Manipulation of time perception using magnetic stimulation

• Project/Area Number: 18K03185
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 10040:Experimental psychology-related
• Research Institution: Showa University (2019-2021); Kyorin University (2018)
• Principal Investigator: Honma Motoyasu 昭和大学, 医学部, 講師 (20434194)
• Co-Investigator(Kenkyū-buntansha): 谷部 好子 日本電信電話株式会社NTTコミュニケーション科学基礎研究所, 柏野多様脳特別研究室, リサーチスペシャリスト (30582829)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 時間感覚 / 磁気刺激 / 背外側前頭前皮質 / 誤学習 / パーキンソン病 / 前頭前野

Outline of Final Research Achievements

Time perception is a fundamental ability in human life, but there are many unresolved aspects of its processing mechanisms. In this study, we investigated the learning mechanism in the correction and retention of time duration perception. We conducted a learning task in which participants were asked to memorize incorrect time intervals, and analyzed the natural recovery of time duration perception after the incorrect learning over time. As a result, the incorrectly memorized time durations were restored after about 2 hours. Next, magnetic stimulation was applied to specific brain regions to enhance plasticity, and then mislearning was performed to examine the prolongation of the learning effect. The results showed that the effect of mislearning was prolonged for about 4 hours under conditions in which magnetic stimulation was applied to the dorsolateral prefrontal cortex. These results suggest that the dorsolateral prefrontal cortex is associated with memory of novel time durations.

Academic Significance and Societal Importance of the Research Achievements

ヒトの時間感覚がどのような仕組みで行われているのか不明な点が多い．そのような中，本研究はヒトの時間感覚を修正・操作できるかを検証した．本研究の結果から，特定の脳部位に磁気刺激を与えることで時間感覚は操作できることを示した．この知見は時間感覚のメカニズムに新しい示唆を与えることが期待できる．ヒトの時間感覚を修正・操作する試みから，時間感覚の障害を持つ疾患患者への臨床応用を提案したい．

