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Neural Mechanisms of Functional Recovery via Artificial Neural Connection

Research Project

Project/Area Number 18H05287
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Review Section Broad Section I
Research InstitutionTokyo Metropolitan Institute of Medical Science

Principal Investigator

NISHIMURA Yukio  公益財団法人東京都医学総合研究所, 脳・神経科学研究分野, プロジェクトリーダー (20390693)

Project Period (FY) 2018-06-11 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥147,160,000 (Direct Cost: ¥113,200,000、Indirect Cost: ¥33,960,000)
Fiscal Year 2022: ¥23,270,000 (Direct Cost: ¥17,900,000、Indirect Cost: ¥5,370,000)
Fiscal Year 2021: ¥23,270,000 (Direct Cost: ¥17,900,000、Indirect Cost: ¥5,370,000)
Fiscal Year 2020: ¥23,270,000 (Direct Cost: ¥17,900,000、Indirect Cost: ¥5,370,000)
Fiscal Year 2019: ¥23,270,000 (Direct Cost: ¥17,900,000、Indirect Cost: ¥5,370,000)
Fiscal Year 2018: ¥54,080,000 (Direct Cost: ¥41,600,000、Indirect Cost: ¥12,480,000)
Keywordscerebral cortex / Spinal cord / brain computer interface / neuron / adaptation / 人工神経接続 / 脊髄損傷 / 運動機能 / 上肢 / 歩行機能 / 脊髄 / 機能回復 / 機能再建 / 適応 / 可塑性
Outline of Final Research Achievements

We aimed to clarify what neural mechanisms are responsible for the flexible adaptation of the nervous system to a novel neural connection. The neurons in the monkey motor cortex change their activity patterns in response to the role of the spinal cord to which they are connected via computer interface. In spinal cord injury patients with residual pathways, the artificial neural connection via computer interface improved walking ability and reorganized the functional maps in both the brain and spinal cord. In summary, we found that the motor cortex adapts to the novel neural connections by altering its activity to match the role of the lower spinal cord newly connected by the artificial neural connection.

Academic Significance and Societal Importance of the Research Achievements

日本には10万人の脊髄損傷患者がおり、患者の麻痺した運動機能を取り戻すための革新的な治療戦略が待望されている。本研究の成果から、脊髄損傷患者の運動機能の再獲得に対する人工神経接続の有効性と作用機序が明らかとなった。研究の成果は、人工神経接続がこれまで不治の病であると考えられていた脊髄損傷に対する革新的な治療法となりうることを示している。

Assessment Rating
Ex-post Assessment Comments (Rating)

A: In light of the aim of introducing the research area into the research categories, expected outcomes of research have been produced.

Assessment Rating
Interim Assessment Comments (Rating)

A: In light of the aim of introducing the research area into the research categories, the expected progress has been made in research.

Report

(11 results)
  • 2023 Ex-post Assessment (Comments) ( PDF )
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Abstract (Interim Assessment) ( PDF )   Annual Research Report   Interim Assessment (Comments) ( PDF )
  • 2019 Annual Research Report
  • 2018 Abstract ( PDF )   Comments on the Screening Results ( PDF )   Annual Research Report
  • Research Products

    (102 results)

All 2023 2022 2021 2020 2019 2018 Other

All Journal Article (28 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 22 results,  Open Access: 15 results) Presentation (70 results) (of which Int'l Joint Research: 24 results,  Invited: 17 results) Remarks (4 results)

  • [Journal Article] Corticospinal interface to restore voluntary control of joint torque in a paralyzed forearm following spinal cord injury in non-human primates2023

    • Author(s)
      Obara Kei、Kaneshige Miki、Suzuki Michiaki、Yokoyama Osamu、Tazoe Toshiki、Nishimura Yukio
    • Journal Title

      Frontiers in Neuroscience

      Volume: 17 Pages: 1127095-1127095

    • DOI

      10.3389/fnins.2023.1127095

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Tuning of motor outputs produced by spinal stimulation during voluntary control of torque directions in monkeys2022

    • Author(s)
      Kaneshige Miki、Obara Kei、Suzuki Michiaki、Tazoe Toshiki、Nishimura Yukio
    • Journal Title

      eLife

      Volume: 11 Pages: 1-27

    • DOI

      10.7554/elife.78346

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Non-invasive brain-spine interface: Continuous control of trans-spinal magnetic stimulation using EEG2022

