Multi Regulatory System for Gut Homeostasis and Inflammation

• Project/Area Number: 18H05280
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Review Section: Broad Section I
• Research Institution: Chiba University (2022); The University of Tokyo (2018-2021)
• Principal Investigator: Hiroshi Kiyono 千葉大学, 未来医療教育研究機構, 卓越教授 (10271032)
• Co-Investigator(Kenkyū-buntansha): 倉島 洋介 千葉大学, 大学院医学研究院, 准教授 (30729372)
• Project Period (FY): 2018-06-11 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥191,360,000 (Direct Cost: ¥147,200,000、Indirect Cost: ¥44,160,000); Fiscal Year 2022: ¥37,960,000 (Direct Cost: ¥29,200,000、Indirect Cost: ¥8,760,000); Fiscal Year 2021: ¥37,960,000 (Direct Cost: ¥29,200,000、Indirect Cost: ¥8,760,000); Fiscal Year 2020: ¥37,960,000 (Direct Cost: ¥29,200,000、Indirect Cost: ¥8,760,000); Fiscal Year 2019: ¥37,050,000 (Direct Cost: ¥28,500,000、Indirect Cost: ¥8,550,000); Fiscal Year 2018: ¥40,430,000 (Direct Cost: ¥31,100,000、Indirect Cost: ¥9,330,000)
• Keywords: 炎症性腸疾患 / 臓器連関 / 上皮細胞 / 腸内細菌 / 慢性炎症 / 粘膜免疫 / パネート細胞 / 線維芽細胞 / 微小環境 / 蠕動運動 / 間葉系細胞 / 抗菌ペプチド / 膵臓 / 陰窩 / 腸間膜脂肪

Outline of Final Research Achievements

Inflammatory bowel disease (IBD) and its complications are chronic and difficult　to treat. In addition, the complete mechanism underlying their pathogenesis is not fully understood. In this study, we aimed to elucidate the maintenance mechanism of intestinal mucosal homeostasis and establish new methods for disease control by investigating the multi regulatory system in the mucosal tissues. Through analysis of organ and cellular interactive connections both inside and outside the mucosal tissues, we discovered a new biological defense mechanism by which the pancreas protects the intestine from bacterial infections, identified a new subset of intestinal "Paneth cells" responsible for the producing antimicrobial peptides and their differentiation mechanism, and also identified a novel group of mesenchymal cells as therapeutic targets for IBD. These achievements are expected to serve as an applied foundation for the disease prevention and the development of new therapies.

Academic Significance and Societal Importance of the Research Achievements

本研究は、炎症性腸疾患の発症や重症化につながる組織恒常性の破綻について、粘膜免疫システムに留まることなく、それを取り巻く「腸管粘膜外支持組織」との相互作用による「階層的粘膜支持連関システム」という新しい視点からの生体高次複雑系の一翼を担う腸管監視・防御機構を明らかにした。炎症遷延化に関わる新たな治療標的細胞の同定のみならず、腸を保護する他の臓器の機能への介入による腸疾患制御法の開発につながる重要な成果が得られた。これらの研究成果は「階層的粘膜支持連関システム」を標的とした炎症性疾患ならびにその合併症に対する新たな画期的な予防・治療法の開発に繋がる可能性を有している。

Assessment Rating

Ex-post Assessment Comments (Rating)

A: In light of the aim of introducing the research area into the research categories, expected outcomes of research have been produced.

Research Products

• [Int'l Joint Research] カリフォルニア大学サンディエゴ校(米国)
• [Int'l Joint Research] University of California, San Diego(米国)
• [Int'l Joint Research] NIAID NIH(米国)
• [Int'l Joint Research] Noguchi Memorial Institute/Ghana Health Service Institute/NIID(ガーナ)
• [Int'l Joint Research] UCSD/Hiroshima University/Chiba University(米国)
• [Int'l Joint Research] Universiti Sains Malaysia/Universidad de Concepcion, Chile/University of Tokyo(マレーシア)
• [Journal Article] Nasal vaccines: solutions for respiratory infectious diseases (2023)
  • Author(s): Nakahashi-Ouchida Rika、Fujihashi Kohtaro、Kurashima Yosuke、Yuki Yoshikazu、Kiyono Hiroshi
  • Journal Title: Trends in Molecular Medicine Volume: 29 Issue: 2 Pages: 124-140
  • DOI: 10.1016/j.molmed.2022.10.009
  • Peer Reviewed / Open Access
• [Journal Article] TLR4 agonist activity of Alcaligenes lipid a utilizes MyD88 and TRIF signaling pathways for efficient antigen presentation and T cell differentiation by dendritic cells (2023)
  • Author(s): Sun Xiao、Hosomi Koji、Shimoyama Atsushi、Yoshii Ken、Lan Huangwenxian、Wang Yunru、Yamaura Haruki、Nagatake Takahiro、Ishii Ken J.、Akira Shizuo、Kiyono Hiroshi、Fukase Koichi、Kunisawa Jun
  • Journal Title: International Immunopharmacology Volume: 117 Pages: 109852-109852
  • DOI: 10.1016/j.intimp.2023.109852
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Endotoxin-Free Stx2B-C-CPE Vaccine and Its Optimized Adjuvant Regimen for Preventing Food Poisoning (2023)
  • Author(s): Hosomi Koji、Shimoyama Atsushi、Hinenoya Atsushi、Hatanaka Noritoshi、Noguchi Takafumi、Ebina Hirotaka、Tojima Yoko、Furuta Mari、Kondoh Masuo、Kiyono Hiroshi、Yamasaki Shinji、Fukase Koichi、Kunisawa Jun
  • Journal Title: Frontiers in Bioscience-Landmark Volume: 28 Issue: 1 Pages: 15-15
  • DOI: 10.31083/j.fbl2801015
  • Peer Reviewed / Open Access
• [Journal Article] Gut microbiota at the crossroads of pancreas-intestinal barrier axis (2022)
  • Author(s): Zhang Z., Tanaka I., Pan Z., Ernst P.B., Kiyono H., Kurashima Y.
  • Journal Title: Eur J Immunol. Volume: 52 Pages: 1035-1046
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Utilizing mast cells in a positive manner to overcome inflammatory and allergic diseases. (2022)
  • Author(s): Zhang Z., Ernst P.B., Kiyono H., Kurashima Y.
  • Journal Title: 13 Volume: 13 Pages: 937120-937120
  • DOI: 10.3389/fimmu.2022.937120
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Diarrhea-Causing Bacteria and Their Antibiotic Resistance Patterns Among Diarrhea Patients From Ghana. (2022)
  • Author(s): Afum T., Asandem D.A., Asare P., Asante-Poku A., Mensah G.I., Musah A.B., Opare D., Taniguchi K., Guinko N.M., Aphour T., Arhin D., Ishikawa K., Matano T., Mizutani T., Asiedu-Bekoe F., Kiyono H., Anang A.K., Koram and K.A., Yeboah-Manu D.
