分子の自己組織化を活用した迅速・簡便な光学純度決定マイクロアレイ・デバイスの構築

• Project/Area Number: 18J21190
• Research Category: Grant-in-Aid for JSPS Fellows
• Allocation Type: Single-year Grants
• Section: 国内
• Research Field: Analytical chemistry
• Research Institution: The University of Tokyo
• Principal Investigator: 佐々木 由比 東京大学, 工学系研究科, 特別研究員(PD)
• Project Period (FY): 2018-04-25 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥3,100,000 (Direct Cost: ¥3,100,000); Fiscal Year 2020: ¥1,000,000 (Direct Cost: ¥1,000,000); Fiscal Year 2019: ¥1,000,000 (Direct Cost: ¥1,000,000); Fiscal Year 2018: ¥1,100,000 (Direct Cost: ¥1,100,000)
• Keywords: ケモセンサアレイ / パターン認識 / 自己組織化現象 / 化学センサ / 分子認識 / 有機トランジスタ

Outline of Annual Research Achievements

ケモセンサは，分子間・分子内相互作用を合目的に組み込み設計することで，標的種の捕捉・認識に伴うミクロな情報を我々が知覚可能なレベルにまで増幅することができる。交差応答性を示す複数のケモセンサから構築されるセンサアレイは，パターン認識を駆使することにより，多成分の迅速かつ同時検出を可能にすることから，多岐に渡る分野での活用が期待されている。しかし，従来のケモセンサアレイは，標的種の同時検出に必要な光学応答変化を多数のケモセンサを用いて作り出しているため，各ケモセンサ分子を一つ一つ合成する労力は多大となる。合成化学者の視点では，その労力は問題にはならない一方，分析化学者から見るとその難度は非常に高く，実分析へと展開する上での大きな障壁となっている。他方，アレイを構築する数多くのセンサ数に対し，実際に判別に寄与するセンサはそのうちのごく一部である。従って，ケモセンサ自体の機能を最大限に引き出し，並べたミニマムセンサアレイが構築できれば，上述の課題解決に繋がると考える。
ミニマムセンサアレイの達成には，少ない構成分子数であっても多彩な光学応答パターンを創出するセンサ設計が必要となる。本研究では，分子間相互作用を基軸としたケモセンサの開発を指向し，動的共有結合及び配位結合に着目した。これらの結合が示す可逆性は，複数種の複合体形成を可能とするため，指示薬，認識部位，標的種間で生じる複合化に基づき，多彩な色調変化をもたらす。すなわち，当該分子間相互作用を活用したケモセンサを設計することが出来れば，比較的簡便にケモセンサが調製可能となるだけでなく，少数の分子数あってもその組み合わせによって指紋パターンが得られる。本研究では，それぞれの分子間相互作用を活用したミニマムセンサアレイを用いて，カチオン，アニオン，糖類，キラル種の包括的検出を実証した。

Research Progress Status

令和2年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和2年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Extended-gate-type Organic Field-effect Transistors for the Detection of Potential Psychological Stress Markers (2021)
  • Author(s): Didier Pierre, Blomenkamp Hans, Kubota Riku, Sasaki Yui, Minami Tsuyoshi
  • Journal Title: Sensors and Materials Volume: 33 Issue: 1 Pages: 211
  • DOI: 10.18494/SAM.2021.3066
  • ISSN: 0914-4935, 2435-0869
  • Year and Date: 2021-01-22
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A minimized fluorescent chemosensor array utilizing carboxylate-attached polythiophenes on a chip for metal ions detection (2021)
  • Author(s): Sasaki Yui, Lyu Xiaojun, Zhang Zhoujie, Minami Tsuyoshi
  • Journal Title: Frontiers of Chemical Science and Engineering Volume: - Issue: 1 Pages: 72-80
  • DOI: 10.1007/s11705-021-2037-y
  • Peer Reviewed
• [Journal Article] A Printed Paper‐Based Anion Sensor Array for Multi‐Analyte Classification : On‐Site Quantification of Glyphosate (2021)
  • Author(s): Zhang Zhoujie, Hamedpour Vahid, Lyu Xiaojun, Sasaki Yui, Minami Tsuyoshi
  • Journal Title: ChemPlusChem Volume: - Issue: 6 Pages: 798-802
  • DOI: 10.1002/cplu.202100041
  • Peer Reviewed / Open Access
• [Journal Article] Indicator Displacement Assay-based Chemosensor Arrays for Saccharides using Off-the-shelf Materials toward Simultaneous On-site Detection on Paper (2021)
  • Author(s): Sasaki Yui, Lyu Xiaojun, Zhou Qi, Minami Tsuyoshi
  • Journal Title: Chemistry Letters Volume: 50 Issue: 5 Pages: 987-995
  • DOI: 10.1246/cl.200962