Research Products

• [Journal Article] Reading on a smartphone affects sigh generation, brain activity, and comprehension (2022)
  • Author(s): Honma Motoyasu、Masaoka Yuri、Iizuka Natsuko、Wada Sayaka、Kamimura Sawa、Yoshikawa Akira、Moriya Rika、Kamijo Shotaro、Izumizaki Masahiko
  • Journal Title: Scientific Reports Volume: 12 Issue: 1 Pages: 1589-1589
  • DOI: 10.1038/s41598-022-05605-0
  • Peer Reviewed / Open Access
• [Journal Article] White Matter Lesions May Aid in Differentiating Idiopathic Normal Pressure Hydrocephalus and Alzheimer’s Disease (2022)
  • Author(s): Kuroda Takeshi、Honma Motoyasu、Mori Yukiko、Futamura Akinori、Sugimoto Azusa、Kasai Hideyo、Yano Satoshi、Hieda Sotaro、Kasuga Kensaku、Ikeuchi Takeshi、Ono Kenjiro
  • Journal Title: Journal of Alzheimer's Disease Volume: 85 Issue: 2 Pages: 851-862
  • DOI: 10.3233/jad-215187
  • Peer Reviewed
• [Journal Article] Inducing Cortical Plasticity to Manipulate and Consolidate Subjective Time Interval Production (2021)
  • Author(s): Honma Motoyasu、Saito Shoko、Atsumi Takeshi、Tokushige Shin‐ichi、Inomata‐Terada Satomi、Chiba Atsuro、Terao Yasuo
  • Journal Title: Neuromodulation: Technology at the Neural Interface Volume: - Issue: 4 Pages: 511-519
  • DOI: 10.1111/ner.13413
  • Peer Reviewed / Open Access
• [Journal Article] Stopwatch training improves cognitive functions in patients with Parkinson's disease (2021)
  • Author(s): Honma Motoyasu、Murakami Hidetomo、Yabe Yoshiko、Kuroda Takeshi、Futamura Akinori、Sugimoto Azusa、Terao Yasuo、Masaoka Yuri、Izumizaki Masahiko、Kawamura Mitsuru、Ono Kenjiro
  • Journal Title: Journal of Neuroscience Research Volume: 99 Issue: 5 Pages: 1325-1336
  • DOI: 10.1002/jnr.24812
  • Peer Reviewed
• [Journal Article] Cascade process mediated by left hippocampus and left superior frontal gyrus affects relationship between aging and cognitive dysfunction (2021)
  • Author(s): Kokudai Yumika、Honma Motoyasu、Masaoka Yuri、Yoshida Masaki、Sugiyama Haruko、Yoshikawa Akira、Koiwa Nobuyoshi、Kubota Satomi、Iizuka Natsuko、Wada Sayaka、Kamijo Shotaro、Uchida Yuki、Yano Satoshi、Ida Masahiro、Ono Kenjiro、Izumizaki Masahiko
  • Journal Title: BMC Neuroscience Volume: 22 Issue: 1 Pages: 75-75
  • DOI: 10.1186/s12868-021-00680-x
  • Peer Reviewed / Open Access
• [Journal Article] Volume of the right supramarginal gyrus is associated with a maintenance of emotion recognition ability (2021)
  • Author(s): Wada Sayaka、Honma Motoyasu、Masaoka Yuri、Yoshida Masaki、Koiwa Nobuyoshi、Sugiyama Haruko、Iizuka Natsuko、Kubota Satomi、Kokudai Yumika、Yoshikawa Akira、Kamijo Shotaro、Kamimura Sawa、Ida Masahiro、Ono Kenjiro、Onda Hidetoshi、Izumizaki Masahiko
  • Journal Title: PLOS ONE Volume: 16 Issue: 7 Pages: e0254623-e0254623
  • DOI: 10.1371/journal.pone.0254623
  • Peer Reviewed / Open Access
• [Journal Article] Time Distortion in Parkinsonism (2021)
  • Author(s): Terao Yasuo、Honma Motoyasu、Asahara Yuki、Tokushige Shin-ichi、Furubayashi Toshiaki、Miyazaki Tai、Inomata-Terada Satomi、Uchibori Ayumi、Miyagawa Shinji、Ichikawa Yaeko、Chiba Atsuro、Ugawa Yoshikazu、Suzuki Masahiko
  • Journal Title: Frontiers in Neuroscience Volume: 15 Pages: 648814-648814
  • DOI: 10.3389/fnins.2021.648814
  • Peer Reviewed / Open Access
• [Journal Article] Contribution of Somatosensory and Parietal Association Areas in Improving Standing Postural Stability Through Standing Plantar Perception Training in Community-Dwelling Older Adults (2021)
  • Author(s): Matsuno S, Yoshiike T, Yoshimura A, Morita S, Fujii Y, Honma M, Ozeki Y, Kuriyama K.
