| Budget Amount *help |
¥193,570,000 (Direct Cost: ¥148,900,000、Indirect Cost: ¥44,670,000)
Fiscal Year 2022: ¥32,370,000 (Direct Cost: ¥24,900,000、Indirect Cost: ¥7,470,000)
Fiscal Year 2021: ¥32,370,000 (Direct Cost: ¥24,900,000、Indirect Cost: ¥7,470,000)
Fiscal Year 2020: ¥32,370,000 (Direct Cost: ¥24,900,000、Indirect Cost: ¥7,470,000)
Fiscal Year 2019: ¥51,350,000 (Direct Cost: ¥39,500,000、Indirect Cost: ¥11,850,000)
Fiscal Year 2018: ¥45,110,000 (Direct Cost: ¥34,700,000、Indirect Cost: ¥10,410,000)
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| Outline of Final Research Achievements |
We have developed unique biochemical systems that take out the entire "reaction platforms" for piRNAs from cells into test tubes with retaining their proper functions. We have also developed bioinformatic frameworks that can extract the "rules" behind those biochemical reactions. By combining these two approaches, we uncovered how piRNA precursors are processed into mature piRNAs on the outer membrane of mitochondria. Moreover, we discovered a new reaction platform for piRNAs in silkworms and proposed its biological significance. We have also identified novel accessory factors that highly accelerate the piRNA biogenesis reaction. Finally, we carefully characterized a representative "piRNA cluster," the genomic region from which piRNAs are produced.
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| Assessment Rating |
Ex-post Assessment Comments (Rating)
A+: In light of the aim of introducing the research area into the research categories, more research outcomes have been produced than expected.
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Assessment Rating |
Interim Assessment Comments (Rating)
A: In light of the aim of introducing the research area into the research categories, the expected progress has been made in research.
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