    • Author(s)
      Insausti-Delgado Ainhoa、L?pez-Larraz Eduardo、Nishimura Yukio、Ziemann Ulf、Ramos-Murguialday Ander
    • Journal Title

      Frontiers in Bioengineering and Biotechnology

      Volume: 10 Pages: 975037-975037

    • DOI

      10.3389/fbioe.2022.975037

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of human spinal locomotor circuitry using transvertebral magnetic stimulation2022

    • Author(s)
      Kawai Kazutake、Tazoe Toshiki、Yanai Toshimasa、Kanosue Kazuyuki、Nishimura Yukio
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 16 Pages: 1016064-1016064

    • DOI

      10.3389/fnhum.2022.1016064

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The ventral striatum contributes to the activity of the motor cortex and motor outputs in monkeys2022

    • Author(s)
      Suzuki Michiaki、Nishimura Yukio
    • Journal Title

      Frontiers in Systems Neuroscience

      Volume: 16 Pages: 979272-979272

    • DOI

      10.3389/fnsys.2022.979272

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quantitative comparison of corticospinal tracts arising from different cortical areas in humans2022

    • Author(s)
      Noboru Usuda, Sho K. Sugawara, Hiroyuki Fukuyama, Kimitaka Nakazawa, Kiyomi Amemiya, Yukio Nishimura
    • Journal Title

      Neuroscience Research

      Volume: 183 Pages: 30-49

    • DOI

      10.1016/j.neures.2022.06.008

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The dorsal premotor cortex encodes the step-by-step planning processes for goal-directed motor behavior in humans2022

    • Author(s)
      Yoshihisa Nakayama, Sho K. Sugawara, Masaki Fukunaga, Yuki H. Hamano, Norihiro Sadato, Yukio Nishimura
    • Journal Title

      NeuroImage

      Volume: 256 Pages: 119221-119221

    • DOI

      10.1016/j.neuroimage.2022.119221

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Origin of Multisynaptic Corticospinal Pathway to Forelimb Segments in Macaques and Its Reorganization After Spinal Cord Injury2022

    • Author(s)
      Ninomiya Taihei、Nakagawa Hiroshi、Inoue Ken-ichi、Nishimura Yukio、Oishi Takao、Yamashita Toshihide、Takada Masahiko
    • Journal Title

      Frontiers in Neural Circuits

      Volume: 16 Pages: 847100-847100

    • DOI

      10.3389/fncir.2022.847100

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A multisynaptic pathway from the ventral midbrain toward spinal motoneurons in monkeys2022

    • Author(s)
      Suzuki Michiaki、Inoue Ken‐ichi、Nakagawa Hiroshi、Ishida Hiroaki、Kobayashi Kenta、Isa Tadashi、Takada Masahiko、Nishimura Yukio
    • Journal Title

      The Journal of Physiology

      Volume: 600 Issue: 7 Pages: 1731-1752

    • DOI

      10.1113/jp282429

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Nucleus accumbens as the motivation center is essential for functional recovery after spinal cord injury2021

    • Author(s)
      Suzuki M, Nishimura Y
    • Journal Title

      Journal of Rehabilitation Neurosciences

      Volume: 21 Issue: JPN Pages: 23-28

    • DOI

      10.24799/jrehabilneurosci.201115

    • NAID

      130008112389

    • ISSN
      2434-2629, 2434-2637
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 閉回路型脊髄刺激によるニューロモジュレーションの誘導2021

    • Author(s)
      田添 歳樹, 西村 幸男.
    • Journal Title

      運動器リハビリテーション

      Volume: 32(3) Pages: 255-262

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Assessment of safety of self-controlled repetitive trans-vertebral magnetic stimulation2021

    • Author(s)
      Sasada S, Kadowaki S, Tazoe T, Murayama T, Kato K, Nakao Y, Matsumoto H, Nishimura Y, Ugawa Y
    • Journal Title

      Clinical Neurophysiology

      Volume: 132(12) Issue: 12 Pages: 3166-3176

    • DOI

      10.1016/j.clinph.2021.09.016

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Role of the nucleus accumbens in functional recovery from spinal cord injury2021

    • Author(s)
      Sawada M, Nishimura Y
    • Journal Title

      Neurosci Res

      Volume: 172 Pages: 1-6

    • DOI

      10.1016/j.neures.2021.04.006

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Changes in beta and high-gamma power in resting-state electrocorticogram induced by repetitive transcranial magnetic stimulation of primary motor cortex in unanesthetized macaque monkeys.2021

    • Author(s)
      Honda Y, Nakamura S, Ogawa K, Yoshino R, Tobler PN, Nishimura Y, Tsutsui KI
    • Journal Title

      Neuroscience Research

      Volume: 171 Pages: 41-48

    • DOI

      10.1016/j.neures.2021.02.002

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Neurotechnology for Bypassing Damaged Neural Pathway2021

    • Author(s)
      Kenji KATO, *Nishimura Y
    • Journal Title

      J Aging Sci.