  • Journal Title: Front Microbiol. Volume: 13 Pages: 894319-894319
  • DOI: 10.3389/fmicb.2022.894319
  • Peer Reviewed
• [Journal Article] Organoid-derived intestinal epithelial cells are a suitable model for preclinical toxicology and pharmacokinetic studies (2022)
  • Author(s): Takahashi Yu、Noguchi Makoto、Inoue Yu、Sato Shintaro、Shimizu Makoto、Kojima Hirotatsu、Okabe Takayoshi、Kiyono Hiroshi、Yamauchi Yoshio、Sato Ryuichiro
  • Journal Title: iScience Volume: 25 Issue: 7 Pages: 104542-104542
  • DOI: 10.1016/j.isci.2022.104542
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lactobacilli as a Vector for Delivery of Nanobodies against Norovirus Infection (2022)
  • Author(s): Yuki Yoshikazu、Zuo Fanglei、Kurokawa Shiho、Uchida Yohei、Sato Shintaro、Sakon Naomi、Hammarstr?m Lennart、Kiyono Hiroshi、Marcotte Harold
  • Journal Title: Pharmaceutics Volume: 15 Issue: 1 Pages: 63-63
  • DOI: 10.3390/pharmaceutics15010063
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lactic acid bacteria?derived γ-linolenic acid metabolites are PPARδ ligands that reduce lipid accumulation in human intestinal organoids (2022)
  • Author(s): Noguchi Makoto、Shimizu Makoto、Lu Peng、Takahashi Yu、Yamauchi Yoshio、Sato Shintaro、Kiyono Hiroshi、Kishino Shigenobu、Ogawa Jun、Nagata Koji、Sato Ryuichiro
  • Journal Title: Journal of Biological Chemistry Volume: 298 Issue: 11 Pages: 102534-102534
  • DOI: 10.1016/j.jbc.2022.102534
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Correlation Analysis between Gut Microbiota Alterations and the Cytokine Response in Patients with Coronavirus Disease during Hospitalization (2022)
  • Author(s): Mizutani Taketoshi、Ishizaka Aya、Koga Michiko、Ikeuchi Kazuhiko、Saito Makoto、Adachi Eisuke、Yamayoshi Seiya、Iwatsuki-Horimoto Kiyoko、Yasuhara Atsuhiro、Kiyono Hiroshi、Matano Tetsuro、Suzuki Yutaka、Tsutsumi Takeya、Kawaoka Yoshihiro、Yotsuyanagi Hiroshi
  • Journal Title: Microbiology Spectrum Volume: 10 Issue: 2 Pages: 1-13
  • DOI: 10.1128/spectrum.01689-21
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Oral MucoRice-CTB vaccine is safe and immunogenic in healthy US adults (2022)
  • Author(s): Yuki Yoshikazu、Nojima Masanori、Kashima Koji、Sugiura Kotomi、Maruyama Shinichi、Kurokawa Shiho、Yamanoue Tomoyuki、Nakahashi-Ouchida Rika、Nakajima Hiroyuki、Hiraizumi Takashi、Kohno Hitoshi、Goto Eiji、Fujihashi Kohtaro、Kiyono Hiroshi
  • Journal Title: Vaccine Volume: 40 Issue: 24 Pages: 3372-3379
  • DOI: 10.1016/j.vaccine.2022.04.051
  • Peer Reviewed
• [Journal Article] Super high-resolution single-molecule sequence-based typing of HLA class I alleles in HIV-1 infected individuals in Ghana (2022)
  • Author(s): Nii-Trebi Nicholas I.、Matsuoka Saori、Kawana-Tachikawa Ai、Bonney Evelyn Y.、Abana Christopher Z.、Ofori Sampson B.、Mizutani Taketoshi、Ishizaka Aya、Shiino Teiichiro、Ohashi Jun、Naruse Taeko K.、Kimura Akinori、Kiyono Hiroshi、Ishikawa Koichi、Ampofo William K.、Matano Tetsuro
  • Journal Title: PLOS ONE Volume: 17 Issue: 6 Pages: e0269390-e0269390
  • DOI: 10.1371/journal.pone.0269390
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Role of Interleukin-6 in the Antigen-Specific Mucosal Immunoglobulin A Responses Induced by CpG Oligodeoxynucleotide-Loaded Cationic Liposomes (2022)
  • Author(s): Tada Rui、Honjo Emi、Muto Shoko、Takayama Noriko、Kiyono Hiroshi、Kunisawa Jun、Negishi Yoichi
  • Journal Title: Membranes Volume: 12 Issue: 6 Pages: 635-635
  • DOI: 10.3390/membranes12060635
  • Peer Reviewed / Open Access
• [Journal Article] Intestinal commensal microbiota and cytokines regulate Fut2 ⁺ Paneth cells for gut defense (2022)
  • Author(s): Kamioka Mariko、Goto Yoshiyuki、Nakamura Kiminori、Yokoi Yuki、Sugimoto Rina、Ohira Shuya、Kurashima Yosuke、Umemoto Shingo、Sato Shintaro、Kunisawa Jun、Takahashi Yu、Domino Steven E.、Renauld Jean-Christophe、Nakae Susumu、Iwakura Yoichiro、Ernst Peter B.、Ayabe Tokiyoshi、Kiyono Hiroshi
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 119 Issue: 3 Pages: 1-10
  • DOI: 10.1073/pnas.2115230119
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Fecal Microbiome Composition in Healthy Adults in Ghana (2021)
  • Author(s): Parbie Prince Kofi、Mizutani Taketoshi、Ishizaka Aya、Kawana-Tachikawa Ai、Runtuwene Lucky Ronald、Seki Sayuri、Abana Christopher Zaab-Yen、Kushitor Dennis、Bonney Evelyn Yayra、Ofori Sampson Badu、Uematsu Satoshi、Imoto Seiya、Kimura Yasumasa、Kiyono Hiroshi、Ishikawa Koichi、Ampofo William Kwabena、Matano Tetsuro
  • Journal Title: Japanese Journal of Infectious Diseases Volume: 74 Issue: 1 Pages: 42-47
  • DOI: 10.7883/yoken.JJID.2020.469
  • NAID: 130007973724
  • ISSN: 1344-6304, 1884-2836
  • Year and Date: 2021-01-29
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lipopolysaccharide from Gut‐Associated Lymphoid‐Tissue‐Resident Alcaligenes faecalis : Complete Structure Determination and Chemical Synthesis of Its Lipid?A (2021)
  • Author(s): Shimoyama A、Di Lorenzo F、Yamaura H、Mizote K、Palmigiano A、Pither MD.、Speciale I、Uto T、Masui S、Sturiale L、Garozzo D、Hosomi K、Shibata N、Kabayama K、Fujimoto Y、Silipo A、Kunisawa Jun、Kiyono H、Molinaro A、Fukase K
  • Journal Title: Angewandte Chemie International Edition Volume: 60 Issue: 18 Pages: 10023-10031
  • DOI: 10.1002/anie.202012374
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Enzymatically polymerised polyphenols prepared from various precursors potentiate antigen-specific immune responses in both mucosal and systemic compartments in mice (2021)
  • Author(s): Tada, R., Ogasawara, M., Yamanaka, D., Sakurai, Y., Negishi, Y., Kiyono, H., Ohno, N., Kunisawa, J. and Aramaki, Y.
  • Journal Title: PLoS One Volume: eCollection 16(2) Issue: 2 Pages: e0246422-e0246422
  • DOI: 10.1371/journal.pone.0246422
  • Peer Reviewed / Open Access
• [Journal Article] Functional Restoration of Bacteriomes and Viromes by Fecal Microbiota Transplantation (2021)
  • Author(s): Fujimoto, Kosuke, et al.
  • Journal Title: Gastroenterology Volume: - Issue: 6 Pages: 400-405
  • DOI: 10.1053/j.gastro.2021.02.013
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pancreatic glycoprotein 2 is a first line of defense for mucosal protection in intestinal inflammation (2021)
  • Author(s): Kurashima Yosuke、Kigoshi Takaaki、Murasaki Sayuri、Arai Fujimi、Shimada Kaoru、Seki Natsumi、Kim Yun-Gi、Hase Koji、Ohno Hiroshi、Kawano Kazuya、Ashida Hiroshi、Suzuki Toshihiko、Morimoto Masako、Saito Yukari、Sasou Ai、Goda Yuki、Yuki Yoshikazu、Inagaki Yutaka、Iijima Hideki、Suda Wataru、Hattori Masahira
  • Journal Title: Nature Communications Volume: 12 Issue: 1 Pages: 1067-1067
  • DOI: 10.1038/s41467-021-21277-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Distinct Age-Specific miRegulome Profiling of Isolated Small and Large Intestinal Epithelial Cells in Mice (2021)
  • Author(s): Lee Juneyoung、Mohsen Attayeb、Banerjee Anik、McCullough Louise D.、Mizuguchi Kenji、Shimaoka Motomu、Kiyono Hiroshi、Park Eun Jeong
  • Journal Title: International Journal of Molecular Sciences Volume: 22 Issue: 7 Pages: 3544-3544
  • DOI: 10.3390/ijms22073544
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Characterization and specification of a trivalent protein-based Pneumococcal vaccine formulation using an adjuvant-free nanogel nasal delivery system. (2021)
  • Author(s): Yuki, Y., Uchida, Y., Sawada, S., Nakahashi-Ouchida, R., Sugiura, K., Mori, H., Yamanoue, T., Machita, T., Honma, A., Kurokawa, S., Mukerji, R., Briles, D.E., Akiyoshi, K. and Kiyono, H.
