Sulfur-mediated energy metabolism, sulfur respiration: Its discovery and physiological functions

• Project/Area Number: 18H05277
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Review Section: Broad Section H
• Research Institution: Tohoku University
• Principal Investigator: 赤池 孝章 東北大学, 医学系研究科, 教授 (20231798)
• Co-Investigator(Kenkyū-buntansha): 本橋 ほづみ 東北大学, 医学系研究科, 教授 (00282351) ; 西田 基宏 大学共同利用機関法人自然科学研究機構(新分野創成センター、アストロバイオロジーセンター、生命創成探究, 生命創成探究センター, 教授 (90342641)
• Project Period (FY): 2018-06-11 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥193,310,000 (Direct Cost: ¥148,700,000、Indirect Cost: ¥44,610,000); Fiscal Year 2022: ¥31,850,000 (Direct Cost: ¥24,500,000、Indirect Cost: ¥7,350,000); Fiscal Year 2021: ¥31,850,000 (Direct Cost: ¥24,500,000、Indirect Cost: ¥7,350,000); Fiscal Year 2020: ¥31,850,000 (Direct Cost: ¥24,500,000、Indirect Cost: ¥7,350,000); Fiscal Year 2019: ¥45,110,000 (Direct Cost: ¥34,700,000、Indirect Cost: ¥10,410,000); Fiscal Year 2018: ¥52,650,000 (Direct Cost: ¥40,500,000、Indirect Cost: ¥12,150,000)
• Keywords: イオウ呼吸 / システインパースルフィド / イオウメタボローム / エネルギー代謝 / ミトコンドリア機能

Outline of Annual Research Achievements

本研究では、根本的な生命のしくみでありながら、いまだに未知のエネルギー代謝であるイオウ呼吸の全容を解明することで、人類の健康、疾病および寿命のコントロールを可能にする生命科学のセントラルドクマの創成に挑む。これまでに、我々が開発した高感度タンデム質量分析計(LC-MS/MS)による各種イオウ化合物の検出・同定システムにより、システインパースルフィドをはじめとする活性イオウ分子種が大腸菌から哺乳類に至るまで生物種横断的に生成され、タンパク質翻訳に共役した新規ポリスルフィド生成系としてシステインtRNA合成酵素(CARS)を同定した。本年度は、ミトコンドリア型のCARS2の産生するパースルフィドを電子受容体にした電子伝達系と、イオウ代謝酵素SQR (sulfide:quinone oxidoreductase)を介するプロトン供与によるミトコンドリア膜電位形成が確認された。加えて、真核生物モデルである出芽酵母を用いてパースルフィドによる生理機能解析を行なった結果、CARS変異株(選択的イオウ代謝不全株:タンパク質翻訳は正常)は野生株に比べて、細胞内システンパースルフィド量の減少に伴い、経時寿命の大幅な短縮が認められた。さらに、活性イオウ分子捕捉カプセルを用いて、広く自然界に存在する超イオウ分子が哺乳類・ヒトの生体内において、当初の想定を超える高濃度の蓄積と、超イオウ分子によるミトコンドリアエネルギー代謝への関与を見出した。これらのことから、ミトコンドリア電子伝達系に共役したイオウ代謝経路が、真核生物のイオウ呼吸に重要な役割を果たしていることが示唆された。

Research Progress Status

令和4年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和4年度が最終年度であるため、記入しない。

Assessment Rating

Interim Assessment Comments (Rating)

A: In light of the aim of introducing the research area into the research categories, the expected progress has been made in research.

Research Products

• [Int'l Joint Research] German Cancer Research Center/Helmholtz(ドイツ)
• [Int'l Joint Research] National Institute of Oncology(ハンガリー)
• [Int'l Joint Research] University of Vermont/Brown University(米国)
• [Int'l Joint Research] Birmingham(英国)
• [Int'l Joint Research] National Institute of Oncology(ハンガリー)
• [Int'l Joint Research] Sonoma State University/University of Vermont/University of Alabama at Birmingham(米国)
• [Int'l Joint Research] University of Southampton/King's College London(英国)
• [Int'l Joint Research] National Institute of Oncology(ハンガリー)
• [Int'l Joint Research] Sonoma State University/University of Vermont/University of Alabama at Birmingham(米国)
• [Int'l Joint Research] University of Southampton/King's College London(英国)
• [Journal Article] 2H-Thiopyran-2-thione sulfine, a compound for converting H2S to HSOH/H2S2 and increasing intracellular sulfane sulfur levels (2024)
  • Author(s): Cui Qi、Shieh Meg、Pan Tony W.、Nishimura Akiyuki、Matsunaga Tetsuro、Kelly Shane S.、Xu Shi、Jung Minkyung、Ogata Seiryo、Morita Masanobu、Yoshitake Jun、Chen Xiaoyan、Robinson Jerome R.、Qian Wei-Jun、Nishida Motohiro、Akaike Takaaki、Xian Ming
  • Journal Title: Nature Communications Volume: 15 Issue: 1 Pages: 2453-2453
  • DOI: 10.1038/s41467-024-46652-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Essential role of ROS - 8-Nitro-cGMP signaling in long-term memory of motor learning and cerebellar synaptic plasticity (2024)
  • Author(s): Kakizawa Sho、Arasaki Tomoko、Yoshida Ayano、Sato Ayami、Takino Yuka、Ishigami Akihito、Akaike Takaaki、Yanai Shuichi、Endo Shogo
  • Journal Title: Redox Biology Volume: 70 Pages: 103053-103053
  • DOI: 10.1016/j.redox.2024.103053
  • Peer Reviewed / Open Access
• [Journal Article] Regulation of innate immune and inflammatory responses by supersulfides (2024)
  • Author(s): Tsutsuki Hiroyasu、Zhang Tianli、Akaike Takaaki、Sawa Tomohiro
  • Journal Title: International Immunology Volume: 36 Issue: 4 Pages: 143-154
  • DOI: 10.1093/intimm/dxad057
  • Peer Reviewed / Open Access
• [Journal Article] Longevity control by supersulfide-mediated mitochondrial respiration and regulation of protein quality (2024)
  • Author(s): Nishimura Akira、Yoon Sunghyeon、Matsunaga Tetsuro、Ida Tomoaki、Jung Minkyung、Ogata Seiryo、Morita Masanobu、Yoshitake Jun、Unno Yuka、Barayeu Uladzimir、Takata Tsuyoshi、Takagi Hiroshi、Motohashi Hozumi、van der Vliet Albert、Akaike Takaaki
  • Journal Title: Redox Biology Volume: 69 Pages: 103018-103018
  • DOI: 10.1016/j.redox.2023.103018
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Quantitative profiling of supersulfides naturally occurring in dietary meats and beans (2024)
  • Author(s): Kasamatsu Shingo、Kinno Ayaka、Miura Chiharu、Hishiyama Jun-ichi、Fukui Kensuke、Kure Shoji、Tsumura Kazunobu、Ida Tomoaki、Matsunaga Tetsuro、Akaike Takaaki、Ihara Hideshi
  • Journal Title: Analytical Biochemistry Volume: 685 Pages: 115392-115392
  • DOI: 10.1016/j.ab.2023.115392
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Supersulfides support bone growth by promoting chondrocyte proliferation in the growth plates (2024)
  • Author(s): Sasama Yuji、Yoshimura Kentaro、Hoshino Marie、Sasa Kiyohito、Akaike Takaaki、Morita Masanobu、Baba Kazuyoshi、Shirota Tatsuo、Miyamoto Yoichi
  • Journal Title: Journal of Oral Biosciences Volume: 66 Issue: 1 Pages: 76-81
  • DOI: 10.1016/j.job.2023.11.004
  • Peer Reviewed / Open Access
• [Journal Article] Redox regulation of xenobiotics by reactive sulfur and supersulfide species (2024)
  • Author(s): Zhang Tianli、Akaike Takaaki、Sawa Tomohiro
  • Journal Title: Antioxidants Redox Signaling Volume: 40 Issue: 10-12 Pages: 679-690
  • DOI: 10.1089/ars.2022.0172
  • Peer Reviewed / Open Access
• [Journal Article] Alkyl gallates inhibit serine O-acetyltransferase in bacteria and enhance susceptibility of drug-resistant Gram-negative bacteria to antibiotics (2023)
  • Author(s): Toyomoto Touya、Ono Katsuhiko、Shiba Tomoo、Momitani Kenta、Zhang Tianli、Tsutsuki Hiroyasu、Ishikawa Takeshi、Hoso Kanae、Hamada Koma、Rahman Azizur、Wen Liping、Maeda Yosuke、Yamamoto Keiichi、Matsuoka Masao、Hanaoka Kenjiro、Niidome Takuro、Akaike Takaaki、Sawa Tomohiro
  • Journal Title: Frontiers in Microbiology Volume: 14 Pages: 1276447-1276447
  • DOI: 10.3389/fmicb.2023.1276447
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Supersulfide biology and translational medicine for disease control (2023)
