Study on the self-organization and heat generation of magnetic nanoparticles for hyperthermia application

• Project/Area Number: 18K03991
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 19020:Thermal engineering-related
• Research Institution: Toyo University
• Principal Investigator: Morimoto Hisao 東洋大学, 理工学部, 教授 (00385957)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 磁性ナノ粒子 / 温熱療法 / 自己配列化 / 交流磁場

Outline of Final Research Achievements

In this study, the self-organization and the heat generation of ferromagnetic nanoparticles subjected to a radio frequency alternating magnetic field were investigated numerically and experimentally aimed at application to magnetic hyperthermia for cancer therapy. It was found that ferromagnetic nanoparticles formed clusters under an ac magnetic field and the heat generation efficiency of the nanoparticles was varied depending on the cluster structures. The dependence of the cluster structures and the amount of heat generated by the nanoparticles on the experimental parameters such as the amplitude of the ac magnetic field and the volume fraction of the nanoparticles was analyzed and the effect of the cluster formation on the heat generation efficiency of the nanoparticles was clarified.

Academic Significance and Societal Importance of the Research Achievements

近年，交流磁場中における強磁性ナノ粒子の発熱を利用したガンの温熱療法に関する研究が数多く行われているが，それらの多くは粒子個々の機能をより高めることによってガン治療の効率化を図ろうとするものである．一方，本研究では粒子集団の振る舞いに着目し，強磁性ナノ粒子の自己組織化が粒子の発熱効率におよぼす効果を解析した．本研究成果は従来研究にて開発された様々な新規磁性ナノ粒子にももちろん適用可能であり，粒子個々の機能と集団としての機能を組み合わせることによって温熱治療のさらなる効率化，さらにはナノ粒子を利用した新たなガン治療法の開発に繋がるものと期待される．

Research Products

• [Journal Article] Nonequilibrium cluster structures formed in a thin magnetorheological fluid layer subjected to a dc magnetic field (2020)
  • Author(s): Ukai Tomofumi、Dong Jun、Maekawa Toru、Morimoto Hisao
  • Journal Title: AIP Advances Volume: 10 Issue: 5 Pages: 055012-055012
  • DOI: 10.1063/1.5144574
  • Peer Reviewed / Open Access
• [Presentation] Enzymatic activity and thermostability of α-amylase used as a cross-linker for the creation of ferromagnetic nanoparticle clusters (2019)
  • Author(s): M. Suzuki, T. Mizuki, T. Maekawa and H. Morimoto
  • Organizer: An International Conference on Colloid & Surface Science (OKINAWA COLLOIDS 2019)
  • Int'l Joint Research
• [Presentation] Immobilization of α-amylase on ferromagnetic colloidal particles and its enzymatic activity under an ac/dc combined magnetic field (2019)
  • Author(s): M. Karube, M. Suzuki, T. Mizuki, T. Maekawa and H. Morimoto
  • Organizer: An International Conference on Colloid & Surface Science (OKINAWA COLLOIDS 2019)
  • Int'l Joint Research
• [Presentation] Two-dimensional percolation in a thin magnetorheological fluid layer induced by an external dc magnetic field (2019)
  • Author(s): Y. Hamada, T. Ukai and H. Morimoto
  • Organizer: An International Conference on Colloid & Surface Science (OKINAWA COLLOIDS 2019)
  • Int'l Joint Research
• [Presentation] Active control of cluster patterns formed by magnetic particles in a fluctuating magnetic field (2019)
  • Author(s): A. B. Salah, T. Ukai, S. Kurosu, H. Morimoto and T. Maekawa
  • Organizer: An International Conference on Colloid & Surface Science (OKINAWA COLLOIDS 2019)
  • Int'l Joint Research
• [Presentation] Clusters formed by superparamagnetic colloidal particles in a thin magnetorheological fluid layer induced by a dc magnetic field (2019)
  • Author(s): T. Ukai, Y. Hamada, T. Maekawa and H. Morimoto
  • Organizer: An International Conference on Colloid & Surface Science (OKINAWA COLLOIDS 2019)
  • Int'l Joint Research
• [Presentation] Controlled pattern formation consisting of fullerene on a substrate via the coffee-ring effect (2019)
  • Author(s): S. Kurosu, H. Morimoto, K. Takahashi and T. Maekawa
  • Organizer: An International Conference on Colloid & Surface Science (OKINAWA COLLOIDS 2019)
  • Int'l Joint Research
• [Presentation] Cluster formation and enzymatic activity of enzyme/ferromagnetic particle hybrids under an ac/dc combined magnetic field (2018)
  • Author(s): M. Karube, M. Suzuki, T. Mizuki, T. Ukai, T. Maekawa and H. Morimoto
  • Organizer: 13th International Conference on Surfaces, Coatings and Nanostructured Materials (NANOSMAT)
  • Int'l Joint Research
• [Presentation] Formation of concentric patterns composed of fullerene nano-fibres via convective self-assembly (2018)
  • Author(s): S. Kurosu, H. Morimoto, G. Takase, T. Masuda and T. Maekawa
  • Organizer: 13th International Conference on Surfaces, Coatings and Nanostructured Materials (NANOSMAT)
  • Int'l Joint Research
• [Presentation] PCR utilizing the photothermal effect of carbon-encapsulated iron nanoparticles (2018)
  • Author(s): T. Kawamata, M. Suzuki, T. Mizuki, T. Maekawa and H. Morimoto
  • Organizer: 13th International Conference on Surfaces, Coatings and Nanostructured Materials (NANOSMAT)
  • Int'l Joint Research
• [Presentation] Nanostructures composed of enzyme and ferromagnetic nanoparticles, and their enzymatic activity under external magnetic fields (2018)
  • Author(s): M. Suzuki, T. Mizuki, T. Maekawa and H. Morimoto
  • Organizer: 13th International Conference on Surfaces, Coatings and Nanostructured Materials (NANOSMAT)
  • Int'l Joint Research
• [Presentation] Structures formed via self-assembly in a superparamagnetic colloidal suspension subjected to an external magnetic field (2018)
  • Author(s): T. Ukai, Y. Hamada, T. Maekawa and H. Morimoto
  • Organizer: 13th International Conference on Surfaces, Coatings and Nanostructured Materials (NANOSMAT)
  • Int'l Joint Research
• [Presentation] Activation of enzymes utilizing magnetic particles (2018)
  • Author(s): H. Morimoto
  • Organizer: Workshop "New Opportunities for Interdisciplinary Research in BIO-NANO-SCIENCE", Politehnica University of Timisoara
  • Invited