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Interaction between cell membrane and nuclear hormone receptor in brain development and its modification by environmental chemicals

Research Project

Project/Area Number 18J23449
Research Category

Grant-in-Aid for JSPS Fellows

Allocation TypeSingle-year Grants
Section国内
Research Field Risk sciences of radiation and chemicals
Research InstitutionGunma University

Principal Investigator

アリヤニ ウィンダ  群馬大学, 医学系研究科, 特別研究員(PD)

Project Period (FY) 2018-04-25 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2018: ¥800,000 (Direct Cost: ¥800,000)
KeywordsThyroid hormone / non-genomic / migration / proliferation / integrin / GPER / gadolinium / isoflavones
Outline of Annual Research Achievements

Last year, I have tried to finish my research project in the interaction of environmental chemicals and thyroid hormones (TH) with the nuclear receptor (thyroid hormone receptor and estrogen receptor) or cell surface receptor (integrin and GPER1/GPR30) that regulate cell proliferation, migration, neuritogenesis, and synaptogenesis. The results revealed that thyroid hormones induced cell migration and proliferation through TRα-dependent and TR-independent pathways. The thyroid hormone-induced cell migration and proliferation through the activation of Grb2 leads to activate the TR-independent pathways. In addition, environmental chemicals such as isoflavones or gadolinium-based contrast agents (GBCAs) accelerate cell migration through GPER1 or integrin activation, which leads to activate FAK/PI3K/Akt/Rho-GTPase pathways that induced F-actin re-arrangement. TH and isoflavones also induced dendritogenesis and synaptogenesis in Purkinje cells via different mechanism pathways, TRα and ERα, respectively. Cell fractionation assays showed that isoflavones induced localization of SNARE protein to the membrane and dendritic fraction, indicate the synapse formation. Isoflavones and TH also increased the expression level of both pre- and post-synaptic proteins. Now, I am preparing several manuscripts to publish my research results. We plan to publish our results in several international journals.

Research Progress Status

令和2年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和2年度が最終年度であるため、記入しない。

Report

(3 results)
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (14 results)

All 2021 2020 2019 2018

All Journal Article (6 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 5 results,  Open Access: 3 results) Presentation (8 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results)

  • [Journal Article] A Novel Role of Nuclear and Membrane Receptor on Isoflavone-Induced Neuritogenesis and Synaptogenesis2021

    • Author(s)
      Ariyani Winda、Miyazaki Wataru、Koibuchi Noriyuki
    • Journal Title

      Journal of the Endocrine Society

      Volume: 5 Issue: Supplement_1 Pages: A802-A803

    • DOI

      10.1210/jendso/bvab048.1632

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Soy Isoflavones Accelerate Glial Cell Migration via GPER-Mediated Signal Transduction Pathway2020

    • Author(s)
      Ariyani Winda、Miyazaki Wataru、Amano Izuki、Hanamura Kenji、Shirao Tomoaki、Koibuchi Noriyuki
    • Journal Title

      Frontiers in Endocrinology

      Volume: 11 Pages: 554941-554941

    • DOI

      10.3389/fendo.2020.554941

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] EID1 suppresses lipid accumulation by inhibiting the expression of GPDH in 3T3‐L1 preadipocytes2020

    • Author(s)
      Sato Tomohiko、Vargas Diana、Miyazaki Kakushin、Uchida Kaoru、Ariyani Winda、Miyazaki Mitsue、Okada Junichi、Lizcano Fernando、Koibuchi Noriyuki、Shimokawa Noriaki
    • Journal Title

      Journal of Cellular Physiology

      Volume: in-press Issue: 10 Pages: 1-11

    • DOI

      10.1002/jcp.29567

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A novel mechanism of S-equol action in neurons and astrocytes: the possible involvement of GPR30/GPER12019

    • Author(s)
      Ariyani W, Miyazaki W, Koibuchi N
    • Journal Title

      Int J Mol Sci

      Volume: 20 Issue: 20 Pages: 5178-5178

    • DOI

      10.3390/ijms20205178

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The effects of gadolinium-based contrast agents on cerebellum: From basic research to neurological practice and from pregnancy to adulthood Cerebellum.2018

    • Author(s)
      Ariyani W, Khairinisa MA, Perrotta G, Manto M, Koibuchi N
    • Journal Title

      Cerebellum

      Volume: 17 Issue: 3 Pages: 247-251

    • DOI

      10.1007/s12311-017-0903-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A possible novel mechanism of action of genistein and daidzein for activating thyroid hormone receptor (TR)-mediated transcription2018

    • Author(s)
      Ariyani Winda、Iwasaki Toshiharu、Miyazaki Wataru、Lu Yu、Takeda Shigeki、Koibuchi Noriyuki
    • Journal Title

      Toxicological Sciences

      Volume: 印刷中 Issue: 2 Pages: 417-427

    • DOI

      10.1093/toxsci/kfy097

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 甲状腺ホルモンは膜受容体を介し、星状膠細胞の移動に影響する.2021

    • Author(s)
      Winda Ariyani, 航 宮崎, 鯉淵 典之
    • Organizer
      第98回 日本生理学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] A novel role of nuclear and membrane receptor on isoflavone-induced neuritogenesis and synaptogenesis2021

    • Author(s)
      Winda Ariyani, Wataru Miyazaki, Noriyuki Koibuchi
    • Organizer
      The 103rd Annual Meeting of the Endocrine Society: ENDO2021
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Gadolinium-based contrast agents induced cell migration through integrin αvβ3 signaling pathway2020

    • Author(s)
      Winda Ariyani, Wataru Miyazaki, Yoshito Tsushima, Noriyuki Koibuchi.
    • Organizer
      The Kitakanto Medical Journal Annual Meeting
    • Related Report
      2020 Annual Research Report
  • [Presentation] Thyroid hormone (TH) induced cell proliferation and migration through TH receptor (TR)-dependent and -independent pathways2020

    • Author(s)
      Winda Ariyani, Wataru Miyazaki, Izuki Amano, Noriyuki Koibuchi.
    • Organizer
      The 97th Annual Meeting of the Physiological Society of Japan
    • Related Report
      2019 Annual Research Report
  • [Presentation] The effect of soybean isoflavones in developing cerebellum2020

    • Author(s)
      Winda Ariyani, Wataru Miyazaki, Izuki Amano, Noriyuki Koibuchi.
    • Organizer
      ENDO2020
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Thyroid hormone (TH) and its derivatives induced cell proliferation and migration through non-genomics pathway2019

    • Author(s)
      Winda Ariyani, Wataru Miyazaki, Noriyuki Koibuchi.
    • Organizer
      The 62nd Annual Meeting of the Japan Thyroid Association
    • Related Report
      2019 Annual Research Report
  • [Presentation] Genistein and daidzein augments thyroid hormone-mediated dendritogenesis of cerebellar Purkinje cell.2019

    • Author(s)
      Winda Ariyani, Toshiharu Iwasaki, Wataru Miyazaki, Lu Yu, Shigeki Takeda, Noriyuki Koibuchi.
    • Organizer
      9th Federation of the Asian and Oceanian Physiological Society (FAOPS2019)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Genistein and daidzein induces thyroid hormone-mediated dendritogenesis of cerebellar Purkinje cell via nuclear thyroid hormone receptor.2018

    • Author(s)
      Winda Ariyani, Toshiharu Iwasaki, Wataru Miyazaki, Lu Yu, Shigeki Takeda, Noriyuki Koibuchi.
    • Organizer
      27th International Physiology Seminar
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research

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Published: 2018-05-01   Modified: 2024-03-26  

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