| Budget Amount *help |
¥194,740,000 (Direct Cost: ¥149,800,000、Indirect Cost: ¥44,940,000)
Fiscal Year 2022: ¥32,500,000 (Direct Cost: ¥25,000,000、Indirect Cost: ¥7,500,000)
Fiscal Year 2021: ¥32,500,000 (Direct Cost: ¥25,000,000、Indirect Cost: ¥7,500,000)
Fiscal Year 2020: ¥32,500,000 (Direct Cost: ¥25,000,000、Indirect Cost: ¥7,500,000)
Fiscal Year 2019: ¥43,420,000 (Direct Cost: ¥33,400,000、Indirect Cost: ¥10,020,000)
Fiscal Year 2018: ¥53,820,000 (Direct Cost: ¥41,400,000、Indirect Cost: ¥12,420,000)
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| Outline of Final Research Achievements |
This project aimed to propose a novel concept of dynamic regulation and RNA modifications involved in various biological contexts, so as to establish a paradigm shift in epitranscriptomics. We discovered a cap-specific m6A writer for mRNA (Science, 2019), and a reversible phosphorylation of RNA and their physiological functions (Nature, 2022). We also idendified two tRNA-glycosylation enzymes, QTGAL and QTMAN, that introduces galactose and mannose to tRNA queuosine modifications in mammals (Cell, 2023). These findings will greatly contribute to our understanding of the physiological functions of RNA modifications and their dynamic regulation.
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| Assessment Rating |
Ex-post Assessment Comments (Rating)
A: In light of the aim of introducing the research area into the research categories, expected outcomes of research have been produced.
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Assessment Rating |
Interim Assessment Comments (Rating)
A: In light of the aim of introducing the research area into the research categories, the expected progress has been made in research.
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