okubo-Suzuki R., Soya S., Nishizono H., Matsuo M. , Osanai M., Sato M., Ohkura M., Nakai J., Hayashi Y., Sakurai T., Kitamura T., Fukai T., and Inokuchi K.
  • Organizer: Neuroscience 2018, Annual Meeting of Society for Neuroscience
  • Int'l Joint Research
• [Presentation] APPノックインマウスの若齢期における行動表現型解析 (2018)
  • Author(s): 木村公洋, 藤井一希, 腰高由美恵, 安達真由美, 松尾美奈, 柳橋裕子, 斉藤貴志, 西道隆臣, 高雄啓三
  • Organizer: 第65回日本実験動物学会総会
• [Presentation] 合成オピオイドフェンタニルの慢性投与がマウスの行動特性に与える影響 (2018)
  • Author(s): 藤井一希, 腰高由美恵, 安達真由美, 高雄啓三
  • Organizer: 第65回日本実験動物学会総会
• [Presentation] 精神疾患モデルマウスにおける軽度慢性炎症 (2018)
  • Author(s): 高雄啓三
  • Organizer: 第8回オルソオルガノジェネシス検討会
• [Presentation] Pelizaeus-Merzbacher disease様ヒト先天性大脳白質形成不全症に関わるグリシンレセプターα4ノックアウトマウスの作製と病熊解析 Generation and characterization of glycine receptor algha 4 subunit (Glra4) knockout mice. (2018)
  • Author(s): 西園啓文, Darwish Mohamed lbrahem, 澤田瞳子, 高雄啓三
  • Organizer: 第41回日本神経科学大会
• [Presentation] Cdkl5ノックアウトマウスの網羅的行動解析の結果、不安・恐怖関連行動の著しい亢進、うつ様行動と社会性の特異な変化と、空間記憶の獲得と保持の障害が明らかとなった。 (2018)
  • Author(s): 田中輝幸, 奥田耕助, 高雄啓三, 渡邉 紀, 水口 雅, 宮川 剛
  • Organizer: 第41回日本神経科学大会
• [Presentation] CASK-interacting_protein 1 (Gaskin 1)の中枢神経系における機能的特徴の解析 (2018)
  • Author(s): 片野泰代, 高雄啓三, 阿部 学, 山崎真弥, 渡辺雅彦, 宮川 剛, 崎村建司, 伊藤誠二
  • Organizer: 第41回日本神経科学大会
• [Presentation] ミクログリアに発現する電位依存性プロトンチャンネルの加齢依存的な機能 (2018)
  • Author(s): 河合喬文, 高雄啓三, 崎村健司, 宮川 剛 , 岡村康司
  • Organizer: 第41回日本神経科学大会
• [Presentation] 神経軸索ガイダンス分子FLRT2による社会性行動制御 Repulsive axon guidance molecule FLRT2 regulates neuronal migration and Social Behavior (2018)
  • Author(s): 山岸 覚, 篠田陽, 小川修平, 宮川 剛 , 高雄啓三, 佐藤康二
  • Organizer: 第41回日本神経科学大会
• [Presentation] Repulsive axon guidance molecule FLRT2 regulates neuronal migration and social behavior. (2018)
  • Author(s): S. Yamagishi, Y. Shinoda, S. Ogawa, T. Miyakawa, K. Takao, K. Sato
  • Organizer: 48th Annual meeting of Society for Neuroscience
  • Int'l Joint Research
• [Presentation] Protein distributionand functional characterization of CASK-interacting protein 1 (Caskin1) in mice. (2018)
  • Author(s): T. Katano, K. Takao, M. Abe, M. Yamazaki, M. Watanabe, T. MIiyakawa, K. Sakimura, S. Ito
  • Organizer: 48th Annual meeting of Society for Neuroscience
  • Int'l Joint Research
• [Presentation] Generation of glycine receptor alpha 4 knockout mice using high-efficient modified CRISPR-Cas9 protocol. (2018)
  • Author(s): M. I. Darwish, K. Uno, K. Takao, H. Nishizono
  • Organizer: 48th Annual meeting of Society for Neuroscience
  • Int'l Joint Research
• [Presentation] ストレス応答性翻訳制御因子NFAR2の天然変性領域欠損マウスの網羅的行動解析 (2018)
  • Author(s): 山下 映, 藤井一希, 腰高由美恵, 安達真由美, 笹川恵理, 中川真一, 高雄啓三、椎名伸之
  • Organizer: 第41回日本分子生物学会年会
• [Remarks] DEPARTMENT OF BIOCHEMISTRY INOKUCHI LAB.
  • URL: http://www.med.u-toyama.ac.jp/bmb/index-j.html
• [Remarks] 深井研究室ホームページ
  • URL: https://groups.oist.jp/ncbc
• [Remarks] 富山大学大学院 医学部生化学講座
  • URL: http://www.med.u-toyama.ac.jp/bmb/index-j.html
• [Remarks] 富山大学医学部生化学講座ホームページ
  • URL: http://www.med.u-toyama.ac.jp/bmb/index-j.html
• [Remarks] 富山大学大学院医学薬学研究部(医学)生化学講座
  • URL: http://www.med.u-toyama.ac.jp/bmb/index-j.html