| Project/Area Number |
18J11446
|
|---|
| Research Category |
Grant-in-Aid for JSPS Fellows
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| Allocation Type | Single-year Grants |
|---|
| Section | 国内 |
|---|
| Research Field |
Applied pharmacology
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
Karpati Aniko 東北大学, 医学系研究科, 特別研究員(DC2)
|
|---|
| Project Period (FY) |
2018-04-25 – 2020-03-31
|
| Project Status |
Completed (Fiscal Year 2019)
|
| Budget Amount *help |
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 2019: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2018: ¥1,000,000 (Direct Cost: ¥1,000,000)
|
|---|
| Keywords | histamine / histamine H1 receptor / astrocyte / neuron / behaviour / sleep / aggression / anxiety / cognition |
|---|
| Outline of Annual Research Achievements |
Behavioural assessment uncovered significant changes in histamine H1 receptor (H1R) conditional knockout mice compared to controls and highlighted a role of H1R in astrocytes and neurons in different aspects of mouse behaviour. Neuronal H1R was important for memory function and anxiety-like behaviour. Astrocytic H1R played a role in anxiety, aggression, circadian rhythm, and wakefulness.
The study underlines the importance of H1R on both, astrocytes and neurons, and it supports the concept that both cell types are a target of histamine to contribute to distinct physiological processes.
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| Research Progress Status |
令和元年度が最終年度であるため、記入しない。
|
| Strategy for Future Research Activity |
令和元年度が最終年度であるため、記入しない。
|
