| Budget Amount *help |
¥193,440,000 (Direct Cost: ¥148,800,000、Indirect Cost: ¥44,640,000)
Fiscal Year 2022: ¥37,960,000 (Direct Cost: ¥29,200,000、Indirect Cost: ¥8,760,000)
Fiscal Year 2021: ¥37,960,000 (Direct Cost: ¥29,200,000、Indirect Cost: ¥8,760,000)
Fiscal Year 2020: ¥37,960,000 (Direct Cost: ¥29,200,000、Indirect Cost: ¥8,760,000)
Fiscal Year 2019: ¥37,960,000 (Direct Cost: ¥29,200,000、Indirect Cost: ¥8,760,000)
Fiscal Year 2018: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
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| Outline of Final Research Achievements |
We found that spermatogonial stem cells use glutamine for producing glutathione to protect themselves from damages by reactive oxygen species (ROS) produced by Nox1. They also possess stronger base excision repair activity than embryonic stem cells or somatic cells to minimize mutations. We also discovered that ROS induce Nox1 expression via translocation of BCL6B into the nucleus, which creates a postive feedback loop. In the course of our study to analyze the impact of long-term SSC culture, we accidentally found that in vitro fertilization and intrancytoplasmic sperm injection, both of which are widely used for human infertility treatment, can cause implantation failure and congenital abnormalities in F2 offspring.
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| Assessment Rating |
Ex-post Assessment Comments (Rating)
A: In light of the aim of introducing the research area into the research categories, expected outcomes of research have been produced.
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Assessment Rating |
Interim Assessment Comments (Rating)
A: In light of the aim of introducing the research area into the research categories, the expected progress has been made in research.
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