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Development of intensity-modulated radiation therapy treatment planning by actively utilizing nonlinear dynamics

Research Project

Project/Area Number 18K04169
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 21030:Measurement engineering-related
Research InstitutionThe University of Tokushima

Principal Investigator

YOSHINAGA Tetsuya  徳島大学, 大学院医歯薬学研究部(医学域), 教授 (40220694)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords強度変調放射線治療計画 / 最適化問題 / 微分方程式 / 非線形問題 / 強度変調放射線治療 / 数理工学 / 計測工学 / 医療・福祉
Outline of Final Research Achievements

We give a novel approach for obtaining an intensity-modulated radiation therapy (IMRT) optimization solution. The proposed method can handle not only dose-volume but also mean-dose constraints directly in IMRT treatment planning. A theoretical proof for the convergence to an equilibrium corresponding to the desired IMRT planning is given. By introducing the concept of acceptable and by using the proposed method for an acceptable IMRT planning, one can resolve the issue that the objective and evaluation are different in the conventional planning process. Moreover, in the case where the target planning is totally unacceptable and partly acceptable except for one group of dose constraints, we give a procedure that enables us to obtain a nearly optimal solution close to the desired solution for unacceptable planning. The performance of the proposed approach for an acceptable or unacceptable planning is confirmed through numerical experiments simulating a clinical setup.

Academic Significance and Societal Importance of the Research Achievements

強度変調放射線治療は,少ない副作用で高い効果が得られる がん治療法として高精度化が期待されている.本研究において,腫瘍組織には高い線量を正確に照射し,正常組織にはより少ない線量に抑えることが可能となる新しい演算法を考案した.従来法の課題であった線量制約条件を再設定して演算を繰り返す試行錯誤の手続きが無くなり,線量体積制約を直接の評価関数とした逆問題に基づく高精度な治療計画法が開発できた.

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (21 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (6 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 6 results,  Open Access: 5 results) Presentation (13 results) (of which Int'l Joint Research: 10 results) Remarks (1 results)

  • [Int'l Joint Research] Tanta University(エジプト)

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Hybrid Euler Method for Discretizing Continuous-Time Tomographic Dynamical System2020

    • Author(s)
      Kasai Ryosuke、Yamaguchi Yusaku、Kojima Takeshi、Yoshinaga Tetsuya
    • Journal Title

      Journal of Signal Processing

      Volume: 24 Issue: 4 Pages: 183-186

    • DOI

      10.2299/jsp.24.183

    • NAID

      130007873169

    • ISSN
      1342-6230, 1880-1013
    • Year and Date
      2020-07-15
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intensity-Modulated Radiation Therapy Optimization for Acceptable and Remaining-One Unacceptable Dose-Volume and Mean-Dose Constraint Planning2020

    • Author(s)
      Nakada Ryosei、Abou Al-Ola Omar M.、Yoshinaga Tetsuya
    • Journal Title

      Computational and Mathematical Methods in Medicine

      Volume: 2020 Pages: 1-14

    • DOI

      10.1155/2020/3096067

    • NAID

      120006999405

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Extended ordered-subsets expectation-maximization algorithm with power exponent for noise-robust image reconstruction in computed tomography2019

    • Author(s)
      Yusaku Yamaguchi, Moe Kudo, Takeshi Kojima, Omar M. Abou Al-Ola and Tetsuya Yoshinaga
    • Journal Title

      Radiation Environment and Medicine

      Volume: 8 Pages: 105-112

    • NAID

      40022011708

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Tomographic Inverse Problem with Estimating Missing Projections2019

    • Author(s)
      Kimura Masashi、Yamaguchi Yusaku、Abou Al-Ola Omar M.、Yoshinaga Tetsuya
    • Journal Title

      Mathematical Problems in Engineering

      Volume: 2019 Issue: 1 Pages: 1-11

    • DOI

      10.1155/2019/7932318

    • NAID

      120006814113

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Tomographic Image Reconstruction Based on Minimization of Symmetrized Kullback-Leibler Divergence2018

    • Author(s)
      Kasai Ryosuke、Yamaguchi Yusaku、Kojima Takeshi、Yoshinaga Tetsuya
    • Journal Title

      Mathematical Problems in Engineering

      Volume: 2018 Pages: 1-9

    • DOI

      10.1155/2018/8973131

    • NAID

      120006814112

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chaotic Itinerancy Observed in Mutually Coupled Gaussian Maps2018

    • Author(s)
      Kobayashi Mio、Yoshinaga Tetsuya
    • Journal Title

      International Journal of Bifurcation and Chaos

      Volume: 28 Issue: 04 Pages: 1830011-1830011

    • DOI

      10.1142/s0218127418300112

    • NAID

      120007144492

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 線量体積制約に基づく強度変調放射線治療計画の最適化2021