      Volume: 9(1) Pages: 246-246

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cerebellar outputs contribute to spontaneous and movement-related activity in the motor cortex of monkeys2020

    • Author(s)
      Sano Nobuya、Nakayama Yoshihisa、Ishida Hiroaki、Chiken Satomi、Hoshi Eiji、Nambu Atsushi、Nishimura Yukio
    • Journal Title

      Neuroscience Research

      Volume: - Pages: 10-21

    • DOI

      10.1016/j.neures.2020.03.010

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Artificial cortico-muscular connection via neural interface to regain volitional control of limb movements2020

    • Author(s)
      Kenji KATO, *Nishimura Y
    • Journal Title

      Journal of Rehabilitation Neurosciences.

      Volume: 20-1 Pages: 1-6

    • NAID

      130007924930

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 意欲は身体運動に影響を与えるのか.2020

    • Author(s)
      菅原翔, 鈴木迪諒, 西村幸男
    • Journal Title

      Clinical Neuroscience

      Volume: 36-6 Pages: 740-742

    • Related Report
      2020 Annual Research Report
  • [Journal Article] 人工神経接続の臨床応用2020

    • Author(s)
      田添歳樹,加藤健司,西村幸男
    • Journal Title

      医学の歩み

      Volume: 275 Pages: 1271-1274

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Stimulus outputs induced by subdural electrodes on the cervical spinal cord in monkeys2020

    • Author(s)
      Kato K、Nishihara Y、Nishimura Y
    • Journal Title

      Journal of Neural Engineering

      Volume: 17 Issue: 1 Pages: 016044-016044

    • DOI

      10.1088/1741-2552/ab63a3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 歩行障害2020

    • Author(s)
      田添歳樹, 兼重美希, 西村幸男
    • Journal Title

      Clinical Neuroscience, Non-invasive Neuromodulation-基礎・検査・治療

      Volume: 38 Pages: 80-84

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 特集 "スポーツ"を生み出す脳 アスリート脳の理解に向けて2019

    • Author(s)
      横山修, 田添歳樹, 西村幸男
    • Journal Title

      BRAIN and NERVE

      Volume: 71 Issue: 2 Pages: 99-103

    • DOI

      10.11477/mf.1416201228

    • ISSN
      1344-8129, 1881-6096
    • Year and Date
      2019-02-01
    • Related Report
      2018 Annual Research Report
  • [Journal Article] Input-output relations of the spinal locomotor circuitry in humans.2019

    • Author(s)
      Kawai K,Tazoe T,Kanosue K,Nishimura Y
    • Journal Title

      Sport Science Research

      Volume: 16 Pages: 49-61

    • NAID

      120006891844

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Ventral Striatum is a Key Node for Functional Recovery of Finger Dexterity After Spinal Cord Injury in Monkeys2019

    • Author(s)
      Suzuki Michiaki、Onoe Kayo、Sawada Masahiro、Takahashi Nobuaki、Higo Noriyuki、Murata Yumi、Tsukada Hideo、Isa Tadashi、Onoe Hirotaka、Nishimura Yukio
    • Journal Title

      Cerebral Cortex

      Volume: 30 Issue: 5 Pages: 3259-3270

    • DOI

      10.1093/cercor/bhz307

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bypassing stroke-damaged neural pathways via a neural interface induces targeted cortical adaptation2019

    • Author(s)
      Kato K、Sawada M、Nishimura Y
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1

    • DOI

      10.1038/s41467-019-12647-y

    • NAID

      120006733080

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Somatosensation Evoked by Cortical Surface Stimulation of the Human Primary Somatosensory Cortex2019

    • Author(s)
      Kirin St. Clair、Yanagisawa T、Oshino S、Edakawa K、Tanaka M、Kishima H、Nishimura Y
    • Journal Title

