• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

New Roles of Histamine in Astrocyte Function

Research Project

Project/Area Number 18J11446
Research Category

Grant-in-Aid for JSPS Fellows

Allocation TypeSingle-year Grants
Section国内
Research Field Applied pharmacology
Research InstitutionTohoku University

Principal Investigator

Karpati Aniko  東北大学, 医学系研究科, 特別研究員(DC2)

Project Period (FY) 2018-04-25 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 2019: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2018: ¥1,000,000 (Direct Cost: ¥1,000,000)
Keywordshistamine / histamine H1 receptor / astrocyte / neuron / behaviour / sleep / aggression / anxiety / cognition
Outline of Annual Research Achievements

Behavioural assessment uncovered significant changes in histamine H1 receptor (H1R) conditional knockout mice compared to controls and highlighted a role of H1R in astrocytes and neurons in different aspects of mouse behaviour. Neuronal H1R was important for memory function and anxiety-like behaviour. Astrocytic H1R played a role in anxiety, aggression, circadian rhythm, and wakefulness.
The study underlines the importance of H1R on both, astrocytes and neurons, and it supports the concept that both cell types are a target of histamine to contribute to distinct physiological processes.

Research Progress Status

令和元年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和元年度が最終年度であるため、記入しない。

Report

(2 results)
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (9 results)

All 2019 2018

All Journal Article (5 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 3 results,  Open Access: 4 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Histamine H1 receptor on astrocytes and neurons controls distinct aspects of mouse behaviour2019

    • Author(s)
      Karpati Aniko、Yoshikawa Takeo、Naganuma Fumito、Matsuzawa Takuro、Kitano Haruna、Yamada Yo、Yokoyama Mariko、Futatsugi Akira、Mikoshiba Katsuhiko、Yanai Kazuhiko
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 16451-16451

    • DOI

      10.1038/s41598-019-52623-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] New roles of histamine in astrocyte function.2019

    • Author(s)
      Karpati A
    • Journal Title

      東北医学雑誌

      Volume: 131 Pages: 89-89

    • Related Report
      2019 Annual Research Report
  • [Journal Article] New advances in astrocyte research.2019

    • Author(s)
      Karpati A
    • Journal Title

      東北大クロスオーバー

      Volume: 40 Pages: 3-3

    • Related Report
      2019 Annual Research Report
    • Open Access
  • [Journal Article] Histamine elicits glutamate release from cultured astrocytes2018

    • Author(s)
      Karpati Aniko、Yoshikawa Takeo、Nakamura Tadaho、Iida Tomomitsu、Matsuzawa Takuro、Kitano Haruna、Harada Ryuichi、Yanai Kazuhiko
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 137 Issue: 2 Pages: 122-128

    • DOI

      10.1016/j.jphs.2018.05.002

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Heparan sulfate in pancreatic β-cells contributes to normal glucose homeostasis by regulating insulin secretion.2018

    • Author(s)
      Matsuzawa T, Yoshikawa T, Iida T, Karpati A, Kitano H, Harada R, Nakamura T, Sugawara A, Yamaguchi Y, Yanai K.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: - Issue: 3 Pages: 688-695

    • DOI

      10.1016/j.bbrc.2018.03.213

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Histamine, a new key player in astrocyte function?2019

    • Author(s)
      Karpati A, Yoshikawa T, and Yanai K
    • Organizer
      4th DIARE/FRIS Joint workshop
    • Related Report
      2019 Annual Research Report
  • [Presentation] Histamine H1 receptors on astrocytes regulate aggressive behavior, circadian rhythm, and wakefulness in mice2019

    • Author(s)
      Karpati A, Yoshikawa T, Naganuma F, and Yanai K
    • Organizer
      The 42nd Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2019 Annual Research Report
  • [Presentation] Involvement of Astrocyte Histamine H1 Receptors in the Regulation of Behavior2019

    • Author(s)
      Karpati A, Yoshikawa T, Naganuma F, and Yanai K
    • Organizer
      XIV European Meeting on Glial Cells in Health and Disease
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Histamine, a new key player in astrocyte function?2018

    • Author(s)
      Karpati A, Yoshikawa T, Yanai K
    • Organizer
      DIARE Joint Workshop
    • Related Report
      2018 Annual Research Report

URL: 

Published: 2018-05-01   Modified: 2024-03-26  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi