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Elucidation of the biological foundation of children with intermittent explosive disorder and construction of an effective comprehensive support system

Research Project

Project/Area Number 18K02955
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 09080:Science education-related
Research InstitutionUniversity of Fukui

Principal Investigator

Kawatani Masao  福井大学, 学術研究院医学系部門, 特別研究員 (10362047)

Co-Investigator(Kenkyū-buntansha) 高橋 哲也  福井大学, 学術研究院医学系部門, 客員准教授 (00377459)
水野 賀史  福井大学, 子どものこころの発達研究センター, 准教授 (50756814)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords間欠爆発症 / 注意欠如・多動症 / 多職種連携 / 支援 / 神経発達症 / 医療と教育の連携 / 脳波 / 連携 / キレる子ども / 機能的MRI / 包括的支援
Outline of Final Research Achievements

We conducted research with the aim of clarifying the current situation and pathophysiology of children with intermittent explosive disorder (IED) which have been increasing in recent years. According to of elementary and junior high schools in Fukui Prefecture, children with IED accounted for 0.84% of elementary school students and 0.28% of junior high school students, and there were too many boys. It was effective appropriate understanding and support according to the neurodevelopmental characteristics, cooperate with related organizations including family members, and respond as one team. Children with IED often have coexistence of attention-deficit/hyperactivity disorder (ADHD), and in patients with ADHD, ADHD treatments (especially guanfacine) are effective in reducing not only ADHD symptoms but also symptoms such as irritability and tantrum. EEG examinations for assessing the pathology of IEDs were not effective with normal linear EEG analysis alone.

Academic Significance and Societal Importance of the Research Achievements

本研究結果により、近年増加している「キレる子ども」の実態の把握と対応のポイントが明らかになった。「キレる子ども」は小学生の0.84%、中学生の0.28%に相当し男児が非常に多く、周囲の発達特性の理解と特性に応じた対応、家族を含めた関係機関との連携、チームとしての対応が有効であった。間欠爆発症(IED)の小児は注意欠如・多動症(ADHD)の併存が多く、ADHD併存例にはADHD治療薬(特にグアンファシン)がADHD症状だけでなく、いらいらや癇癪といった症状の軽減に有効であった。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (12 results)

All 2021 2020 2019 2018

All Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (7 results) (of which Int'l Joint Research: 1 results) Book (1 results)

  • [Journal Article] Low threshold to Vestibular and Oral Sensory stimuli might affect quality of sleep among children with autism spectrum disorder2021

    • Author(s)
      Kosaka Takuya、Kawatani Masao、Ohta Genrei、Mizuno Yoshifumi、Takiguchi Shinichiro、Kumano Asami、Hayashi Hisako、Fujine Akio、Tsuda Akemi、Fujisawa Takashi X.、Tomoda Akemi、Ohshima Yusei
    • Journal Title

      Brain and Development

      Volume: 43 Issue: 1 Pages: 55-62

    • DOI

      10.1016/j.braindev.2020.07.010

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Survey of Explosive Children in Fukui Prefecture Elementary and Junior High Schools2021

    • Author(s)
      川谷 正男、小坂 拓也、巨田 元礼、友田 明美、平谷 美智夫、大嶋 勇成
    • Journal Title

      Psychiatria et neurologia paediatrica japonica

      Volume: 61 Issue: 1 Pages: 53-62

    • DOI

      10.24782/jsppn.61.1_53

    • NAID

      130008014273

    • ISSN
      0559-9040, 2434-1339
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case of early myoclonic encephalopathy with intractable seizures successfully treated with high-dose phenobarbital.2019

    • Author(s)
      Kosaka T, Ohta G, Kometani H, Kawatani M, Ohshima Y.
    • Journal Title

      Brain Dev.

      Volume: 41(8) Issue: 8 Pages: 717-720

    • DOI

      10.1016/j.braindev.2019.04.007

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structural brain abnormalities in children and adolescents with comorbid autism spectrum disorder and attention-deficit/hyperactivity disorder2019

    • Author(s)
      Mizuno Y, Kagitani-Shimono K, Jung M, Makita K, Takiguchi S, Fujisawa TX, Tachibana M, Nakanishi M, Mohri I, Taniike M, Tomoda A.
    • Journal Title

      Transl Psychiatry.

      Volume: 9 Issue: 1 Pages: 332-332

    • DOI

      10.1038/s41398-019-0679-z

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] ”キレる子ども”における脳波学的検討2020

    • Author(s)
      川谷 正男、小坂 拓也、巨田 元礼、友田 明美、平谷 美智夫、大嶋 勇成
    • Organizer
      第62回日本小児神経学会
    • Related Report
      2020 Research-status Report
  • [Presentation] ADHDに併存したキレる症状に対するグアンファシンの有効性2019

    • Author(s)
      川谷正男、小坂拓也、巨田元礼、米谷博、大嶋勇成、友田明美、平谷美智夫
    • Organizer
      第61回日本小児神経学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Clinical analysis of children with intermittent explosive disorder2019

    • Author(s)
      Masao Kawatani, Takuya Kosaka, Genrei Ohta, Hiroshi Kometani, Shinichiro Takiguchi, Yusei Ohshima, Akemi Tomoda, Michio Hiratani
    • Organizer
      15th Asian Oceanian Congress of Child Neurology (AOCCN2019)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 福井県の小・中学校における「キレる子ども」の実態調査2019

    • Author(s)
      川谷正男、小坂拓也、巨田元礼、友田明美、平谷美智夫
    • Organizer
      第122回日本小児精神神経学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 未成年の保因者検査の是非 ~副腎白質ジストロフィーの症例を通じて~2019

    • Author(s)
      川谷正男、杉原啓一、小坂拓也、巨田元礼、井川正道、畑郁江、大嶋勇成
    • Organizer
      第64回日本人類遺伝学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 福井県の小・中学校における「間欠爆発症の疑いのある子ども」に関するアンケート調査2019

    • Author(s)
      川谷正男、小坂拓也、巨田元礼、友田明美、大嶋勇成
    • Organizer
      第62回福井県小児保健協会
    • Related Report
      2018 Research-status Report
  • [Presentation] 「キレる子ども」の臨床背景2018

    • Author(s)
      川谷正男、小坂拓也、巨田元礼、米谷博 、大嶋勇成、友田明美、平谷美智夫
    • Organizer
      第60回日本小児神経学会学術集会
    • Related Report
      2018 Research-status Report
  • [Book] 各科スペシャリストが伝授 内科医が知っておくべき疾患1022020

    • Author(s)
      宮地良樹
    • Total Pages
      224
    • Publisher
      中山書店
    • ISBN
      9784521748054
    • Related Report
      2020 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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