      Frontiers in Neuroscience

      Volume: 13 Pages: 1019-1019

    • DOI

      10.3389/fnins.2019.01019

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The somatosensory cortex receives information about motor output2019

    • Author(s)
      Umeda Tatsuya、Isa Tadashi、Nishimura Yukio
    • Journal Title

      Science Advances

      Volume: 5 Issue: 7 Pages: 5388-5388

    • DOI

      10.1126/sciadv.aaw5388

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] アスリート脳の理解に向けて2019

    • Author(s)
      横山修, 田添歳樹, 西村幸男
    • Journal Title

      Brain and Nerve - 神経研究の進歩

      Volume: 71 Pages: 99-103

    • Related Report
      2019 Annual Research Report
  • [Presentation] neural interfaceによるartificial neural connection2023

    • Author(s)
      Nishimura Y
    • Organizer
      ASENT2023 Annual Meeting Virtual Neurotherapeutics Conference
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Stimulus intensity- and location-specific activation of human locomotor circuitry by non-invasive transvertebral magnetic stimulation2022

    • Author(s)
      Kawai K, Tazoe T, Nishimura Y
    • Organizer
      51st annual meeting of the Society for Neuroscience
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Reorganization of human spinal locomotor circuitry after spinal cord injury2022

    • Author(s)
      Tazoe T, Murayama T, Tosaka T, Kaneshige M, Suzuki M, Kikuchi N, Ugawa Y, Nishimura Y
    • Organizer
      51st annual meeting of the Society for Neuroscience
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evolving contralateral dominance of hand movements from the caudal cingulate motor area to the primary motor cortex via the supplementary motor area in monkeys2022

    • Author(s)
      Nakayama Y, Yokoyama O, Hoshi E, Nishimura Y
    • Organizer
      51st annual meeting of the Society for Neuroscience
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The ventral midbrain commonly representing approach and avoidance motivations encodes future force generation.2022

    • Author(s)
      Sugawara S.K, Nakayama Y, Yamamoto T, Hamano H.Y, Fukanaga M, Sadato N, Nishimura Y
    • Organizer
      51st annual meeting of the Society for Neuroscience
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Quantitative comparison of corticospinal tracts in humans based on diffusion fiber taractography2022

    • Author(s)
      Usuda N, Sugawara S.K, Fukuyama H, Nakazawa K, Amemiya K, Nishimura Y
    • Organizer
      51st annual meeting of the Society for Neuroscience
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Chemogenetic activation of convergent inputs to the spinal motoneurons enhances motor outputs in monkeys2022

    • Author(s)
      Suzuki M, Kobayashi K, Nishimura Y
    • Organizer
      51st annual meeting of the Society for Neuroscience
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Adaptation to cortico-spinal interface to restore forearm paralysis in spinal cord injury2022

    • Author(s)
      Obara K, Kaneshige M, Suzuki M, Tazoe T, Nishimura Y
    • Organizer
      51st annual meeting of the Society for Neuroscience
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 人工神経接続~ココロと身体をつなぐ~2022

    • Author(s)
      西村幸男
    • Organizer
      一般社団法人応用脳科学コンソーシアム
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] サル頚髄への収束ニューロン群の化学遺伝学的な活性化による上肢運動パフォーマンスの増強2022

    • Author(s)
      鈴木迪諒、小林憲太、西村幸男
    • Organizer
      第16回Motor Control研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 人工的な皮質-脊髄路に対して脊髄損傷モデルサルは大脳皮質運動野のニューロン群を適応させる2022

    • Author(s)
      尾原圭、兼重美希、鈴木迪諒、横山修、田添歳樹、西村幸男
    • Organizer
      第16回Motor Control研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 随意運動における一次運動野-一次体性感覚野間の運動過程・周波数依存的な双方向情報伝達2022

    • Author(s)
      横山修、鈴木迪諒、西村幸男
    • Organizer
      第16回Motor Control研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 脊髄損傷後の運動機能の回復過程において、増大した脊髄のアウトプットは、一次運動野神経細胞活動の変調の減少と関連する2022

    • Author(s)
      兼重美希、尾原圭、鈴木迪諒、田添歳樹、西村幸男
    • Organizer
      第16回Motor Control研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 完全脊髄損傷者における脊髄歩行中枢の活動亢進2022

    • Author(s)
      田添歳樹、村山尊司、戸坂友也、兼重美希、鈴木迪諒、菊地尚久、宇川義一、西村幸男
    • Organizer
      第45回日本神経科学大会
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脊髄損傷後の運動機能回復における上昇した脊髄のアウトプットは、運動野神経細胞活動の変化と関連する2022