  • Author(s): Barayeu Uladzimir、Sawa Tomohiro、Nishida Motohiro、Wei Fan-Yan、Motohashi Hozumi、Akaike Takaaki
  • Journal Title: British Journal of Pharmacology Volume: - Pages: 1-11
  • DOI: 10.1111/bph.16271
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Untargeted polysulfide omics analysis of alternations in polysulfide production during the germination of broccoli sprouts (2023)
  • Author(s): Kasamatsu Shingo、Owaki Takuma、Komae Somei、Kinno Ayaka、Ida Tomoaki、Akaike Takaaki、Ihara Hideshi
  • Journal Title: Redox Biology Volume: 67 Pages: 102875-102875
  • DOI: 10.1016/j.redox.2023.102875
  • Peer Reviewed / Open Access
• [Journal Article] Hypoxic erythrocytes mediate cardioprotection through activation of soluble guanylate cyclase and release of cyclic GMP (2023)
  • Author(s): Yang Jiangning、Sundqvist Michaela L.、Zheng Xiaowei、Jiao Tong、Collado Aida、Tratsiakovich Yahor、Mahdi Ali、Tengbom John、Mergia Evanthia、Catrina Sergiu-Bogdan、Zhou Zhichao、Carlstrom Mattias、Akaike Takaaki、Cortese-Krott Miriam M.、Weitzberg Eddie、Lundberg Jon O.、Pernow John
  • Journal Title: Journal of Clinical Investigation Volume: 133 Issue: 17
  • DOI: 10.1172/jci167693
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Persulfide biosynthesis conserved evolutionarily in all organisms (2023)
  • Author(s): Ogata Seiryo、Matsunaga Tetsuro、Jung Minkyung、Barayeu Uladzimir、Morita Masanobu、Akaike Takaaki
  • Journal Title: Antioxidants Redox Signaling Volume: 39 Issue: 13-15 Pages: 983-999
  • DOI: 10.1089/ars.2023.0405
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Supersulfide catalysis for nitric oxide and aldehyde metabolism (2023)
  • Author(s): Kasamatsu Shingo、Nishimura Akira、Alam Md. Morshedul、Morita Masanobu、Shimoda Kakeru、Matsunaga Tetsuro、Jung Minkyung、Ogata Seiryo、Barayeu Uladzimir、Ida Tomoaki、Nishida Motohiro、Nishimura Akiyuki、Motohashi Hozumi、Akaike Takaaki
  • Journal Title: Science Advances Volume: 9 Issue: 33 Pages: 1-11
  • DOI: 10.1126/sciadv.adg8631
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sulfur metabolic response in macrophage limits excessive inflammatory response by creating a negative feedback loop. (2023)
  • Author(s): Takeda H, Murakami S, Liu Z, Sawa T, Takahashi M, Izumi Y, Bamba T, Sato H, Akaike T, Sekine H, Motohashi H*.
  • Journal Title: Redox Biology Volume: 65 Pages: 102834-102834
  • DOI: 10.1016/j.redox.2023.102834
  • Peer Reviewed / Open Access
• [Journal Article] Supersulphides provide airway protection in viral and chronic lung diseases (2023)
  • Author(s): Matsunaga Tetsuro、Sano Hirohito、Takita Katsuya、Morita Masanobu、Yamanaka Shun、Ichikawa Tomohiro、Numakura Tadahisa、Ida Tomoaki、Jung Minkyung、Ogata Seiryo、Yoon Sunghyeon、Fujino Naoya、Kyogoku Yorihiko、Akaike Takaaki、et al.
  • Journal Title: Nature Communications Volume: 14 Issue: 1 Pages: 4476-4476
  • DOI: 10.1038/s41467-023-40182-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Glutathione trisulfide prevents lipopolysaccharide-induced retinal inflammation via inhibition of proinflammatory cytokine production in glial cells (2023)
  • Author(s): Tawarayama Hiroshi、Umeki Kota、Inoue-Yanagimachi Maki、Takahashi Naoki、Hasegawa Hirokazu、Himori Noriko、Tsuda Satoru、Kunikata Hiroshi、Akaike Takaaki、Nakazawa Toru
  • Journal Title: Scientific Reports Volume: 13 Issue: 1 Pages: 11513-11513
  • DOI: 10.1038/s41598-023-38696-4
  • Peer Reviewed / Open Access
• [Journal Article] Development of methods for quantitative determination of the total and reactive polysulfides: Reactive polysulfide profiling in vegetables (2023)
  • Author(s): Kasamatsu Shingo、Kinno Ayaka、Hishiyama Jun-ichi、Akaike Takaaki、Hideshi IharaIhara Hideshi
  • Journal Title: Food Chemistry Volume: 413 Pages: 135610-135610
  • DOI: 10.1016/j.foodchem.2023.135610
  • Peer Reviewed / Open Access
• [Journal Article] Presence of <i>Helicobacter cinaedi</i> in Atherosclerotic Abdominal Aortic Aneurysmal Wall (2023)
  • Author(s): Horii Shinichiro、Sugawara Hirofumi、Goto Hitoshi、Hashimoto Munetaka、Matsunaga Tetsuro、Akamatsu Daijirou、Tajima Yuta、Umetsu Michihisa、Akaike Takaaki、Kamei Takashi
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 261 Issue: 1 Pages: 35-41
  • DOI: 10.1620/tjem.2023.J049
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cystathionine γ-lyase self-inactivates by polysulfidation during cystine metabolism (2023)
  • Author(s): Araki Shoma、Takata Tsuyoshi、Ono Katsuhiko、Sawa Tomohiro、Kasamatsu Shingo、Ihara Hideshi、Kumagai Yoshito、Akaike Takaaki、Watanabe Yasuo、Tsuchiya Yukihiro
  • Journal Title: International Journal of Molecular Sciences Volume: 24 Issue: 12 Pages: 9982-9982
  • DOI: 10.3390/ijms24129982
  • Peer Reviewed / Open Access
• [Journal Article] Reactive sulfur species omics analysis in the brain tissue of the 5xFAD mouse model of Alzheimer’s disease (2023)
  • Author(s): Kinno Ayaka、Kasamatsu Shingo、Akaike Takaaki、Ihara Hideshi
  • Journal Title: Antioxidants Volume: 12 Issue: 5 Pages: 1105-1105
  • DOI: 10.3390/antiox12051105
  • Peer Reviewed / Open Access
• [Journal Article] Synthesis of sulfides and persulfides is not impeded by disruption of three canonical enzymes in sulfur metabolism (2023)
  • Author(s): Zainol Abidin Qamarul Hafiz、Ida Tomoaki、Morita Masanobu、Matsunaga Tetsuro、Nishimura Akira、Jung Minkyung、Hassan Naim、Takata Tsuyoshi、Ishii Isao、Kruger Warren、Wang Rui、Motohashi Hozumi、Tsutsui Masato、Akaike Takaaki
  • Journal Title: Antioxidants Volume: 12 Issue: 4 Pages: 868-868
  • DOI: 10.3390/antiox12040868
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Polysulfide metabolizing enzymes influence SqrR-mediated sulfide-induced transcription by impacting intracellular polysulfide dynamics (2023)
  • Author(s): Shimizu Takayuki、Ida Tomoaki、Antelo Giuliano T、Ihara Yuta、Fakhoury Joseph N、Masuda Shinji、Giedroc David P、Akaike Takaaki、Capdevila Daiana A、Masuda Tatsuru
  • Journal Title: PNAS Nexus Volume: 2 Issue: 3 Pages: 1-11
  • DOI: 10.1093/pnasnexus/pgad048
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Contribution of NRF2 to sulfur metabolism and mitochondrial activity (2023)
  • Author(s): Alam Md Morshedul、Kishino Akihiro、Sung Eunkyu、Sekine Hiroki、Abe Takaaki、Murakami Shohei、Akaike Takaaki、Motohashi Hozumi
  • Journal Title: Redox Biology Volume: 60 Pages: 102624-102624
  • DOI: 10.1016/j.redox.2023.102624
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Echinochrome prevents sulfide catabolism-associated chronic heart failure after myocardial infarction in mice (2023)