  • NAID: 130008040429
  • Peer Reviewed / Open Access
• [Journal Article] Molecular self-assembled chemosensors and their arrays (2021)
  • Author(s): Sasaki Yui, Kubota Riku, Minami Tsuyoshi
  • Journal Title: Coordination Chemistry Reviews Volume: 429 Pages: 213607-213607
  • DOI: 10.1016/j.ccr.2020.213607
  • Peer Reviewed
• [Journal Article] An extended-gate type organic transistor with a solution-processable small molecule semiconductor capable of detecting glutathione in water (2020)
  • Author(s): Asano Koichiro、Aiko Michio、Yamanashi Yusuke、Sasaki Yui、Nakahara Katsumasa、Minamiki Tsukuru、Koike Toshihiro、Minami Tsuyoshi
  • Journal Title: Japanese Journal of Applied Physics Volume: 59 Issue: SG Pages: SGGG07-SGGG07
  • DOI: 10.7567/1347-4065/ab5b6e
  • Peer Reviewed
• [Journal Article] Microfluidic System with Extended‐Gate‐Type Organic Transistor for Real‐Time Glucose Monitoring (2020)
  • Author(s): Didier Pierre、Lobato‐Dauzier Nicolas、Clement Nicolas、Genot Anthony J.、Sasaki Yui、Leclerc Eric、Minamiki Tsukuru、Sakai Yasuyuki、Fujii Teruo、Minami Tsuyoshi
  • Journal Title: ChemElectroChem Volume: 7 Issue: 6 Pages: 1332-1336
  • DOI: 10.1002/celc.201902013
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Fluorescence Anion Chemosensor Array Based on Pyrenylboronic Acid (2020)
  • Author(s): Cao Zhenbo、Cao Yang、Kubota Riku、Sasaki Yui、Asano Koichiro、Lyu Xiaojun、Zhang Zhoujie、Zhou Qi、Zhao Xiaolei、Xu Xu、Wu Si、Minami Tsuyoshi、Liu Yuanli
  • Journal Title: Frontiers in Chemistry Volume: 8 Pages: 414-414
  • DOI: 10.3389/fchem.2020.00414
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Porous microneedles on a paper for screening test of prediabetes (2020)
  • Author(s): Lee Hakjae、Bonfante Gwena?l、Sasaki Yui、Takama Nobuyuki、Minami Tsuyoshi、Kim Beomjoon
  • Journal Title: MEDICAL DEVICES & SENSORS Volume: 3 Issue: 4 Pages: 10109-10109
  • DOI: 10.1002/mds3.10109
  • Peer Reviewed
• [Journal Article] Accurate chiral pattern recognition for amines from just a single chemosensor (2020)
  • Author(s): Sasaki Yui、Kojima Soya、Hamedpour Vahid、Kubota Riku、Takizawa Shin-ya、Yoshikawa Isao、Houjou Hirohiko、Kubo Yuji、Minami Tsuyoshi
  • Journal Title: Chemical Science Volume: 11 Issue: 15 Pages: 3790-3796
  • DOI: 10.1039/d0sc00194e
  • Peer Reviewed / Open Access
• [Journal Article] Supramolecular Sensor for Astringent Procyanidin C1: Fluorescent Artificial Tongue for Wine Components (2020)
  • Author(s): Sasaki Yui、Ito Satoshi、Zhang Zhoujie、Lyu Xiaojun、Takizawa Shin‐ya、Kubota Riku、Minami Tsuyoshi
  • Journal Title: Chemistry-A European Journal Volume: 26 Issue: 69 Pages: 16236-16240
  • DOI: 10.1002/chem.202002262
  • Peer Reviewed / Open Access
• [Journal Article] A Water‐Gated Organic Thin‐Film Transistor for Glyphosate Detection : A Comparative Study with Fluorescence Sensing (2020)
  • Author(s): Sasaki Yui, Asano Koichiro, Minamiki Tsukuru, Zhang Zhoujie, Takizawa Shin‐ya, Kubota Riku, Minami Tsuyoshi
  • Journal Title: Chemistry -A European Journal Volume: 26 Issue: 64 Pages: 14525-14529
  • DOI: 10.1002/chem.202003529
  • Peer Reviewed / Open Access
