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Elucidation of distribution of advanced glycation end-products (AGEs) in food and drink and factors on the formation of AGEs

Research Project

Project/Area Number 18K02263
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 08030:Family and consumer sciences, and culture and living-related
Research InstitutionNigata University of Phermacy and Applied Life Sciences

Principal Investigator

Nomi Yuri  新潟薬科大学, 応用生命科学部, 助教 (20614887)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsメイラード反応 / 終末糖化産物(AGEs) / ジカルボニル化合物 / 終末糖化産物 / AGEs / α-ジカルボニル化合物 / 糖質 / 糖化 / 食品
Outline of Final Research Achievements

Advanced glycation end-products (AGEs) produced in the late stages of the Maillard reaction are contained in various foods and are possible to be involved in the development of chronic diseases. In this study, we comprehensively evaluated the Maillard reaction products and attempted to elucidate the factors that influence the production of AGEs in foods. Validation using model reaction systems showed that not only the reducing ability of sugars, but also the type and binding mode of sugars are involved in the formation of specific AGEs and their precursors, α-dicarbonyl compounds (α-DCs). In addition, validation using foods led us to clarify formation mechanism of AGEs contained in baked bread.

Academic Significance and Societal Importance of the Research Achievements

本研究では多種類のAGEsやα-DCsをモニターできる分析系を新たに構築し、AGEsおよび関連成分(糖質、アミノ化合物、アマドリ化合物、α-DCs)を包括的に解析することが可能となった。モデル系と実際の飲食品での検証を組み合わせることで、AGEs生成に関与する因子を新たに複数同定することができた。本研究で見出されたAGEs生成メカニズムに関する知見は、AGEs低減に向けた方策を講じるための一助となりうる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (6 results)

All 2020 2019 2018

All Journal Article (3 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (2 results) Book (1 results)

  • [Journal Article] Free advanced glycation end product distribution in blood components and the effect of genetic polymorphisms2020

    • Author(s)
      Nomi Y, Kudo H, Miyamoto K, Okura T, Yamamoto K, Shimohiro H, Kitao S, Ito Y, Egawa S, Kawahara K,Otsuka Y , Ueta E
    • Journal Title

      Biochemie

      Volume: 179 Pages: 69-76

    • DOI

      10.1016/j.biochi.2020.09.010

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Isolation, identification, and proposed formation mechanism of a novel hydrophilic compound formed by Maillard reaction between pyridoxamine and pentose2020

    • Author(s)
      Nomi Yuri、Otsuka Yuzuru
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1

    • DOI

      10.1038/s41598-020-58727-8

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] AGEsの精密分析と食品化学,医学への応用2018

    • Author(s)
      OTSUKA Yuzuru、UETA Etsuko、NOMI Yuri
    • Journal Title

      KAGAKU TO SEIBUTSU

      Volume: 56 Issue: 4 Pages: 242-243

    • DOI

      10.1271/kagakutoseibutsu.56.242

    • NAID

      130007616569

    • ISSN
      0453-073X, 1883-6852
    • Year and Date
      2018-03-20
    • Related Report
      2018 Research-status Report
  • [Presentation] 各種糖質の終末糖化産物(AGEs)の生成能評価2019

    • Author(s)
      森友樹, 久代孝一, 能見祐理, 松本 均
    • Organizer
      日本食品科学工学会第66回大会
    • Related Report
      2019 Research-status Report
  • [Presentation] カルノシンとキシロースのメイラード反応で形成される低分子黄色色素の同定2019

    • Author(s)
      能見祐理, 山崎健人, 佐藤眞治, 松本均
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Research-status Report
  • [Book] グリケーションの制御とメイラード反応の利用2020

    • Author(s)
      有原圭三
    • Total Pages
      379
    • Publisher
      シーエムシー出版
    • ISBN
      9784781315645
    • Related Report
      2020 Annual Research Report

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Published: 2018-04-23   Modified: 2022-01-27  

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