  • Journal Title: Journal of Aging and Physical Activity Volume: 18 Issue: 5 Pages: 1-10
  • DOI: 10.1123/japa.2020-0130
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Entorhinal cortex and parahippocampus volume reductions impact olfactory decline in aged subjects (2021)
  • Author(s): izuka N, Masaoka Y, Kubota S, Sugiyama H, Yoshida M, Yoshikawa A, Koiwa N, Honma M, Watanabe K, Kamijo S, Kamimura S, Ida M, Ono K, Izumizaki M.
  • Journal Title: Brain and Behavior Volume: 11 Issue: 5
  • DOI: 10.1002/brb3.2115
  • Peer Reviewed / Open Access
• [Journal Article] Heart Rate and Respiration Affect the Functional Connectivity of Default Mode Network in Resting-State Functional Magnetic Resonance Imaging (2020)
  • Author(s): Yoshikawa Akira、Masaoka Yuri、Yoshida Masaki、Koiwa Nobuyoshi、Honma Motoyasu、Watanabe Keiko、Kubota Satomi、Natsuko Iizuka、Ida Masahiro、Izumizaki Masahiko
  • Journal Title: Frontiers in Neuroscience Volume: 14 Pages: 631-631
  • DOI: 10.3389/fnins.2020.00631
  • Peer Reviewed / Open Access
• [Journal Article] Hippocampus and Parahippocampus Volume Reduction Associated With Impaired Olfactory Abilities in Subjects Without Evidence of Cognitive Decline (2020)
  • Author(s): Kubota Satomi、Masaoka Yuri、Sugiyama Haruko、Yoshida Masaki、Yoshikawa Akira、Koiwa Nobuyoshi、Honma Motoyasu、Kinno Ryuta、Watanabe Keiko、Iizuka Natsuko、Ida Masahiro、Ono Kenjiro、Izumizaki Masahiko
  • Journal Title: Frontiers in Human Neuroscience Volume: 14 Pages: 556519-556519
  • DOI: 10.3389/fnhum.2020.556519
  • Peer Reviewed / Open Access
• [Journal Article] Increased Presence of Cerebral Microbleeds Correlates With Ventricular Enlargement and Increased White Matter Hyperintensities in Alzheimer’s Disease (2020)
  • Author(s): Kuroda Takeshi、Honma Motoyasu、Mori Yukiko、Futamura Akinori、Sugimoto Azusa、Yano Satoshi、Kinno Ryuta、Murakami Hidetomo、Ono Kenjiro
  • Journal Title: Frontiers in Aging Neuroscience Volume: 12 Pages: 1-8
  • DOI: 10.3389/fnagi.2020.00013
  • Peer Reviewed / Open Access
• [Journal Article] Contraction of distance and duration production in autism spectrum disorder (2019)
  • Author(s): Honma, M., Itoi, C., Midorikawa, A., Terao, Y., Masaoka, Y., Kuroda, T., Futamura, A., Shiromaru, A., Kawamura, M., Ono, K.
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 8806-8806
  • DOI: 10.1038/s41598-019-45250-8
  • NAID: 130008126764
  • Peer Reviewed / Open Access
• [Journal Article] Bright light exposure advances consolidation of motor skill accuracy in humans (2019)
  • Author(s): Yoshiike, T., Honma, M., Ikeda, H., Kuriyama, K.
  • Journal Title: Neurobiology of Learning and Memory Volume: 166 Pages: 107084-107084
  • DOI: 10.1016/j.nlm.2019.107084
  • Peer Reviewed
• [Journal Article] Impaired cognitive modification for estimating time duration in Parkinson’s disease (2018)
  • Author(s): Honma Motoyasu、Masaoka Yuri、Koyama Shinichi、Kuroda Takeshi、Futamura Akinori、Shiromaru Azusa、Terao Yasuo、Ono Kenjiro、Kawamura Mitsuru
  • Journal Title: PLOS ONE Volume: 13 Issue: 12 Pages: e0208956-e0208956
  • DOI: 10.1371/journal.pone.0208956
  • NAID: 120007128126
  • Peer Reviewed / Open Access
• [Journal Article] The subjective perception of past, present, and future time in patients with Alzheimer's disease: a qualitative study (2018)
  • Author(s): Shiromaru-Sugimoto Azusa、Murakami Hidetomo、Futamura Akinori、Honma Motoyasu、Kuroda Takeshi、Kawamura Mitsuru、Ono Kenjiro