  • Author(s): Tang Xiaokang、Nishimura Akiyuki、Ariyoshi Kohei、Nishiyama Kazuhiro、Kato Yuri、Vasileva Elena A.、Mishchenko Natalia P.、Fedoreyev Sergey A.、Stonik Valentin A.、Kim Hyoung-Kyu、Han Jin、Kanda Yasunari、Umezawa Keitaro、Urano Yasuteru、Akaike Takaaki、Nishida Motohiro
  • Journal Title: Marine Drugs Volume: 21 Issue: 1 Pages: 52-52
  • DOI: 10.3390/md21010052
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cysteine hydropersulfide reduces lipid peroxidation and protects against myocardial ischaemia-reperfusion injury - Are endogenous persulfides mediators of ischaemic preconditioning? (2023)
  • Author(s): Griffiths Kayleigh、Ida Tomoaki、Morita Masanobu、Lamb Reece J.、Lee Jordan J.、Frenneaux Michael P.、Fukuto Jon M.、Akaike Takaaki、Feelisch Martin、Madhani Melanie
  • Journal Title: Redox Biology Volume: 60 Pages: 102605-102605
  • DOI: 10.1016/j.redox.2023.102605
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 8-Nitro-cGMP suppresses mineralization by mouse osteoblasts (2022)
  • Author(s): Kaneko K, Miyamoto Y, Ida T, Morita M, Yoshimura K, Nagasaki K, Toba K, Sugisaki R, Motohashi H, Akaike T, Chikazu D, Kamijo R
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 71 Issue: 3 Pages: 191-197
  • DOI: 10.3164/jcbn.21-129
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed / Open Access
• [Journal Article] Cystine-dependent antiporters buffer against excess intracellular reactive sulfur species-induced stress (2022)
  • Author(s): Akiyama Masahiro、Unoki Takamitsu、Aoki Hanako、Nishimura Akiyuki、Shinkai Yasuhiro、Warabi Eiji、Nishiyama Kazuhiro、Furumoto Yuka、Anzai Naohiko、Akaike Takaaki、Nishida Motohiro、Kumagai Yoshito
  • Journal Title: Redox Biology Volume: 57 Pages: 102514-102514
  • DOI: 10.1016/j.redox.2022.102514
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Development of an anti-oxidative intraocular irrigating solution based on reactive persulfides (2022)
  • Author(s): Kunikata Hiroshi、Tawarayama Hiroshi、Tsuda Satoru、Akaike Takaaki、Nakazawa Toru
  • Journal Title: Scientific Reports Volume: 12 Issue: 1 Pages: 19243-12316
  • DOI: 10.1038/s41598-022-21677-4
  • Peer Reviewed / Open Access
• [Journal Article] Coupled discrete phase model and Eulerian wall film model for numerical simulation of respiratory droplet generation during coughing (2022)
  • Author(s): Anzai Hitomi、Shindo Yugo、Kohata Yutaro、Hasegawa Masahiro、Takana Hidemasa、Matsunaga Tetsuro、Akaike Takaaki、Ohta Makoto
  • Journal Title: Scientific Reports Volume: 12 Issue: 1 Pages: 14849-14849
  • DOI: 10.1038/s41598-022-18788-3
  • Peer Reviewed / Open Access
• [Journal Article] Shining a light on SSP4: A comprehensive analysis and biological applications for the detection of sulfane sulfurs (2022)
  • Author(s): Shieh Meg、Ni Xiang、Xu Shi、Lindahl Stephen P.、Yang Moua、Matsunaga Tetsuro、Flaumenhaft Robert、Akaike Takaaki、Xian Ming
  • Journal Title: Redox Biology Volume: 56 Pages: 102433-102433
  • DOI: 10.1016/j.redox.2022.102433
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Subtilase cytotoxin from Shiga-toxigenic Escherichia coli impairs the inflammasome and exacerbates enteropathogenic bacterial infection. (2022)
  • Author(s): Tsutsuki Hiroyasu, Zhang Tianli, Yahiro Kinnosuke, Ono Katsuhiko, Fujiwara Yukio, Iyoda Sunao, Wei Fan-Yan, Monde Kazuaki, Seto Kazuko, Ohnishi Makoto, Oshiumi Hiroyuki, Akaike Takaaki, Sawa Tomohiro.
  • Journal Title: iScience Volume: 25 Issue: 4 Pages: 104050-104050
  • DOI: 10.1016/j.isci.2022.104050
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Regulation of nitric oxide/reactive oxygen species redox signaling by nNOS splicing variants. (2022)
  • Author(s): Kasamatsu Shingo, Tsutsuki Hiroyasu, Ida Tomoaki, Sawa Tomohiro, Watanabe Yasuo, Akaike Takaaki, Ihara Hideshi.
  • Journal Title: Nitric Oxide Volume: 120 Pages: 44-52
  • DOI: 10.1016/j.niox.2022.01.004
  • Peer Reviewed
• [Journal Article] What triggers inflammation in COVID-19? (2022)
  • Author(s): Sawa Tomohiro, Akaike Takaaki.
  • Journal Title: eLife Volume: 11
  • DOI: 10.7554/elife.76231
  • Peer Reviewed / Open Access
• [Journal Article] Redox-dependent internalization of the purinergic P2Y6 receptor limits colitis progression (2022)
  • Author(s): Nishiyama Kazuhiro、Nishimura Akiyuki、Shimoda Kakeru、Tanaka Tomohiro、Kato Yuri、Shibata Takahiro、Tanaka Hiroshi、Kurose Hitoshi、Azuma Yasu-Taka、Ihara Hideshi、Kumagai Yoshito、Akaike Takaaki、Eaton Philip、Uchida Koji、Nishida Motohiro
  • Journal Title: Science Signaling Volume: 15 Issue: 716 Pages: 716-716
  • DOI: 10.1126/scisignal.abj0644
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] GRIM-19 is a target of mycobacterial Zn2+ metalloprotease 1 and indispensable for NLRP3 inflammasome activation. (2022)
  • Author(s): Kurane, T., Matsunaga, T., Ida, T., Sawada, K., Nishimura, A., Fukui, M., Umemura, M., Nakayama, M., Ohara, N., Matsumoto, S., Akaike, T., Matsuzaki, G., Takaesu, G.
  • Journal Title: FASEB Journal Volume: 36 Issue: 1
  • DOI: 10.1096/fj.202101074rr
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Chemical biology of reactive sulfur species: Hydrolysis-driven equilibrium of polysulfides as a determinant of physiological functions. (2022)
  • Author(s): Sawa Tomohiro, Takata Tsuyoshi, Matsunaga Tetsuro, Ihara Hideshi, Motohashi Hozumi, Akaike Takaaki.
  • Journal Title: Antioxidants & Redox Signaling Volume: 36 Issue: 4-6 Pages: 327-336
  • DOI: 10.1089/ars.2021.0170
  • Peer Reviewed / Open Access
• [Journal Article] Virucidal effect of monogalactosyl diacylglyceride from a green microalga, Coccomyxa sp. KJ, against clinical isolates of SARS-CoV-2 as assessed by a plaque assay. (2021)
  • Author(s): Hayashi Kyoko, Asai Satomi, Umezawa Kazuo, Kakizoe Hidehumi, Miyachi Hayato, Morita Masanobu, Akaike Takaaki, Kuno Hitoshi, Komatsu Satoko, Watanabe Takumi, Kawahara Toshio.
  • Journal Title: Journal of Clinical Laboratory Analysis Volume: 36 Issue: 1
  • DOI: 10.1002/jcla.24146
  • Peer Reviewed / Open Access
• [Journal Article] Reprogrammed transsulfuration promotes basal-like breast tumor progression via realigning cellular cysteine persulfidation. (2021)
  • Author(s): Erdelyi Katalin, Ditroi Tamas, Johansson Henrik J., Czikora Agnes, Balog Noemi, Silwal-Pandit Laxmi, Ida Tomoaki, Olasz Judit, Hajdu Dorottya, Matrai Zoltan, Csuka Orsolya, Uchida Koji, Tovari Jozsef, Engebraten Olav, Akaike Takaaki, Borresen Dale Anne-Lise, Kasler Miklos, Lehtio Janne, Nagy Peter.