• [Journal Article] Easy-to-Prepare Mini-Chemosensor Array for Simultaneous Detection of Cysteine and Glutathione Derivatives (2020)
  • Author(s): Sasaki Yui, Lyu Xiaojun, Kubota Riku, Takizawa Shin-ya, Minami Tsuyoshi
  • Journal Title: ACS Applied Bio Materials Volume: 4 Issue: 3 Pages: 2113-2119
  • DOI: 10.1021/acsabm.0c01275
  • Peer Reviewed
• [Journal Article] 96-Well Microtiter Plate Made of Paper: A Printed Chemosensor Array for Quantitative Detection of Saccharides (2020)
  • Author(s): Lyu Xiaojun, Hamedpour Vahid, Sasaki Yui, Zhang Zhoujie, Minami Tsuyoshi
  • Journal Title: Analytical Chemistry Volume: 93 Issue: 2 Pages: 1179-1184
  • DOI: 10.1021/acs.analchem.0c04291
  • Peer Reviewed
• [Journal Article] 比色ケモセンサを用いた糖類の定性・定量的検出と紙基板型センサアレイへの展開 (2020)
  • Author(s): 佐々木 由比、南 豪
  • Journal Title: 日本画像学会誌 Volume: 59 Pages: 541-545
  • NAID: 130007925011
  • Peer Reviewed
• [Journal Article] Sensitive Detection of Glyphosate by a Water-Gated Organic Transistor (2020)
  • Author(s): Asano Koichiro、Sasaki Yui、Minamiki Tsukuru、Minami Tsuyoshi
  • Journal Title: ECS Transactions Volume: 98 Issue: 12 Pages: 41-46
  • DOI: 10.1149/09812.0041ecst
  • Peer Reviewed
• [Journal Article] Protein Assays on Organic Electronics: Rational Device and Material Designs for Organic Transistor‐Based Sensors (2020)
  • Author(s): Minamiki Tsukuru、Kubota Riku、Sasaki Yui、Asano Koichiro、Minami Tsuyoshi
  • Journal Title: ChemistryOpen Volume: 9 Issue: 5 Pages: 573-581
  • DOI: 10.1002/open.202000025
  • Peer Reviewed
• [Journal Article] Simplest Chemosensor Array for Phosphorylated Saccharides (2019)
  • Author(s): Sasaki Yui、Leclerc Eric、Hamedpour Vahid、Kubota Riku、Takizawa Shin-ya、Sakai Yasuyuki、Minami Tsuyoshi
  • Journal Title: Analytical Chemistry Volume: 91 Issue: 24 Pages: 15570-15576
  • DOI: 10.1021/acs.analchem.9b03578
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Simple Colorimetric Chemosensor Array for Oxyanions: Quantitative Assay for Herbicide Glyphosate (2019)
  • Author(s): Hamedpour Vahid、Sasaki Yui、Zhang Zhoujie、Kubota Riku、Minami Tsuyoshi
  • Journal Title: Analytical Chemistry Volume: 91 Issue: 21 Pages: 13627-13632
  • DOI: 10.1021/acs.analchem.9b02822
  • Peer Reviewed
• [Journal Article] Chemical Sensing Platforms Based on Organic Thin-Film Transistors Functionalized with Artificial Receptors (2019)
  • Author(s): Kubota Riku、Sasaki Yui、Minamiki Tsukuru、Minami Tsuyoshi
  • Journal Title: ACS Sensors Volume: 4 Issue: 10 Pages: 2571-2587
  • DOI: 10.1021/acssensors.9b01114
  • Peer Reviewed
• [Journal Article] Facile Indicator Displacement Assay-based Supramolecular Chemosensor: Quantitative Colorimetric Determination of Xylose and Glucose in the Presence of Ascorbic Acid (2019)
  • Author(s): Sasaki Yui、Hamedpour Vahid、Kubota Riku、He Yixiang、Torii Yosuke、Minami Tsuyoshi
  • Journal Title: Chemistry Letters Volume: 48 Issue: 11 Pages: 1368-1370
  • DOI: 10.1246/cl.190570
  • NAID: 130007741799
  • Peer Reviewed
• [Journal Article] A Saccharide Chemosensor Array Developed Based on an Indicator Displacement Assay Using a Combination of Commercially Available Reagents (2019)