  • Journal Title: Mol Pharm. Volume: 18 Issue: 4 Pages: 1582-1592
  • DOI: 10.1021/acs.molpharmaceut.0c01003
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Gut microbiota signature of pathogen-dependent dysbiosis in viral gastroenteritis. (2021)
  • Author(s): Mizutani, T, Aboagye, SY, Ishizaka, A, Afum, T, Mensah, GI, Asante-P, A, Asandem, DA, Parbie, PK, Abana, CZ, Kushitor, D., Bonney, EY, Adachi, M, Hori, H., Ishikawa, K, Matano, T, Taniguchi, K, Opare, D, Arhin, D, Asiedu-B, F, Ampofo, WK, Yeboah-Manu, D, Koram, KA, Anang, AK, Kiyono, H.
  • Journal Title: Sci. Rep. Volume: 11 Issue: 1 Pages: 13945-13945
  • DOI: 10.1038/s41598-021-93345-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lipopolysaccharide Derived From the Lymphoid-Resident Commensal Bacteria Alcaligenes faecalis Functions as an Effective Nasal Adjuvant to Augment IgA Antibody and Th17 Cell Responses (2021)
  • Author(s): Wang Yunru、Hosomi Koji、Shimoyama Atsushi、Yoshii Ken、Nagatake Takahiro、Fujimoto Yukari、Kiyono Hiroshi、Fukase Koichi、Kunisawa Jun
  • Journal Title: Frontiers in Immunology Volume: 12 Pages: 699349-699349
  • DOI: 10.3389/fimmu.2021.699349
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dysbiotic Fecal Microbiome in HIV-1 Infected Individuals in Ghana (2021)
  • Author(s): Parbie Prince Kofi、Mizutani Taketoshi、Ishizaka Aya、Kawana-Tachikawa Ai、Runtuwene Lucky Ronald、Seki Sayuri、Abana Christopher Zaab-Yen、Kushitor Dennis、Bonney Evelyn Yayra、Ofori Sampson Badu、Uematsu Satoshi、Imoto Seiya、Kimura Yasumasa、Kiyono Hiroshi、Ishikawa Koichi、Ampofo William Kwabena、Matano Tetsuro
  • Journal Title: Frontiers in Cellular and Infection Microbiology Volume: 11 Pages: 646467-646467
  • DOI: 10.3389/fcimb.2021.646467
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A nanogel-based trivalent PspA nasal vaccine protects macaques from intratracheal challenge with pneumococci. (2021)
  • Author(s): Nakahashi-Ouchida, R, Uchida, Y., Yuki, Y., Katakai, Y., Yamanoue, T., Ogawa, H., Munesue, Y., Nakano, N., Hanari, K., Miyazaki, T., Saito, Y., Umemoto, S., Sawada, S.I., Mukerji, R., Briles, D.E., Yasutomi, Y., Akiyoshi, K., and Kiyono, H.
  • Journal Title: Vaccine. Volume: 39 Issue: 25 Pages: 3353-3364
  • DOI: 10.1016/j.vaccine.2021.04.069
  • Peer Reviewed / Open Access
• [Journal Article] Oral MucoRice-CTB vaccine for safety and microbiota-dependent immunogenicity in humans: a phase 1 randomized trial. (2021)
  • Author(s): Yuki, Y., Nojima, M., Hosono, O., Tanaka, H., Kimura, Y., Satoh, T., Imoto, S., Uematsu, S., Kurokawa, S., Kashima, K., Mejima, M., Nakahashi-Ouchida, R., Uchida, Y., Marui, T., Yoshikawa, N., Nagamura, F., Fujihashi, K. and Kiyono, H.
  • Journal Title: Lancet Microbe. Volume: 2
  • Peer Reviewed / Open Access
• [Journal Article] Unique gut microbiome in HIV patients on ART suggests association with chronic inflammation. (2021)
  • Author(s): Ishizaka, A., Koga, M., Mizutani, T., Parbie, P., Prawisuda, D., Yusa, N., Sedohara, A., Kikuchi, T., Ikeuchi, K., Adachi, E., Koibuchi, T., Furukawa, Y., Tojo, A., Imoto, S., Suzuki, Y., Tsutsumi,T., Kiyono, H., Matano, T. and Yotsuyanagi, H.
  • Journal Title: Microbiology Spectrum. Volume: 9 Issue: 1
  • DOI: 10.1128/spectrum.00708-21
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Two Sides of the Coin: Mast Cells as a Key Regulator of Allergy and Acute/Chronic Inflammation (2021)
  • Author(s): Zhang Zhongwei、Kurashima Yosuke
  • Journal Title: Cells Volume: 10 Issue: 7 Pages: 1615-1615
  • DOI: 10.3390/cells10071615
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy. (2021)
  • Author(s): Takasato Y, Kurashima Y, Kiuchi M, Hirahara K, Murasaki S, Arai F, Izawa K, Kaitani A, Shimada k, Saito Y, Toyoshima S, Nakamura M, Fujisawa K, Okayama Y, Kunisawa J, Kubo M, Takemura N, Uematsu S, Akira S, Kitaura J, Takahashi T, Nakayama T, Kiyono H
  • Journal Title: Mucosal Immunol Volume: 14 Issue: 3 Pages: 640-651
  • DOI: 10.1038/s41385-020-00358-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Comparative whole-genome and proteomics analyses of the next seed bank and the original master seed bank of MucoRice-CTB 51A line, a rice-based oral cholera vaccine (2021)
  • Author(s): Sasou Ai、Yuki Yoshikazu、Honma Ayaka、Sugiura Kotomi、Kashima Koji、Kozuka-Hata Hiroko、Nojima Masanori、Oyama Masaaki、Kurokawa Shiho、Maruyama Shinichi、Kuroda Masaharu、Tanoue Shinjiro、Takamatsu Narushi、Fujihashi Kohtaro、Goto Eiji、Kiyono Hiroshi
  • Journal Title: BMC Genomics Volume: 22 Issue: 1 Pages: 59-59
  • DOI: 10.1186/s12864-020-07355-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 特集 腸内細菌と全身疾患 Ⅰ 腸内細菌と消化器疾患 腸内細菌と炎症性腸疾患 (2020)
  • Author(s): Shibata, N. and Kiyono, H.
