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Quantitative Reconstruction of Electrical Properties and Proton Density of Human Body Using MRI

Research Project

Project/Area Number 18J21876
Research Category

Grant-in-Aid for JSPS Fellows

Allocation TypeSingle-year Grants
Section国内
Research Field Measurement engineering
Research InstitutionThe University of Tokyo

Principal Investigator

伏見 幹史  東京大学, 情報理工学系研究科, 特別研究員(DC1)

Project Period (FY) 2018-04-25 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2020: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2019: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2018: ¥800,000 (Direct Cost: ¥800,000)
KeywordsMRI / 導電率 / 誘電率 / 磁化率 / 弾性率 / 粘性率 / 再構成 / 電気特性 / 磁気特性 / 同時再構成 / 三次元モデル / 境界条件 / 解剖モデル
Outline of Annual Research Achievements

本研究は,がん部位の診断や生体加熱の評価に有用な人体組織の電気特性(導電率・誘電率)分布をMRI画像から再構成するものである.本年度は,大きな目標であった三次元対象に有効な再構成手法の構築を行ったほか,前年度に行った電磁気特性(導電率・磁化率)の同時再構成を進展させ,さらに新たに機械特性(弾性率・粘性率)の再構成へと研究対象を広げた。
電気特性再構成のモダリティであるEPTに対しては,これまで課題であった二次元近似を用いない手法としてHelmholtz分解に基づく積分方程式を導出した。大域的な積分表現式を基礎としているため計測ノイズに対する頑健性も有する。脳の解剖モデルを用いた数値シミュレーションおよびファントム実験にて,従来手法と比較して高精度で安定的な再構成が可能であることが確かめられた。以上の成果は英文雑誌2本(PIER C, PIER M)に採録済みである。
電気特性のうち導電率のみを再構成するモダリティはQCMと呼ばれる。QCMに対しても同様にHelmholtz分解に基づいて導電率に対する積分方程式を導出し,新たな三次元再構成手法を提案した。前年度に米国コーネル大学で取得したヒトのin vivo脳データに対して適用しその有効性を確認した。以上の成果を国際会議(ISMRM)にて口頭発表し受賞しており,現在論文誌への投稿を進めている。
機械特性画像化のモダリティであるMREもEPTと共通の定式化が可能であることを見出し,Helmholtz分解に基づく大局的・直接的な三次元再構成手法を導出した。有効性を数値シミュレーションにて検証済みであり,今後ファントム実験データへの適用を予定している。
以上を総合すると,本研究ではMRIを用いて物性値の定量画像を再構成する新たなモダリティ群に対して,統一的な数理的枠組みを提示し,電磁気特性や機械特性の高精度で安定的な再構成を実現した。

Research Progress Status

令和2年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和2年度が最終年度であるため、記入しない。

Report

(3 results)
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (16 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (3 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (11 results) (of which Int'l Joint Research: 10 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] Weill Cornell Medicine(米国)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Three-Dimensional Magnetic Resonance Electrical Properties Tomography Based on Linear Integral Equation Derived from the Generalized Cauchy Formula2020

    • Author(s)
      Fushimi Motofumi、Nara Takaaki
    • Journal Title

      Progress In Electromagnetics Research C

      Volume: 105 Pages: 147-159

    • DOI

      10.2528/pierc20052101

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Boundary Value-Free Magnetic Resonance Electrical Properties Tomography Based on the Generalized Cauchy Formula with the Complex-Derivative Boundary Condition2020

    • Author(s)
      M. Fushimi and T. Nara
    • Journal Title

      Progress In Electromagnetics Research M

      Volume: 96 Pages: 1-8

    • DOI

      10.2528/pierm20062202

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Principles of Magnetic Resonance Imaging2019

    • Author(s)
      伏見幹史
    • Journal Title

      Journal of The Society of Instrument and Control Engineers

      Volume: 58 Issue: 7 Pages: 520-524

    • DOI

      10.11499/sicejl.58.520

    • NAID

      130007678435

    • ISSN
      0453-4662, 1883-8170
    • Year and Date
      2019-07-10
    • Related Report
      2019 Annual Research Report
  • [Presentation] A Noniterative Three-Dimensional Electrical Property Tomography Reconstruction Method Based on an Integral Equation for the Electric Field2020

    • Author(s)
      Naohiro Eda, Motofumi Fushimi, Keisuke Hasegawa, Takaaki Nara
    • Organizer
      ICE 59th Annual Conference
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Morphology Enabled Quantitative Conductivity–Susceptibility Mapping with B1 and B0 Estimation from Complex Multi-echo Gradient Echo Signal,2020

    • Author(s)
      Motofumi Fushimi, Thanh Nguyen, Yi Wang
    • Organizer
      ISMRM 28th Annual Meeting
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Computation of H- from H+ and its application to regularization for Magnetic Resonance Electrical Properties Tomography (MREPT)2020

    • Author(s)
      Takaaki Nara, Motofumi Fushimi
    • Organizer
      ISMRM 28th Annual Meeting
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Noniterative Electrical Properties Tomography Reconstruction Method Based on Three-Dimensional Integral Equation for the Electric Field2020

    • Author(s)
      Naohiro Eda, Motofumi Fushimi, Keisuke Hasegawa, Takaaki Nara
    • Organizer
      ISMRM 28th Annual Meeting
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ヘルムホルツ分解に基づくMRIを用いた人体内部の電場および電気特性分布の反復再構成手法2020

    • Author(s)
      Naohiro Eda, Motofumi Fushimi, Takaaki Nara
    • Organizer
      第37回センシングフォーラム
    • Related Report
      2020 Annual Research Report
  • [Presentation] Morphology Enabled Quantitative Conductivity Susceptibility Mapping with B1 and B0 Estimation from Complex Multi-echo Gradient Echo Signal2020

    • Author(s)
      Motofumi Fushimi
    • Organizer
      ISMRM 28th Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Simultaneous Conductivity and Susceptibility Mapping from Multi-echo GRE Data by the Nonlinear Least Square Field Estimation on the Complex Signal Equation2019

    • Author(s)
      Motofumi Fushimi
    • Organizer
      5th International Workshop on MRI Phase Contrast and QSM
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A suppression method of a spread of the spot-like artifact for EPT by zero-point adjusting of the electric field2019

    • Author(s)
      Motofumi Fushimi
    • Organizer
      IMEP 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An Explicit EPT Reconstruction Method Based on the Dbar Equation Incorporating Longitudinal Magnetic Field Variations2019

    • Author(s)
      Motofumi Fushimi
    • Organizer
      ISMRM Annual Meeting 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An Explicit Method for MR-Based Electrical Properties Reconstruction Free from Their Boundary Values2018

    • Author(s)
      Motofumi Fushimi
    • Organizer
      ISMRM Annual Meeting 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Magnetic Resonance Based Electrical Properties Reconstruction with Total Variation Regularization and Zero-point Control of Electric Fields2018

    • Author(s)
      Motofumi Fushimi
    • Organizer
      PIERS 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Patent(Industrial Property Rights)] 情報処理装置及び情報処理方法2021

    • Inventor(s)
      奈良高明、伏見幹史、江田尚弘、新誠一、山形仁、矢野亨治、藤田博之
    • Industrial Property Rights Holder
      奈良高明、伏見幹史、江田尚弘、新誠一、山形仁、矢野亨治、藤田博之
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Related Report
      2020 Annual Research Report

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Published: 2018-05-01   Modified: 2024-03-26  

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