| Budget Amount *help |
¥193,310,000 (Direct Cost: ¥148,700,000、Indirect Cost: ¥44,610,000)
Fiscal Year 2022: ¥31,850,000 (Direct Cost: ¥24,500,000、Indirect Cost: ¥7,350,000)
Fiscal Year 2021: ¥31,850,000 (Direct Cost: ¥24,500,000、Indirect Cost: ¥7,350,000)
Fiscal Year 2020: ¥31,850,000 (Direct Cost: ¥24,500,000、Indirect Cost: ¥7,350,000)
Fiscal Year 2019: ¥45,110,000 (Direct Cost: ¥34,700,000、Indirect Cost: ¥10,410,000)
Fiscal Year 2018: ¥52,650,000 (Direct Cost: ¥40,500,000、Indirect Cost: ¥12,150,000)
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| Outline of Final Research Achievements |
Sulfur played a crucial role in early respiration before oxygen appeared on Earth. However, its physiological functions were not well understood. Our research identified cysteinyl-tRNA synthetase as reactive persulfides synthase, which is essential for energy metabolism. Reactive persulfides, acting as electron acceptors in mitochondrial respiration, highlighted their evolutionary conservation and their role in modulating protein function and signaling pathways. Reactive persulfides (R-Sn-H/R’), abundantly synthesized in mitochondria, played a key role in redox regulation and antioxidant responses. Rich in electrons, they significantly contributed to biological processes and disease models. This study clarified sulfur's role in mammalian energy metabolism, particularly its impact on mitochondrial function and cellular energy regulation. Reactive persulfides are crucial for maintaining cellular homeostasis and could be key targets for therapeutic interventions in metabolic diseases.
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