  • Journal Title: Pharma Medica Volume: 38 Issue: 12 Pages: 17-22
  • DOI: 10.34449/J0001.38.12_0017-0022
  • ISSN: 0289-5803
  • Year and Date: 2020-12-20
  • Open Access
• [Journal Article] Commensal-bacteria-derived butyrate promotes the T-cell-independent IgA response in the colon. (2020)
  • Author(s): Junya Isobe, Shintarou Maeda, Yuuki Obata, Keito Iizuka, Yutaka Nakamura, Yumiko Fujimura, Tatsuki Kimizuka, Kouya Hattori, Yun-Gi Kim, Tatsuya Morita, Ikuo Kimura, Stefan Offermanns, Takahiro Adachi, Atsuhito Nakao, Hiroshi Kiyono, Daisuke Takahashi, Koji Hase
  • Journal Title: International Immunology Volume: 32 Issue: 4 Pages: 243-258
  • DOI: 10.1093/intimm/dxz078
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A heterodimeric antibody fragment for passive immunotherapy against norovirus infection (2020)
  • Author(s): Yuki Yoshikazu、Kurokawa Shiho、Sato Shintaro、Sasou Ai、Matsumoto Naomi、Suzuki Akio、Sakon Naomi、Goda Yuki、Takeyama Natsumi、Miyoshi Tatsuya、Marcotte Harold、Tanaka Tomoyuki、Hammarstrom Lennart、Kiyono Hiroshi
  • Journal Title: The Journal of Infectious Diseases Volume: － Issue: 3 Pages: 470-478
  • DOI: 10.1093/infdis/jiaa115
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Microfold cell-dependent antigen transport alleviates infectious colitis by inducing antigen-specific cellular immunity (2020)
  • Author(s): Nakamura Yutaka、Mimuro Hitomi、Kunisawa Jun、Furusawa Yukihiro、Takahashi Daisuke、Fujimura Yumiko、Kaisho Tsuneyasu、Kiyono Hiroshi、Hase Koji
  • Journal Title: Mucosal Immunology Volume: in press Issue: 4 Pages: 679-690
  • DOI: 10.1038/s41385-020-0263-0
  • Peer Reviewed / Open Access
• [Journal Article] Adjuvant Activity of Synthetic Lipid A of Alcaligenes, a Gut-Associated Lymphoid Tissue-Resident Commensal Bacterium, to Augment Antigen-Specific IgG and Th17 Responses in Systemic Vaccine (2020)
  • Author(s): Wang Yunru、Hosomi Koji、Shimoyama Atsushi、Yoshii Ken、Yamaura Haruki、Nagatake Takahiro、Nishino Tomomi、Kiyono Hiroshi、Fukase Koichi、Kunisawa Jun
  • Journal Title: Vaccines Volume: 8 Issue: 3 Pages: 395-395
  • DOI: 10.3390/vaccines8030395
  • Peer Reviewed / Open Access
• [Journal Article] Chemically Synthesized Alcaligenes Lipid A Shows a Potent and Safe Nasal Vaccine Adjuvant Activity for the Induction of Streptococcus pneumoniae-Specific IgA and Th17 Mediated Protective Immunity (2020)
  • Author(s): Yoshii Ken、Hosomi Koji、Shimoyama Atsushi、Wang Yunru、Yamaura Haruki、Nagatake Takahiro、Suzuki Hidehiko、Lan Huangwenxian、Kiyono Hiroshi、Fukase Koichi、Kunisawa Jun
  • Journal Title: Microorganisms Volume: 8 Issue: 8 Pages: 1102-1102
  • DOI: 10.3390/microorganisms8081102
  • Peer Reviewed / Open Access
• [Journal Article] Maternal omega-3 docosapentaenoic acid inhibits infant allergic dermatitis through TRAIL-expressing plasmacytoid dendritic cells in mice (2020)
  • Author(s): Hirata SI, Nagatake T, Sawane K, Hosomi K, Honda T, Ono S, Shibuya N, Saito E, Adachi J, Abe Y, Isoyama J, Suzuki H, Matsunaga A, Tomonaga T, Kiyono H, Kabashima K, Arita M, and Kunisawa J
  • Journal Title: Allergy Volume: - Issue: 8 Pages: 0-0
  • DOI: 10.1111/all.14217
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Metagenome Data on Intestinal Phage-Bacteria Associations Aids the Development of Phage Therapy against Pathobionts (2020)
  • Author(s): Fujimoto Kosuke、Kimura Yasumasa、Shimohigoshi Masaki、Satoh Takeshi、Sato Shintaro、Tremmel Georg、Uematsu Miho、Kawaguchi Yunosuke、Usui Yuki、Nakano Yoshiko、Hayashi Tetsuya、Kashima Koji、Yuki Yoshikazu、Yamaguchi Kiyoshi、Furukawa Yoichi、Kakuta Masanori、Akiyama Yutaka、Yamaguchi Rui、Crowe Sheila E. et al
  • Journal Title: Cell Host & Microbe Volume: 28 Issue: 3 Pages: 380-389
  • DOI: 10.1016/j.chom.2020.06.005
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lymphoid Tissue Resident Alcaligenes Establish an Intracellular Symbiotic Environment by Creating a Unique Energy Shift in Dendritic Cells (2020)
  • Author(s): Hosomi Koji、Shibata Naoko、Shimoyama Atsushi、Uto Tomoya、Nagatake Takahiro、Tojima Yoko、Nishino Tomomi、Takeyama Haruko、Fukase Koichi、Kiyono Hiroshi、Kunisawa Jun
  • Journal Title: Frontiers in Microbiology Volume: 11 Pages: 561005-561005
  • DOI: 10.3389/fmicb.2020.561005
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The global response to the COVID-19 pandemic: how have immunology societies contributed? (2020)
  • Author(s): Osier, F., Ting, J., Fraser, J., Lambrecht B, Romano, M., Gazzinelli, R., Bortoluci, K., Zamboni, D., Akbar, A., Evans, J., Brown, D., Patel, K., Wu, Y., Perez, A., Perez, O., Kamradt, T., Falk, C., Barda-Saad, M., Ariel, A., Santoni, A., Annunziato, F., Cassatella, M. Kiyono, H., els.
  • Journal Title: Nat Rev Immunol Volume: 10 Issue: 10 Pages: 594-602
  • DOI: 10.1038/s41577-020-00428-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Stratified layer analysis reveals intrinsic leptin stimulates cryptal mesenchymal cells for controlling mucosal inflammation (2020)
  • Author(s): Matsumura Seiichi、Kurashima Yosuke、Murasaki Sayuri、Morimoto Masako、Arai Fujimi、Saito Yukari、Katayama Nana、Kim Dayoung、Inagaki Yutaka、Kudo Takahiro、Ernst Peter B.、Shimizu Toshiaki、Kiyono Hiroshi
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 18351-18351
  • DOI: 10.1038/s41598-020-75186-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 粘膜免疫の今昔そして未来へ (2020)
  • Author(s): Fujihashi, K. and Kiyono, H.
  • Journal Title: 感染・炎症・免疫 Volume: 50-2 Pages: 116-138
  • Open Access
• [Journal Article] Fatty Acid Metabolism in the Host and Commensal Bacteria for the Control of Intestinal Immune Responses and Diseases (2019)
  • Author(s): Hosomi K, Kiyono H, Kunisawa J.
