| Project/Area Number |
18K03564
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 13040:Biophysics, chemical physics and soft matter physics-related
|
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| Research Institution | Osaka University (2023)
Yamaguchi University (2018-2022) |
|---|
Principal Investigator |
Ariga Takayuki 大阪大学, 大学院生命機能研究科, 准教授 (30452262)
|
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| Project Period (FY) |
2018-04-01 – 2024-03-31
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| Project Status |
Completed (Fiscal Year 2023)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
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| Keywords | 生体分子モーター / １分子計測・操作 / エネルギー変換 / 非平衡物理学 / 生物物理 / 生体物質の物理 |
|---|
| Outline of Final Research Achievements |
Kinesins that carry vesicles in cells are biomolecular motors that convert chemical energy into mechanical work. Despite progress in understanding their kinetic mechanisms, our understanding of energy conversion has not progressed. In this study, we constructed a mathematical model to explain nontrivial phenomena such as internal dissipation and fluctuation-induced acceleration of kinesins, which we found in our previous studies and in other projects. As a result, we succeeded in constructing a model that can explain various experimental results while satisfying thermodynamic requirements.
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| Academic Significance and Societal Importance of the Research Achievements |
エネルギーをいかにして効率よく利用するのかは、人類にとって重要な課題である。生物が作りだす小さな分子モーターは、環境の熱揺らぎを有効に使いながら化学的なエネルギーを力学的な仕事へと効率よく変換している。その仕組みを実験と理論を通じてミクロなスケールから理解することは、人類が今まで活用していなかったエネルギー利用の仕組みを、将来的に応用可能としうる意義を持つ。
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