| Budget Amount *help |
¥193,440,000 (Direct Cost: ¥148,800,000、Indirect Cost: ¥44,640,000)
Fiscal Year 2022: ¥37,960,000 (Direct Cost: ¥29,200,000、Indirect Cost: ¥8,760,000)
Fiscal Year 2021: ¥37,960,000 (Direct Cost: ¥29,200,000、Indirect Cost: ¥8,760,000)
Fiscal Year 2020: ¥37,960,000 (Direct Cost: ¥29,200,000、Indirect Cost: ¥8,760,000)
Fiscal Year 2019: ¥37,960,000 (Direct Cost: ¥29,200,000、Indirect Cost: ¥8,760,000)
Fiscal Year 2018: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
|
|---|
| Outline of Final Research Achievements |
In many eukaryotic cells, two distinct condensin complexes (condensins I and II) cooperate to support mitotic chromosome assembly. To understand the molecular mechanisms of action of the two complexes, we performed a comprehensive set of functional analyses of recombinant complexes (wild type and various mutants) using frog egg extracts. As a result, we were able to identify functional similarities and differences between condensins I and II. We also found that an intrinsically disordered region unique to each complex is involved in phosphorylation-mediated cell cycle regulation. Mathematical modeling and simulations revealed the possibility that the superhelical tension introduced by condensins contributes to mitotic chromosome assembly.
|