  • Journal Title: Gut Microbes Volume: 23 Issue: 3 Pages: 1-1
  • DOI: 10.1080/19490976.2019.1612662
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Persistent colonization of non-lymphoid tissue-resident macrophages by Stenotrophomonas maltophilia (2019)
  • Author(s): Takahashi Ichiro, Hosomi Koji, Nagatake Takahiro, Tobou Hirokazu, Yamamoto Daiki, Hayashi Ikue, Kurashima Yosuke, Sato Shintaro, Shibata Naoko, Goto Yoshiyuki, Maruyama Fumito, Nakagawa Ichiro, Kuwae Asaomi, Abe Akio, Kunisawa Jun, Kiyono Hiroshi
  • Journal Title: International Immunology Volume: 32 Issue: 2 Pages: 133-141
  • DOI: 10.1093/intimm/dxz071
  • NAID: 120006888456
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A role for the CCR5?CCL5 interaction in the preferential migration of HSV-2-specific effector cells to the vaginal mucosa upon nasal immunization (2019)
  • Author(s): Joo Sunyi、Suwanto Aldina、Sato Ayuko、Nakahashi-Ouchida Rika、Mori Hiromi、Uchida Yohei、Sato Shintaro、Kurashima Yosuke、Yuki Yoshikazu、Fujihashi Kohtaro、Kawaguchi Yasushi、Kiyono Hiroshi
  • Journal Title: Mucosal Immunology Volume: 12 Issue: 6 Pages: 1391-1403
  • DOI: 10.1038/s41385-019-0203-z
  • Peer Reviewed / Open Access
• [Journal Article] Mast cells play role in wound healing through the ZnT2/GPR39/IL-6 axis (2019)
  • Author(s): Nishida K, Hasegawa A, Yamasaki S, Uchida R, Ohashi W, Kurashima Y, Kunisawa J, Kimura S, Iwanaga T, Watarai H, Hase K, Ogura H, Nakayama M, Kashiwakura J, Okayama Y, Kubo M, Ohara O, Kiyono H, Koseki H, Murakami M, Hirano T
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 10842-10842
  • DOI: 10.1038/s41598-019-47132-5
  • Peer Reviewed / Open Access
• [Journal Article] Antigen-Specific Mucosal Immunity Regulates Development of Intestinal Bacteria-Mediated Diseases (2019)
  • Author(s): Fujimoto Kosuke、Kawaguchi Yunosuke、Shimohigoshi Masaki、Gotoh Yoshiyuki、Nakano Yoshiko、Usui Yuki、Hayashi Tetsuya、Kimura Yasumasa、Uematsu Miho、Yamamoto Takuya、Akeda Yukihiro、Rhee Joon Haeng、Yuki Yoshikazu、Ishii Ken J.、Crowe Sheila E.、Ernst Peter B.、Kiyono Hiroshi、Uematsu Satoshi
  • Journal Title: Gastroenterology Volume: 157 Issue: 6 Pages: 1530-1543
  • DOI: 10.1053/j.gastro.2019.08.021
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Autonomous regulation of immunoglobulin E-mediated mast cell degranulation and immediate hypersensitivity reaction by an inhibitory receptor CD300a. (2019)
  • Author(s): Noval Rivas M, Wakita D, Franklin MK, Carvalho TT, Abolhesn A, Gomez AC, Fishbein MC, Chen S, Lehman TJ, Sato K, Shibuya A, Fasano A, Kiyono H, Abe M, Tatsumoto N, Yamashita M, Crother TR, Shimada K, Arditi M
  • Journal Title: Immunity Volume: 51(3) Issue: 3 Pages: 508-521
  • DOI: 10.1016/j.immuni.2019.05.021
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Fucosyltransferase 2 induces lung epithelial fucosylation and exacerbates house dust mite-induced airway inflammation. (2019)
  • Author(s): Saku A, Hirose K, Ito T, Iwata A, Sato T, Kaji H, Tamachi T, Suto A, Goto Y, Domino SE, Narimatsu H, Kiyono H, Nakajima H
  • Journal Title: J Allergy Clin Immunol. Volume: 144(3) Issue: 3 Pages: 698-709
  • DOI: 10.1016/j.jaci.2019.05.010
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Distinct Roles for Peyer’s Patch B Cells for Induction of Antigen-specific IgA Antibody Responses in Mice Administered Oral Recombinant Salmonella (2019)
  • Author(s): Hashizume-Takizawa Tomomi、Shibata Naoko、Kurashima Yosuke、Kiyono Hiroshi、Kurita-Ochiai Tomoko、Fujihashi Kohtaro
  • Journal Title: International Immunology Volume: - Issue: 8 Pages: 531-541
  • DOI: 10.1093/intimm/dxz029
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dietary coconut oil ameliorates skin contact hypersensitivity through mead acid production in mice (2019)
  • Author(s): Tiwari Prabha、Nagatake Takahiro、Hirata So‐ichiro、Sawane Kento、Saika Azusa、Shibata Yuki、Morimoto Sakiko、Honda Tetsuya、Adachi Jun、Abe Yuichi、Isoyama Junko、Tomonaga Takeshi、Kiyono Hiroshi、Kabashima Kenji、Kunisawa Jun
  • Journal Title: Allergy Volume: NA Issue: 8 Pages: 1522-1532
  • DOI: 10.1111/all.13762
  • Peer Reviewed
• [Journal Article] Human Norovirus Propagation in Human Induced Pluripotent Stem Cell?Derived Intestinal Epithelial Cells (2019)
  • Author(s): Sato Shintaro、Hisaie Kota、Kurokawa Shiho、Suzuki Akio、Sakon Naomi、Uchida Yohei、Yuki Yoshikazu、Kiyono Hiroshi
  • Journal Title: Cellular and Molecular Gastroenterology and Hepatology Volume: 7 Issue: 3 Pages: 164-4
  • DOI: 10.1016/j.jcmgh.2018.11.001
  • Peer Reviewed / Open Access
• [Journal Article] Intrinsic Control of Surface Immune and Epithelial Homeostasis by Tissue-Resident Gut Stromal Cells (2019)
  • Author(s): Kurashima Yosuke、Tokuhara Daisuke、Kamioka Mariko、Inagaki Yutaka、Kiyono Hiroshi
  • Journal Title: Frontiers in Immunology Volume: 10 Pages: 01281-01281
  • DOI: 10.3389/fimmu.2019.01281
  • Peer Reviewed / Open Access
• [Journal Article] New trends in mucosal immunology and allergy (2019)
  • Author(s): Kiyono, H. Izuhara, K.
  • Journal Title: Allergology International Volume: 68 Issue: 1 Pages: 1-3
  • DOI: 10.1016/j.alit.2018.12.002
  • NAID: 130007557931
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed
• [Journal Article] A comprehensive understanding of the gut mucosal immune system in allergic inflammation (2019)
  • Author(s): Tokuhara Daisuke、Kurashima Yosuke、Kamioka Mariko、Nakayama Toshinori、Ernst Peter、Kiyono Hiroshi
  • Journal Title: Allergology International Volume: 68 Issue: 1 Pages: 17-25
  • DOI: 10.1016/j.alit.2018.09.004
  • NAID: 130007557958
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Current status and future directions of study on glycosylation for gut microbiota and the mucosal immune network. (2019)
  • Author(s): Goto, Y., Kiyono, H.