  • Author(s): Yui Sasaki, Zhoujie Zhang, Tsuyoshi Minami
  • Journal Title: Frontiers in Chemistry Volume: 7 Pages: 49-49
  • DOI: 10.3389/fchem.2019.00049
  • Peer Reviewed / Open Access
• [Journal Article] Development of Enzymatic Sensors Based on Extended-gate-type Organic Field-effect Transistors (2018)
  • Author(s): Tsuyoshi Minami, Tsukuru Minamiki, Yui Sasaki
  • Journal Title: Electrochemistry Volume: 86 Issue: 6 Pages: 303-308
  • DOI: 10.5796/electrochemistry.18-6-E2672
  • NAID: 130007504967
  • ISSN: 1344-3542, 2186-2451
  • Year and Date: 2018-11-05
  • Peer Reviewed / Open Access
• [Journal Article] Development of Supramolecular Sensor Devices Based on Organic Transistors (2018)
  • Author(s): Yui Sasaki, Tsukuru Minamiki, Tsuyoshi Minami
  • Journal Title: Journal of Synthetic Organic Chemistry, Japan Volume: 76 Issue: 10 Pages: 1086-1097
  • DOI: 10.5059/yukigoseikyokaishi.76.1086
  • NAID: 130007496442
  • ISSN: 0037-9980, 1883-6526
  • Year and Date: 2018-10-01
  • Peer Reviewed
• [Journal Article] Fabrication of Supramolecular Sensor Arrays Using Intramolecular/Intermolecular Interactions (2018)
  • Author(s): Yui Sasaki, Tsuyoshi Minami
  • Journal Title: BUNSEKI KAGAKU Volume: 67 Issue: 9 Pages: 519-529
  • DOI: 10.2116/bunsekikagaku.67.519
  • NAID: 130007495781
  • ISSN: 0525-1931
  • Year and Date: 2018-09-05
  • Peer Reviewed / Open Access
• [Journal Article] Fabrication of a Molecular Self-assembled Colorimetric Chemosensor Array and Its Application for Simultaneous Detection of Metal Ions in an Aqueous Solution (2018)
  • Author(s): 佐々木由比, 南豪
  • Journal Title: SEISAN KENKYU Volume: 70 Issue: 3 Pages: 193-196
  • DOI: 10.11188/seisankenkyu.70.193
  • NAID: 130007377719
  • ISSN: 0037-105X, 1881-2058
  • Year and Date: 2018-05-01
  • Peer Reviewed / Open Access
• [Journal Article] Development of polymer field-effect transistor-based immunoassays (2018)
  • Author(s): Tsukuru Minamiki, Yui Sasaki, Shiwei Su, Tsuyoshi Minami
  • Journal Title: Polymer Journal Volume: 51 Issue: 1 Pages: 1-9
  • DOI: 10.1038/s41428-018-0112-0
  • NAID: 40021935726
  • Peer Reviewed / Open Access
• [Journal Article] An electrolyte-gated polythiophene transistor for the detection of biogenic amines in water (2018)
  • Author(s): Tsukuru Minamiki, Yuki Hashima, Yui Sasaki, Tsuyoshi Minami
  • Journal Title: Chemical Communications Volume: 54 Issue: 50 Pages: 6907-6910
  • DOI: 10.1039/c8cc02462f
  • Peer Reviewed
• [Presentation] Chemosensor Arrays for Glyphosate (2019)
  • Author(s): Sasaki Yui、Hamedpour Vahid、Zhang Zhoujie、Minami Tsuyoshi
  • Organizer: CEMSupra 2019
  • Int'l Joint Research
• [Presentation] Development of glyphosate sensors utilizing polythiophene derivatives (2019)
  • Author(s): Sasaki Yui、Minami Tsuyoshi
  • Organizer: 第68回高分子学会年次大会
• [Presentation] ポリチオフェンを用いたグリホサートセン (2019)
  • Author(s): 佐々木由比、相子美智雄、南豪
  • Organizer: 第17回ホスト―ゲスト・超分子化学シンポジウム
• [Presentation] ポリチオフェンを用いたグリホサートセンサ (2019)
  • Author(s): 佐々木由比、張 舟傑、南豪
  • Organizer: 第17回ホスト―ゲスト・超分子化学シンポジウム
• [Presentation] 分子の自己組織化現象を活用した比色糖ケモセンサアレイ (2019)
  • Author(s): 佐々木由比、張 舟傑、南豪