    • Author(s)
      兼重美希、尾原圭、鈴木迪諒、田添歳樹、西村幸男
    • Organizer
      第45回日本神経科学大会
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 上肢到達運動の制御過程に小脳を起点とし筋肉に至る神経経路が関与する2022

    • Author(s)
      中山義久、佐野暢哉、知見聡美、南部篤、西村幸男
    • Organizer
      第45回日本神経科学大会
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 運動パフォーマンスの長期的変動に関わる神経基盤2022

    • Author(s)
      菅原翔、臼田升、福山博幸、雨宮きよみ、西村幸男
    • Organizer
      第45回日本神経科学大会
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 化学遺伝学的手法による下行性運動路の活性化は筋活動を高める2022

    • Author(s)
      鈴木迪諒、小林憲太、西村幸男
    • Organizer
      第45回日本神経科学大会
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ヒト同側皮質脊髄路の定量比較2022

    • Author(s)
      臼田升、菅原翔、福山博幸、雨宮きよみ、西村幸男
    • Organizer
      第45回日本神経科学大会
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 人工的な皮質脊髄路への適応に伴う脊髄損傷サルの一次運動野ニューロン群の同調2022

    • Author(s)
      尾原圭、兼重美希、鈴木迪諒、田添歳樹、西村幸男
    • Organizer
      第45回日本神経科学大会
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 随意運動において下行性入力と感覚フィードバック信号は連続的に筋活動生成に寄与する2022

    • Author(s)
      梅田達也、伊佐正、西村幸男
    • Organizer
      第45回日本神経科学大会
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] XGBoostを用いたサルの皮質脳波に基づく前肢筋活動デコーディングの検討2022

    • Author(s)
      伊勢崎隆司、鈴木迪諒、青木良輔、小池幸生、西村幸男
    • Organizer
      第45回日本神経科学大会
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Plastic change of locomotor circuits in humans2022

    • Author(s)
      西村幸男
    • Organizer
      第99回日本生理学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ヒト脊髄歩行中枢の柔軟性2021

    • Author(s)
      西村幸男
    • Organizer
      第56回日本脊髄障害医学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 神経インターフェイスによる神経損傷のバイパス2021

    • Author(s)
      西村幸男
    • Organizer
      日本脳神経外科学会第80回学術総会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Origin of corticospinal tracts in humans; diffusion weighted imaging study2021

    • Author(s)
      Usuda N, Sugawara S.K,Hiroyuki F,Nakazawa K,Amemiya K,Nishimura Y
    • Organizer
      第5回ヒト脳イメージング研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 中枢・末梢神経系の統合的解析による随意運動制御の神経機構2021

    • Author(s)
      梅田達也、横山修、鈴木迪諒、兼重美希、伊佐正、西村幸男
    • Organizer
      第15回Motor Control研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 人工神経接続システムによる脳機能再建2021

    • Author(s)
      西村幸男
    • Organizer
      第4回 医工連携マッチング例会 世代医療システム産業化フォーラム2021
    • Related Report
      2021 Annual Research Report
  • [Presentation] Differential involvement of the dorsal premotor cortex in each stage of conditional visuo-goal behavior in humans.2021

    • Author(s)
      Nakayama Y, Sugawara SK,Fukanaga M,Hamano HY,Sadato N, and Nishimura Y
    • Organizer
      第44回日本神経科学大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Location specific excitation of human spinal locomotor circuitry by transvertebral magnetic stimulation2021

    • Author(s)
      Tazoe T, Nishimura Y
    • Organizer
      第44回日本神経科学大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Activation of human spinal locomotor circuitry using transvertebral magnetic stimulation2021

    • Author(s)
      Kawai K, Tazoe T, Kanosue K, Nishimura Y
    • Organizer
      第44回日本神経科学大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Bypassing spinal lesion via artificial cortico-spinal pathway induces task-related modulations in an ensemble of neurons in monkey primary motor cortex.2021

    • Author(s)
      Obara K, Kaneshige M, Suzuki M,Tazoe T, Nishimura Y
    • Organizer
      第44回日本神経科学大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] The primary motor cortex implements internal models of spinal reflex action during voluntary movement2021

