Preparation of stretchable collagen hydrogels introduced by supramolecular cross-linkers
| Project/Area Number |
18J14112
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| Research Category |
Grant-in-Aid for JSPS Fellows
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| Allocation Type | Single-year Grants |
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| Section | 国内 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
LEE Daehoon 東京医科歯科大学, 大学院医歯学総合研究科, 特別研究員(DC2)
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| Project Period (FY) |
2018-04-25 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 2019: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2018: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | Hysteresis loss / Stretchable hydrogels / Slide-ring gels / Cell orientation / Polyrotaxane / Gelatin / Stretchable hydrogel / Slide-ring gel |
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| Outline of Annual Research Achievements |
As implant materials, high mechanical properties of hydrogels and biocompatibility are required. To accomplish these requirements, carboxymethyl ether group-modified polyrotaxanes (CME-PRXs) were introduced to gelatin hydrogels. Firstly, not only stretchability and toughness but also hysteresis in gelatin hydrogels cross-linked by CME-PRXs were significantly improved than those of EDC/NHS. Next, the gelatin hydrogels cross-linked CME-PRXs also had cytocompatibility compared to EDC/NHS-cross-linked gelatin hydrogels and the cellular orientation on gelatin hydrogels could be regulated by the threaded number of α-CDs onto CME-PRXs under stretching state. It was verified that gelatin hydrogels cross-linked by CME-PRXs can be applied as implant materials.
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| Research Progress Status |
令和元年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
令和元年度が最終年度であるため、記入しない。
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Report
(2 results)
Research Products
(8 results)