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 118 Issue: 45
  • DOI: 10.1073/pnas.2100050118
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Methods in sulfide and persulfide research. (2021)
  • Author(s): Takata Tsuyoshi, Jung Minkyung, Matsunaga Tetsuro, Ida Tomoaki, Morita Masanobu, Motohashi Hozumi, Shen Xinggui, Kevil Christopher G., Fukuto Jon M., Akaike Takaaki.
  • Journal Title: Nitric Oxide Volume: 116 Pages: 47-64
  • DOI: 10.1016/j.niox.2021.09.002
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sulfide catabolism ameliorates hypoxic brain injury. (2021)
  • Author(s): Marutani E, Morita M, Hirai S, Kai S, Grange RMH, Miyazaki Y, Nagashima F, Traeger L, Magliocca A, Ida T, Matsunaga T, Batten A, Li R, Tanaka T, Ikeda T, Nakagawa A, Atochin DN, Ihara H, Olenchock BA, Shen X, Nishida M, Hanaoka K, Kevil CG, Xian M, Bloch DB, Akaike T, Hindle AG, Motohashi H, Ichinose F, et al.
  • Journal Title: Nature Communications Volume: 12 Issue: 1 Pages: 3108-3108
  • DOI: 10.1038/s41467-021-23363-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cysteine hydropersulfide inactivates β-lactam antibiotics to form ring opened carbothioic S-acids in bacteria. (2021)
  • Author(s): Ono, K., Kitamura, Y., Zhang, T., Tsutsuki, H., Rahman, A., Akaike, T., Ihara, T., Sawa, T.
  • Journal Title: ACS Chem Biol. Volume: 16 Issue: 4 Pages: 731-739
  • DOI: 10.1021/acschembio.1c00027
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Comment on “Evidence that the ProPerDP method is inadequate for protein persulfidation detection due to lack of specificity”. (2021)
  • Author(s): Doka Eva, Arner Elias SJ, Schmidt Edward E, Dick Tobias P, Vliet Albert van der, Yang Jing, Szatmari Reka, Ditroi Tamas, Wallace John L, Cirino Giuseppe , Olson Kenneth, Motohashi Hozumi, Fukuto Jon M, Pluth Michael D, Feelisch Martin, Akaike Takaaki, Wink David A, Ignarro Louis J, Nagy Peter.
  • Journal Title: Science Advances Volume: 7 Issue: 17
  • DOI: 10.1126/sciadv.abe7006
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Antioxidative and anti-inflammatory actions of reactive cysteine persulfides (2021)
  • Author(s): T. Zhang, H. Tsutsuki, K. Ono, T. Akaike, T. Sawa
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 68 Issue: 1 Pages: 5-8
  • DOI: 10.3164/jcbn.20-13
  • NAID: 130007965274
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] On-tissue polysulfide visualization by surface-enhanced Raman spectroscopy benefits patients with ovarian cancer to predict post-operative chemosensitivity (2021)
  • Author(s): Honda Kazufumi、Hishiki Takako、Yamamoto Sohe、Naito Yoshiko、Matsuura Tomomi、Iwaisako Keiko、Masui Toshihiko、Sakuma Tomohiro、Matsubara Osamu、Huang Wilber、Ida Tomoaki、Akaike Takaaki、Masugi Yohei、Sakamoto Michiie、Kato Tomoyasu、Kabe Yasuaki、Suematsu Makoto
  • Journal Title: Redox Biology Volume: 41 Pages: 101926-101926
  • DOI: 10.1016/j.redox.2021.101926
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Loss of cell wall integrity genes cpxA and mrcB causes flocculation in Escherichia coli (2021)
  • Author(s): Sugawara Keita、Toyoda Hayato、Kimura Mami、Hayasaka Shunsuke、Saito Hiromi、Kobayashi Hiroshi、Ihara Kunio、Ida Tomoaki、Akaike Takaaki、Ando Eiji、Hyodo Mamoru、Hayakawa Yoshihiro、Hamamoto Shin、Uozumi Nobuyuki
  • Journal Title: Biochemical Journal Volume: 478 Issue: 1 Pages: 41-59
  • DOI: 10.1042/bcj20200723
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] High-Precision Sulfur Metabolomics Innovated by a New Specific Probe for Trapping Reactive Sulfur Species (2021)
  • Author(s): Kasamatsu Shingo、Ida Tomoaki、Koga Taisei、Asada Kosho、Motohashi Hozumi、Ihara Hideshi、Akaike Takaaki
  • Journal Title: Antioxidants & Redox Signaling Volume: in press Issue: 18 Pages: 1407-1419
  • DOI: 10.1089/ars.2020.8073
  • Peer Reviewed / Open Access
• [Journal Article] ATP exposure stimulates glutathione efflux as a necessary switch for NLRP3 inflammasome activation. (2021)
  • Author(s): Zhang, T., Tsutsuki, H., Islam, W., Ono, K., Takeda, K., Akaike, T. and Sawa, T.
  • Journal Title: Redox Biology Volume: 41 Pages: 101930-101930
  • DOI: 10.1016/j.redox.2021.101930
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Glutathione Trisulfide Prevents Lipopolysaccharide-induced Inflammatory Gene Expression in Retinal Pigment Epithelial Cells (2020)
  • Author(s): Tawarayama Hiroshi、Suzuki Noriyuki、Inoue-Yanagimachi Maki、Himori Noriko、Tsuda Satoru、Sato Kota、Ida Tomoaki、Akaike Takaaki、Kunikata Hiroshi、Nakazawa Toru
  • Journal Title: Ocular Immunology and Inflammation Volume: in press Issue: 4 Pages: 1-12
  • DOI: 10.1080/09273948.2020.1833224
  • Peer Reviewed
• [Journal Article] Enzymatic Regulation and Biological Functions of Reactive Cysteine Persulfides and Polysulfides (2020)
  • Author(s): Sawa Tomohiro、Motohashi Hozumi、Ihara Hideshi、Akaike Takaaki
  • Journal Title: Biomolecules Volume: 10 Issue: 9 Pages: 1245-1245
  • DOI: 10.3390/biom10091245
  • Peer Reviewed / Open Access
• [Journal Article] 8-Nitro-cGMP modulates exocytosis in adrenal chromaffin cells (2020)
  • Author(s): Tsutsuki Hiroyasu、Kasamatsu Shingo、Kunieda Kohei、Ida Tomoaki、Sawa Tomohiro、Sasakawa Nobuyuki、Akaike Takaaki、Ihara Hideshi
  • Journal Title: Biochemical and Biophysical Research Communications Volume: in press Issue: 1 Pages: 225-230
  • DOI: 10.1016/j.bbrc.2020.03.045
  • Peer Reviewed / Open Access
• [Journal Article] Control of Protein Function Through Oxidation and Reduction of Persulfidated States (2020)
  • Author(s): E Doka, T Ida, M Dagnell, Y Abiko, N C Luong, N Balog, T Takata, B Espinosa, A Nishimura, Q Cheng, Y Funato, H Miki, J M Fukuto, J R Prigge, E E Schmidt, E S J Arner, Y Kumagai, T Akaike, P Nagy
  • Journal Title: Sci Adv Volume: 6 Issue: 1 Pages: 8358-8358
  • DOI: 10.1126/sciadv.aax8358
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Long-lasting blood pressure lowering effects of nitrite are NO-independent and mediated by hydrogen peroxide, persulfides, and oxidation of protein kinase G1α redox signalling (2019)
  • Author(s): Feelisch Martin、Akaike Takaaki、Griffiths Kayleigh、Ida Tomoaki、Prysyazhna Oleksandra、Goodwin Joanna J、Gollop Nicholas D、Fernandez Bernadette O、Minnion Magdalena、Cortese-Krott Miriam M、Borgognone Alessandra、Hayes Rosie M、Eaton Philip、Frenneaux Michael P、Madhani Melanie
  • Journal Title: Cardiovascular Research Volume: 116 Issue: 1 Pages: 51-62
  • DOI: 10.1093/cvr/cvz202
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] AUTACs: Cargo-Specific Degraders Using Selective Autophagy (2019)
  • Author(s): Takahashi Daiki、Moriyama Jun、Nakamura Tomoe、Miki Erika、Takahashi Eriko、Sato Ayami、Akaike Takaaki、Itto-Nakama Kaori、Arimoto Hirokazu
  • Journal Title: Molecular Cell Volume: 76 Issue: 5 Pages: 797-810.e10
  • DOI: 10.1016/j.molcel.2019.09.009
  • Peer Reviewed / Open Access
• [Journal Article] Rational Design of a Dual-Reactivity-Based Fluorescent Probe for Visualizing Intracellular HSNO. (2019)
  • Author(s): Chen W, Matsunaga T, Neill DL, Yang CT, Akaike T, Xian M.