    • Author(s)
      中田良成,オマル・アボウアルオラ,兒島雄志,吉永哲哉
    • Organizer
      日本放射線腫瘍学会 第34回高精度放射線外部照射部会学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Convergence Study of Iterative Image Reconstruction Algorithm with Power Exponent for Computed Tomography2020

    • Author(s)
      Yusaku Yamaguchi, Kudo Moe, Takeshi Kojima and Tetsuya Yoshinaga
    • Organizer
      2020 RISP International Workshop on Nonlinear Circuits, Communications and Signal Processing
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Hybrid Euler method for discretizing continuous-time tomographic dynamical system2020

    • Author(s)
      Ryosuke Kasai, Yusaku Yamaguchi, Takeshi Kojima and Tetsuya Yoshinaga
    • Organizer
      2020 RISP International Workshop on Nonlinear Circuits, Communications and Signal Processing
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Continuous-time image reconstruction based on Hellinger distance minimization for medical X-ray CT imaging2019

    • Author(s)
      Yusaku Yamaguchi, Moe Kudo, Ryosuke Kasai, Takeshi Kojima and Tetsuya Yoshinaga
    • Organizer
      8th International Conference on Biomedical Engineering and Biotechnology
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Hybrid of ML-EM and MART algorithms for X-ray CT image reconstruction2019

    • Author(s)
      Ryosuke Kasai, Yusaku Yamaguchi, Takeshi Kojima and Tetsuya Yoshinaga
    • Organizer
      8th International Conference on Biomedical Engineering and Biotechnology
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Hybrid algorithm of maximum-likelihood expectation-maximization and multiplicative algebraic reconstruction technique for iterative tomographic image reconstruction2019

    • Author(s)
      Ryosuke Kasai, Yusaku Yamaguchi, Takeshi Kojima and Tetsuya Yoshinaga
    • Organizer
      International Workshop on Advanced Image Technology (IWAIT) 2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Nonautonomous Nonlinear Dynamical System for Reconstructing Magnetic Resonance Image2018

    • Author(s)
      Yusaku Yamaguchi, Michiko Mori, Takeshi Kojima and Tetsuya Yoshinaga
    • Organizer
      International Symposium on Nonlinear Theory and its Applications (NOLTA) 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Discretization of Continuous Analog to Accelerated Expectation-Maximization Algorithm for Computed Tomography2018

    • Author(s)
      Takeshi Kojima, Kiyoko Tateishi, Yusaku Yamaguchi and Tetsuya Yoshinaga
    • Organizer
      International Symposium on Nonlinear Theory and its Applications (NOLTA) 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Nonlinear Dynamical System with Order-Preserving Function for Inverse Problem of Intensity-Modulated Radiation Therapy Treatment Planning2018

    • Author(s)
      Ryosei Nakada, Takeshi Kojima and Tetsuya Yoshinaga
    • Organizer
      International Symposium on Nonlinear Theory and its Applications (NOLTA) 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Total-Variation Minimization with Regularization for Continuous-Time Dynamical Image Reconstruction in Computed Tomography2018

    • Author(s)
      Masashi Kimura, Akira Kinokiri, Takeshi Kojima, Yusaku Yamaguchi and Tetsuya Yoshinaga
    • Organizer
      International Symposium on Nonlinear Theory and its Applications (NOLTA) 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Associative Memory by Using Coupled Gaussian Maps2018

    • Author(s)
      Mio Kobayashi and Tetsuya Yoshinaga
    • Organizer
      2018 5th International Conference on Advanced Informatics: Concept Theory and Applications (ICAICTA)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 一般化ヘリンガー距離の最小化に基づく逐次画像再構成法2018

    • Author(s)
      工藤 萌, 山口 雄作, アボウ アルオラ M. オマル, 兒島 雄志, 吉永 哲哉
    • Organizer
      116th Scientific Meeting of JSMP
    • Related Report
      2018 Research-status Report
  • [Presentation] 連続時間断層画像再構成法の加法的・乗法的及びその混成による離散化2018

    • Author(s)
      山口 雄作, 笠井 亮佑, 兒島 雄志, 吉永 哲哉
    • Organizer
      116th Scientific Meeting of JSMP
    • Related Report
      2018 Research-status Report
  • [Remarks] 徳島大学大学院医歯薬学研究部医用画像機器工学分野Webページ

    • URL

      https://www.tokushima-u.ac.jp/med/health_science/course/iyohoshasen/iyo_gazokiki/

    • Related Report
      2020 Annual Research Report

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

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