| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
(1) Fluctuating diffusivity: Cytoplasm is crowded with macromolecules. Due to the crowding, diffusivity in cytoplasm is about 10 times less than that at infinite dilution. In this study, the reduction rate of diffusivity in a coarse-grained model of cytoplasm is derived.
(2) Non-Gaussianity and anomalous diffusion: Single particle experiments have revealed that relatively large molecules in cytoplasm exhibit complex diffusion. In particular, intrinsic statistical properties such as non-Gaussianity and anomalous diffusion have been found. Therefore, a novel stochastic equation of motion (a generalized Langevin equation with fluctuating diffusivity) is proposed.
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