  • Journal Title: Angew Chem Volume: 58 Issue: 45 Pages: 16067-16070
  • DOI: 10.1002/anie.201908950
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Nitrosative stress in patients with asthma?chronic obstructive pulmonary disease overlap (2019)
  • Author(s): Kyogoku Yorihiko、Sugiura Hisatoshi、Ichikawa Tomohiro、Numakura Tadahisa、Koarai Akira、Yamada Mitsuhiro、Fujino Naoya、Tojo Yutaka、Onodera Katsuhiro、Tanaka Rie、Sato Kei、Sano Hirohito、Yamanaka Shun、Itakura Koji、Mitsune Ayumi、Tamada Tsutomu、Akaike Takaaki、Ichinose Masakazu
  • Journal Title: Journal of Allergy and Clinical Immunology Volume: 144 Issue: 4 Pages: 972-983
  • DOI: 10.1016/j.jaci.2019.04.023
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Data‐Driven Identification of Hydrogen Sulfide Scavengers (2019)
  • Author(s): Yang Chun‐tao、Wang Yingying、Marutani Eizo、Ida Tomoaki、Ni Xiang、Xu Shi、Chen Wei、Zhang Hui、Akaike Takaaki、Ichinose Fumito、Xian Ming
  • Journal Title: Angewandte Chemie International Edition Volume: 58 Issue: 32 Pages: 10898-10902
  • DOI: 10.1002/anie.201905580
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Environmental Electrophile-Mediated Toxicity in Mice Lacking Nrf2, CSE, or Both (2019)
  • Author(s): Akiyama Masahiro、Unoki Takamitsu、Shinkai Yasuhiro、Ishii Isao、Ida Tomoaki、Akaike Takaaki、Yamamoto Masayuki、Kumagai Yoshito
  • Journal Title: Environmental Health Perspectives Volume: 127 Issue: 6 Pages: 067002-067002
  • DOI: 10.1289/ehp4949
  • NAID: 120007133174
  • Peer Reviewed / Open Access
• [Journal Article] Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension (2019)
  • Author(s): Rudyk Olena、Rowan Alice、Prysyazhna Oleksandra、Krasemann Susanne、Hartmann Kristin、Zhang Min、Shah Ajay M.、Ruppert Clemens、Weiss Astrid、Schermuly Ralph T.、Ida Tomoaki、Akaike Takaaki、Zhao Lan、Eaton Philip
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 116 Issue: 26 Pages: 13016-13025
  • DOI: 10.1073/pnas.1904064116
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Enhanced Cellular Polysulfides Negatively Regulate TLR4 Signaling and Mitigate Lethal Endotoxin Shock (2019)
  • Author(s): Zhang Tianli、Ono Katsuhiko、Tsutsuki Hiroyasu、Ihara Hideshi、Islam Waliul、Akaike Takaaki、Sawa Tomohiro
  • Journal Title: Cell Chemical Biology Volume: in press Issue: 5 Pages: 686-698.e4
  • DOI: 10.1016/j.chembiol.2019.02.003
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The active-site cysteine residue of Ca2+/calmodulin-dependent protein kinase I is protected from irreversible modification via generation of polysulfidation (2019)
  • Author(s): Takata Tsuyoshi、Tsukuda Ayaka、Tsuchiya Yukihiro、Akaike Takaaki、Watanabe Yasuo
  • Journal Title: Nitric Oxide Volume: 86 Pages: 68-75
  • DOI: 10.1016/j.niox.2019.02.008
  • Peer Reviewed / Open Access
• [Journal Article] Distribution of Polysulfide in Human Biological Fluids and Their Association with Amylase and Sperm Activities (2019)
  • Author(s): Ikeda Mayumi、Ishima Yu、Chuang Victor T. G.、Sakai Maki、Osafune Hiroki、Ando Hidenori、Shimizu Taro、Okuhira Keiichiro、Watanabe Hiroshi、Maruyama Toru、Otagiri Masaki、Akaike Takaaki、Ishida Tatsuhiro
  • Journal Title: Molecules Volume: 24 Issue: 9 Pages: 1689-1689
  • DOI: 10.3390/molecules24091689
  • NAID: 120006995454
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension. (2019)
  • Author(s): Rudyk O, Rowan A, Prysyazhna O, Krasemann S, Hartmann K, Zhang M, Shah MA, Ruppert C, Weiss A, Schermuly RT, Ida T, Akaike T, Zhao L, Eaton P.
  • Journal Title: Proc Natl Acad Sci USA Volume: 印刷中
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 8-Nitro-cGMP attenuates context-dependent fear memory in mice. (2019)
  • Author(s): Kishimoto Y, Kasamatsu S, Yanai S, Endo S, Akaike T, Ihara H.
  • Journal Title: Biochem Biophys Res Commun Volume: 511 Issue: 1 Pages: 141-147
  • DOI: 10.1016/j.bbrc.2019.01.138
  • Peer Reviewed
• [Journal Article] The Uptake and Release of Polysulfur Cysteine Species by Cells: Physiological and Toxicological Implications. (2019)
  • Author(s): Lin J, Akiyama M, Bica I, Long FT, Henderson CF, Goddu RN, Suarez V, Baker B, Ida T, Shinkai Y, Nagy P, Akaike T, Fukuto JM, Kumagai Y.
  • Journal Title: Chem Res Toxicol Volume: 32 Issue: 3 Pages: 447-455
  • DOI: 10.1021/acs.chemrestox.8b00340
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Polysulfide stabilization by tyrosine and hydroxyphenyl-containing derivatives that is important for a reactive sulfur metabolomics analysis. (2019)
  • Author(s): Hamid HA, Tanaka A, Ida T, Nishimura A, Matsunaga T, Fujii S, Morita M, Sawa T, Fukuto JM, Nagy P, Tsutsumi R, Motohashi H, Ihara H, Akaike T.
  • Journal Title: Redox Biol Volume: 21 Pages: 101096-101096
  • DOI: 10.1016/j.redox.2019.101096
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Production of 8-nitro-cGMP in osteocytic cells and its upregulation by parathyroid hormone and prostaglandin E2. (2019)
  • Author(s): Nagayama K, Miyamoto Y, Kaneko K, Yoshimura K, Sasa K, Akaike T, Fujii S, Izumida E, Uyama R, Chikazu D, Maki K, Kamijo R.
  • Journal Title: In Vitro Cell Dev Biol Anim Volume: 55 Issue: 1 Pages: 45-51
  • DOI: 10.1007/s11626-018-0304-0
  • Peer Reviewed
• [Journal Article] SNAP-25 S-Guanylation and SNARE Complex Formation. (2019)
  • Author(s): Kishimoto Y, Akaike T, Ihara H.
  • Journal Title: Methods Mol Biol Volume: 1860 Pages: 163-173
  • DOI: 10.1007/978-1-4939-8760-3_9
  • ISBN: 9781493987597, 9781493987603
  • Peer Reviewed
• [Journal Article] Persulfide synthases that are functionally coupled with translation mediate sulfur respiration in mammalian cells. (2019)
  • Author(s): Fujii S, Sawa T, Motohashi H, Akaike T.
  • Journal Title: Br J Pharmacol Volume: 176 Issue: 4 Pages: 607-615
  • DOI: 10.1111/bph.14356
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence. (2018)
  • Author(s): Nishimura A, Shimauchi T, Tanaka T, Shimoda K, Toyama T, Kitajima N, Ishikawa T, Shindo N, Numaga-Tomita T, Yasuda S, Sato Y, Kuwahara K, Kumagai Y, Akaike T, Ide T, Ojida A, Mori Y, Nishida M.
