Mechanism of new diabetes onset in low fasting glucose level

• Project/Area Number: 18K02242
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 08030:Family and consumer sciences, and culture and living-related
• Research Institution: Fukushima Medical University
• Principal Investigator: Ogata Emi 福島県立医科大学, 医学部, 博士研究員 (80627307)
• Co-Investigator(Kenkyū-buntansha): 島袋 充生 福島県立医科大学, 医学部, 教授 (60271144) ; 旭 浩一 岩手医科大学, 医学部, 教授 (60274966)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2020: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2019: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
• Keywords: 糖尿病

Outline of Final Research Achievements

In current study, we investigated the risk of new-onset diabetes mellitus relative to fasting plasma glucose levels at various ranges. In an annual health check program in 2008, participants without diabetes were classified into 8 categories according to their fasting plasma glucose levels :<70 mg/dL, 70-79 mg/dL, 80-84 mg/dL,85-89 mg/dL, 90-94 mg/dL, 95-99 mg/dL, 100-109 mg/dL, and 110-125 mg/dL. We measured the odds ratio (OR) of new-onset diabetes mellitus. In all participants, multivariable-adjusted OR increased when fasting plasma glucose levels were <70 mg/dL or 90-125 mg/dL. Focus on the increased incidence of cardiovascular disease (CVD) below fasting blood glucose levels of 70 mg/dL, we measured the OR with or without history of CVD. Participants without CVD showed increased OR when glucose levels were <70 mg/dL or 90-125 mg/dL. Participants with a history of CVD showed increased OR with glucose levels of 95-125 mg/dL.

Academic Significance and Societal Importance of the Research Achievements

本研究で、空腹時血糖値 <70 mg/dlからの糖尿病発症オッズ比はJ-カーブを示すこと、CVDの既往の有無においてCVD無群でのみ空腹時血糖値 <70 mg/dLで糖尿病発症オッズ比が上昇することが示された。CVD無群で、空腹時血糖値 70mg/dL未満の集団を今後糖尿病発症の新たなリスクととらえていく必要が示唆された。本研究結果は、今後の糖尿病予防や診断、治療に貢献することが期待される。

Research Products

• [Journal Article] Low fasting plasma glucose level as a predictor of new-onset diabetes mellitus on a large cohort from a Japanese general population (2018)
  • Author(s): Ogata Emi、Asahi Koichi、Yamaguchi Satoshi、Iseki Kunitoshi、Sato Hiroaki、Moriyama Toshiki、Yamagata Kunihiro、Tsuruya Kazuhiko、Fujimoto Shouichi、Narita Ichiei、Konta Tsuneo、Kondo Masahide、Shibagaki Yugo、Kasahara Masato、Watanabe Tsuyoshi、Shimabukuro Michio
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 13927-13927
  • DOI: 10.1038/s41598-018-31744-4
  • Peer Reviewed / Open Access