  • Journal Title: Neuropsychiatric Disease and Treatment Volume: Volume 14 Pages: 3185-3192
  • DOI: 10.2147/ndt.s186081
  • Peer Reviewed / Open Access
• [Journal Article] Effects of bright light exposure on human fear conditioning, extinction, and associated prefrontal activation (2018)
  • Author(s): Yoshiike Takuya、Honma Motoyasu、Yamada Naoto、Kim Yoshiharu、Kuriyama Kenichi
  • Journal Title: Physiology & Behavior Volume: 194 Pages: 268-276
  • DOI: 10.1016/j.physbeh.2018.06.015
  • Peer Reviewed
• [Journal Article] Diagonistic Apraxia: A Unique Case of Corpus Callosal Disconnection Syndrome and Neuromyelitis Optica Spectrum Disorder (2018)
  • Author(s): Shozawa Hidenobu、Futamura Akinori、Saito Yu、Honma Motoyasu、Kawamura Mitsuru、Miller Michael W.、Ono Kenjiro
  • Journal Title: Frontiers in Neurology Volume: 9 Pages: 653-653
  • DOI: 10.3389/fneur.2018.00653
  • Peer Reviewed / Open Access
• [Journal Article] Impairment of cross-modality of vision and olfaction in Parkinson’s disease. (2018)
  • Author(s): Honma, M., Masaoka, Y., Kuroda, T., Futamura, A., Shiromaru, A., Izumizaki, M., Kawamura, M.
  • Journal Title: NEUROLOGY Volume: 90 Issue: 11 Pages: 977-984
  • DOI: 10.1212/wnl.0000000000005110
  • Peer Reviewed / Int'l Joint Research
• [Presentation] 表情認知能力は右縁上回を媒介して教育年数と関連する (2021)
  • Author(s): 本間元康，政岡ゆり，和田清花，吉田正樹，小岩信義，杉山東子，飯塚奈都子，久保田怜美，石代優美香，吉川輝，上條翔太朗，上村佐和，井田正博，小野賢二郎，恩田秀寿，泉﨑雅彦.
  • Organizer: 第10回日本情動学会
• [Presentation] Contraction of distance and duration production in autism spectrum disorder (2021)
  • Author(s): Honma, M., Itoi, C., Midorikawa, A., Terao, Y., Masaoka, Y., Kuroda, T., Futamura, A., Shiromaru, A., Ohta, H., Kato, N., Kawamura, M., Ono, K.
  • Organizer: 32nd International Congress of Psychology
  • Int'l Joint Research
• [Presentation] 自閉症スペクトル障害者における時空間表出の収縮 (2020)
  • Author(s): 本間元康・糸井千尋・緑川晶・寺尾安生・政岡ゆり・黒田岳志・二村明徳・杉本あずさ・太田晴久・加藤進昌・河村満・小野賢二郎
  • Organizer: 日本心理学会第84回大会
• [Presentation] 嗅覚障害者の嗅覚領域における脳の形態的変化に先立って観察される浅い嗅覚溝 (2020)
  • Author(s): 上村佐和・政岡ゆり・吉井伸之・村上幸三・吉川輝・吉田正樹・本間元康・上條翔太朗・井田正博・泉﨑雅彦
  • Organizer: 日本生理学会第98回大会
• [Presentation] 高齢者における香りと自伝的記憶：眼窩前頭葉と側頭葉内側の機能的接続性の検証 (2020)
  • Author(s): 政岡ゆり・杉山東子・渡辺慶子・吉田正樹・吉川輝・小岩信義・本間元康・上條翔太朗・上村佐和・井田正博・小野賢二郎・泉﨑雅彦
  • Organizer: 日本生理学会第98回大会
• [Presentation] 香りの記憶と呼吸: 前頭前野との関連 (2019)
  • Author(s): 政岡ゆり・渡辺慶子・井田正博・吉田正樹・小岩信義・吉川輝・本間元康・飯塚奈都子・小野賢二郎・泉崎雅彦
  • Organizer: 第42回日本神経科学大会
• [Presentation] パーキンソン病における感覚間統合障害 (2019)
  • Author(s): 本間元康・政岡ゆり・黒田岳士・二村明徳・杉本あずさ・小野賢二朗・河村 満
  • Organizer: 第9回日本情動学会
• [Presentation] nternal clock in Parkinsonism - Is it slow or fast and does it correlate with the clinical stage? (2019)
  • Author(s): Terao, Y., Miyazaki, T., Honma, M., Tokushige, S. I., Inomata-Terada, S., Uchibori, A., Ichikawa, Y., Chiba, A. Ugawa, Y., Suzuki, M.
  • Organizer: Society for Neuroscience 49th annual meeting
  • Int'l Joint Research
• [Presentation] Impairment of cognitive alteration for duration production in Parkinson’s disease (2018)
  • Author(s): Honma Motoyasu、Masaoka Yuri、Koyama Shinichi、Kuroda Takeshi、Futamura Akinori、Shiromaru Azusa、Terao Yasuo、Ono Kenjiro、Kawamura Mitsuru
  • Organizer: Society for Neuroscience 48th annual meeting
  • Int'l Joint Research
• [Presentation] Recalibration and consolidation of body image in illusionary environment (2018)
  • Author(s): 本間元康
  • Organizer: 第41回日本神経科学大会
• [Book] Cross-modality dysfunction between visual and olfactory systems in Parkinson’s disease (2019)
  • Author(s): Honma, M.
  • Total Pages: 12
  • Publisher: IntechOpen