  • Journal Title: Sci Signal Volume: 11 Issue: 556 Pages: 5185-5195
  • DOI: 10.1126/scisignal.aat5185
  • Peer Reviewed / Open Access
• [Journal Article] Reactive Persulfides from Salmonella Typhimurium Downregulate Autophagy-Mediated Innate Immunity in Macrophages by Inhibiting Electrophilic Signaling (2018)
  • Author(s): Khan Shahzada、Fujii Shigemoto、Matsunaga Tetsuro、Nishimura Akira、Ono Katsuhiko、Ida Tomoaki、Ahmed Khandaker Ahtesham、Okamoto Tatsuya、Tsutsuki Hiroyasu、Sawa Tomohiro、Akaike Takaaki
  • Journal Title: Cell Chemical Biology Volume: 25 Issue: 11 Pages: 1403-1413
  • DOI: 10.1016/j.chembiol.2018.08.007
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Speciation of reactive sulfur species and their reactions with alkylating agents: do we have any clue about what is present inside the cell? (2018)
  • Author(s): Bogdandi Virag、Ida Tomoaki、Sutton Thomas R、Bianco Christopher、Ditroi Tamas、Koster Grielof、Henthorn Hillary A、Minnion Magda、Toscano John P、van der Vliet Albert、Pluth Michael D、Feelisch Martin、Fukuto Jon M、Akaike Takaaki、Nagy Peter
  • Journal Title: British Journal of Pharmacology Volume: 176 Issue: 4 Pages: 646-670
  • DOI: 10.1111/bph.14394
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The reaction of hydrogen sulfide with disulfides: formation of a stable trisulfide and implications for biological systems (2018)
  • Author(s): Bianco Christopher L、Akaike Takaaki、Ida Tomoaki、Nagy Peter、Bogdandi Virag、Toscano John P、Kumagai Yoshito、Henderson Catherine F、Goddu Robert N、Lin Joseph、Fukuto Jon M
  • Journal Title: British Journal of Pharmacology Volume: 176 Issue: 4 Pages: 671-683
  • DOI: 10.1111/bph.14372
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Biological hydropersulfides and related polysulfides - a new concept and perspective in redox biology (2018)
  • Author(s): Fukuto Jon M.、Ignarro Louis J.、Nagy Peter、Wink David A.、Kevil Christopher G.、Feelisch Martin、Cortese-Krott Miriam M.、Bianco Christopher L.、Kumagai Yoshito、Hobbs Adrian J.、Lin Joseph、Ida Tomoaki、Akaike Takaaki
  • Journal Title: FEBS Letters Volume: 592 Issue: 12 Pages: 2140-2152
  • DOI: 10.1002/1873-3468.13090
  • NAID: 120007133961
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 超硫黄分子のラマン分光イメージングを駆使した定量分析 (2023)
  • Author(s): 赤池 孝章
  • Organizer: CREST多細胞領域 第5回領域会議プログラム 連携課題
• [Presentation] 超硫黄分子の発見と生理機能の解明 (2023)
  • Author(s): 赤池孝章
  • Organizer: 第96回日本生化学会大会 特別講演
  • Invited
• [Presentation] 定量的超硫黄オミックス・イメージング技術の開発と標準化プロトコールの確立 (2023)
  • Author(s): 赤池 孝章
  • Organizer: 令和3（2021）年度 学術変革領域研究(A) 新興硫黄生物学が拓く生命原理変革（硫黄生物学） 第3回 領域会議・超硫黄フロンティアシンポジウム2023
• [Presentation] Supersulfide biology and translational medicine for disease control (2023)
  • Author(s): Takaaki Akaike
  • Organizer: Chemical Biology/Redox Biology Seminar
  • Int'l Joint Research / Invited
• [Presentation] 超硫黄分子によるエネルギー産生と過酸化脂質・カルボニル代謝制御 (2023)
  • Author(s): 赤池孝章
  • Organizer: 名古屋大学大学院 生命農学研究科 食品機能化学研究室 特別セミナー
  • Invited
• [Presentation] 活性酸素シグナル~酸素生物学~そして硫黄生物学：三つの領域のレドックス生命科学研究から俯瞰される世界 (2023)
  • Author(s): 赤池孝章
  • Organizer: 第96回日本細菌学会総会
  • Invited
• [Presentation] Nitric Oxide Synthases, a New Family of NADPH-Dependent Sulfur Oxidoreductases (2023)
  • Author(s): Takaaki Akaike
  • Organizer: Nitric Oxide Gordon Research Conference
  • Int'l Joint Research / Invited
• [Presentation] 空間生体情報メタオミックス解析と呼気医療 (2023)
  • Author(s): 赤池孝章
  • Organizer: JASIS関西2023トピックスセミナー
  • Invited
• [Presentation] 環化超硫黄分子の生体内検出と機能解明 (2023)
  • Author(s): 赤池孝章
  • Organizer: CREST多細胞領域 第4回領域会議プログラム
  • Invited
• [Presentation] Physiological formation and function of new supersulfide, cyclic octa-sulfur in mammals (2023)
  • Author(s): Takaaki Akaike
  • Organizer: 3rd STINT-JSPS Redox Biology Conference
  • Int'l Joint Research / Invited
• [Presentation] The physiological functions of cyclic octa-sulfur (S8) formed endogenously in diverse organisms including mammals (2022)
  • Author(s): Takaaki Akaike
  • Organizer: Redox week in Sendai 2022
  • Int'l Joint Research / Invited
• [Presentation] Sulfur biology and redox signaling in energy metabolism, infection, and immunity (2022)
  • Author(s): Takaaki Akaike
  • Organizer: The 15th Korea-Japan International Symposium on Microbiology
  • Int'l Joint Research / Invited
• [Presentation] 呼気オミックスから空間バイオミックスへの新展開 (2022)
  • Author(s): 赤池孝章
  • Organizer: レドックス R&D 戦略委員会第3回企画シンポジウム「ホルミシスおよび気道環境ストレスに 対する生体の防御機構」
  • Invited
• [Presentation] Cyclo-octasulfur, S8, formed endogenously in mammals: its biosynthesis and physiological functions (2022)
  • Author(s): Takaaki Akaike
  • Organizer: GRC “Thiol-Based Redox Regulation and Signaling: The Chemical Biology of Sulfur”
  • Int'l Joint Research / Invited
• [Presentation] Reactive persulfide regulation of redox signaling and immune response (2022)
  • Author(s): Takaaki Akaike
  • Organizer: 6th World Congress on Hydrogen Sulfide in Biology & Medicine Keynote Lecture, Molecular Mechanisms (online)
  • Int'l Joint Research / Invited
• [Presentation] 呼気オミックスによる硫黄代謝解析と新型コロナ感染症 (2022)
  • Author(s): 赤池孝章
  • Organizer: 第99回日本生理学会大会
  • Invited
• [Presentation] 超硫黄分子の発見と感染防御・免疫・代謝制御に関する研究 (2022)
  • Author(s): 赤池孝章
  • Organizer: 第3回 太田原豊一賞 受賞講演
  • Invited
• [Presentation] 活性酸素シグナル~酸素生物学~そして硫黄生物学:三つの領域を超えて見えてきた世界 (2022)
  • Author(s): 赤池孝章
  • Organizer: 第2回レドックスR&D戦略委員会 春のシンポジウム ―最先端技術が切り拓くレドックスバイオロジー
  • Invited
• [Presentation] 呼気オミックスと未来型医療:ヒューマンエアローム事業の創成 (2022)
  • Author(s): 赤池孝章
  • Organizer: SAカレッジ21年度コースIII月例会
  • Invited
• [Presentation] 定量的超硫黄オミックス・イメージング技術の開発と標準化プロトコールの確立 (2021)
  • Author(s): 赤池孝章
  • Organizer: 令和3(2021)年度 学術変革領域研究(A) 新興硫黄生物学が拓く生命原理変革(硫黄生物学) 第2回月例領域プログレスミーティング
  • Invited
• [Presentation] 硫黄呼吸の生命進化論 (2021)
  • Author(s): 赤池孝章
  • Organizer: 第20回日本ミトコンドリア学会
  • Invited
• [Presentation] レドックスとエネルギー代謝の超硫黄パラダイム (2021)
