Retrieval induced forgetting in mice

• Project/Area Number: 18K03169
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 10040:Experimental psychology-related
• Research Institution: Waseda University (2019-2020); Gunma University (2018)
• Principal Investigator: Haijima Asahi 早稲田大学, 人間科学学術院, 講師(任期付) (70555672)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 検索誘導性忘却 / 記憶 / マウス / 物体再認記憶試験

Outline of Final Research Achievements

The aim of this study was to investigate the retrieval induced forgetting (RIF) in mice. Modified spontaneous object recognition test was used in this study. Mice showed RIF irrespective of sex and age. In addition, the present study founed that RIF continued for a limited period of time. Analysis of c-fos messenger RNA expression suggested that prefrontal and perirhinal cortex may be involved in RIF.

Academic Significance and Societal Importance of the Research Achievements

われわれの記憶は日々の経験によって促進されたり抑制されたりさまざまな影響を受ける。そのため記憶研究においては経験が記憶に及ぼす影響を考慮に入れ，その仕組みを解明することが必要となる。本研究で着目した検索誘導性忘却は，ある事柄を思い出すことを経験すると，それに関連した記憶が抑制される現象である。本研究で得られた成果により，経験が記憶に及ぼす影響についての新たな知見を提供できたといえる。

Research Products

• [Journal Article] Neurotoxic effects of lactational exposure to perfluorooctane sulfonate on learning and memory in adult male mouse (2020)
  • Author(s): Mshaty Abdallah、Haijima Asahi、Takatsuru Yusuke、Ninomiya Ayane、Yajima Hiroyuki、Kokubo Michifumi、Khairinisa Miski Aghnia、Miyazaki Wataru、Amano Izuki、Koibuchi Noriyuki
  • Journal Title: Food and Chemical Toxicology Volume: 145 Pages: 111710-111710
  • DOI: 10.1016/j.fct.2020.111710
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A mouse model of Timothy syndrome exhibits altered social competitive dominance and inhibitory neuron development. (2020)
  • Author(s): Horigane SI, Ozawa Y, Zhang J, Todoroki H, Miao P, Haijima A, Yanagawa Y, Ueda S, Nakamura S, Kakeyama M, Takemoto-Kimura S.
  • Journal Title: FEBS Open Bio Volume: 10 Issue: 8 Pages: 1436-1446
  • DOI: 10.1002/2211-5463.12924
  • Peer Reviewed / Open Access
• [Journal Article] Early-life stress induces cognitive disorder in middle-aged mice. (2018)
  • Author(s): Yajima H, Haijima A, Khairinisa MA, Shimokawa N, Amano I, Takatsuru Y.
  • Journal Title: Neurobiology of Aging Volume: 64 Pages: 139-146
  • DOI: 10.1016/j.neurobiolaging.2017.12.021
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effects of Mild Perinatal Hypothyroidism on Cognitive Function of Adult Male Offspring (2018)
  • Author(s): Amano Izuki、Takatsuru Yusuke、Khairinisa Miski Aghnia、Kokubo Michifumi、Haijima Asahi、Koibuchi Noriyuki
  • Journal Title: Endocrinology Volume: 159 Issue: 4 Pages: 1910-1921
  • DOI: 10.1210/en.2017-03125
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] In Utero and Postnatal Propylthiouracil-Induced Mild Hypothyroidism Impairs Maternal Behavior in Mice (2018)
  • Author(s): Khairinisa Miski Aghnia、Takatsuru Yusuke、Amano Izuki、Kokubo Michifumi、Haijima Asahi、Miyazaki Wataru、Koibuchi Noriyuki
  • Journal Title: Frontiers in Endocrinology Volume: 9 Pages: 228-228
  • DOI: 10.3389/fendo.2018.00228
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 周産期ガドリニウム造影剤曝露による認知機能への影響 (2020)
  • Author(s): 鯉淵 典之，Khairinisa A. Miski，Ariyani Winda，宮崎 航，蓜島 旭，天野 出月，対馬 義人
  • Organizer: 第97回日本生理学会大会
• [Presentation] 甲状腺ホルモン受容体による小脳プルキンエ細胞におけるシナプス可塑性の調節機構 (2020)
  • Author(s): 二ノ宮 彩音，細井 延武，小久保 倫文，天野 出月，蓜島 旭，宮崎 航，平井 宏和，鯉淵 典之
  • Organizer: 第97回日本生理学会大会
• [Presentation] The Impact of Chronic Excess Iodine Intake in Adult Mice Behavior. (2020)
  • Author(s): Izuki Amano, Yusuke Takatsuru, Asahi Haijima, Shogo Haraguchi, Noriyuki Koibuchi
  • Organizer: Endocrine Society’s Annual Meeting
  • Int'l Joint Research
• [Presentation] A Novel Role of Thyroid Hormone Receptor in Synaptic Plasticity in Cerebellar Purkinje Cells. (2020)
  • Author(s): Ayane Ninomiya, Nobutake Hosoi, Michifumi Kokubo, Izuki Amano, Asahi Haijima, Wataru Miyazaki, Hirokazu Hirai, Noriyuki Koibuchi.
  • Organizer: Endocrine Society’s Annual Meeting
  • Int'l Joint Research
• [Presentation] 若齢マウスにおける検索誘導性忘却 (2019)
  • Author(s): 蓜島旭、伊藤大貴、鯉淵典之
  • Organizer: 第96回日本生理学会大会
• [Presentation] Retrieval-Induced Forgetting in Young Mice (2019)
  • Author(s): Asahi Haijima, Noriyuki Koibuchi
  • Organizer: 9th Federation of the Asian and Oceanian Physiological Societies congress
  • Int'l Joint Research
• [Presentation] Effects of perinatal hypothyroidism on brain development (2019)
  • Author(s): Izuki Amano, Yusuke Takatsuru, Ayane Kate Ninomiya, Hiroyuki Yajima, Miski Aghnia Khairinisa, Michifumi Kokubo, Machiko Suda, Asahi Haijima, Noriyuki Koibuchi
  • Organizer: 9th Federation of the Asian and Oceanian Physiological Societies congress
  • Int'l Joint Research
• [Presentation] Neonatal motor coordination is impaired by moderate perinatal hypothyroidism in mice (2019)
  • Author(s): Michifumi Kokubo, Izuki Amano, Wataru Miyazaki, Yusuke Takatsuru, Asahi Haijima, Shogo Haraguchi, Noriyuki Koibuchi
  • Organizer: 9th Federation of the Asian and Oceanian Physiological Societies congress
  • Int'l Joint Research
• [Presentation] The effect of post-natal PFOS exposure on cerebellar development and motor coordination (2019)
  • Author(s): Abdallah Mshaty , Asahi Haijima, Wataru Miyazaki, Noriyuki Koibuchi
  • Organizer: 9th Federation of the Asian and Oceanian Physiological Societies congress
  • Int'l Joint Research
• [Presentation] Impairment of Long-term Plasticity in Purkinje Cell with Dominant- negative Thyroid Hormone Receptor (2019)
  • Author(s): Ayane Ninomiya, Nobutake Hosoi, Michifumi Kokubo, Izuki Amano, Asahi Haijima, Wataru Miyazaki, Hirokazu Hirai, Noriyuki Koibuchi
  • Organizer: 9th Federation of the Asian and Oceanian Physiological Societies congress
  • Int'l Joint Research
• [Presentation] 老齢マウスにおける検索誘導性忘却 (2018)
  • Author(s): 蓜島 旭，伊藤 大貴，鯉淵 典之
  • Organizer: 第95回日本生理学会大会