  • Journal Title: Glycoscience: Basic Science to Applications - Insights from the Japan Consortium. Volume: Mar2019 Pages: 92-94
• [Journal Article] Polymeric Caffeic Acid Is a Safer Mucosal Adjuvant That Augments Antigen-Specific Mucosal and Systemic Immune Responses in Mice (2018)
  • Author(s): Tada Rui、Yamanaka Daisuke、Ogasawara Miki、Saito Momoko、Ohno Naohito、Kiyono Hiroshi、Kunisawa Jun、Aramaki Yukihiko
  • Journal Title: Molecular Pharmaceutics Volume: 15 Issue: 9 Pages: 4226-4234
  • DOI: 10.1021/acs.molpharmaceut.8b00648
  • Peer Reviewed
• [Journal Article] Development of immune and microbial environment is independently regulated in the mammary gland (2018)
  • Author(s): Niimi K, Usami K, Fujita Y, Abe M, Furukawa M, Suyama Y, Sakai Y, Kamioka M, Shibata N, Park EJ, Sato S, Kiyono H, Yoneyama H, Kitazawa H, Watanabe K, Nochi T, Aso H
  • Journal Title: Mucosal Immunology Volume: 印刷中 Issue: 3 Pages: 643-653
  • DOI: 10.1038/mi.2017.90
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Lymphoid tissue-resident Alcaligenes LPS induces IgA production without excessive inflammatory responses via weak TLR4 agonist activity (2018)
  • Author(s): N. Shibata, J. Kunisawa, K. Hosomi, Y. Fujimoto, K. Mizote, N. Kitayama, A. Shimoyama, H. Mimuro, S. Sato, N. 5 Kishishita, K. J. Ishii, K. Fukase, and H. Kiyono
  • Journal Title: Mucosal Immunology Volume: － Issue: 3 Pages: 693-702
  • DOI: 10.1038/mi.2017.103
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] ATP as a Pathophysiologic Mediator of Bacteria-Host Crosstalk in the Gastrointestinal Tract (2018)
  • Author(s): Inami Akie、Kiyono Hiroshi、Kurashima Yosuke
  • Journal Title: International Journal of Molecular Sciences Volume: 19 Issue: 8 Pages: 2371-2371
  • DOI: 10.3390/ijms19082371
  • Peer Reviewed / Open Access
• [Journal Article] 共生と排除を司る粘膜マスト細胞 (2018)
  • Author(s): 倉島洋介
  • Journal Title: 腸内細菌学雑誌 Volume: 32 Pages: 159-166
  • NAID: 130007501993
• [Journal Article] 17,18-EpETE-GPR40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques (2017)
  • Author(s): Nagatake T, Shiogama Y, Inoue A, Kikuta J, Honda T, Tiwari P, Kishi T, Yanagisawa A, Isobe Y, Matsumoto N, Shimojou M, Morimoto S, Suzuki H, Hirata S, Steneberg P, Edlund H, Aoki J, Arita M, Kiyono H, Yasutomi Y, Ishii M, Kabashima K, Kunisawa J
  • Journal Title: Journal of Allergy and Clinical Immunology Volume: S0091-6749 Issue: 2 Pages: 32949-32944
  • DOI: 10.1016/j.jaci.2017.09.053
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 臓器・細胞連関による腸管粘膜保護, (2023)
  • Author(s): 倉島洋介
  • Organizer: SAMURAI研究会 3rd
  • Invited
• [Presentation] Identification of Pancreas GP2-binding Bacteria and Elucidation of its Pathogenicity in Intestinal Inflammation (2023)
  • Author(s): Zhang Z., Pan Z., Saito Y., Tanaka I., Black A., Ernst P.B., Kiyono H., Kurashima Y.
  • Organizer: Mucosal Vaccine R&D WorkShop
  • Int'l Joint Research
• [Presentation] Elucidation of mucosal defense mechanism by hierarchical support system of digestive tract, Kurashima Y. (2023)
  • Author(s): Kurashima Y.
  • Organizer: International Symposium for Future Mucosal Vaccines: Safeguards and Innovations against Infectious Diseases
  • Int'l Joint Research / Invited
• [Presentation] Elucidation of Disease-associated Mesenchymal Cells in the Tissue Microenvironment in Mice Colon, (2023)
  • Author(s): Tanaka I., Murasaki S., Zhang Z., Black A., Ernst P.B., Kiyono H.
  • Organizer: Mucosal Vaccine R&D WorkShop
  • Int'l Joint Research
• [Presentation] Gut Microbiota at the Crossroads of Pancreas-Intestinal Barrier Axis (2023)
  • Author(s): 倉島洋介
  • Organizer: 第100回日本生理学会大会
  • Invited
• [Presentation] 膵による腸管感染防御機構 (2022)
  • Author(s): 倉島洋介
  • Organizer: 第65回日本糖尿病学会年次学術集会
  • Invited
• [Presentation] 腸管バリア機能を強化する Lactobacillus 株のスクリーニングと有効性の検証 (2022)
  • Author(s): 倉島洋介
  • Organizer: 第22回DIJFカンファランス
  • Invited
• [Presentation] 口腔科学が寄与した粘膜免疫学創生から未来ワクチン開発戦略 (2022)
  • Author(s): 清野宏
  • Organizer: 第76回日本口腔科学会学術集会
• [Presentation] 粘膜免疫が導く未来型ワクチンの研究開発 (2022)
  • Author(s): 清野宏
  • Organizer: 第60回日本小児歯科学会
• [Presentation] Mucosal Vaccine: Bringing the old wisdom to reality (2022)
  • Author(s): Kiyono H
  • Organizer: 2022 ISV Annual Congress
• [Presentation] 粘膜免疫研究が導く次世代ワクチン (2022)
  • Author(s): 清野宏
  • Organizer: 第1回臨床粘膜免疫研究会
• [Presentation] Microbiota-dependent Immunogenicity of Cold-chain and Needle-free Oral Vaccine, MucoRice-CTB (2021)
  • Author(s): Hiroshi Kiyono
  • Organizer: The 5th International Immunological Memory and Vaccine Forum (IIMVF)
  • Int'l Joint Research / Invited
• [Presentation] Influence of intestinal microbiota on the vaccine induced immunity (2021)
  • Author(s): Hiroshi Kiyono
  • Organizer: The 11th Probiotics, Prebiotics & New Foods, Nutraceuticals and Botanicals for Nutrition & Human and Microbiota Health
  • Int'l Joint Research / Invited
• [Presentation] Intestinal commensal bacteria for mucosal homeostasis and vaccine immunity (2021)
  • Author(s): Hiroshi Kiyono
  • Organizer: The 16th Biennial Meeting on International Endotoxin and Innate Immunity Society (IEIIS2021)
  • Int'l Joint Research / Invited
• [Presentation] Past, Present and Future of Mucosal Vaccine: Vital Contributions Made by Dentistry (2021)
  • Author(s): 清野 宏
  • Organizer: 第69国際歯科研究学会総会JADR ・学術大会
  • Int'l Joint Research / Invited
• [Presentation] 粘膜免疫学が開く未来型ワクチン (2021)
  • Author(s): 清野 宏
  • Organizer: 第49回日本臨床免疫学会総会
  • Invited
• [Presentation] Mucosal Immunology leads "Post-injection vaccine" Era (2021)
  • Author(s): Hiroshi Kiyono
  • Organizer: Handai Drug Discovery Symposium of "Approaching the full picture of the COVID-19, Research on infectious diseases and development of therapeutic agents in the post-COVID-19 era"
  • Invited
• [Presentation] Pancreas-intestinal barrier axis and the control of commensal bacteria in intestinal inflammation (2021)
  • Author(s): 倉島 洋介
  • Organizer: 15th World Immune Regulation Meeting
  • Int'l Joint Research / Invited
• [Presentation] 腸内細菌の調整役としての「膵臓」の役割 (2021)
  • Author(s): 倉島 洋介
  • Organizer: SPC（Science Pioneers Consortium）2021
  • Invited
• [Presentation] Two sides of the coin: mast cells as a key regulator of allergy and inflammation (2021)
  • Author(s): 倉島 洋介
  • Organizer: 第50回日本免疫学会学術集会
  • Invited
• [Presentation] Pancreatic-Gut Axis for the Mucosal Protection (2021)
  • Author(s): Kurashima, Y.
  • Organizer: Joint Webinar of ‘Chiba University Tenure Track Seminar Program and International Research and Development Center for Mucosal Vaccines (IMSUT) Vaccine Center Seimnar
  • Invited
• [Presentation] 共生細菌による粘膜免疫制御 (2021)
  • Author(s): Kiyono, H.
  • Organizer: Nagasaki Intestinal Microbiology Study Group Webinar
  • Invited
• [Presentation] Considering Vaccination (2021)
  • Author(s): Kiyono, H.