    • Author(s)
      梅田達也、横山修、鈴木迪諒、兼重美希、伊佐正、西村幸男
    • Organizer
      第44回日本神経科学大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Pre-movement activity in human spinal-cord: Preliminary brain-spinal cord stimulations fMRI study2021

    • Author(s)
      Sugawara SK, Usuda N, Fukuyama H, Amemiya K, Nishimura Y
    • Organizer
      第44回日本神経科学大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Long-lasting reinforcement in motor task through nucleus accumbens stimulation2021

    • Author(s)
      Suzuki M, Nishimura Y
    • Organizer
      第44回日本神経科学大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Top-down control of distributed attention by the supplementary eye field in monkeys2021

    • Author(s)
      横山修、西村幸男
    • Organizer
      第44回日本神経科学大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Boosting motor outputs and inducing cortical adaptation via artificial neural connection2021

    • Author(s)
      Kaneshige M,Obara K, Suzuki M,Tazoe T, Nishimura Y
    • Organizer
      第44回日本神経科学大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Quantitative comparison of corticospinal tracts from cerebral cortex in humans.2021

    • Author(s)
      Usuda N, Sugawara SK Fukuyama H, Amemiya K, Nakazawa K,Nishimura Y
    • Organizer
      第44回日本神経科学大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ブレインマシーンインターフェース(BMI)と脳科学2021

    • Author(s)
      西村幸男
    • Organizer
      第10回 神経法学研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 人工神経接続による脳機能再建2020

    • Author(s)
      西村幸男
    • Organizer
      第 8 回日本難病医療ネットワーク学会 合同学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Bypassing damaged neural pathways via a neural interface2020

    • Author(s)
      西村幸男
    • Organizer
      第 61 回日本神経 学会 学術大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 硬膜下脊髄刺激は随意筋活動を ブーストする2020

    • Author(s)
      兼重美希, 尾原圭, 鈴木迪諒, 田添歳樹, 西村幸男
    • Organizer
      第 43 回日本神経科学大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] The functional role of ventral midbrain for motivated motor outputs in humans.2020

    • Author(s)
      Sho K. SUGAWARA, Yoshihisa NAKAYAMA, Tetsuya YAMAMOTO, Yuki H. HAMANO, Masaki FUKUNAGA, Norihiro SADATO, and Nishimura Y
    • Organizer
      日本神経 科学学会第 43 回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 人工神経接続による脳機能再建2020

    • Author(s)
      西村幸男
    • Organizer
      第6回Neuroscience Network in Kobeシンポジウム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] BMI、それは日本で現実化する2020

    • Author(s)
      西村幸男
    • Organizer
      第26回 Tonomachi Cafe
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Bypassing damaged neural pathways via neural interfaces2020

    • Author(s)
      Nishimura Y
    • Organizer
      The 6th CiNet Conference
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 人工神経接続による脳機能再建2020

    • Author(s)
      西村幸男
    • Organizer
      第59回日本定位・機能神経外科学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 自分自身を自分で制御することを実現する人工神経接続2020

    • Author(s)
      西村幸男
    • Organizer
      THINK講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 脊髄損傷後の機能回復を支える腹側線条体の治療標的としての可能性2020

    • Author(s)
      Suzuki M, Nishimura Y
    • Organizer
      第97回日本生理学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Activation of human spinal locomotor circuitry using transvertebral magnetic stimulation2020

    • Author(s)
      Kawai K, Tazeo T, Nishimura Y
    • Organizer
      第97回日本生理学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Restoring lost voluntary limb control using neural oscillations.2019

    • Author(s)
      Nishimura Y
    • Organizer
      Neural Oscillation Conference 2019: Towards Integrative Understanding of Human Nature
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 位置について、ヨーイ、ドンの神経科学2019

    • Author(s)
      西村幸男
    • Organizer
      第27回脳の世紀シンポジウム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 人工神経接続による脳機能再建2019

    • Author(s)
      西村幸男
    • Organizer
      Biblioミニセミナー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 人工神経接続による脳機能再建2019

    • Author(s)
      西村幸男
    • Organizer
      第42回日本神経科学大会・第62回日本神経化学会大会合同大会(Neuro2019)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 人工神経接続による脳機能再建2019

    • Author(s)
      西村幸男
    • Organizer
      第37回神経科学研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 人工神経接続による神経可塑性の誘導2019

    • Author(s)
      西村幸男
    • Organizer
      第60回日本神経学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Coupling between the nucleus accumbens and motor cortex appears during demanding motor control.2019