  • Organizer: 第17回ホスト―ゲスト・超分子化学シンポジウム
• [Presentation] リン酸化糖検出を指向した超簡便なケモセンサアレイの開発 (2019)
  • Author(s): 佐々木由比、南豪
  • Organizer: 第19回生命科学シンポジウム
• [Presentation] A Saccharide Chemosensor Array Based on an Indicator Displacement Assay Using a Combination of Commercially Available Reagents (2019)
  • Author(s): Sasaki Yui、Zhang Zhoujie、Minami Tsuyoshi
  • Organizer: Workshop on advanced materials and devices
  • Int'l Joint Research
• [Presentation] Development of A Glyphosate Sensor Based on Polythiophene Derivatives (2019)
  • Author(s): Sasaki Yui、Minami Tsuyoshi
  • Organizer: The 14th International Symposium on Macrocyclic and Supramolecular Chemistry (ISMSC2019)
  • Int'l Joint Research
• [Presentation] Elegantな分子認識を目指して (2019)
  • Author(s): 佐々木由比
  • Organizer: 令和元年度日本分析化学会関東支部若手交流会
  • Invited
• [Presentation] Development of Glyphosate Sensors utilizing Polythiophene Derivatives (2019)
  • Author(s): 佐々木由比, 南豪
  • Organizer: 日本化学会第99春季年会
• [Presentation] ポリチオフェンを活用した光学センサアレイの構築 (2018)
  • Author(s): 佐々木由比, 南豪
  • Organizer: 日本分析化学会第67年会
• [Presentation] 金属錯体型比色センサアレイによるオキソアニオン類の同時検出 (2018)
  • Author(s): 佐々木由比, 南豪
  • Organizer: 第16回ホスト－ゲスト・超分子化学シンポジウム
• [Presentation] Molecular Self-Assembled Chemosensor Array for Metal Ions (2018)
  • Author(s): Yui Sasaki, Tsuyoshi Minami
  • Organizer: The 9th Shanghai International Symposium on Analytical Chemistry（国際学会）
  • Int'l Joint Research
• [Presentation] Molecular Self-assembled Chemosensor Arrays for Simultaneous Detection of Saccharides (2018)
  • Author(s): Yui Sasaki, Tsuyoshi Minami
  • Organizer: 13th International Symposium on Macrocyclic and Supramolecular Chemistry (2018 ISMSC)（国際学会）
  • Int'l Joint Research
• [Presentation] 電解質ゲート型ポリチオフェントランジスタによる生体アミン類の検出 (2018)
  • Author(s): 南豪, 南木創, 橋間裕貴, 佐々木由比
  • Organizer: 第16回ホスト-ゲスト・超分子化学シンポジウム
• [Remarks] 東京大学生産技術研究所・南研究室
  • URL: http://www.tminami.iis.u-tokyo.ac.jp/
• [Remarks] OPTRONICS ONLINE，東大の学生発明コンテスト，光関連技術2件が入賞
  • URL: http://www.optronics-media.com/news/20190304/55909/
• [Remarks] 一般財団法人 丸文財団 国際交流助成受領者／国際会議参加レポート
  • URL: https://www.marubun-zaidan.jp/r01_sasaki.html
• [Remarks] OPTRONICS ONLINE，東大の学生発明コンテスト，光関連技術2件が入賞，2019年3月
  • URL: http://www.optronics-media.com/news/20190304/55909/
• [Remarks] Chemical CommunicationsのTwitterアカウントにおける論文紹介
  • URL: https://twitter.com/ChemCommun/status/1019945074103406592
• [Patent(Industrial Property Rights)] 電解効果トランジスタ、ガスセンサー、及びその製造方法 (2021)
  • Inventor(s): 鵜飼 順三，汐月 大志，南豪，佐々木由比
  • Industrial Property Rights Holder: 鵜飼 順三，汐月 大志，南豪，佐々木由比
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2021-014413
  • Filing Date: 2021
  • Overseas
• [Patent(Industrial Property Rights)] 電解効果トランジスタ、ガスセンサー、及びその製造方法 (2020)
  • Inventor(s): 鵜飼 順三，汐月 大志，南豪，佐々木由比
  • Industrial Property Rights Holder: 鵜飼 順三，汐月 大志，南豪，佐々木由比
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2020-075290
  • Filing Date: 2020
• [Patent(Industrial Property Rights)] グリホサート検出用センサ材料及び検出方法 (2019)
  • Inventor(s): 南 豪, 佐々木 由比
  • Industrial Property Rights Holder: 南 豪, 佐々木 由比
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2019-103022
  • Filing Date: 2019