  • Organizer: SMBC Nikko Securities Inc.’s Economic and Science Webinar, “Acknowledge COVID-19 correctly,”
  • Invited
• [Presentation] 腸内細菌の制御を担う新たな「膵臓」の役割 (2020)
  • Author(s): 倉島 洋介
  • Organizer: 第24回腸内細菌学会（誌上開催）
  • Invited
• [Presentation] 骨免疫学と粘膜免疫学の接点：そこから生まれるイノベーション (2020)
  • Author(s): 清野宏
  • Organizer: The 17th Osteoimmunology Forum
  • Invited
• [Presentation] 粘膜免疫を基盤とした予防・治療戦略 (2019)
  • Author(s): 清野宏
  • Organizer: 第６回アレルギー講習会
  • Invited
• [Presentation] 次世代型粘膜ワクチンによる感染症予防・治療戦略 (2019)
  • Author(s): 清野宏
  • Organizer: 第34階日本国際保健医療学会学術大会
  • Invited
• [Presentation] Fruitful collaboration between Ghana and Japan for SATREPS to mucosal vaccine development (2019)
  • Author(s): 清野宏
  • Organizer: The symposium for the 40th anniversary of Noguchi Memorial Institute, Accra, Ghana
  • Int'l Joint Research
• [Presentation] Introduction of cMAV Research Project (2019)
  • Author(s): 清野宏
  • Organizer: 千葉大創立70周年記念シンポジウム
• [Presentation] Mucosal multi-immunological ecological system to vaccine development (2019)
  • Author(s): 清野宏
  • Organizer: NIH-Japan-JSPS Symposium, Maryland, USA
  • Int'l Joint Research / Invited
• [Presentation] 粘膜免疫学創生から径鼻粘膜ワクチン開発へ (2019)
  • Author(s): 清野宏
  • Organizer: 第55回日本移植学会総会
  • Invited
• [Presentation] Intratissue commensal bacteria mediates balancing act between gut symbiosis and inflammation (2019)
  • Author(s): 清野宏
  • Organizer: The 10th Probiotics, Prebiotics and New foods, Nutraceuticals and Botanicals for Nutrition and Human and Microbiota Health/1st Science and Business Symposium, Rome, Itally
  • Int'l Joint Research / Invited
• [Presentation] Mucosal multi-ecological system for symbiosis, inflammation and vaccine (2019)
  • Author(s): 清野宏
  • Organizer: University of Bari, Medical Center, Bari, Italy
  • Int'l Joint Research / Invited
• [Presentation] 粘膜免疫：共生と排除、そしてワクチンへ (2019)
  • Author(s): 清野宏
  • Organizer: 第34回日本ショック学会
  • Invited
• [Presentation] 次世代型粘膜ワクチンによる感染症予防・治療戦略 (2019)
  • Author(s): 清野宏
  • Organizer: 第13回緩和医療薬学会年会講演会
  • Invited
• [Presentation] 粘膜免疫学創生から未来型ワクチン開発へ (2019)
  • Author(s): 清野宏
  • Organizer: 第120回日本耳鼻咽喉科学会学術講演会
  • Invited
• [Presentation] Orally-desensitized mast cells acquired regulatory characteristics for the control of allergy (2019)
  • Author(s): Kurashima, Y.
  • Organizer: 3rd Annual Symposium for the Center for Mucosal Immunology, Allergy and Vaccine Development
  • Int'l Joint Research
• [Presentation] The Mucosal Immune System for Symbiosis, Elimination and Vaccine (2019)
  • Author(s): Kiyono, H.
  • Organizer: Interdisciplinary Seminar on Mucosal Immunology at Tohoku University.
• [Presentation] Mesenchymal-myeloid cell interactions in microenvironment for novel fibrogenic machinery in tissue fibrosis (2019)
  • Author(s): Kurashima, Y., Murasaki, S., Morimoto, M., Shimizu, K., Kiyono, H.
  • Organizer: 第3回千葉大学グローバルプロミネント研究基幹シンポジウム
• [Presentation] Gut-multi Ecosystem for Immunity, Inflammation and Vaccine (2018)
  • Author(s): Kiyono, H.
  • Organizer: UCSD Gastroenterology Tuesday Morning Conference, San Diego, CA, USA
  • Invited
• [Presentation] Metagenome Analysis; Great Impact on the Next-Generation Surveillance System for Diarrheal and HIV Diseases (2018)
  • Author(s): Kiyono, H.
  • Organizer: Noguchi Hideyo Memorial Museum, Symposium on Infectious Disease and Immunity,
  • Int'l Joint Research / Invited
• [Presentation] Mucosal Equilibrium of Immunity and Symbiosis: From Basic to Vaccine Development (2018)
  • Author(s): Kiyono, H.
  • Organizer: University of Florida, Florida, USA
  • Int'l Joint Research / Invited
• [Presentation] Mucosal Multi-Ecological Loop of Intra- and Extra-Tissue Commensal Microbiota, Epithelial Cells and Immune Cells for Gut Homeostasis and InflammationMucosal Multi-Ecological Loop of Intra- and Extra-Tissue Commensal Microbiota, Epithelial Cells and Immune Cells for Gut Homeostasis and Inflammation (2018)
  • Author(s): Kiyono, H.
  • Organizer: TOLLerant final event "Microbiota/host dialogue, the molecular language”
  • Invited
• [Presentation] “Mucosal Immunology: Mucosal Homeostasis, Development of Novel Oral Vaccines for Global Health (2018)
  • Author(s): Kiyono, H.
  • Organizer: CU-UCSD cMAV Symposium 2019, San Diego, USA
  • Invited
• [Presentation] Mucosal Multi-ecological System Creates Novel Strategy for the Prevention and Treatment of Diseases (2018)
  • Author(s): Kiyono, H.
  • Organizer: The 67th Annual Meeting of Japanese Society of Allergology
• [Presentation] The Mucosal Immune System for Symbiosis, Elimination and Vaccine (2018)
  • Author(s): Kiyono, H.
  • Organizer: Japanese Society of Immunology’s Immunology Summer School
• [Presentation] Intestine as a Super Immunological Organ (2018)
  • Author(s): Kiyono, H.
  • Organizer: Intercompany Seminar of Asahi Kogyosha Co., Ltd.
• [Presentation] Equilibrium of Immunity & Symbiosis: From Basic to Vaccine Development (2018)
  • Author(s): Kiyono, H.
  • Organizer: Max Plank Institute for Infection Biology Alumni Meeting
• [Presentation] Mucosal tissue axis for the induction and regulation of immunity, inflammation and symbiosis (2018)
  • Author(s): Kiyono, H.
  • Organizer: Japan-German Immunology Workshop,
• [Presentation] 小腸パイエル板組織内共生細菌アルカリゲネスの免疫機能とアジュバント応用 (2018)
  • Author(s): 柴田納央子、細見晃司、下山敦史、王韻茹、吉井健、深瀬浩一、清野宏、國澤純
  • Organizer: 第15回日本小児消化管感染症研究会
• [Presentation] 共生と排除を司る粘膜マスト細胞の研究/Elucidation of the function of mucosal mast cells for symbiosis and elimination (2018)
  • Author(s): 倉島洋介
  • Organizer: 第22回腸内細菌学会 受賞講演
  • Invited
• [Presentation] 間葉系細胞による免疫末梢教育/Mesenchymal-myeloid cell interactions in renal microenvironment for novel fibrogenic machinery in kidney fibrosis (2018)
  • Author(s): 倉島洋介
  • Organizer: 第42回日本リンパ学会
• [Presentation] Mesenchymal cell-mediated local inflammatory loop in intestinal inflammation (2018)
  • Author(s): Kurashima, Y.
  • Organizer: 2nd Korea-Japan Joint Meeting on Mucosal Immunology
• [Presentation] Bringing mast cells over to our side to overcome allergy” (2018)
  • Author(s): Kurashima, Y.
