| Project/Area Number |
18K02237
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 08030:Family and consumer sciences, and culture and living-related
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| Research Institution | Gifu University |
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Principal Investigator |
Shimada Masaya 岐阜大学, 応用生物科学部, 准教授 (10576755)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | フルクトース / 単純性脂肪肝 / 脂肪合成系遺伝子 / プロモーター / ChREBP / アセチル化ヒストン / ヒストンアセチル化 / 果糖 / 脂肪酸合成 / FASN |
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| Outline of Final Research Achievements |
We investigated epigenetic regulation, especially histone acetylation on lipogenic genes in fatty liver induced by a dietary factor, fructose. Expression of lipogenic genes (Pklr, Acly, Acaca, Fasn, Elovl6, Scd1) was induced in simple fatty liver of rats fed a high-fructose diet. In addition, the high-fructose enhanced acetylation of histones H3 and H4 as well as binding of a lipogenic transcription factor ChREBP, not SREBP-1, at the Elovl6 and Scd1 gene promoters.
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| Academic Significance and Societal Importance of the Research Achievements |
日々の食生活で摂取し得るフルクトースは，肝臓において糖から脂肪への変換を調節する転写因子ChREBPおよびヒストンアセチル化の活性化を介して脂肪合成系遺伝子の発現を上方調節することが示唆された。今後これらの因子を抑制するような食生活を探索することが脂肪肝を含めた代謝性疾患を予防に重要である。
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