    • Author(s)
      Suzuki M, Nishimura Y
    • Organizer
      第42回日本神経科学大会・第62回日本神経化学会大会合同大会(Neuro2019)
    • Related Report
      2019 Annual Research Report
  • [Presentation] Control of visual spatial attention in the frontal eye field and supplementary eye field of monkeys.2019

    • Author(s)
      Yokoyama O, Nishimura Y
    • Organizer
      第42回日本神経科学大会・第62回日本神経化学会大会合同大会(Neuro2019)
    • Related Report
      2019 Annual Research Report
  • [Presentation] VTA-M1 pathway contributes to human motivated motor outputs.2019

    • Author(s)
      Sugawara S, Nakayama Y, Fukunaga M, Yamamoto T, Sadato N, Nishimura Y
    • Organizer
      The 25th annual meeting of the Organization for Human Brain Mapping
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Involvement of the Dorsal Premotor Cortex in Goal-directed Motor Behavior.2019

    • Author(s)
      Nakayama Y, Sugawara S, Fukunaga M, Hamano Y, Sadato N, Nishimura Y
    • Organizer
      The 25th annual meeting of the Organization for Human Brain Mapping
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Non-invasive transvertebral magnetic stimulation discloses residual motor function of sublesional spinal circuitry in humans with spinal cord injury.2019

    • Author(s)
      Tazoe T, Suzuki M, Kaneshige M, Iwatsuki K, Nishimura Y
    • Organizer
      49th annual meeting of Society for Neuroscience
    • Related Report
      2019 Annual Research Report
  • [Presentation] Spinal stimulus effects altered by voluntary muscle activity in monkeys.2019

    • Author(s)
      Kaneshige M, Obara K, Suzuki M, Tazoe T and Nishimura Y.
    • Organizer
      The 2019 Annual Meeting of the Society tor the Neural Control of Movement
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Macaque ventral midbrain facilitates the output to forelimb muscles via the primary motor cortex.2019

    • Author(s)
      Suzuki M, Inoue K-I, Nakagawa H, Takada M, Isa T and Nishimura Y
    • Organizer
      he 2019 Annual Meeting of the Society tor the Neural Control of Movement
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Functional organization of spinal motor map in sport athletes2019

    • Author(s)
      Toshiki Tazoe
    • Organizer
      9th Federation of the Asian and Oceanian Physiological Societies Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Muscle representations in spinal motor circuitry in intact humans and an individual with SCI2019

    • Author(s)
      Toshiki Tazoe, Koichi Iwatsuki, Yukio Nishimura
    • Organizer
      9th Federation of the Asian and Oceanian Physiological Societies Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 経脊椎磁気刺激によるヒト脊髄神経回路の体部位局在2018

    • Author(s)
      田添歳樹,岩月幸一,西村幸男
    • Organizer
      次世代脳プロジェクト冬のシンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 磁気刺激による脊髄歩行中枢の刺激強度特性2018

    • Author(s)
      河合一武,田添歳樹,西村幸男
    • Organizer
      次世代脳プロジェクト冬のシンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 人工神経接続による神経機能再建2018

    • Author(s)
      西村幸男
    • Organizer
      日本脳神経外科学会 第77回総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Bypassing damaged neural pathways via a neural interface2018

    • Author(s)
      Yukio Nishimura
    • Organizer
      German-Japanese Workshop on New Directions in System Neuroscience
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Bypassing damaged neural pathways via a neural interface2018

    • Author(s)
      Yukio Nishimura
    • Organizer
      FAOPS2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Remarks] コンピュータ―による(略)についてFrontiers in Neuroscience に発表

    • URL

      https://www.igakuken.or.jp/topics/2023/0307.html

    • Related Report
      2022 Annual Research Report
  • [Remarks] 運動指令信号と(略)についてPNASに発表

    • URL

      https://www.igakuken.or.jp/topics/2022/1121.html

    • Related Report
      2022 Annual Research Report
  • [Remarks] 動機づけを司る(略)ついて「The Journal of Physiology」に発表しました。

    • URL

      https://www.igakuken.or.jp/topics/2022/0205.html

    • Related Report
      2022 Annual Research Report
  • [Remarks] 脳機能再建プロジェクトのホームページ

    • URL

      https://neural-prosthetics.jp/

    • Related Report
      2022 Annual Research Report

URL: 

Published: 2018-06-12   Modified: 2024-03-28  

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