  • Author(s): 赤池孝章
  • Organizer: 第94回日本生化学会大会
  • Invited
• [Presentation] 最近の超硫黄計測技術の展開 (2021)
  • Author(s): 赤池孝章
  • Organizer: 令和3(2021)年度学術変革領域研究(A) 新興硫黄生物学が拓く生命原理変革(硫黄生物学) 第1回総括班会議
  • Invited
• [Presentation] 硫黄呼吸の革新的イメージングの開発と応用 (2021)
  • Author(s): 赤池孝章
  • Organizer: 新領域創成のための挑戦研究デュオ~Frontier Research in Duo (FRiD)~ 公開セミナー
  • Invited
• [Presentation] 呼気オミックスと未来型医療 (2021)
  • Author(s): 赤池孝章
  • Organizer: 第46回日本医用マススペクトル学会
  • Invited
• [Presentation] 超硫黄分子による生体防御学の新たな潮流 (2021)
  • Author(s): 赤池孝章
  • Organizer: 第32回日本生体防御学会学術集会
  • Invited
• [Presentation] 超硫黄分子による感染免疫制御とエネルギー代謝 (2021)
  • Author(s): 赤池孝章
  • Organizer: 第41回阿蘇シンポジウム
  • Invited
• [Presentation] 超硫黄分子による電子転移反応とエネルギー代謝 (2021)
  • Author(s): 赤池孝章
  • Organizer: 生理研研究会2021「生命を支える硫黄生物学研究の最前線」
  • Invited
• [Presentation] Sulfur respiration highly conserved and evolved in microbiota and organisms including humans. (2021)
  • Author(s): Takaaki Akaike
  • Organizer: World Microbe Forum 2021
  • Invited
• [Presentation] 呼気オミックスによる新型コロナ感染診断法と未来型医療 (2021)
  • Author(s): 赤池孝章
  • Organizer: 第81回分析化学討論会
  • Invited
• [Presentation] 超硫黄代謝と呼気オミックス (2021)
  • Author(s): 赤池孝章
  • Organizer: 第3回国際活性硫黄研究会
  • Int'l Joint Research / Invited
• [Presentation] 超硫黄生物学:エネルギー代謝とレドックスシグナル (2021)
  • Author(s): 赤池孝章
  • Organizer: 第74回日本酸化ストレス学会・第21回日本NO学会合同学術集会
  • Invited
• [Presentation] 新型コロナの呼気オミックス解析と未来型呼気医療 (2021)
  • Author(s): 赤池孝章
  • Organizer: 第30回バイオメディカル研究会「健康を測るセンシング技術」
  • Invited
• [Presentation] コロナの時代の環境予防医学とポストコロナの感染症研究 (2021)
  • Author(s): 赤池孝章
  • Organizer: 第20回分子予防環境医学研究会大会
  • Invited
• [Presentation] 超硫黄による呼吸とレドックスシグナル (2021)
  • Author(s): 赤池孝章
  • Organizer: 第1回 レドックスR&D戦略委員会シンポジウム
  • Invited
• [Presentation] 活性硫黄分子によるシグナル伝達と代謝制御 (2021)
  • Author(s): 赤池孝章
  • Organizer: 日本農芸化学会2021年度大会
  • Invited
• [Presentation] 新型コロナの感染予防制御とポストコロナ時代の先進医療 (2021)
  • Author(s): 赤池孝章
  • Organizer: 第94回日本細菌学会総会
  • Invited
• [Presentation] NO・活性酸素シグナルから始まる硫黄生物学研究 (2020)
  • Author(s): 赤池孝章
  • Organizer: プラズマバイオコンソーシアム2020 年度研究会
  • Invited
• [Presentation] Cysteine persulfide synthases mediate redox signaling and energy metabolism. (2019)
  • Author(s): Akaike T.
  • Organizer: The 9th Biennial Meeting of Society for Free Radical Research-Asia (SFRR-Asia)
  • Int'l Joint Research / Invited
• [Presentation] 環境医学におけるイオウ毒性学のニューパラダイム：イオウ医学生物学の黎明 (2019)
  • Author(s): 赤池孝章
  • Organizer: 第46回日本毒性学会学術年会
  • Invited
• [Presentation] 硫黄呼吸の新規代謝経路の発見と生命科学へのインパクト (2019)
  • Author(s): 赤池孝章
  • Organizer: ライフサイエンス イノベーションセミナー
  • Invited
• [Presentation] 進化する硫黄生物学:新しいレドックスバイオロジーの黎明 (2019)
  • Author(s): 赤池孝章
  • Organizer: フリーラジカルスクール2019
  • Invited
• [Presentation] 細菌を起点とした硫黄代謝の生命進化論と硫黄サイエンス (2019)
  • Author(s): 赤池孝章
  • Organizer: 第72回 日本細菌学会九州支部総会
  • Invited
• [Presentation] ミトコンドリアに硫黄呼吸を発見~古代生物の残存が現代に生きていた~ (2019)
  • Author(s): 赤池孝章
  • Organizer: JASIS2019 ライフサイエンスイノベーションゾーン
  • Invited
• [Presentation] 活性イオウ分子種の代謝と抗酸化・抗炎症・免疫制御機能 (2019)
  • Author(s): 赤池孝章
  • Organizer: JADCI/JSHDR2019
  • Invited
• [Presentation] Reactive persulfide mediates versatile redox signal functions with canonical signaling mimetics. (2019)
  • Author(s): Akaike T.
  • Organizer: 1st STINT-JSPS Joint Symposium in Sendai.
  • Int'l Joint Research / Invited
• [Presentation] 活性パースルフィドによるエネルギー代謝とタンパク質機能のレドックス制御 (2019)
  • Author(s): 赤池孝章
  • Organizer: 第92回日本生化学学会大会
  • Invited
• [Presentation] 活性硫黄シグナルと硫黄呼吸:哺乳類の新しいエネルギー代謝 (2019)
  • Author(s): 赤池孝章
  • Organizer: 第2回大隅ライフサイエンス研究会
  • Invited
• [Presentation] Reactive persulfide mediates versatile redox signal functions with canonical signaling mimetics. (2019)
  • Author(s): Akaike T.
  • Organizer: 2019 NIH-Japan-JSPS symposium.
  • Int'l Joint Research / Invited
• [Presentation] Reactive persulfide mediates versatile redox signal functions with canonical signaling mimetics. (2019)
  • Author(s): Akaike T.
  • Organizer: International Joint Conference of SFRR-Korea & HDRC 2019.
  • Int'l Joint Research / Invited
• [Presentation] 活性イオウ分子によるレドックスシグナルと代謝制御 (2019)
  • Author(s): 赤池孝章
  • Organizer: 第4回黒潮カンファレンス
  • Invited
• [Presentation] Reactive persulfide mediate sulfur respiration in mitochondria via sulfide:quinone oxidoreductase. (2019)
  • Author(s): Akaike T.
  • Organizer: The Society for Redox Biology and Medicine's 26th Annual Conference.
  • Int'l Joint Research / Invited
• [Presentation] Signaling and energy metabolism regulated by reactive sulfur species. (2019)
  • Author(s): Akaike T.
  • Organizer: The 2020 Oxygen Radicals, Gordon Research Conference.
  • Int'l Joint Research / Invited
• [Presentation] Reactive sulfur species (RSS) mediate sulfur respiration in mitochondria and redox signaling (2019)
  • Author(s): Akaike T.
  • Organizer: 第 7 回 IRG(Inflammation and ReGeneration)Meeting（東京）
  • Invited
• [Presentation] Cysteine persulfide synthases mediate sulfur respiration and energy metabolism (2019)
  • Author(s): Akaike T.
  • Organizer: The Kick-off Symposium of Advanced Graduate Program for Future Medicine and Health Care（仙台）
  • Int'l Joint Research / Invited
• [Presentation] Chemical biology of reactive sulfur species and its metabolome analysis (2018)
  • Author(s): Akaike T.
  • Organizer: 2018 Annual Medical Technology Conference 3rd Annual Conference New Frontiers in Mass Spectrometry Clinical and Biomedical Applications（タイ）
  • Int'l Joint Research / Invited
• [Presentation] ミトコンドリアのイオウ呼吸とイオウストレス (2018)
  • Author(s): 赤池孝章
  • Organizer: 山形分子生物研究会（山形）
  • Invited
• [Presentation] 新しいエネルギー代謝機構：イオウ呼吸の発見と生理機能解明 (2018)
  • Author(s): 赤池孝章
  • Organizer: 平成30年度東北大学医学系病理同窓会特別公演（仙台）
  • Invited
• [Presentation] Translation-coupled persulfide synthases (PERSs) involved critically in sulfur respiration and energy metabolism (2018)
  • Author(s): Akaike T.