  • Organizer: 第67回日本アレルギー学会学術大会 シンポジウム18
  • Invited
• [Presentation] 腸管粘膜・皮膚などにおける上皮－間葉－神経系ネットワークによる末梢免疫教育機構 (2018)
  • Author(s): 倉島洋介
  • Organizer: アステラス製薬招待講演
• [Presentation] Synthesis and function of symbiotic bacterial lipopolysaccharide partial structures. (2018)
  • Author(s): Shimoyama, A., Mizote, K., Uto, T., Shibata, N., Lorenzo, F.D., Molinaro, A., Fujimoto, Y., Kunisawa, J., Kiyono, H., Fukase, K.,
  • Organizer: 5th Asian Chemical Biology Conference (Oral)
  • Int'l Joint Research
• [Presentation] Synthesis and Function of Symbiotic Bacterial Lipopolysaccharide Partial Structures, (2018)
  • Author(s): Shimoyama, A., Mizote, K., Uto, T., Shibata, N., Lorenzo F.D., Molinaro, A., Kunisawa, J., Kiyono, H., Fujimoto, Y., Fukase, K.
  • Organizer: Joint Meeting of the Society for Leukocyte Biology (SLB) & the International Endotoxin and Innate Immunity Society(IEIIS
  • Int'l Joint Research
• [Presentation] Synthesis and functions of symbiotic bacterial lipopolysaccharide partial structures. (2018)
  • Author(s): Shimoyama, A., Mizote, K., Uto, T., Lorenzo, F.D., Shibata, N., Fujimoto, Y., Kunisawa, J., Kiyono, K.
  • Organizer: MicrobiotaMi2018 Milano, Italy
• [Presentation] Synthesis and function of symbiotic bacterial lipopolysaccharide partial structures (2018)
  • Author(s): Shimoyama, A., Mizote, K., Uto, T., Shibata, N., Lorenzo, F.D., Molinaro, A., Fujimoto, Y., Kunisawa, J., Kiyono, H., Fukase, K.
  • Organizer: 5th Asian Chemical Biology Conference (Poster)
  • Int'l Joint Research
• [Presentation] Synthesis and immunological function of symbiotic bacterial lipopolysaccharide partial structures. (2018)
  • Author(s): Shimoyama, A., Mizote, K., Uto, T., Lorenzo, F.D., Shibata, N., Fujimoto, Y., Kunisawa, J., Kiyono, H., Molinaro, A. Fukase, K.
  • Organizer: The 14th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC14)
• [Presentation] CCL28-mediated chemotaxis for the recruitment of IgA-producing plasma cells into the mammary gland depends on the lactation-related but not bacterial stimulus (2018)
  • Author(s): Nochi, T., Niimi, K., Usami, K., Furukawa, M., Sasaki, S., Kiyono, H., Watanabe, K. and Aso, H.
  • Organizer: Mucosal Immunology Course & Symposium (MICS2018)
  • Int'l Joint Research
• [Presentation] 寄生・共生菌由来リポ多糖部分構造の合成と免疫調節機能の解明 (2018)
  • Author(s): 下山敦史、溝手啓介、宇戸智哉、柴田納央子、Flaviana Di Lorenzo、Antonio Molinaro、國澤純、清野宏、藤本ゆかり、深瀬浩一、
  • Organizer: 第37回日本糖質学会年会
• [Presentation] LPS from lymphoid tissue-resident Alcaligenes induces IgA without excessive inflammation via its weak TLR4 agonist activity (2018)
  • Author(s): Shibata, N., Kunisawa, J., Hosomi, K., Fujimoto, Y., Mizote, K., Kitayama, N., Shimoyama, A., Ishii, K.J., Fukase, K. and Kiyono, H.
  • Organizer: 第47回日本免疫学会
• [Presentation] 間葉系細胞による免疫恒常性維持機構 (2018)
  • Author(s): 倉島洋介, 松村成一, 村崎さゆり, 清野宏
  • Organizer: 第8回オルソオルガノジェネシス検討会
• [Presentation] Orally-desensitized mast cells acquired regulatory characteristics for the control of food allergy (2018)
  • Author(s): Kurashima, Y., Takasato, Y., Kiuchi, M., Hirahara, K., Murasaki, S., Kunisawa, J., Kubo, M., Uematsu, S., Nakayama, T., Kiyono, H.
  • Organizer: 第47回日本免疫学会学術集会
• [Book] アロスエルゴン Vol.1 No.2 免疫応答の万事屋、マスト細胞の細胞間相互作用 (2022)
  • Author(s): 田中 和、倉島 洋介
  • Publisher: クリニコ出版
• [Book] 臨床免疫・アレルギー科. 77(2) 膵臓Glycoprotein2による恒常性維持と腸炎回避機構 (2022)
  • Author(s): 田中 和、潘 臻、倉島 洋介、清野 宏
  • Publisher: 科学評論社
• [Book] 臨床免疫・アレルギー科. 76(4) 免疫療法の成功の秘訣：マスト細胞が持つアレルギー抑制機能をいかに 引き出せるか (2021)
  • Author(s): 倉島 洋介
  • Publisher: 科学評論社
• [Book] 臨床免疫・アレルギー科. 76(2) 粘膜間葉系細胞による 修復と炎症遷延化 (2021)
  • Author(s): 香取 明都、潘 臻、齊藤 ゆかり、倉島 洋介
  • Publisher: 科学評論社
• [Book] Mucosal vaccines, Innovation for preventing infectious diseases, Second Edition (2020)
  • Author(s): Kiyono, H., Pascual, D.W.
  • Total Pages: 940
  • Publisher: Elsevier
  • ISBN: 9780128119242
• [Book] Handbook of Immunosenescence: Basic Understanding and Clinical Implications (2019)
  • Author(s): Fujihashi, K., McGhee, J. R., and Kiyono, H.
  • Publisher: Springer Science
• [Book] Lymph Node Metastasis in Gastrointestinal Cancer (2019)
  • Author(s): Nagatake, T., Kunisawa, J., and Kiyono, H.
  • Publisher: Springer
  • ISBN: 9789811046995
• [Book] 免疫生物学（原書第9版）(翻訳) (2019)
  • Author(s): 籠谷領二, 倉島洋介, 清野宏、
  • Publisher: 南江堂
• [Book] SMI textbook of Principles of Mucosal Immunology. 2nd Edition. (2018)
  • Author(s): Kiyono, H., Fujihashi, K., Mestecky, J.
  • Publisher: Garland Science, Taylor & Francis Group, LLC
• [Book] 腎臓内科・泌尿器科7 (2018)
  • Author(s): 山本智久、 倉島洋介、 清野宏
  • Publisher: 科学評論社
• [Book] リンパ学41-2 (2018)
  • Author(s): 切真里奈, 清野宏, 倉島洋介
  • Publisher: 日本リンパ学会
• [Remarks] cMAV
  • URL: https://medschool.ucsd.edu/som/medicine/divisions/gastro/research/CMAV/Pages/default.aspx
• [Remarks] 地球規模保健課題解決推進のための研究事業（日米医学協力計画）
  • URL: https://www.niaid.nih.gov/research/us-japan-cooperative-medical-science-program-delegation
• [Remarks] SATREPS(地球規模課題対応国際科学技術協力プログラム)
  • URL: https://www.jst.go.jp/global/public/shiryo/brochure2019_J.pdf
• [Remarks] Mucosal Immu., Allergy & Vaccine Development
  • URL: https://medschool.ucsd.edu/som/medicine/divisions/gastro/research/CMAV/Pages/default.aspx
• [Remarks] M Vaccine, Tuberculosis Using Antibody Engineering
  • URL: https://www.ghitfund.org/investment/portfoliodetail/detail/95
• [Patent(Industrial Property Rights)] ノロウイルス抗体 (2021)
  • Inventor(s): 幸 義和、黒河 志保、清野 宏
  • Industrial Property Rights Holder: 幸 義和、黒河 志保、清野 宏
  • Industrial Property Rights Type: 特許
  • Filing Date: 2021
  • Acquisition Date: 2021
• [Patent(Industrial Property Rights)] 肺炎球菌表層タンパク質 (2019)
  • Inventor(s): 幸義和、中橋理佳、清野宏
  • Industrial Property Rights Holder: 幸義和、中橋理佳、清野宏
  • Industrial Property Rights Type: 特許
  • Filing Date: 2019