  • Organizer: 10th Internatinal Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide（イギリス）
  • Int'l Joint Research / Invited
• [Presentation] Persulfide synthase coupled with translation mediates sulfur respiration in mammals (2018)
  • Author(s): Akaike T.
  • Organizer: KCL Redox Biology & Medicine Symposium（イギリス）
  • Int'l Joint Research / Invited
• [Presentation] Sulfur respiration as a target for mitochondrial disease (2018)
  • Author(s): 赤池孝章
  • Organizer: 7 SEAS PROJECT Research meeting 2018
  • Invited
• [Presentation] イオウ呼吸：レドックス研究の新たなパラダイム (2018)
  • Author(s): 赤池孝章
  • Organizer: Free Radical Summer School 2018
  • Invited
• [Presentation] Cysteine persulfide synthases coupled with translation mediate sulfur respiration and redox signaling (2018)
  • Author(s): Akaike T.
  • Organizer: The 43rd FEBS Congress（トルコ）
  • Int'l Joint Research / Invited
• [Presentation] Cysteunyl-tRNA synthetase (CARS) controls endgeneous hydropersulfide production and mitochondrial respiration (2018)
  • Author(s): Akaike T.
  • Organizer: The 19th biennial meeting for the Society for Free Radical Research International (SFRRI)（ポルトガル）
  • Int'l Joint Research / Invited
• [Book] 呼吸器疾患最新の治療2025-2026（超硫黄分子による呼吸器疾患制御と呼気オミックス） (2024)
  • Author(s): 緒方星陵, 松永哲郎, 赤池孝章
  • Total Pages: 6
  • Publisher: 南江堂
• [Book] 酸化ストレスの医学 改訂第３版（超硫黄分子の化学と生理機能） (2024)
  • Author(s): 緒方星陵, Uladzimir Barayeu, 赤池孝章
  • Total Pages: 7
  • Publisher: 診断と治療社
• [Book] メディカルサイエンスダイジェスト（［特集］環境化学物質と生体応答） (2023)
  • Author(s): 赤池孝章
  • Total Pages: 56
  • Publisher: ニューサイエンス社
• [Book] メディカルサイエンスダイジェスト（環境物質と生命の起源：超硫黄生物学プロローグ） (2023)
  • Author(s): 松永哲郎, 赤池孝章
  • Total Pages: 5
  • Publisher: ニューサイエンス社
• [Book] Sulfurtransferases（A persulfide shield） (2023)
  • Author(s): Hamid Hisyam Abdul、Takata Tsuyoshi、Matsunaga Tetsuro、Akaike Takaaki
  • Total Pages: 16
  • Publisher: Elsevier
• [Book] 呼気オミックスと個別化医療 (2021)
  • Author(s): 赤池孝章、松永哲郎、井田智章、高田 剛、Jung Minkyung、守田匡伸、本橋ほづみ
  • Total Pages: 94
  • Publisher: Precision Medicine (株)北隆館
• [Book] 生命を支える超硫黄分子の代謝と革新的な計測技術 (2021)
  • Author(s): 本橋ほづみ、赤池孝章
  • Total Pages: 204
  • Publisher: 生化学 (公社)日本生化学会
• [Book] 超硫黄分子の化学と代謝:超硫黄生物学の創成とオミックス先制医療への展望 (2021)
  • Author(s): 赤池孝章、松永哲郎、高田 剛
  • Total Pages: 204
  • Publisher: 生化学 (公社)日本生化学会
• [Book] 超硫黄代謝物の化学と代謝 (2021)
  • Author(s): 高田 剛、松永哲郎、赤池孝章
  • Total Pages: 139
  • Publisher: 実験医学 (株)羊土社
• [Book] 活性硫黄分子種によるエネルギー代謝とタンパク質劣化防止機能 (2021)
  • Author(s): 高田剛, 松永哲郎, 赤池孝章
  • Total Pages: 33
  • Publisher: バイオサイエンスとインダストリー
• [Book] 4. 抗酸化:活性パースルフィドによる制御 (2020)
  • Author(s): 高田剛, 松永哲郎, 赤池孝章
  • Total Pages: 241
  • Publisher: 実験医学【食と健康を結ぶメディカルサイエンス】
• [Book] 硫黄呼吸は幹細胞のエネルギー代謝を担っているか? (2019)
  • Author(s): 高田剛、松永哲郎、赤池孝章
  • Publisher: 再生医療
• [Book] エレクトロンバイオダイナミクスが支える生命の生存戦略【活性イオウに よる生体防御とエネルギー代謝】 (2019)
  • Author(s): 西村明、本橋ほづみ、赤池孝章
  • Publisher: 月刊細胞
• [Book] 活性硫黄研究の新展開 (2019)
  • Author(s): 居原秀、本橋ほづみ、赤池孝章
  • Publisher: 生化学
• [Book] 生物のエネルギー代謝. イオウ呼吸の再発見 (2019)
  • Author(s): 赤池孝章
  • Publisher: 学士会会報
• [Book] 活性イオウ分子によるエネルギー代謝制御 (2019)
  • Author(s): 西村 明、本橋ほづみ、赤池孝章
  • Total Pages: 6
  • Publisher: 基礎老化研究
• [Book] 活性イオウ分子：システインパースルフィドの新規生合成経路の発見とその生理機能 (2018)
  • Author(s): 西村 明、赤池孝章
  • Total Pages: 2
  • Publisher: 化学と生物
• [Book] ポリスルフィド化 (2018)
  • Author(s): 西村 明、井田智章、赤池孝章
  • Total Pages: 2
  • Publisher: 生体の科学
• [Book] SH(ポリスルフィド)の酸化 (2018)
  • Author(s): 西村 明、井田智章、赤池孝章
  • Total Pages: 2
  • Publisher: 生体の科学
• [Book] 哺乳類におけるイオウ呼吸の発見 (2018)
  • Author(s): 西村 明、赤池孝章
  • Total Pages: 2
  • Publisher: 医学のあゆみ
• [Remarks] 東北大学大学院医学系研究科環境医学分野ホームページ
  • URL: http://www.toxicosci.med.tohoku.ac.jp/index.html
• [Remarks] Research Mapマイポータル
  • URL: https://researchmap.jp/AkaikeT
• [Remarks] 「島津製作所×東北大学 超硫黄生命科学共創研究所」を設置
  • URL: https://www.tohoku.ac.jp/japanese/2024/03/press20240313-04-shimazu.html
• [Remarks] 「超硫黄分子」の寿命延長効果を発見 ～新たなサプリメントや健康法の開発に期待～
  • URL: https://www.tohoku.ac.jp/japanese/2024/01/press20240119-01-supersulfides.html
• [Remarks] 超硫黄分子による心機能の制御メカニズムを解明 心疾患の診断・治療への応用に期待
  • URL: https://www.tohoku.ac.jp/japanese/2023/08/press20230821-02-no.html
• [Remarks] 学術変革領域研究(A) 新興硫黄生物学が拓く生命原理変革(硫黄生物学)ホームページ
  • URL: https://supersulfide-proj.com/
• [Remarks] 東北大学大学院医学系研究科環境医学分野ホームページ
  • URL: http://www.toxicosci.med.tohoku.ac.jp/
• [Remarks] Researchmap マイポータルページ
  • URL: https://researchmap.jp/AkaikeT
• [Patent(Industrial Property Rights)] 活性硫黄の定量方法 (2022)
  • Inventor(s): 國澤研大，遠山敦彦，赤池孝章，飯伏翼
  • Industrial Property Rights Holder: 國澤研大，遠山敦彦，赤池孝章，飯伏翼
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2022-209942
  • Filing Date: 2022
• [Patent(Industrial Property Rights)] 感染症のバイオマーカ (2022)
  • Inventor(s): 赤池孝章
  • Industrial Property Rights Holder: 赤池孝章
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2021-084723
  • Filing Date: 2022
  • Overseas
• [Funded Workshop] The 1st International G-ReXS Conference in Sendai (2024)
• [Funded Workshop] Redox Week in Sendai 2022 (2022)
• [Funded Workshop] 第3回国際活性硫黄研究会 (2021)
• [Funded Workshop] The 1st International Conference on Persulfide and Sulfur Metabolism in Biology and Medicine (2019)